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Yoo, Dae Hyun,Suh, Chang-Hee,Shim, Seung Cheol,Jeka, Slawomir,Molina, Francisco Fidencio Cons,Hrycaj, Pawel,Wiland, Piotr,Lee, Eun Young,Medina-Rodriguez, Francisco G.,Shesternya, Pavel,Radominski, Se Springer International Publishing 2017 BioDrugs Vol.31 No.4
<P><B>Background</B></P><P>CT-P10 is a biosimilar of innovator rituximab (RTX), a biological therapy used to treat patients with rheumatoid arthritis (RA) who have responded inadequately to anti-tumor necrosis factor agents.</P><P><B>Objective</B></P><P>Our objective was to compare the clinical profile of CT-P10 versus RTX in patients with RA who received up to two courses of treatment and were followed for up to 72 weeks.</P><P><B>Methods</B></P><P>In this multicenter double-blind phase I study, patients were randomized 2:1 to receive CT-P10 1000 mg or RTX 1000 mg at weeks 0 and 2. Based on disease activity, patients could receive a second course of treatment between weeks 24 and 48. Efficacy endpoints, including mean change from baseline in Disease Activity Score using 28 joints (DAS28), safety, immunogenicity, pharmacokinetics, and pharmacodynamics were evaluated.</P><P><B>Results</B></P><P>In total, 154 patients were randomized to CT-P10 or RTX (<I>n</I> = 103 and 51, respectively); 137 (<I>n</I> = 92 and 45) completed the first course of treatment, of whom 83 (<I>n</I> = 60 and 23) were re-treated. Improvements from baseline in all efficacy endpoints were highly similar between the CT-P10 and RTX groups over both treatment courses. At week 24 after the second course, mean change from week 0 of the first course in DAS28 erythrocyte sedimentation rate was −2.47 and −2.04 for CT-P10 and RTX, respectively, (<I>p</I> = 0.1866) and in DAS28 C-reactive protein was −2.32 and −2.00, respectively (<I>p</I> = 0.3268). The proportion of patients positive for antidrug antibodies at week 24 after the second treatment course was 20.0% and 21.7% in the CT-P10 and RTX groups, respectively. The safety profile of CT-P10 was comparable to that of RTX, and pharmacokinetic and pharmacodynamic properties were similar.</P><P><B>Conclusions</B></P><P>In patients with RA, efficacy, safety, and other clinical data were comparable between CT-P10 and RTX after up to two courses of treatment over 72 weeks.</P><P>(ClinicalTrials.gov identifier NCT01534884).</P><P><B>Electronic supplementary material</B></P><P>The online version of this article (doi:10.1007/s40259-017-0232-7) contains supplementary material, which is available to authorized users.</P>
Se Eun Kim,Kyung Mi Shim,Jong Choon Kim,Yun Hee Choi,Jin Cheol Yoo,Seong Soo Kang 충북대학교 동물의학연구소 2015 Journal of Biomedical and Translational Research Vol.16 No.1
Antibiotics have been used to prevent disease, promote growth rate, and improve feed efficiency. However, the use of antibiotics in livestock has been restricted worldwide due to problems such as bacterial resistance. Therefore, probiotics among alternatives to antibiotics have gained attention in the livestock feed industry these days. This study was conducted to investigate the effects of dietary supplementation with probiotic 379D on safety, growth rate, and feed efficiency. In this study, bacterial strain 379D was isolated from soil and identified as a Bacillus sp. according to 16S rRNA sequence analysis. In an in vitro test, in-gel activity assay and antimicrobial susceptibility test were conducted to evaluate 379D. In an in vivo study, 379D was administered at concentrations of 0.1% and 1% to broiler chickens for 28 days. The results of in-gel activity assay and antimicrobial susceptibility test showed that strain 379D had broad spectrum antimicrobial activity. Furthermore, no adverse 379D-related effects were observed in 0.1% and 1% groups. Feed efficiency was higher in the 379D-treated groups than in the control group. In conclusion, 379D is expected to be used as a safe alternative to antibiotics in a feed supplement and will improve feed efficiency in broiler chickens.
( Se Ok Lee ),( Dong Hyun Sinn ),( Geum Youn Gwak ),( Yong Han Paik ),( Moon Seok Choi ),( Joon Hyeok Lee ),( Kwang Cheol Koh ),( Seung Woon Paik ),( Byung Chul Yoo ) 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1
Background: FOLFOX chemotherapy (folinic acid + fluorouracil + oxaliplatin) is a standard adjuvant regimen following curative resection of colorectal cancer (CRC). Some patients undergoing FOLFOX chemotherapy are reported to experience chemotherapy-related hepatotoxicity; however, the incidence and risk factors for the development of hepatotoxicity in these patients are not well described. Patients and methods: A total of 849 patients aged between 17 and 79 years who were treated with adjuvant FOLFOX chemotherapy after curative resection for CRC were recruited from Samsung Medical Center in October 2005 to June 2012. Their medical records were retrospectively collected and analyzed. Hepatotoxicity was graded according to Common Terminology Criteria for Adverse Events (CTCAE) Version 4.0. Results: Six hundreds and eighty six of 849 patients (80.8%) experienced hepatotoxicity during or shortly after FOLFOX chemotherapy, in which 586 were in grade 1, 84 in grade 2 and 16 patients in grade 3. However, most of these episodes were transient and spontaneously recovered. Risk factors associated with the development of any grade of hepatotoxicity were age < 60 years (HR 2.390, CI 1.667-3.425), female (HR 1.51, CI 1.038-2.234), baseline ALT>20 IU/mL (HR 1.717, CI 1.065- 2.768). Risk factors associated with the development of ≥ grade 2 of hepatotoxicity were age<60 years (HR 5.393, CI 2.951- 9.858), HCV carrier (HR 5.373, CI 1.181-24.442). There was no relation between the development of hepatotoxicity and obesity, baseline level of AST, PT (INR), cholesterol and platelet, and HBsAg status. Three of 22 HBsAg positive patients who were not given prophylactic antiviral treatment during FOLFOX chemotherapy did experience ≥ grade 2 of hepatotoxicity during or shortly after chemotherapy. However, the incidence was not different from those of HBsAg positive patients who were given antiviral therapy or HBsAg negative patients. All these three patients recovered without any specific treatment for HBV. Conclusion: Hepatotoxicity induced by adjuvant FOLFOX chemotherapy after curative resection for CRC is not uncommon; however, most episodes were mild and self-limited. Age<60 years and HCV carrier were risk factors for ≥ grade 2 of hepatotoxicity. Moreover, it is unlikely that a short course of FOLFOX chemotherapy influences HBV reactivation.
Se-Chul Chun(천세철),Mung Hwa Yoo(류명화),Young Sook Moon(문영숙),Mi Ho Shin(신미호),Ki-Cheol Son(손기철),Ill-Min Chung(정일민),Stanley J. Kays 한국원예학회 2010 원예과학기술지 Vol.28 No.3
실내식물 9종의 근권부 하이드볼 배지에서 배양된 세균집단이 공기중 벤젠과 같은 휘발성 유기화합물의 제거효과에 미치는 영향이 조사되었다. 여러 식물 근권부의 배양토에서 배양된 세균 집단은 벤젠을 제거할 수 있었는데, Spathiphyllum wallisii Regel, Pachira aquatica, Ficus elastica, Dieffenbachia sp. ‘arrianne’Hort., Chamaedorea elegans 식물들은 벤젠의 초기농도를 1.000으로 기준하였을 때, 세균 집단이 전혀 없는 배지의 대조구 초기 농도 대비 잔류율이 0.596이었으나 상기 언급한 식물들은 0.741-1.000으로서 벤젠의 농도를 현저히 감소시켰다(LSD, P=0.05). 이와 같은 경향은 식물의 종류에 따라 차이는 있었지만 톨루엔의 경우에도 비슷하게 나타났다. 이러한 결과를 바탕으로 P. aquatic 근권부의 배양토로부터 배양된 세균 집단을 P. aquatica, F. elastica, S. podophyllum에 접종하였을 때 접종하지 않은 식물들에 비하여 벤젠과 톨루엔을 현저히 제거하는 효과가 나타나, 근권부의 미생물 집단을 이용하여 공기 중 휘발성 유기화합물(VOC)을 제거할 수 있음을 보여 주었다. Total bacterial populations were cultured from the Hydroball cultivation media in the rhizospheres of 9 different plants including Hedera helix L. and Dracaena deremensis cv. Warneckii Compacta, etc. These cultured bacterial populations were studied to test if the bacterial populations in the plant growing pots may play a role on removal of volatile organic compounds (VOCs) such as benzene and toluene in the air. To meet this objective, first, we tested the possibility of removal of VOCs by the cultured total bacteria alone. The residual rates of benzene by the inoculation of total bacterial populations from the different plant growth media were significantly different, ranging from 0.741-1.000 of Spathiphyllum wallisii ‘Regal’, Pachira aquatica, Ficus elastica, Dieffenbachia sp. ‘Marrianne’ Hort., Chamaedorea elegans, compared to the control with residual rate of 0.596 (LSD, P=0.05). This trend was also similar with toluene, depending on different plants. Based on these results, we inoculated the bacterial population cultured from P. aquatica into the plant-growing pots of P. aquatica, F. elastica, and S. podophyllum inside the chamber followed by the VOCs injection. The inoculated bacteria had significant effect on the removal of benzene and toluene, compared to the removal efficacy by the plants without inoculation, indicating that microbes in the rhizosphere could play a significant role on the removal of VOCs along with plants.
Henoch-Schonlein 자반증 임상양상으로 나타나 진단이 늦어졌던 웨게너 육아종증
송세빈 ( Se Bin Song ),최혜숙 ( Hye Sook Choi ),김이형 ( Yee Hyung Kim ),최천웅 ( Cheon Woong Choi ),박명재 ( Myung Jae Park ),유지홍 ( Jee Hong Yoo ),강홍모 ( Hong Mo Kang ),김윤화 ( Yoon Hwa Kim ),박주철 ( Joo Cheol Park ) 대한결핵 및 호흡기학회 2007 Tuberculosis and Respiratory Diseases Vol.63 No.6
Wegener`s granulomatosis is a systemic vasculitis of the medium and small arteries, as well as of the venules, arterioles, and occasionally large arteries, and primarily involves the upper and lower respiratory tracts and the kidneys. Renal symptoms of Wegener`s granulomatosis are indistinguishable from those of vasculitis such as Henoch-Schonlein purpura and microscopic polyangiitis. This case, though initially diagnosed as Henoch-Schonlein purpura, was confirmed as Wegener`s granulomatosis from a lung biopsy fifteen years after the initial diagnosis. We report this case with a review of the literature. (Tuberc Respir Dis 2007;63:531-536)
유세은(Se-Eun Yoo),오하경(Ha Kyung Oh),윤철구(Cheol-Ku Youn),김주형(Ju Hyoung Kim),김영호(Young-Ho Kim) 한국원예학회 2021 한국원예학회 학술발표요지 Vol.2021 No.10
체리(Prunus avium L.)는 5월~6월에 수확되는 초여름 과실로 2020년을 기준으로 5년간 재배면적이 336ha에서 845ha로 급격하게 증가하였다. 재배면적 증가와 더불어 재배품종도 다양해졌으나 각 품종별 생육 특성 등에 관한 자료는 부족한 실정이다. 따라서 본 연구는 체리 수집 품종의 초기 생육 특성을 조사하고 조기결실 가능성에 관한 기초자료를 확보하고자 실시하였다. 레드크라운, 블랙골드 등 9종에 대해서 2019년 2월 노지에 4 × 3m 간격으로 재식하였고, 수형은 KGB형으로 구성하였으며, 발아기, 수고, 주간경, 신초수, 신초장, 신초경 및 꽃눈 발생상황을 3반복으로 조사하였다. 발아기의 경우, 2020년에는 3월 9일~3월 23일까지 품종 간 최대 14일의 발아기 차이가 있었고, 2021년에는 3월 23일~3월 29일로 6일의 발아기 차이를 보였으며, 2년 평균으로는 10일의 발아기 차이가 있는 것으로 조사되었다. 수체생육 조사결과, 수고는 레드크라운이 283.3cm로 가장 높았으며, 주간경은 브룩스 품종에서 85.3mm로 굵은 경향을 보였다. 신초 발생수는 승리 품종이 11.7개로 가장 많았던 반면, 신초 생육은 레드크라운 품종에서 신초장 173cm, 신초경 24.7mm로 가장 좋은 것으로 나타났다. 꽃눈 발생상황을 살펴본 결과, 방옥 품종의 평균 화총수가 68.3개/주로 가장 많았고, 다크뷰트 품종이 15.3개/주로 가장 적었다. 방옥, 베니테마리 품종에서 꽃눈이 60개 이상 나온 것으로 보아, 다른 품종에 비해 조기 결실에 유리할 것으로 예상되었다.