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최지훈(Ji Hoon Choi)ㆍ강민규(Min Kyu Kang)ㆍ김명세(Myung Se Kim)ㆍ김성규(Sung Kyu Kim)ㆍ윤상모(Sang Mo Yun)ㆍ김성훈(Sung Hoon Kim) 대한방사선종양학회 2010 Radiation Oncology Journal Vol.28 No.2
목 적: 본 연구는 위암 환자에서 근치적 수술과 수술 중 방사선치료(intraoperative radiotherapy)를 시행한 장기 추적 결과를 보고하고자 한다.대상 및 방법: 1988년부터 1994년까지, 51명의 원발성 국소진행성 위암 환자에게 근치적 수술과 수술 중 방사선치료를 시행하였다. 수술 후 외부방사선치료는 30명의 환자에서, 보조 항암화학요법은 35명의 환자에서 시행되었다.수술 중 방사선치료는 9 MeV의 전자선을 이용하여 15 Gy를 조사하였으며, 외부방사선치료 조사선량의 중앙값은43.2 Gy (7.2∼45 Gy)이었다. 보조 항암화학요법은 35명에서 시행되었다. 추적관찰기간의 중앙값은 64개월(1∼ 254개월)이었다.결 과: 환자의 나이는 30∼71세(중앙값, 58세)였다. American Joint Committee on Cancer (AJCC) tumor-notemetastasis(TNM) 병기(2002)는 병기 I 13명(25.5%), 병기 II 10명(19.6%), 병기 III 25명(49.0%), 병기 IV 3명(5.9%)이었다. 주된 재발은 원격전이로 11명이었으며, 이 중 1명에서 국소재발이 동시에 발견되었다. 전체 환자의 5년 국소영역제어율, 무병생존율, 전체생존율은 각각 94.7%, 66.5%, 51.7%이었다. 다변량분석에서 전체생존율에 영향을 주는 인자에는 나이, TNM 병기, 외부방사선치료가 있었으며, 무병생존율에 대해서는 TNM 병기만이 유의한 인자였다. 결 론: 국소 진행성 위암에서 근치적 수술과 수술 중 방사선치료로 높은 국소제어율을 얻을 수 있었다. 그러나 수술 중 방사선치료의 생존율에 대한 영향에 대해서는 연구가 더 필요할 것으로 생각된다. Purpose: We retrospectively analyzed the long-term results of radical surgery and intraoperative radiation therapy(IORT) in patients with stomach cancer. Materials and Methods: From 1988 to 1994, 51 patients were treated with curative surgery and IORT. Postoperative external beam radiotherapy (EBRT) was administered to 30 patients, while adjuvant chemotherapy was administered to 35 patients. A dose of 15 Gy was irradiated with a 9 MeV electron beam as the IORT and a median dose of EBRT was 43.2 Gy (range, 7.2 to 45 Gy). The follow-up period ranged from 1∼254 months, with a median follow-up period of 64 months. Results: The median age of all the patients was 58 years (range, 30 to 71 years). The distribution of pathologic stage (American Joint Committee on Cancer [AJCC] 2002 tumor-note-metastasis [TNM]) was as follows: 13 stage I (25.5%), 10 stage II (19.6%), 25 stage III (49.0%), and 3 stage IV (5.9%). Distant metastases occurred in 11 patients (10 in the peritoneum and 1 in bone), including one patient with concurrent local recurrence (anastomosis site). The 5-year locoregional control, disease free survival and overall survival rates were 94.7%, 66.5%, and 51.7%, respectively. For the multivariate analysis, age, TNM stage, and EBRT were significant prognostic factors for overall survival, and only TNM stage for disease free survival. Conclusion: We could have achieved a high loco-regional control rate in patients with locally advanced stomach cancer by adding IORT to radical surgery. However, the benefit of IORT on survival remains to be elucidated.
Study of the proton-beam irradiation effects on TlH<sub>2</sub>PO<sub>4</sub>
Kim, Se Hun,Lee, Kyu Won,Jang, Jae Won,Lee, Cheol Eui,Lee, K-S.,Noh, S.J. Elsevier 2006 CURRENT APPLIED PHYSICS Vol.6 No.2
<P><B>Abstract</B></P><P>The H<SUP>+</SUP>-ion treatment effect on TlH<SUB>2</SUB>PO<SUB>4</SUB>, a KH<SUB>2</SUB>PO<SUB>4</SUB> (KDP)-type ferroelectrics, was studied by nuclear magnetic resonance (NMR) and AC dielectric constant measurements. A sample of TlH<SUB>2</SUB>PO<SUB>4</SUB> was irradiated by 1-MeV H<SUP>+</SUP> ion beams to a dose of 10<SUP>15</SUP>ions/cm<SUP>2</SUP>. The change in the NMR relaxation behaviors after the irradiation was attributed that in the hydrogen-bond geometry, presumably affecting the order–disorder proton dynamics. A prominent decrease in the dielectric constant was also observed after the irradiation. The macroscopic and microscopic changes due to the irradiation are discussed in the light of the proton dynamics.</P>
Kim, Se-Jin,Ho Hur, Joon,Park, Channy,Kim, Hyung-Jin,Oh, Gi-Su,Lee, Joon No,Yoo, Su-Jin,Choe, Seong-Kyu,So, Hong-Seob,Lim, David J,Moon, Sung K,Park, Raekil Nature Publishing Group 2015 Experimental and molecular medicine Vol.47 No.2
<P>Bucillamine is used for the treatment of rheumatoid arthritis. This study investigated the protective effects of bucillamine against cisplatin-induced damage in auditory cells, the organ of Corti from postnatal rats (P2) and adult Balb/C mice. Cisplatin increases the catalytic activity of caspase-3 and caspase-8 proteases and the production of free radicals, which were significantly suppressed by pretreatment with bucillamine. Bucillamine induces the intranuclear translocation of Nrf2 and thereby increases the expression of γ-glutamylcysteine synthetase (γ-GCS) and glutathione synthetase (GSS), which further induces intracellular antioxidant glutathione (GSH), heme oxygenase 1 (HO-1) and superoxide dismutase 2 (SOD2). However, knockdown studies of HO-1 and SOD2 suggest that the protective effect of bucillamine against cisplatin is independent of the enzymatic activity of HO-1 and SOD. Furthermore, pretreatment with bucillamine protects sensory hair cells on organ of Corti explants from cisplatin-induced cytotoxicity concomitantly with inhibition of caspase-3 activation. The auditory-brainstem-evoked response of cisplatin-injected mice shows marked increases in hearing threshold shifts, which was markedly suppressed by pretreatment with bucillamine <I>in vivo</I>. Taken together, bucillamine protects sensory hair cells from cisplatin through a scavenging effect on itself, as well as the induction of intracellular GSH.</P>
Trafficking Inhibition of Bruceanol B as a Radical-Producing Antibiotic
Dong-Sun Lee,Doseung Lee,부경환,Jin-Kyu Woo,Quanchun Hong,Somi K. Cho,Se Pill Park,Key Zung Riu 한국응용생명화학회 2011 Applied Biological Chemistry (Appl Biol Chem) Vol.54 No.2
Bruceanol B, isolated from a soil microbe strain DS4, generated oxygen radicals in Bacillus subtilis lysates. Bruceanol B inhibited the trafficking of viral glycoprotein in virus-infected baby hamster kidney (BHK) cells. Bruceanol B also effectively inhibited syncytium formation in a dosedependent manner. However, glycoprotein synthesis was not affected by the compound. Results indicate that bruceanol B generating oxygen radical has inhibitory activity in the trafficking of viral glycoprotein of BHK cell.
Structural Basis for the Reaction Mechanism of UDP-Glucose Pyrophosphorylase
Kim, Hun,Choi, Jong-Keun,Kim, Truc,Lokanath, Neratur K.,Ha, Sung-Chul,Suh, Se-Won,Hwang, Hye-Yeon,Kim, Kyeong-Kyu Korean Society for Molecular and Cellular Biology 2010 Molecules and cells Vol.29 No.4
UDP-glucose pyrophosphorylases (UGPase; EC 2.7.7.9) catalyze the conversion of UTP and glucose-1-phosphate to UDP-glucose and pyrophosphate and vice versa. Prokaryotic UGPases are distinct from their eukaryotic counterparts and are considered appropriate targets for the development of novel antibacterial agents since their product, UDP-glucose, is indispensable for the biosynthesis of virulence factors such as lipopolysaccharides and capsular polysaccharides. In this study, the crystal structures of UGPase from Helicobacter pylori (HpUGPase) were determined in apo- and UDP-glucose/$Mg^{2+}$-bound forms at 2.9 ${\AA}$ and 2.3 A resolutions, respectively. HpUGPase is a homotetramer and its active site is located in a deep pocket of each subunit. Magnesium ion is coordinated by Asp130, two oxygen atoms of phosphoryl groups, and three water molecules with octahedral geometry. Isothermal titration calorimetry analyses demonstrated that $Mg^{2+}$ ion plays a key role in the enzymatic activity of UGPase by enhancing the binding of UGPase to UTP or UDP-glucose, suggesting that this reaction is catalyzed by an ordered sequential Bi Bi mechanism. Furthermore, the crystal structure explains the specificity for uracil bases. The current structural study combined with functional analyses provides essential information for understanding the reaction mechanism of bacterial UGPases, as well as a platform for the development of novel antibacterial agents.