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The electrochemical glucose sensing based on the chitosan-carbon nanotube hybrid
Choi, Young-Bong,Kim, Han-Sem,Jeon, Won-Yong,Lee, Bo-Hee,Shin, Ueon Sang,Kim, Hyug-Han Elsevier 2019 Biochemical engineering journal Vol.144 No.-
<P><B>Abstract</B></P> <P>In glucose sensors, the direct electron transfer (DET) method delivers electrons from glucose oxidase (GOx) to an electrode without the intervention of a mediator. Many researchers have developed the DET method using carbon nanotube (CNT)-based composites for the permeation into the enzyme co-factor. We synthesized chitosan (Chit) core-shelled CNTs that were hydrophilic, biocompatible, and easily prepared. Electrodes with three different Chit-CNT weight ratios were prepared, and their morphological and physicochemical properties were characterized by Fourier-transform infrared spectroscopy (FT-IR), X-ray photoelectron spectroscopy (XPS), x-ray diffraction (XRD), scanning electron microscopy (SEM), and transition electron microscopy (TEM). The Chit-CNT85 composite (85 wt% Chit) performed optimally by cyclic voltammetry (CV), and was covalently modified with GOx via a routine coupling protocol to form the GOx-Chit-CNT85/ITO electrode. This electrode was electrochemically characterized by impedance spectroscopy (EIS). The GOx loading and pH were optimized against the CV redox potential. The electrode exhibited a fast electron-transfer constant (<I>k<SUB>s</SUB> </I>) of 8.2 s<SUP>−1</SUP>. The cathodic peak of GOx decreased in response to increasing glucose concentrations, but no changes were observed in the presence of physiological interfering substances such as ascorbic acid and uric acid. Therefore, our GOx-Chit-CNT85/ITO electrode has the potential for use in glucose sensing directly without a mediator.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The chitosan-carbon nanotube hybrid was prepared by homogenizer easily. </LI> <LI> And chitosan-carbon nanotube hybrid was applied for sensing the glucose electrochemically. </LI> <LI> The electrochemical performance of glucose was characterized by cyclic voltammetry. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Hwang, Ji-Young,Kim, Han-Sem,Kim, Jeong Hun,Shin, Ueon Sang,Lee, Sang-Hoon American Chemical Society 2015 Langmuir Vol.31 No.28
<P>Carbon nanotubes (CNTs) have an important role in nanotechnology due to their unique properties, retaining the inherent material flexibility, superior strength, and electrical conductivity, unless the bottleneck of CNTs persists and the aggregated structure is overcome. Here, we report on the highly enhanced mechanical and electrical properties of the CNT–chitosan nanocomposites through homogeneous dispersion of CNTs into chitosan solution using a high-pressure homogenizer. The optimal condition is a 50% (w/w) chitosan–CNT film, providing about 7 nm thickness of homogeneous chitosan layer on CNTs, a good tensile strength of 51 MPa, high electrical conductivity under 16 Ω/sq, and a stable bending and folding performance. This CNT–chitosan nanocomposite with highly enhanced properties is an amenable material to fabricate structures of various shapes such as films, sensors, and circuits and also enables a simple and cost-effective approach to improve the performance of a device that presents the first flexible and soft electric circuits yet reported using only CNT–chitosan as the conductor.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/langd5/2015/langd5.2015.31.issue-28/acs.langmuir.5b00845/production/images/medium/la-2015-00845q_0009.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/la5b00845'>ACS Electronic Supporting Info</A></P>