열공형과 비열공형 피질하 혈관성 치매에서 위험인자의 차이에 관한 비교 연구

배희준,정지향,유경호,나덕렬,김상윤,최경규,양동원,손의주,이상도,김재우,박경원,김응규,이재홍,박미영,한일우,함동석,최문성,하충건,최성혜,이애영,이병철,한설희 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.2

Backgrounds and Objectives: Vascular dementia is a group of dementing disoders arising from various stroke syndrome. Among these. subcortical ischemic vascular dementia (SIVD) is regarded as a relatively distinct clinical entity. However, MRI patterns of SIVD are not homogenous. In some patients, lacunes are dominant, and in others, subcortical white matter changes are. This study was designed to compare risk factor profiles between SIVD with and without multiple lacunes. Methods: We divided 47 subjects (22 males, mean age. 68 years) recruited from VADAPET (Multicenter Trial For Evaluation Of The Changes In the PET Images Of Subcortical Vascular Dementia Patient) study into two groups one with more than 5 lacunes in deep gray matter (lacune group) and the other with 5 or less(non-lacune group) Clinical characteristics and laboratory findings of two groups were compared. Results: Nineteen of 47 patients (40%) belonged to the lacune group. The lacune and non-lacune groups d d not differ in the following variables: age, hypertension, diabetes mellitus, hyperlipidemia heart disease, history of stroke or TIA, history of trauma or major surgery, family history of hypertension stroke, or dementia, age at diagnosis of dementia, body mass index, white blood cell count, ESR, CRP, fibrinogen, hemoglobin A1C, total cholesterol. LDL cholesterol creatinine, proteinuria, glucosuria, and microhematuria. However, male sex, smoking alcohol. hemoglobin, and HDL cholesterol were possibly associated more with lacune group SIVD than with non-lacune group (p<0 1) Multivariate analyses revealed that smoking, hemoglobin, and HDL cholesterol were independent predictors of SIVD with multiple lacunes Conclusion: Our study suggests that SIVD with multiple lacunes may be significantly different in smoking habits hemoglobin, and HDL cholesterol from SIVD without multiple lacunes.

(AgCu)_0.43-Au_0.54Pd_0.03 합금의 시효경화 특성

배동화,설효정,이희경,김형일,김교한 대한치과기재학회 2001 대한치과재료학회지 Vol.28 No.3

팔라디움이 함유된, 시효경화성 치과주조용 고금합금의 연구를 위한 기초자료를 얻기 위하여, 4원계 □ 합금의 등온시효경화 거동과 상변태를 경도 시험, X선회절 실험으로 조사하여, 다음과 같은 결과를 얻었다. 본 합금을 250~350℃에서 등온시효처리하면, 면심정방구조를 갖는 준안정상 AuCu Ⅰ'형 규칙상이 면심정방구조를 갖는 AuCu Ⅰ형 규칙상과 면심입방구조를 갖는 Ag-rich a₁상이 생성되기 전에 생성되었다. 본 합금은 시효처리 온도에 따라 다른 시효경화 거동을 보여주었다. 350℃에서 시효처리를 하면, 경도는 시효 초기에 상승하지 않았고, 최고 경도에 도달하여 유지되고나서 시효시간을 연장함에 따라 경도가 급격히 저하하였다. 250℃에서 시효처리를 하면, 경도는 시효 초기부터 뚜렷히 상승하기 시작하였다. 그 후, 약간의 경도 하강을 보이고나서 경도는 다시 서서히 상승을 지속하였다. 350℃에서 경화는 준안정상 AuCu Ⅰ'형 규칙상의 균일핵생성에 기인하였다. 낮은 시효온도에서의 초기 경화는 다른 상변태에 의해 초래되었고, 이어서 일어나는 경화는 준안정상 AuCu Ⅰ'형 규칙상의 생성에 기인하였다. 시효시간을 연장함에 따라 생기는 과시효 연화는 평형상 AuCu Ⅰ형 규칙상의 생성에 기인하는 것으로 생각된다.

치과용 고카라트 금합금의 시효경화와 상변태 과정

배동화,설효정,이희경,김형일 대한치과기재학회 1999 대한치과재료학회지 Vol.26 No.1

The hardening behavior and phase transformation process of a dental high carat gold alloy by isothermal ageing treatment were investigated by means of hardness testing, X-ray diffraction study and scanning electron microscopic observations. The following results were obtained. The a single phase with a face centered cubic structure was finally transformed into the coexistence of the Ag-rich α₁phase with a face centered cubic structure and the AuCu I' type ordered phase with a face centered tetragonal superlattice structure by ageing of the solution-treated specimen at 400℃ and 500℃. By ageing at 500℃, the metastable Ag-rich α₁' and AuCu I' type ordered phases were formed prior to the final formation of the equilibrium Ag-rich α₁ and AuCu I type ordered phases . The hardening effect was more significant and the overageing with softening was slower by ageing at 400℃ than 500℃. By ageing at 500℃, the hardening was attributed to the formation of the metastable AuCu I' type ordered phases from the a phase, the overageing with softening was due to the formation of the AuCu I type ordered phase from the metastable Ag-rich α₁' and AuCu I' type ordered phases. By ageing at 500℃, the incubation period which limited the beginning of the hardening in the early stage of ageing existed, and the formation and growth of the precipitates which contributed the overageing with softening were observed concurrently at the grain boundaries and within grains. By ageing at 400℃, the hardening was attributed to the formation of the AuCu I type ordered phase from the a phase, the overageing with softening was due to the growth of the grain boundary precipitates of the lamellar structure composed of the Ag-rich α₁and AuCu I type ordered phases into the grain interior.

월출산국립공원 수질특성에 관한 연구

최형일,김난희,강영주,채희정,김연풍,조도호,설동화 조선대학교 환경공해연구소 2007 環境公害硏究 Vol.20 No.1

Because mountain streams have narrow widths and steep slopes compared to streams and lakes, hours of immobility are considerably short, and the quality of mountain streams has been greatly influenced by rainfall, land-use, components of the streambed and types of forests. During the summer when heavy rainfall occurs, eroded earth and sand flow into mountain streams and cause temporarily high turbidity. It is also the cause of eutrophication, which is frequently found in downstream. As evaluation standards for the quality of mountain streams were not established in Korea, this quality was evaluated by examining some items based on quality standards for drinkable water and research on the influences of pollution in mountain streams, which showed that these were seldom in downstream water systems. Mountain streams within Wolchulsan National Park flow into a reservoir and when characteristics of mountain streams from forests and rainfall that flow into mountain streams through forest ecosystems were studied, results of measuring its changes are as follows. Monthly changes of pH were low between April and August and higher starting October, and the EC was measured higher in the winter and the spring and tended to be low starting April. The EC on the 19th of May and the 23rd of October and the concentration of floating materials and COD_(Mn) were observed to be higher due to the influence of rainfall on the 19th of May and the 22nd of October, and it was judged that the washing out of dried deposits attached to the water pipe and the leaching of woods were influenced by rainfall. It is considered that real-time monitoring of water quality for a long time and water quality conditions during and after rainfall should be examined for ensuring basic data of water quality and evaluating characteristics and seasonableness of mountain streams, which may be greatly changed by artificial influence in the future.

치과주조용 Ag-Pd-Zn-Sn-In 합금의 시효경화 특성

이재호,김명진,이희경,김형일,설효정 大韓齒科器材學會 2004 대한치과재료학회지 Vol.31 No.1

Cu가 첨가되어 있지 않고, 대신에 상대적으로 많은 양의 Zn 그리고 소량의 Sn과 In이 첨가된 치과주조용 Ag-Pd-Zn-Sn-In 합금의 시효경화 특성을 경도 시험, X선회절 실험, 주사전자현미경 관찰, 전자탐침 미소분석법으로 조사하여, 다음과 같은 결과를 얻었다. 1. 950℃에서 용체화처리된 시편을 500℃와 550℃에서 등온시효처리하면, 시효 초기에 경도가 완만히 상승하여 최고 경도에 도달하였고 최고 경도를 일정 기간 유지하고 나서 서서히 하강하였다. 2. 용체화처리된 시편은 Pd 원자가 고용된 Ag-rich α1상, Pd3Sn인 α2상, Pd2Zn인 α3상의 3상 공존이었고, 등온시효처리함에 따라 Ag-rich α1상에서 Pd-rich 상으로 추정되는 β상이 석출하였다. 3. 시효 초기의 경화는 Ag-rich 기지에서 Pd-rich 상의 석출로 인한 격자변형에 기인하는 것으로 추정된다. 4. 시효처리 시간을 연장함에 따른 과시효 연화는 입계에 Ag-rich α1상과 Pd-rich β상으로 된 층상조직의 석출과 조대화에 기인하였다. 5. Pd3Sn인 α2상과 Pd2Zn인 α3상은 시효경화에 기여하지 않았다. Age-hardening characteristics of a dental casting Ag-Pd-Zn-Sn-In alloy without copper (52.0 wt% Ag - 39.9 wt% Pd - 4.0 wt% Zn - 2.0 wt% Sn - 2.0 wt% In - 0.1 wt% Ir) was investigated by means of hardness test, X-ray diffraction study, scanning electron microscopic observations and electron probe microanalysis. The specimen solution-treated at 950℃ was three phases of the Ag-rich α1 phase containing Pd element, the α2 phase based on Pd3Sn and the α3 phase based on Pd2Zn, and the Pd-rich β phase was precipitated from the Ag-rich α1 phase by the isothermal ageing,. The initial hardening seemed to be attributed to coherency strains which were formed in the Ag-rich matrix by the precipitation of Pd-rich phase. Overageing with softening was due to the formation and coarsening of the lamella precipitates at grain boundaries, which were composed of the Ag-rich α1 and Pd-rich β phases. The α2 phase based on Pd3Sn and the α3 phase based on Pd2Zn did not contribute to the age-hardening of this alloy.

한랭작업 근로자들의 건강위해에 관한 연구

박호추,정설미,문덕환,이종태,김대환,김정호,최재일,황용식,이용희,이채언 大韓産業醫學會 1999 대한직업환경의학회지 Vol.11 No.1

In order to evaluate the status of cold exposure and its health hazards of workers at cold storage workplaces and to provide basic data for effective health care, the author measured core temperature and also observed clinical symptoms and signs, past and present history, and general health examination data on 99 cold exposed workers for exposure group and 96 non-exposed workers for control group working at 2 food refrigerating companies in Pusan area from January 6, 1998 to February 24, 1998. The results were as follows: 1. There was statistically significant difference in water intake between the exposure and control group and increased urine volume, urine frequency in exposure group without statistically significant difference. 2. Past and present illness in exposure group were hypertension (18.2%), hepatopathy (8.1%), gastro-intestinal disease(7.1%), arthritis (4.0%), intervertebral disc herniation(4.0%), and so on, and hypertension, arthritis was statistically significant difference compared to control group. 3. Symptoms in exposure group were fatigue(89.9%), headache (64.6%). drowsy(63.6%), neck stiffness(59.6%), excessive food intake(59.6%). general weakness(58.6%), hunger(58.6%), numbness(54.5%), and so on, and there was statistically significant difference between the exposure and control group except fatigue, drowsy. 4. As results of clinical test abnormality rate of the systolic, diastolic blood pressure and electrocardiogram were significantly higher in exposed group than control. 5. Core temperature in exposure group was statistically significantly lower than control group and the highest statistically significant inverse correlation with the working hours and working frequency of daily mean cold storage. As above results, the author suggested that the further studies should be conducted to evaluate the health status of workers about chronic health effects in cold workplaces and to establish effective health care methods for them.

도로교통소음의 수평·수직적 전달 및 감쇠 특성

최형일,채희정,김연풍,조도호,설동화,정숙경,김정애 조선대학교 생산기술연구소 2007 生産技術硏究 Vol.29 No.1

This study has been conducted to achieve the following objectives: First, in order to understand the horizontal propagation and attenuation characteristics for the road traffic noise, we selected actively developed areas within 100 meters away from the road to measure the level of traffic noise near a road. To measure the noise near a railroad, we selected areas within 100 meters away from the road. In this way, we analyzed the horizontal propagation and attenuation characteristics for the traffic noise occurring in diversified areas. Second, in order to understand the vertical propagation and attenuation characteristics for the road traffic noise, we measured and analyzed the distributional characteristics of vertical sound pressure levels on each floor of multi-storied apartment buildings according to changes of traffic load and types, and the existence or nonexistence of soundproof walls. For the case of the road traffic noise, we also selected we measured and analyzed the different noise levels on each floor of multi-storied apartment buildings from the soundproof wall. The results of Horizontal propagation and attenuation characteristics for the road traffic noise are as follows: In cases of the soundproof wall + raising ground, raising ground, cutting land, and flat land as distance increases, the sound pressure level steadily decreases. The soundproof wall + raising ground has an especially high distance decrease compared to the other areas, and the sound pressure level for the raising ground is higher than that of the cutting land with a measurement of 10.7~12.1dB(A). Vertical propagation and attenuation characteristics for the road traffic noise are as follows: The amount of sound pressure level decrease is 12.6- 14.5dB(A) for first floor when measuring the vertical sound pressure levels at soundproof wall, which indicates a fairly large decrease. At fifth and sixth floor, the amount of decrease is 2.3dB(A), which indicates a small decrease.

Epstein-Barr Virus 감염 Burkitt’s Lymphoma 세포주에 Mitomycin C 처리 시 종양유전자 발현

염범우,박설희,김민경,김철환,김인선,이대일 대한병리학회 2001 Journal of Pathology and Translational Medicine Vol.35 No.4

혈관평활근세포에서 산화에너지대사 억제에 의한 아밀로이드전구단백질 대사의 변화

한문구,최웅,김헌식,안희열,한설희 대한치매학회 2002 Dementia and Neurocognitive Disorders Vol.1 No.1

Background: A reduction in the activity of cytochrome c oxidase(COX) has been recently identified in mitochondria from platelets and postmortem brain tissue of AD patients Sodium azide (NaN₃). a COX inhibitor, is an effective chemical agent producing energy shortage and oxidative stress both in vitro and in vivo system Furthermore it has been suggested that vascular compromise could be either directly involved AD pathogenesis or indirectly associated with triggering pathogenetic events leading to AD This study was performed to investigate amyloid precursor protein (APP) metabolism by inhibition of mitochondrial energy metabolism in cultured vascular smooth muslce cells (VSMCs) Materials and Methods: VSMCs isolated from the aorta of seven weeks old Spraque-Dawley rat were treated with NaN₃in a low concentration (100-500μM) or in a high concentration (1-100mM) Cellular proliferation and viability were determined by MTS (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenly)-2H-tetrazolium) assay Cellular APP was detected with N-terminal specific antibody 22C11. Celldeath was determined by observation of morphology and terminal deoxynucleotidyl transferase-mediated dUTP-fluorescein nick end labeling stain (TUNEL) We used ginkgo biloba extract(EGb761) and melatonin as anti-oxidants to investigate the mechanism of latered APP metabolism Results: The viability of VSMCs was increased after treatment with 1 mM and 10mM NaN₃(p<0.05) unitl 3 hr and then dimnished Many TUNEL positive cells were found in 10mM and 100mM treatment group. but were not apoptotic in nature 22C11 immunoreactivity was not changed at 3 hr, 6hr, 12hr Anti-oxidants reduced cellular proliferation (p<0.05). but did not block TUNEL positivities and did not influence the 22C11 immunoreactivity In a low concentration NaN₃ treatment group the viability of VSMCs was increased concentration dependently(p<0.05) Immunoblot with 22C11 showed the concentration dependent decrease at 145 kDa, 125 kDa. and high molecular weight range (>160kDa) TUNEL staining showed DNA fragmentations and condensations of nuclear chromatin suggesting apoptosis After treatment with anti-oxidants, the cellular proliferation was more decreased (p<0.05), and TUNEL positive cell deaths were blocked Immunoreactivities of 125 kDa (immature APP). 145 kDa (mature APP). and higher molecular weight bands were recovered below 400μM of NaN₃ Immunoreactivity of 145 kDa was recovered in 100 μM NaN₃ treated group Conclusions: The presumed mechanism of low concentration COX inhibitor is the overproduction of reactive oxygen species resulting from a depression of the mitochondiral electron transport chain. whereas potential consequence of high concentration COX inhibitor might be related to decreassion of ATP synthesis and bioenergetic impairment Reactive oxygen radicals in response to low concentration COX inhibitor alter the processing of APP in VSMCs This investigation demonstrated analtered APP metabolism as a peripheral marker of AD Therefore VSMCs treated with low concentration COX inhibitor could be concsidered as a novel in vitro model of AD.

加味鷄血藤湯이 Glutamate receptor와 Free radical 및 뇌손상 보호에 미치는 영향

안종석,김동희,김윤식,이용구,박종오,남궁욱,설인찬 대한동의병리학회 2003 동의생리병리학회지 Vol.17 No.3

This study was investigated to prove the effect of GMGHT on the gultamate receptor, free radical and brain damage in rats sujected to Brain Ischemia The results were as follows ; 1. GMGHT showed significant inhibitory effect of GMGHT on LDH release induced by NMDA, AMPA, and kinate. 2. GMGHT showed significant inhibitory effect of GMGHT on LDH release induced by BSO and Fe^2+. 3. GMGHT decreased coma duration time in a infatal dose of KCN and showed 30% of survival rate in a fatal dose. 4. GMGHT decreased ischemic area and edema incited by the MCA blood flow block. 5. GMGHT showed improvement of forelimb test after MCA occulusion in neurological exemination. 6. GMGHT showed no significant change after MCA occulusion in pathological observation as normal group. These results indicate that GMGHT can be used in the brain damage sujected to Brain Ischemia. Further study will be needed about the functional mechanism and etc.