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( Hyun Jung Lee ),( Ja Young Ryu ),( Ho Cheol Hong ),( Kyung Mook Choi ),( Sei Hyun Baik ),( Hye Jin Yoo ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Fat distribution may become more central, or android, after menopause. Although many studies have been performed to identify superiority among anthropometric indices to predict cardiovascular disease (CVD) risk in individuals with all age ranges or with different ethnic groups or with type-2 diabetes, studies to evaluate the association between menopausal status and indicators of atherosclerosis are limited. Thus, the objective of the present study is to assess the efficacy of body mass index (BMI), waist circumference (WC) and waist-to-hip ratio (WHR) for predicting atherosclerosis in pre and post-menopausal women. Methods: A total of 442 participants (209 pre-menopausal and 233 post-menopausal women), who underwent a health examination between April 2012 and May 2013 were prospectively enrolled. We investigated the efficacy of each anthropometric marker including BMI, WC and WHR for predicting atherosclerosis in pre and post-menopausal women by carotid intima-media thickness (CIMT) and brachial ankle pulse wave velocity (baPWV) in healthy Korean women. Results: Compared with post-menopausal women, pre-menopausal women had a thinner WC (76cm and 71cm respectively), and had a lower BMI (23.2 kg/m2 and 21.8 kg/m2 respectively) and WHR (0.9 and 0.8 respectively). In pre-menopausal women all anthropometric parameters (BMI, WC, WHR) are positively correlated to baPWV (0.20, 0.19 and 0.21, P < 0.01, respectively), and CIMT values (0.36, 0.34 and 0.27, P < 0.01, respectively) whereas in post-menopausal women only WHR was positively correlated to baPWV values (0.27, P < 0.01) and WC, WHR were positively correlated to CIMT (0.15, P < 0.05 and 0.21, P < 0.01, respectively) The correlation coefficient in all parameters of CIMT was significantly higher in WHR than WC in post-menopausal women. Conclusions: This study shows that WHR has the best predict value for predicting atherosclerosis than BMI or WC in post-menopausal women.
Fra-1 Expression in Malignant and Benign Thyroid Tumor
(Yong Hyun Kim),(Jeong Heon Oh),(Nan Hee Kim),(Kyung Muk Choi),(Sang Jin Kim),(Sei Hyun Baik),(Dong Seop Choi),(Eung Seok Lee) 대한내과학회 2001 The Korean Journal of Internal Medicine Vol.16 No.2
N/A Background : The differential diagnosis of thyroid nodules is very important in deciding the treatment modality and the fine needle aspiration is the best diagnostic method. But, there are some limitations in use because of inadequate test materials and difficulty in interpreting. According to the study of oncogene and tumor suppressor gene about the origin of thyroid tumor, expression of Fra-1, one of AP-1 complex, is increased in thyroid neoplasm, though not present in the normal tissue. So, there is a possibility that it will be used as a method for the differential diagnosis of thyroid nodules. We tried to know whether presence or absence of Fra-1 expression can be used as a diagnostic method in differential diagnosis of thyroid nodules using the immunohistochemical (IHC) staining method. Method : In 4 types of thyroid tumor that were confirmed by histologic diagnosis after operation (18 cases of adenomatous goiter, 16 cases of follicular adenoma, 30 cases of papillary cancer, 10 cases of follicular cancer), IHC staining method was performed to evaluate the expression of Fra-1. Result : In papillary and follicular thyroid cancers, the expression of Fra-1 was stronger than in benign thyroid tumor, but there was no difference in Fra-1 expression between the two types of carcinoma. Weak expression of Fra-1 was observed in all cases of follicular adenoma, though it was weaker than in carcinoma, and it was also weakly expressed only in some cases (33%) of adenomatous goiter. Conclusion : The expression of Fra-1 was stronger in thyroid cancer than in benign thyroid tumor, but it was impossible to differentiate thyroid cancer from benign thyroid tumor by presence or absence of Fra-1 expression using IHC staining method.
김용현(Yong Hyun Kim),이은종(Eun Jong Lee),최경묵(Kyung Muk Choi),김상진(Sang Jin Kim),유재명(Jae Myung Yoo),백세현(Sei Hyun Baik),최동섭(Dong Seop Choi) 대한내과학회 1995 대한내과학회지 Vol.48 No.5
N/A Objectives: Primary aldosteronism is one of major causes of secondary hypertension that is characterized by hypertension with hypokalemia, suppressed plasma renin activity and elevated plasma aldosterone level due to excessive secretion of aldosterone from the adrenal. In Korea the first case was reported in 1968 and a clinical study of 10 cases was described in 1983. More cases of primary aldosteronism would have been diagnosed with the advanced method of measuring hormone level and abdominal CT scanning, but we cant find out more cases in the Korean literatures till now. So we performed this clinical study to evaluate systematic diagnostic method and effective treatment modality. Methods: We compared the clinical and laboratory characteristics and treatment outcomes between aldosterone producing adenoma and idiopathic hyperplasia in 15 cases of primary aldosteronism that were diagnosed and followed at Korea University Hospital from 1986 to 1993. Results: 10 cases out of 11 in which abdominal CT scan showed adrenal mass were confirmed as adenoma and remaining 1 case was diagnosed as hyperplasia pathologically, so total 5 cases of hyperplasia were diagnosed finally. Plasma aldosterone concentrations after 4 hours upright posture were increased in all 4 cases of bilateral hyperplasia and decreased or unchanged in 6 adenoma cases out of 7. The case number 6 patient showed increased plasma aldosterone concentration after upright posture in spite of adrenal mass lesion on abdominal CT scan and was diagnosed finally as renin-responsive adenom. 5 adenoma cases out of 10 are maintained normotensive state without medication and remaining 5 cases are taking antihypertensive medication Conclusion: After the diagnosis of primary aldosteronism by measurements of plasma renin activity and aldosterone concentration in hypertensive patient with hypokalemia, the differential diagnosis between aldosterone-producing adenoma and bilateral adrenocortical hyperplasia using upright posture test and abdominal CT scan will be helpful to determine the treatment modality. But occasionally, futher detailed diagnostic study is necessary in cases of small aldosterone producing adenoma that is not detected on abdominal CT scan and in cases of renin-responsive adenoma or glucocorticoid-suppressible aldosteronism.