균열크기 측정기법 개발에 관한 연구

남민우,조찬희,정한섭,김홍덕,신기석 한국비파괴검사학회 2004 학술대회 논문집 Vol.- No.-

본 연구는 증기발생기 건전성 향상기술 개발 과제 일환으로 진행중인 고리 1호기 구 증기발생기 인출 전열관을 대상으로 하는 Round Robin Test의 사전 시험을 위해 수행하였다. 균열결함에 대한 검출 및 크기측정의 기준을 설정하기 위해 SGMP Mock-Up를 제작하였고 신호수집한 Data를 증기발생기 전열관 가동중검사 업무를 수행하고 있는 와전류신호평가자들 4개조가신호평가에 참여하였으며, 그 결과를 요약 정리하였다. 본 연구에서 SGMP Mock-Up Data Crack Sizing의 목적은 고리 1호기 구 증기발생기 전열관을 대상으로 시행될 Round Robin Test 전에 결함 기구별 균열결함의 특성 이해 및 균열결함이 여러 유형의 외부 환경에서 나타나고 있을 때의 균열결함에 대한 정량적인 크기 측정값의 바람직한 모델 적용을 확인하기 위함이다. SGMP Mock-Up에 적용한 와전류검사는 Robbin 및 MRPC 검사를 포함하였다. 본 연구의 주 목적인 MRPC 데이터를 이용한 균열깊이 평가에 2개조는 위상각-깊이 분석법을 적용하여 신호평가를 수행하였고, 2개조는 위상각-깊이 분석법 이외에 진폭-깊이 평가 기법을 적용하여 SGMP Mock-Up에 대한 최적의 기법을 설정하였다.

외측 미칩 갑상선에서 발생하여 다발성 전이로 발현된 유두상 갑상선암 1예

천남일,이창훈,홍세인,정진욱,윤인석,조동혁,강호철,정동진,정민영 대한내분비학회 2001 Endocrinology and metabolism Vol.16 No.4-5

뇌동맥류 파열 환자에서 증후성 뇌혈관연축의 발생 및 회복에 영향을 미치는 인자들

최석민,석종식,권정택,민병국,황성남,김영백,홍현종 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.10

To determine the factors affecting development and recovery of symptomatic vasospasm. the author analysed the results of patients with ruptured intracranial aneurysms treated by nimodipine and prophylactic “triple0H” therapy. From January 1991 to December 1995. 199 patients underwent surgery for ruptured intracerebral aneurysms. Combined hypervolemic hemodilution was initiated at the time of admission. Induced hypertension was added immediately after surgery(aneurysmal neck clipping). All patients received nimodipine intravenously or orally until the 14th day of SAH Sixty patients underwent surgery on Day 0 through 2 after attacks of subarachnoid hemorrhage(Goup A) 105 patients on Day 3 through 14(Group B). and 35 patients after Day 14(Group C). Of 199 patients. 76(38%) patients suffered from symtomatic vasospasm. Symptomatic vasospasm occured in 34% of Group A patients. 33% of Group B patients. and 5% of Group C patients. Symtomatic vasospasm occured more frequently in the older age group. the Fisher group 3 and Hunt & Hess grades 3, 4 and 5 groups. Of 76 patients who suffered from symptomatic vasospasm. 47(62%) patients recovered completely. The author analysed the relationship between recovery rate and sex, age. Hunt & Hess agrde and Fisher group among these 76 patients. Recovery rates between these groups were not significantly different. Based on this experience the author believes that Hunt-Hess grade. Fisher group and age are important factors affecting symptomatic vasospasm development.

타이어 설계인자를 고려한 자동차의 조종 및 안정 특성에 관한 연구

윤성운,홍석주,최규남 朝鮮大學校 機械技術硏究所 2004 機械技術硏究 Vol.7 No.2

As the technique of automobile industry is being advanced, the advancement of performance for vehicle is being required. In order to achieve this purpose, the study on the handling and stability which are produced by moving vehicle is carried out actively. Ability to predict vehicle performance using computer simulation is essential to reducing the development time for tire companies as well as car makers. From the previous research. we showed that handling simulation tool developed for J-turn and lane change maneuvers on ADAMS could be used in predicting the performance difference among tires with different specifications in vehicle mild handling behaviors. Through this study, some meaningful correlations were achieved. Also barriers to direct application of the simulation technique to tire development process and several technical problems that should be resolved were iden tified. In this results, ability to predict vehicle performance using computer simulation is essential to reducing the development time for tire companies as well as car makers.

고속 HMC 이송계의 운동특성 평가 및 운동오차 예측

최헌종,허남환,강은구,이석우,홍원표 한국공작기계학회 2004 한국공작기계학회 추계학술대회논문집 Vol.2004 No.-

Recently, the evolution in production techniques (e.g. high-speed milling) and the complex shapes involved in modern production design has been increasingly popular. The key to the achievement is a drastic improvement of the dynamic behavior of the machine tool axes used in production machinery. The more complex these tool paths the higher the speed and acceleration requirements. But it is very difficult to reach the target for high speed machine tool because of the limitations of servo system and motion control system. However the direct drive design of machine tool axes, which is based on linear motors and which recently appeared on the market, is a viable candidate to meet the ever increasing demands, because of these advantages such as no backlash, less friction, more mechanical simplicity and very higher acceleration and velocity comparing to the traditional system. This paper focused on the performance tests of the high speed horizontal machine tool based on linear motor. Especially, dynamic characteristics were investigated through circular test and circular form machining test is carried out considering many important parameter. Therefore these several experiments is used to be evaluated the model for prediction of circular motion error and circular machined error.

Phosphamidon 분해세균의 분리동정 및 생분해능

강양미,허성남,안태석,송홍규 江原大學校 附設 環境硏究所 1999 環境硏究 Vol.16 No.-

토양으로부터 유기인계 살충제인 phosphamidon을 분해하는 세균들을 분리하고 Biolog system을 이용하여 동정하였다. 그람양성 세균들은 모두 Bacillus 속에 속하는 종들이었으며 그람음성 세균들은 토양에서 우점하지 않는 세균들이 많았다. 이들중 phosphamidon 함유배지에서 생장률이 높은 균주들을 선택하여 phosphamidon 분해능을 조사한 결과 Capnocytophaga gingivalis로 동정된 YD-17 균주가 가장 높은 생분해능을 나타내어 1000 ppm의 phosphamidon이 배양 21일 후 9.4%의 잔류량을 보였으며 이는 대조구에 비해 제거율이 52% 증가된 결과였다. 이 때 균주의 생장을 단백질량으로 측정하였는데 분해균주들이 고농도의 phosphamidon에 의해 저해되지 않고 지속적인 생장을 하여 phosphamidon을 탄소원으로 이용하는 생분해가 일어난 것을 확인할 수 있었다. Organphosphorus insecticide phosphamidon-degrading bacteria were isolated from agricultural soils and identified using Biolog microtiter assay. All Gram-ositive degrading bacterial strains belong to genus Bacillus and many Gram-negative bacteria were rare soil species. Among them fast growing strains on phospamidon-containing minimal medium were selected and their biodegrading capability were measured. YD-17 which was identified as Capnocytophaga gingivalis showed the highest biodegradation rate. It could increase the removal of phosphamidon up to 52%. During the biodegradation continuous increase of amount of cell protein was observed, which, indicated that phosphamidon was utilized as a carbon source for phosphamidon-degrading bacteria.

비정형 기관지 유암종에 의한 이소성 ACTH 증후군 1례

이창훈,천남일,홍세인,정진욱,윤인석,조동혁,강호철,정동진,정민영 全南大醫大 2001 전남의대학술지 Vol.37 No.2

DNA Chip과 고정화 기술

박현규,지홍석,임성춘,장호남 한국화학공학회 2002 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.40 No.3

DNA chip 기술은, 인간 DNA 염기 서열상의 이상징후와 관련된 질병을 진단하거나 신약 개발을 위하여 특정 DNA 발현의 분석 등에 응용될 수 있다. 현재, DNA chip을 제작하고 DNA hybridization 반응 신호를 감지하는 방법에는 다양한 기술들이 있다. 본 글에서는 급성장하고 있는 DNA 칩의 전반적인 원리, 제조기술, 그리고 DNA를 chip에 고정화 시키는 기술을 중점적으로 소개하고자 한다. 또한 젊은 나이에서의 당뇨 발병과 관련된 유전자인 MODY의 유전자 변이를 진단하는 oligonucleotide DNA chip의 예를 보여주고자 한다. The application of DNA chip technology includes the diagnosis of various human diseases associated with DNA sequence anomalies and the comprehensive analysis of expressed sequences with regard to newer drug designs. There are a variety of options for making DNA chips and detecting hybridized signals. Here, we take a close look at the principles and manufacturing technologies of this rapidly growing area, highlighting the DNA immobilization technology on the chip. Finally we present an example of oligonucleotide chip for the analysis of multiple MODY gene mutations, which are related with diabetes of the young.

인후두이상감증 환자들에서 인후두역류의 확인에 있어 음성검사의 임상적 적용

허성철,홍석중,송용진,유승주,김상윤,남순열 대한이비인후과학회 2001 대한이비인후과학회지 두경부외과학 Vol.44 No.11

항결핵 6개월 단기요법의 성과 고찰

서지원,정연채,김남재,홍석철,김주옥,김선영,노흥규 충남대학교 의과대학 지역사회의학연구소 1990 충남의대잡지 Vol.17 No.1

To evaluate the effect of 6-month short term antituberculosis chemotherapy with INH, Rifampin, Ethambutol, and Pyrazinamide(2HREZ/4HRE) in the patients with pulmonary and/or extrapulmonary tuberculosis, the authors prescribed 2HREZ/4HRE regimen in 79 tuberculosis patients for 6 months with measuring the sputum staining for AFB, chest X-ray findings, recurrence rates and possible side reactions of the treatment. The result were as follow; 1. Pulmonary Tuberculosis 1) Among the 56 pulmonary tuberculosis patients who had taken 2HREZ/4HRE regimen. 32 patients showed initial positivity in sputum AFB smear stain(57.2%). Negative conversion occurred usually within 2 months after initiation of chemotherapy and the mean period of negative conversion was 1.4 months. 2) Among the 56 pulmonary tuberculosis patients, chest X-ray finding changed in 41 patients (37.21%). From these 41 patients 39 patients showed continuous improvements in chest X-ray finding, though 3 patients showed initial aggravation in spite of continuous medication. The remainder 2 cases aggravated due to the failure of treatment. 3) Treatment failure occurred in 2 patients (3.57%) during the chemotherapy among 56 patients of pulmonary tuberculosis and they were infected with secondary drug-resistant strains of M. tuberculosis. 2. Extrapulmonary tuberculosis. Among 8 patients with tuberculous pleurisy and 15 patients with superficial tuberculous lymphadenitis, there were no evidence of treatment failure after completion of antituberculosis chemotherapy for 6 months with 2HREZ/4HRE regimen. 3. Follow-up study was performed from 6 months to 50 months after completion of antituberculosis chemotherapy and the relapse was not noted in both pulmonary and extrapulmonary tuberculosis patients group during this period. 4. Serum AST/ALT elevated in 9 patients(11.4%) during the treatment and this occurred usually within 3 months after the initiation of antituberculosis chemotherapy. However treatment interruption occurred in 2 patients (2.5%) due to the development of hepatitisone due to drug-induced hapatitis and the other due to type B viral hepatitis. In conclusion, we could find this 2HREZ/4HRE 6-months short-term antituberculosis regimen is effective and could be recommanded as a promising regimen for the treatment of tuberculosis.