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Metabolic Acidosis and Long-Term Clinical Outcomes in Kidney Transplant Recipients
Park, Seokwoo,Kang, Eunjeong,Park, Sehoon,Kim, Yong Chul,Han, Seung Seok,Ha, Jongwon,Kim, Dong Ki,Kim, Sejoong,Park, Su-Kil,Han, Duck Jong,Lim, Chun Soo,Kim, Yon Su,Lee, Jung Pyo,Kim, Young Hoon American Society of Nephrology 2017 Journal of the American Society of Nephrology Vol.28 No.6
Park, Jung Tak,Lee, Hajeong,Kee, Youn Kyung,Park, Seokwoo,Oh, Hyung Jung,Han, Seung Hyeok,Joo, Kwon Wook,Lim, Chun-Soo,Kim, Yon Su,Kang, Shin-Wook,Yoo, Tae-Hyun,Kim, Dong Ki,Jo, Hyung Ah,Han, Miyeun,L Elsevier 2016 American Journal of Kidney Diseases Vol.68 No.4
<P><B>Background</B></P> <P>Soluble inflammatory mediators are known to exacerbate sepsis-induced acute kidney injury (AKI). Continuous renal replacement therapy (CRRT) has been suggested to play a part in immunomodulation by cytokine removal. However, the effect of continuous venovenous hemodiafiltration (CVVHDF) dose on inflammatory cytokine removal and its influence on patient outcomes are not yet clear.</P> <P><B>Study Design</B></P> <P>Prospective, randomized, controlled, open-label trial.</P> <P><B>Setting & Participants</B></P> <P>Septic patients with AKI receiving CVVHDF for AKI.</P> <P><B>Intervention</B></P> <P>Conventional (40mL/kg/h) and high (80mL/kg/h) doses of CVVHDF for the duration of CRRT.</P> <P><B>Outcomes</B></P> <P>Patient and kidney survival at 28 and 90 days, circulating cytokine levels.</P> <P><B>Results</B></P> <P>212 patients were randomly assigned into 2 groups. Mean age was 62.1 years, and 138 (65.1%) were men. Mean intervention durations were 5.4 and 6.2 days for the conventional- and high-dose groups, respectively. There were no differences in 28-day mortality (HR, 1.02; 95% CI, 0.73-1.43; <I>P</I> =0.9) or 28-day kidney survival (HR, 0.96; 95% CI, 0.48-1.93; <I>P</I> =0.9) between groups. High-dose CVVHDF, but not the conventional dose, significantly reduced interleukin 6 (IL-6), IL-8, IL-1b, and IL-10 levels. There were no differences in the development of electrolyte disturbances between the conventional- and high-dose groups.</P> <P><B>Limitations</B></P> <P>Small sample size. Only the predilution CVVHDF method was used and initiation criteria were not controlled.</P> <P><B>Conclusions</B></P> <P>High CVVHDF dose did not improve patient outcomes despite its significant influence on inflammatory cytokine removal. CRRT-induced immunomodulation may not be sufficient to influence clinical end points.</P>
Bilateral, multifocal renal tumors diagnosed as Birt-Hogg-Dubi syndrome by genetic analysis
( Seokwoo Park ),( Sehoon Park ),( Eunjeong Kang ),( Dong Ki Kim ),( Kwon Wook Joo ),( Yon Su Kim ),( Hajeong Lee ) 대한내과학회 2015 대한내과학회 추계학술대회 Vol.2015 No.1
Birt-Hogg-Dubi syndrome (BHD) is an autosomal dominant cancer susceptibility syndrome characterized by skin fibrofolliculomas, pulmonary cysts and spontaneous pneumothorax, and renal cancers. The syndrome is caused by various mutations of the FLCN gene located in 17p11.2 encoding folliculin. The risk of renal cancer is seven times higher in BHD-affected patients. Bilateral, multifocal and chromophobe renal cell carcinoma is characteristic of renal cancers in BHD. Among about 110 pathogenic mutations reported in BHD, only twenty six of them have been associated with renal cancer. In this study, we described a case of 50-year-old woman with chromophobe renal cell carcinoma who had c.1557delT mutation in the FLCN gene. A 50-year-old-woman presented with flank pain for the past 2 weeks. Computed tomography (CT) of her abdomen and pelvis showed multifocal tumors with heterogeneous enhancement in both kidneys, including a 3.5-cm mass on the upper pole of the right kidney. To differentiate metastatic cancer from primary kidney tumors, we performed positron emission tomography (PET)-CT, which showed no other hypermetabolic lesions. Her chest CT showed a few lentiform cysts of up to 1.5 cm in both lower lungs. A needle biopsy revealed that the 3.5-cm mass was a chromophobe renal cell carcinoma. Given multifocal distribution of the renal cell carcinoma, we suspected an inherited type of kidney cancer, such as Von Hippel-Lindau disease or BHD. In the current case, the cystic change of both lungs and chromophobe renal cell carcinoma pointed towards the possibility of BHD. DNA sequencing of the entire FLCN gene using mononuclear cells found out a heterozygous c.1557delT mutation in exon 14 [p.Phe (TTT) 519Leu (TTA) fs*18]. A son and a daughter of the patient also went through the genetic analysis which illustrated the same mutation, although both of them did not have any clinical signs suggesting BHD. Considering that renal cancer might be the principal determinant of life expectancy, early suspicion and diagnosis of BHD is crucial. In our patient, identification of genetic mutation aided in the diagnosis which is novel DNA sequence variation in BHD-associated renal cancers.
Park, Woon Ik,Yoon, Jong Moon,Park, Moonkyu,Lee, Jinsup,Kim, Sung Kyu,Jeong, Jae Won,Kim, Kyungho,Jeong, Hu Young,Jeon, Seokwoo,No, Kwang Soo,Lee, Jeong Yong,Jung, Yeon Sik American ChemicalSociety 2012 Nano letters Vol.12 No.3
<P>We report the direct formation of ordered memristor nanostructureson metal and graphene electrodes by a block copolymer self-assemblyprocess. Optimized surface functionalization provides stacking structuresof Si-containing block copolymer thin films to generate uniform memristordevice structures. Both the silicon oxide film and nanodot memristors,which were formed by the plasma oxidation of the self-assembled blockcopolymer thin films, presented unipolar switching behaviors withappropriate set and reset voltages for resistive memory applications.This approach offers a very convenient pathway to fabricate ultrahigh-densityresistive memory devices without relying on high-cost lithographyand pattern-transfer processes.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/nalefd/2012/nalefd.2012.12.issue-3/nl203597d/production/images/medium/nl-2011-03597d_0003.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nl203597d'>ACS Electronic Supporting Info</A></P>
Park, Junyong,Park, Jae Hong,Kim, Eunhye,Ahn, Chi Won,Jang, Hyun Ik,Rogers, John A.,Jeon, Seokwoo WILEY‐VCH Verlag 2011 Advanced Materials Vol.23 No.7
<P><B>Defect‐free and dense micropillar arrays with a high aspect ratio</B> are replicated from etched Si masters using high‐modulus polyurethane acrylate. The newly designed conformable solid‐index mask can generate high‐resolution 3D nanostructures that can be patterned through proximity field nanopatterning (PnP) in a single exposure step. The superb optical property proves the quality of 3D nanostructures. </P>
Park, Sehoon,Kim, Myoung-Hee,Kang, Eunjeong,Park, Seokwoo,Jo, Hyung Ah.,Lee, Hajeong,Kim, Sun Moon.,Lee, Jung Pyo.,Oh, Kook-Hwan,Joo, Kwon Wook.,Kim, Yon Su.,Kim, Dong Ki. Wolters Kluwer Health 2016 Medicine Vol.95 No.18
<P><B>Abstract</B></P><P>Conflicting data have been reported on the clinical significance of contrast-induced nephropathy after CT scan (CT-CIN). In addition, the epidemiologic characteristics and clinical outcomes of CT-CIN following proper prophylactic intervention remain elusive.</P><P>We examined the incidence, risk factors, and outcomes of CT-CIN in stable chronic kidney disease (CKD) patients using data collected from our outpatient CT-CIN prophylaxis program conducted between 2007 and 2014. The program recruited patients with an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m<SUP>2</SUP> using an electronic health record-based pop-up alert system and provided an identical protocol of CIN prophylaxis to all patients.</P><P>A total of 1666 subjects were included in this study, and 61 of the 1666 subjects (3.7%) developed CT-CIN. Multivariate analysis showed that baseline eGFR, diabetes mellitus, and low serum albumin were significant risk factors for CT-CIN. The generalized additive model analysis revealed a nonlinear relationship between the baseline eGFR and the risk of CT-CIN. In this analysis, the risk of CT-CIN began to increase below an eGFR threshold of 36.8 mL/min/1.73 m<SUP>2</SUP>. To assess the outcomes of CT-CIN, patients with and without CT-CIN were compared after propensity score-based 1:2 matching. CT-CIN did not increase the mortality rate of patients. However, patients with CT-CIN were significantly more likely to start dialysis within 6 months of follow-up, but not after those initial 6 months.</P><P>CT-CIN developed in only a small number of stable CKD patients who received proper prophylactic intervention, and the risk of CT-CIN was increased in patients with more advanced CKD. Despite the low incidence, CT-CIN conferred a non-negligible risk for the initiation of dialysis in the acute period, even after prophylaxis.</P>
Synthesis and Property of New Propeller Shaped Emitting Materials for Organic Light-Emitting Devices
Kang, Seokwoo,Lee, Hayoon,Kim, Beomjin,Park, Youngil,Park, Jongwook American Scientific Publishers 2016 Journal of nanoscience and nanotechnology Vol.16 No.3
<P>New propeller type emitting compound, namely 3,6-di-anthracen-9-yl-9,10-bis-(4-anthracen-9-yl-phenyl)-phenanthrene[TAnDAP] and 3,6-bis-(10-phenyl-anthracen-9-yl)-9,10-bis-[4-(10-phenylanthracen-9-yl)-phenyl]-phenanthrene [TAnPDAP] were synthesized through Suzuki and McMurry reactions. We investigated their physical properties such as optical, electrochemical, and electroluminescent properties. The two compounds were used as an emitting layer in OLED devices: ITO/2-TNATA (60 nm)/NPB (15 nm)/non-doped: TAnDAP or TAnPDAP (35 nm)/Alq3 (20 nm)/LiF (1 nm)/Al (200 nm). The TAnDAP OLED device showed C.I.E. value of (0.28, 0.41) and luminance efficiency of 3.81 cd/A at 10 mA/cm(2). The TAnPDAP device showed C.I.E. value of (0.20, 0.27) and high luminance efficiency of 5.40 cd/A at 10 mA/cm(2). TAnPDAP was found to show better luminance efficiency and C.I.E. value than TAnDAP because it has a bulky 9-phenylanthracene.</P>