알레르기비염 환자에서 집먼지진드기와 쑥화분에 대한 MAST, 피부단자시험 및 비유발시험 간의 연관성에 관한 연구

장태영,최윤석,김경태 대한천식 및 알레르기학회 2004 천식 및 알레르기 Vol.24 No.1

Objective : Allergic rhinitis is one of the most common diseases in the field of otorhinolaryngology. Correct diagnosis for allergic rhintis is important for its optimal management. Many stuides have been reported for the diagnosis with allergens. This study was performed to identify the relationship between MAST. the skin test, and the nasal provocation test. We attempted to find an appropriate diagnostic method for finding causative allergens. Method : We reviewed the medical records of patients with allergic rhinitis symptoms and physical findings from August 2001 through July 2002 at Inha University Hospital. We selected 197 patients who were examined with MAST, the skin prick test, and the nasal provocation test. The relationship between these tests was detremined with SPSS (Ver 10.0). Results : There was a significant correlation between MAST and the skin prick test (F<.05). There were also significant correlations between MAST and the nasal provocation test, and between the skin prick test and the nasal provocation test(F<.05). Conclusion : MAST might be a useful diagnostic method for finding causative allergens, especially in children and patients with skin hypersensitivity and other skin disorders. (J Asthma Allergy Clin Immunol 24 : 110-5, 2004)

거대 긴장성 낭종으로 내원한 폐 Langerhans 세포 조직주증

양석철,손장원,윤호주,신동호,박성수,함시영,장세진,박용욱 한양대학교 의과대학 2000 한양의대 학술지 Vol.20 No.1

Pulmonary Langerhans cell histiocytosis is a hetergenous group of conditions of unknown etiology characterized by an abnormal proliferation of antigen presenting cell of bone marrow derivation known as Langerhans cells that invade and destroy distal bronchioles. The outcome is highly variable, ranging from rapid spontaneous resolution to irreversible respiratory failure. We describe a patient with biopsy-confirmed pulmonary Langerhans cell histiocytosis who presented with large tension cyst, treated with pneumothorax tube with Heimlich flutter valve.

겨울철 주택내 유기화합물 공기오염농도에 관한 측정연구 : 서울시내 96채의 주택을 대상으로 In case of 96 houses in Seoul

전정윤,박준석,손장열,池田耕一 대한건축학회 2004 대한건축학회논문집 Vol.20 No.5

Measurements on indoor organic compounds air pollution level in 96 houses were conducted. Houses which measurement carried out were collected based on the survey results about house type and constructed year in Seoul city. Indoor air organic compounds were monitored with two diffusive samplers. One was a cartridge treated with 2,4-initrophenylhydrazine for aldehydes sampling. The other was a passive charcoal tube for VOCs sampling. Two samplers were simultaneously exposed in living room during 24 hours. Aldehydes extracted with 2ml acetonitrile from the cartridge were analyzed by HPLC equipped with an UV diode array detector. VOCs were extracted with 2ml carbon disulfide from the charcoal tube by shaking and then analyzed by chromatograph and mass selective detector. The main Results were as follows; 1) Formaldehyde were detected in more than 90% of all homes, and average value of detected level was 54.92ppb. This alue is lower than ASHRAE guideline (100ppb) and WHO guideline (80ppb). 2) Toluene were detected in all homes, and EthylAcetate, 1-Butanol, ethylbenzene, p-Xylene, D-limonen were detected more than 50% of all homes. 24 hours averaged level of sum of VOCs was 179.96㎍/㎥, and this value is lower than WHO‘s TVOC(Total Volatile Organic Compounds) guideline (300㎍/㎥). 3) Mostly frequent detective level of formaldehyde was between 50-60㎍/㎥, and 84.09% of all homes showed lower level than WHO guideline. 4) Mostly frequent detective level of sum of VOCs was between 100-150㎍/㎥, and 86.46% of all homes showed lower level than WHO's TVOCs guideline.

Pastry 마가린 함량과 적층 수에 따른 puff pastry 제조 특성

한장호,김석영,윤여창,이시경 한국응용생명화학회 2003 Applied Biological Chemistry (Appl Biol Chem) Vol.46 No.4

Puff pastry의 제조 공정에서 pastry 마가린 함량과 적층 수의 변화가 제품의 수분 함량, 굽기 손실, 부피, vapor action 등에 미치는 영향을 조사하였다. Pastry 마가린 함량이 90%로 동일하고 적층 수가 27결일 경우 10.8±0.6%의 수분 함량을 나타냈으며, 1024결일 경우 16.7±0.3%로 적층 수가 증가할수록 제품의 수분함량은 증가 하는 경향을 보였다. 적층 수를 256결로 동일하게 하고, pastry 마가린 함량이 50%일 경우는 17.3±0.5%로 나타났으며, 130%에서는 7.5±0.2%로 pastry 마가린 함량이 증가할수록 제품의 수분 함량은 감소하였다. Pastry 마가린 함량을 70%로 동일하게 했을 때 굽기 손실의 변화는 27결일 경우 25.0±0.7%로 나타났으며, 1024결일경우엔 18.8±0.6^로 나타나 적층 수가 증가할수록 제품의 굽기 손실은 감소하는 경향을 보였다. 적층 수를 27결로 동일하게 한 경우에서는 pastry 마가린 함량이 90%일 때 25.4±0.4%의 굽기 손실이 발생하였으며, 110%에서 26.9±0.4%로 굽기 손실이 가장 높게 나타났다. Pastry 마가린 함량이 130%이고 적층수가 81결일 때에 21.87±0.79㎖/g로 최대의 부피를 나타내었다. 또한 vapor action의 크기는 9.15㎜가 pastry 마가린 함량 110%, 적층 수 256결에서 8.25±0.50개로 가장 많이 나타났다. This study was carried out to investigate the effect of pastry margarine content and number of layers on moisture content, baking loss. specific loaf volume and the vapor action in the manufacturing process of puff pastry. As the number of layers of the puff pastry increased the moisture content of the products slightly increased. And the moisture contents of the products decreased, as the pastry margarine contents of the puff pastry increased in the same number of layers. The baking loss of the products tended to decrease as the number of layers increased. On the other hand, as the pastry margarine contents of the puff pastry increased, the baking loss of the product increased. When the pastry margarine content in puff pastries became 130%, 81 layers provided the maximum specific loaf volumes 21.62±0.79 ㎖/g of puff pastries. When 110% of margarine and 256 layers were applied for preparation of puff pastry, the number of vapor action was 8.25±0.50 with the vapor action size of 9-15 ㎜.

서울시 주택내 휘발성 유기화합물 공기오염농도의 계절변화에 관한 연구

전정윤,박준석,손장열 대한건축학회 2005 대한건축학회논문집 Vol.21 No.3

For the purpose of examining about seasonal change in concentration of indoor organic compounds in Seoul, 96 houses in the winter and 49 houses in the summer were investigated. Indoor organic compounds concentration were measured and survey was performed by questionnaire. Indoor organic compounds were monitored with two diffusive samplers. One was a cartridge treated with 2,4-dinitrophenylhydrazine for aldehydes sampling. The other was a passive charcoal tube for VOCs sampling. Two samplers were simultaneously exposed in living room during 24 hours. Aldehydes extracted with 2㎖ acetonitrile from the cartridge were analyzed by HPLC equipped with an UV diode array detector. VOCs were extracted with 2㎖ carbon disulfide from the charcoal tube by shaking and then analyzed by chromatograph and mass selective detector. The main Results were as follows. (1) Both of Formaldehyde and VOCs concentration in the summer are lower than that in the winter. This is because of increasing ventilation rate according to the opening of windows in the summer. (2) Formaldehyde, toluene and ethylbenzene were indicated as the major indoor volatile organic compounds in Seoul Residence. (3) There were 10 times of deference in concentration between non-occupied new house and that of post-occupied. (4) There was no significant relation between house type and indoor concentration.

소아치과 영역에서 전산화 단층촬영술의 임상적 활용에 대한 증례보고

이윤석,이상훈,장기택 大韓小兒齒科學會 1998 大韓小兒齒科學會誌 Vol.25 No.3

1. CT 에 의한 매복치의 위치결정은 적절한 치료계획의 수립을 가능하게 하여 시술시가의 단축과 인접치, 인접구조물의 손상을 줄여 시술후의 부작용을 줄일 수 있었다. 2. 매복된 영귀치의 견인시 CT를 활용한 결과 개창부위의 정확한 위치결정과 예후에 대한 예측이 가능하였다. 3. 평면방사선사진의 판독후 악골내 병소가 의심되어 CT를 활용한 결과 병소의 확진이 가능하였다. 4.. 소아의 CT 촐영은 평면 방사선 촬영에 배해 증가된 방사선 피폭량, 높은 수가 절한 증례의 선택이 중요하다. Computed tomography (CT) has become more widely available in recent years and is recognized as an important diagnostic tool for complex disease and condition of the orofacial structure in adults. In pediatric patients, especially in the mixed dentition period, the number of superimposing dental structures in the jaw bone is much greater than in the permanant dentition period. Therefore, in spite of radiation risk, computed tomography should sometimes be used in pediatric patients in order to obtain a precise and valid diagnosis. This case study presents clinical application of computed tomography on patients visiting department of pediatric dentistry in Seoul National university Dental Hospital. The results obtained through these cases were summarized as follow: 1. Localization of impacted teeth using CT allows for efficient treatment planning leading to reduced postoperative complications. 2. In orthodontic traction of impacted permanent teeth, utilization of CT made exact localization of window site and determination of prognosis possible 3. Use of CT made possible definite diagnosis of lesions in the jaw that were only suspected on plain film radiographs. 4. Careful selection is necessary when applying CT on children due to increased radiation dose and high cost.

자발성 뇌지주막하 출혈 환자에서 최초 뇌실 크기의 임상적 의의

신일영,윤일규,윤석만,도재원,이경석,배학근,최순관,변박장 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.1

The purpose of this study is to invesetigate the clinical significance of initial enlargement of ventricle in the patients who had aneurysmal SAH. Of the total 821 patients with aneursmal SAH who were registerd in SAH data bank system between 1989-1999, 307 patients who had been already measured in the size of ventricle at the time of admission, were studied retrospectively. The size of ventricle was calculated by bifrontal index. Normal size of ventricle was defined as 30% or less, mild enlargement was defined as 31 to 39%, and moderate enlargement of vertricle was defined as more than 39% in bifrontal index. The sizes of ventricle using bifrontal index were analysed according to the age, sex, blood pressure, consciousness at admission, medical history of hypertension, location of ruptured aneurysm, Fisher's grade on CT(computerized tomography) scan at the time of admission, cerebral vasospasm, intraventricular hemorrhage (IVH), performance of external ventricular drainage (EVD), and prognosis at discherge. Chi-square test and ANONA were used in the statistical evaluation. The results were as follows : 1) Of the 307 patients, 235(76.5%) had a mild to moderate enlargement of ventricle at the time of admission (more than 30% in bifrontal index). 2) The size of ventricle was enlarged according to the increase of age (p<0.05). 3) In the patients who had ruptured aneurysm on anterior cerebral artery, the size of ventricle significantly increased and showed a higher incidence in mild enlargement compared with moderate enlargement of ventricle (p<0.05). 4) The size of ventricle increased in th patients who had IVH and the EVD was more frequently performed in th patients who had the enlarged ventricle associated with IVH (p<0.05). 5) In the patients who had high Fisher's grade, the size of ventricle had a tendency to increase, but there was no statistical significance. 6) In the patients who had poor prognosis, the size of ventricle had a tendency to increase, but there was no statistical significance. Conclusively, the initial size of ventricle was enlarged in th aged patients, ruptured aneurysm on anterior communicating artery, high FIsher's grade, patients associated with IVH. Considering those factors, prediction for the enlargement of ventricle size may help to treat the patients suffering aneurysmal SAH.

牛耳島의 植物相과 植生에 關한 硏究

金喆洙,張允錫,吳長根 木浦大學校沿岸生物硏究所 1987 沿岸生物硏究 Vol.4 No.1

The flora and vegetation of Ui-do were investigated two times from July 23th to July 29th in 1985, and from July 8th to July 15th in 1985. The vascular plants identified in these investigations were 102 families, 302 genera, 376 species, 58 varieties and 4 formae, summing up to 438 species total. Of these species, 126 species were found commonly in the lists reported previously by Lee, etc. (1980) and Lee (1981). The total number of species in this island was thus summerized as 104 families, 323 genera and 481 species. Also Fisher's index was calculated as 426.4. This value was higher than that of Hong-do. By the ZM school method, the vegetaion of Ui-do was classified into 15 community types, i.e. the evergreen broad-leaved forests(Camellia japonica-Machilus thunbergii, Camellia japonica-Castanopsis cuspidata var. sieboldii, Camellia japonica community), the evergreen needle-leaved forests (Pinus thunbergii community), the deciduous forests (Mallotus japonicus, Carpinus coreana community), Pseudosasa japonica community, the grassland vegetation (Miscanthus sinensis var. purpurascens, Arundinella hirta-Zoysia japonica, pennisetum alopecuroides-Artemisia princeps var. orientalis, Agrostis clavata-Artemisia princeps var. orientalis community), the sand dune vegetation (Carex pumila, Imperata cylindrica var. koengii-Vitex rotundifolia, Ligustrvm quihoui var. latifolium community) and the grazing land. Each community was described in term of floristic, structual and environmental features. The synthesis table and the actual vegetaion map were prepared.

외상후 발작의 위험인자에 대한 조사

이재학,배학근,윤석만,도재원,이경석,윤일규,최순관,변박장 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.1

Risk Factors for Posttraumatic Seizure The authors evaluate the risk factors for posttraumatic seizures. this prospective study was performed in a series of 470 head injured patient from January 1996 to Decomber 1998. The patients who were dead within 1 week of injury or children from 3 years old and under were excluded. There were 358 male and 112 female with a mean age of 35.2±22.8 years (range, 4-88 years). The results were as follows : 1). Of the 470 patients, pasttraumatic seizure occurred in 48 patients(10.2%): early seizure in 28(6%) and late seizure in 20 patients(4.2%). 2). The clinical risk factors for posttraumatic seizure were poor consciousness at admission, presence of brainstem herniation signs, poor GCS score, and posttraumatic amnesia more than 24 hours after trauma(p<0.001). 3). The radiological risk factors for posttraumatic seizure were subdural hematoma(p<0.001), intracerebral hematoma (p<0.02), mutiple intracranial CT lesions(p<0.001), or delayed lesions on follow-up CT scans(p<0.001). the incidence of seizure increased according to the severity of diffuse brain lesion(p<0.001), and the seizure rate in mass lesion was higher than that in diffuse lesion(p<0.001). 5). Hypoxia and coagulopathy had a statistically significant influence on posttraumatic seizure(p<0.05). Hypoxia had a infuence on occurrence of late seizure(p<0.05). 6). The incidence of posttraumatic seizure signiticantly increased in surgical group compared with coservative group(p<0.001) and significantly increased in patient who underwent decompressive craniectomy compared with those who underwent craniotomy(p<0.001) 7). Preventive administration of antiepileptic drugs decreased the incidence of early seizure, but did not affect on the reduction of late seizure. 8). Multivariate logistic regression analysis showed the subdural hematoma, GCS score, delayed lesion, and intracerebral hematoma in order of importance for seizure risk. in conclusion, the risk factors affecting on the occurrence of seizure were clinical status at admission, CT lesions, and severity of diffuse brain inJury. Considering that hypoxia affected on the late seizure, it is necessary to detect and treat it immediately after trauma. In addition, the patients who underwent decompressive craniectomy should be carefully followed to evaluate the risk of late seizure. Even though preventive administration of antiepileptic drugs had a tendency to decrease the incidence of early seizure, it is unclear whether administration of antiepileptic drugs can reduce the incidence of posttraumatic seizures. Prospective study will be needed in the selected patients.

고빌리루빈혈증을 동반한 자가면역성 간염 1례

서영범,김성욱,장재식,강혁주,이중현,윤병구,김욱년,이광헌,이구,유석동,양창헌,이정호,이영현,이창우,서정일 동국대학교 의학연구소 2000 東國醫學 Vol.7 No.-

자가면역성 간염은 대개 만성 경과를 가지며, 혈중 자가면역항체와 혈청 글로불린치의 상승, 그리고 조직학적으로 괴사 염증성 변화를 특징으로 하는 질환으로 아직 정확한 병인이 밝혀져 있지 않은 상태이다. 발병연령은 대개 젊은 영자(15-25세)에서 호발한다. 이 질환은 급성 간염의 임상경과를 보일 수 있으나, 심한 급성 간염이나 전격성 간염으로도 나타날 수 있는데, 이 경우 아주 나쁜 예후를 보인다고 한다. 치료는 자가면역성 간염 임상 경과의 다양성이나 병인, 병리기전의 불확실성에도 불구하고 대개 steroid 치료에 반응하는 것으로 알려져 있으며 대개 80%의 관해율을 나타내며 궁극적으로 간경변으로의 진행을 막을 수 있는 것으로 보인다. 저자들은 58세 남자에서 발생한 급성의 경과를 가지고 심한 황달을 동반한 자가면역성 간염을 경험하였기에 문헌고찰과 함께 보고하는 바이다. Autoimmune hepatitis (AIH) is a chronic necroinflammatory liver disorder of unknown cause associated with circulating autoantibodies and a high serum globulin level. The age of onset of AIH show a peak between the age of 15 and 25 years. AIH can develop and be manifested as acute hepatitis, but severe form of acute hepatitis or fulminant hepatic failure has a poor prognosis. Although AIH is likely to progress from chronic active hepatitis to cirrhosis, steroid therapy can control the disease activity, prolong survival, improve the quality of life , and defer liver transplantation. In the present report we describe a 58-year-old man who admitted because of progressive jaundice and fatigue. He was diagnosed with AIH from laboratory test result showing positivity for antinuclear antibodies, anti-smooth muscle antibodies, and negativity for hepatitis viral markers and from liver biopsy. Steroid therapy, oral administration of prednisolone, was effective in improving the liver function test. Following liver biopsy 6 months after onset shows markedly improved necroinflammatory activity.