만성알콜중독과 Alzheimer 형 치매의 뇌전산화 단층촬영상 뇌위축의 비교

전석길,박종한 大韓神經精神醫學會 1985 신경정신의학 Vol.24 No.1

저자들은 1981년 1월부터 1984년 6월까지 계명의대 동산의료원에 내한한 Alzheimer형 치매환자 15명 (남 12명, 여 3명, 48∼76세)과 6명의 남자 알콜리즘환자 (51∼69세), 그리고 1982년 3월부터 1983년 8월까지 부산 메리놀병원 신경정신과에 내원했던 7명의 알콜리즘환자 (남 6명, 여 1명, 52~63세)를 "방사선과학적으로 정상" 으로 판독된 같은 연령층의 대조군 18명 (남 11명, 여 7명, 50~73세)과 Evans지수, Frontal horn지수, Bicaudate지수, Cell media지수, 3rd ventricle-sylvian fissure/skull지수, 그리고 4 구의 합을 통해 비교하여서 다음과 같이 그 결과를 요약한다. 1. 알콜리즘환자 및 Alzheimer형 치매 환자의 각 측정치는 모두 대조군보다 현저한 뇌위축을 나타내었다. 2. 알콜리즘환자와 Alzheimer형 치매 환자의 비교에서는 양군간에 모든 측정치가 거의 비슷했다. 3. 각종의 대뇌위축 측정방법들 중에서 구의 확장정도가 가장 예민했다. To study the cerebral atrophy in chronic alcoholics and patients with dementia of Alzheimer type, authors measured the Evans' ratio, frontal horn ratio, bicaudate ratio, cella media ratio, 3rd ventricle-Sylvian fissure/skull ratio, and sum of 4 sulci in brain CT films of 13 chronic alcoholics, 15 patients with dementia of Alzheimer type, and 18 control group of "radiologically normal". The results were as follows: 1. Chronic alcoholics and patients with dementia of Alzheimer type were found significant cerebral atrophy than control group in the all ratios. 2. The difference of the degree of cerebral atrophy score between chronic alcoholics and patients with dementia of Alzheimer type was not statistically significant, and similar score was found on the both groups. 3. The sulcal widening was most sensitive among the variable cerebral atrophy measurements.

이식폐장의 핵의학검사

전석길,현정애 啓明大學校 醫科大學 1995 계명의대학술지 Vol.14 No.4

Interleukin-2를 이용한 진행성 위장관암의 비장을 경유한 자가 LAK Cell의 면역학적 반응

안우섭,강중신,김인호,전석길,손수상 啓明大學校 醫科大學 1993 계명의대학술지 Vol.12 No.3

To elucidate the anticancer effect by observing the effect of LAK cells after infusion of IL-2 through splenic artery for the advanced gastrointestinal cancer, randomized study was performed for the 8 patients who had liver metastasis from gastic and rectal cancer. 4 patients were performed subtotal gastrectomy for stomach cancer and the others were done abdominoperineal resections for rectal cancer. The liver metastasis were noted all of the cases after surgery between October 1989 and December 1992 at the Department of Surgery, Keimyung University School of Medicine. After confirmation of the hepatic metastasis from gastorintestinal cancer, we performed selective splenic arterial infusin of IL-2 with the dosage of 20,000 units/kg B.W. We checked the immune function pre-and post-IL2 infusion therapy, such as total lymphocyte count, T-cell percentage and CMI multitest with blood count and hepatorenal function. There was no difference between the pre-and post IL-2 infusion in the hemoglobin, serum protein, albumin, BUN and creatinin. The total lymphocyte counts of pre-and post IL-2 infusion were 1641.2 and 1727.4, respectively. The T cell percentage of pre-and infusion were 62.51% and 64.27%, respectively and had the tendency to increase in comparison with pre-IL-2 infusion, but there were not stastical differences. The results of CML muiltitest of pre-and post IL-2 infusion were not definite differences. From the above results, it could be suggested that LAK cell after infusion of IL-2 via selective splenc artery had the slightly positive effect of the immune function of advanced gastrointestinal cancer patient, with hepatic metastasis.

Double-phase Tc-99m Tetrofosmin parathyroid scan in hyperparathyroidism: comparison with ultrasonography

( Seok Kil Zeon ),( In Soo Kim ),( Sang Yoon Kim ),( Kyoung Sook Won ) 대한핵의학회 2004 핵의학 분자영상 Vol.38 No.5

영아 자발성 총담관 천공의 간담도 스캔

전석길(Seok Kil Zeon),류종걸(Jong Gul Ryu),이은영(Eun Young Lee),이종길(Jong Gil Lee) 대한핵의학회 1996 핵의학 분자영상 Vol.30 No.1

N/A Spontaneous perforation of CBD in infant is a rare but fatal disease. We report a case of bile leakage from common bile duct in 11 months old girl with progressive abdominal distension and vomiting, preoperatively diagnosed by hepatobiliary scan with Tc-99m-DISIDA, which was confimed by surgery. Operative cholangiogram showed a small perforation at the confluence of cystic duct and common bile duct with mild fusiform dilatation, and no definite abnormality in confluence of the common bile duct and pancreatic duct. Simple drainage of the free peritoneal bilous fluid and T-tube drainage were performed without any evidence of the complication. Patient was inevitable for 6 months OPD follow-up examination.

비장동맥에 선택적으로 투여한 Interleukin - 2 화 99mTc - Phytate 혼합물의 생체내 분포

전석길(Seok Kil Zeon),이희정(Hee Jung Lee),손수상(Soo Sang Sohn) 대한핵의학회 1992 핵의학 분자영상 Vol.26 No.1

N/A Colloidal 32P chromic phosphate is used to prevent hepatic metastasis from colorectal cancer. It is speculated that the intravenous injection of colloidal 32P chromic phosphate can cause genotoxicity. To evaluate the genotoxicity of intravenously injected colloidal 32P chromic phosphate, authors performed a micronuclei test in mice bone marrow. Mice(ICR strain, 25∼30 g) were divided to 4 groups: control, group 1 (19.166 KBq/g, usual therapeutic dose in human), group 2 (191.66 KBq/g), and group 3 (1916.6 KBq/g). Five mice of each group were sacrificed at days 1, 2, 3, 5, 7 and 14. Bone marrow were smeared and stained with Wright-Giemsa method. One thousand polychromatic erythrocytes (PCE) and normochromatic erythrocytes (NCE) were counted under the light microscope, and the number of micronucleated PCEs and NCEs were recorded. The frequency of micronuclei in PCE and NCE in the control group was 0.3±0.06% and 0.45±0.10%, respectively. At group 1, frequency of micronuclei is not different from the control. However, frequencies of micronuclei in PCE at groups 2 and 3 were significantly increased from day 1 and persisted to day 14. The frequency of micronuclei in NCE was increased only at group 3. In conclusion, the frequency of micronuclei increases as the dose of colloidal 32P chromic phosphate increases, while micronuclei was not induced at the usual therapeutic dose. And the frequency of micronuclei persistently elevated for 14 days in the cases of higer doses.

99mTc - MAG3제거지수를 이용한 이식신장의 기능평가

전석길(Seok Kil Zeon),이희정(Hee Jung Lee),전우진(Woo Jin Jeon),김주헌(Ju Heon Kim),박미옥(Mi Ok Park),현정애(Jung Ae Hyun) 대한핵의학회 1995 핵의학 분자영상 Vol.29 No.1

N/A Purpose: We analysed Tc-99m-MAG3 renal scans to evaluate renal function of transplanted kidney and to detect various renal transplant complications, measuring the ratio of renal radioactivity at three minutes to that at 20 minutes(elimination index). Material and Methods: The fifty seven renal transplantation recipients were studied. There were 50 normal functioning transplanted kidneys as group I and 7 abnormal functioning transplanted kidney, including 5 cases of acute renal rejection, 2 Gases of acute tubular necrosis as group II. The protocol consisted of: (1) Tc-99m-MAG3 740MBq injection intravenously; (2) sequential imaging for 2min(60two-second images) followed by 30min(30 sixty-second images); (3) drawing of region of interest(ROI) on renal imaging; (4) time-activity curves were generated from renal ROI after background subtra ction, and time of maximum activity(Tmax) and half time of maximal peak radioactivity(T1/2) were produced in the renogram curve. (5) EI through Bischof-delaoye method as determined on the renogram curve. Results: Normal group(I) shows mean EI of 2.21(95.0% Confidence limit of 2.01-2.87), Tmax, of 154 sec, t1/2 of 1,139 sec. Abnormal group(II) shows mean EI of 0.74, Tmax of 1,466 sec, t1/2 of 19,224 sec. The EI, Tmax, T1/2, BUN and serum creatinine values are significantly different between normal group(I) and abnormal group(II) (p〈0.0001). Conclusion: By measuring EI-with Tc-99m-MAG3, renal function of transplanted kidney could be easily evaluated and various complications could be detected early.

經皮經肝膽湃液術의 放射線學的 考察

全石吉,朱亮求,金洪,禹聖龜,徐修之,金玉培,許定旭 啓明大學校 醫科大學 1987 계명의대학술지 Vol.6 No.1

Percutaneous transhepatic biliary drainage(PTBD) was performed 40 times in 38 patients with obstructive jaundice, from January, 1986 to May at Department of Radiology, Keimyung University School of Medicine. The PTBD is to decrease serum bilirubin level, promote liver function, effectively decompress the severely obstructed biliary tree prior to surgery and palliates the clinical problems in patient with non-operable malignant obstruction and control sepsis effectively. The results were as follow: The cause of obstructive jaundice included 35 malignant diseases and 3 benign diseases. Malignant disease were 23 cases of bile duct carcinoma, 5 cases of hepatoma, 5 cases of pancreas carcinoma and 2 cases of metastasis. The most common level of obstruction was distal common bile duct in 13 cases. The most common indication of PTBD was palliative drainage of obstruction secondary to malignant tumor in 26 cases. The drainage type was internal i 12 cases and external in 24 cases. The most common complication was high fever in 7 cases. The successful drainage with effective decrease in the level of serum bilirubin was observed in 30 cases, ineffective drainage in 4 cases.

난치성 측두엽간질의 발작기 국소뇌혈류 SPECT

전석길,김지언,류종걸,손은익,김순,이상도 啓明大學校 醫科大學 1999 계명의대학술지 Vol.18 No.4

Refractory temporal lobe epilepsy is a disease of non-response to medical treatment, and the surgical resection of the epileptic focus is a treatment of choice. The ictal regional cerebral blood flow(rCBF) SPECT with Tc-99m ECD was done preperatively in ten refractory temporal lobe epilepsy patients. Engel's surgical outcome of one year after surgical resection of epileptic focus were analysed with ictal rCBF SPECT findings. Tc-99m ECD were labeled anticipatively, and placed in patient's bed of the patient monitoring room, and were injected within 7 seconds of seizure onset. Seven interictal rCBF SPECT and six MRI were also performed. There was positive findings in six cases, of which five were increased rCBF, and remaining one revealed decreased rCBF at epileptic focus, and IA to ⅡB of Engel's surgical outcome were noticed. One case of four normal ictal rCBF SPECT showed decreased rCBF in interictal rCBF SPECT. Four cases of seven interictal rCBF SPECT showed normal findings. Five of nine MRI shows normal findings, in which abnormal ictal rCBF SPECT were noticed. As a conclusion, ictal rCBF SPECT could help to find out epileptic focus in refractory temporal lobe epilepsy.

이식 신장에서 시행한 Tc-99m MAG3 SPECT

전석길,류종걸,김순 대한핵의학회 1999 핵의학 분자영상 Vol.33 No.6

Purpose: This study was designed to evaluate the usefulness of a technetium-99m mercaptoacetyltriglycine (Tc-99m MAG3) single photon emission computed tomography (SPECT) performed on transplanted kidney. Materials and Methods: Thirty renal transplant patients were included in this study. Planar scan was performed for 30 minutes using 555 MBq Tc-99m MAG3. A post-voiding SPECT scan was acquired on the third, seventh, fourteenth and twenty eighth day after transplantation. Results: SPECT scan showed interpretable image quality in 26 of 30 patients (86.7%) and 84 in 120 scans (70%). Fourteen of 26 patients with interpretable SPECT image showed decreased or increased radioactivity, but only 5 had abnormal findings on the planar scan. Focal SPECT defects were seen in allografts with normal function (n=3), acute tubular necrosis (n=3), and acute rejection (n=2). The defects are thought to reflect focally underperfused renal parenchyme or, in normal allografts, an artifact from uneven radioactivity distribution. Four of 10 patients with renal arterial variation showed focally decreased radioactivity and SPECT helped guide further studies that confirmed the exact cause. Five of 10 patients with acute tubular necrosis or acute rejection showed focally decreased radioactivity, but its relation to the patients' clinical course was not clear. Focally increased radioactivity was observed in 5 allografts with normal function and 1 with double ureter in which local clearance delay was observed. Conclusion: Tc-99m MAG3 SPECT renal scan can detect additional focal abnormalities compared to planar scan. Further study is necessary to elucidate the exact clinical significance of the SPECT findings.