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한국인 주요우울장애 환자에서 혈중 ACTH, Cortisol 농도와 해밀턴 우울 평가 척도의 신체증상 항목과의 상관관계
여혜빈,김린,함병주,심세훈,권영준,정희연,정한용,한상우,이민수,이화영 대한생물치료정신의학회 2011 생물치료정신의학 Vol.17 No.2
Objectives:Hypothalamic-Pituitary-Adrenocortical(HPA) system dysregulation plays an important role in the pathophysiology of major depressive disorder. Medically unexplained somatic symptoms comprised the predominant complaints of korean patients with major depressive disorder. It might be related to dysregulation of HPA system and somatic symptoms. The aim of this study was to investigate the association between Hamilton Depression Rating Scale severity and the Plasma Adrenocorticotropic Hormone(ACTH) & Serum Cortisol level in Korean patients with major depressive disorder. Methods:Our study design was prospective. A total 111 hospitalized patients with major depressive disorder (DSM-IV) at Anam Hospital, Korea University Medical Center between Jan 2009 and May 2011 were selected. Hamilton Depression Rating Scale was measured by psychiatrist. Plasma ACTH, Serum Cortisol levels were analyzed at the time of admission. Results:There are significant correlations(p<0.05) between Hamilton Depression Rating Scale of somatic component(HAM-D 11-15 item) and Plasma ACTH and Serum Cortisol level. However, other HAM-D sub items were not significantly correlated with Plasma ACTH and Serum Cortisol level except somatic component. Conclusion:Our Study results suggest that hyperactivity of HPA axis might be correlation with somatic symptoms in korean patients with major depressive disorder.
A clinical correlation between henna hair dyeing and contact dermatitis
( Se Uk Oh ),( Chang Hwa Song ),( Dong Seok Shin ),( Young Wook Ko ),( Jeong Eun Kim ),( Young Suck Ro ),( Joo Yeon Ko ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1
Background: Pigmented contact dermatitis (PCD) is a noneczematous hyperpigmented type of contact dermatitis. PCD usually involves the face and neck being caused by repeated exposure to cosmetics, especially P-phenylenediamine (PPD). PPD is often found or reported as an additive in henna, which is widely used as a hair dye. Objectives: This study was to investigate the correlation between henna hair dyeing and PCD or allergic contact dermatitis (ACD). Methods: We performed a retrospective study of 6 patients diagnosed as either PCD or ACD with history of hair dyeing. All of them underwent patch testing including henna ingredient. Results: All of the patients with PCD or ACD had hair dyeing history more than 10 years. Forehead, temple, and zygomatic area were common sites of PCD. Our representative case of PCD patients revealed slate-grey reticulate hyperpigmentation with histopathologic findings of pigmented melanophages in dermis. According to patch test results, five of the patients were positive for Nickel and Cobalt. Two of them were positive at PPD. Also, all patients revealed positive results (one case of 2+, four case of 1+, one case of +-) in pure henna powder regardless of the presence of PCD. Conclusion: Our study showed the clinical correlation between henna hair dyeing and PCD, a rare type of ACD. We suggest to do patch testing or the use test for those who dye frequently for preventing PCD.
Joo, Hee-Kyoung,Lee, Sang-Ki,Kim, Hyo-Shin,Song, Yun-Jeong,Kang, Gun,Park, Jin-Bong,Lee, Kwon-Ho,Cho, Eun-Jung,Lee, Jae-Hwan,Seong, In-Whan,Kim, Se-Hoon,Cho, Chung-Hyun,Jeon, Byeong-Hwa The Korean Society of Ginseng 2008 Journal of Ginseng Research Vol.32 No.3
Vascular inflammation is an important step in the development of cardiovascular disorder. Since it has not been known whether Korean red ginseng has a role to play on the vascular inflammation, we investigated the effects of Korean red ginseng extract (KRGE) on monocyte adhesion and its underlying signaling mechanism. Monocyte adhesion assay and Western blot were conducted on the human umbilical vein endothelial cells to study monocyte adhesion and the expression of adhesion molecules. Intracellular calcium was measured with Fura-2 fluorescent staining, and superoxide production was measured with lucigenin chemiluminescence in the endothelial cells. KRGE inhibits tumor necrosis factor (TNF)-alpha-induced monocyte adhesion on the endothelial cells at the range of $0.03{\sim}1$ mg/ml. TNF-alpha-induced vascular cell adhesion molecule-1 and intercellular cell adhesion molecule-1 expression were inhibited by the pretreatment of KRGE in the endothelial cells. KRGE also inhibits TNF-alpha-induced intracellular calcium and the superoxide production in the endothelial cells. This study first demonstrated that KRGE inhibits TNF-alpha-induced monocyte adhesion by inhibiting the adhesion molecule expression, intracellular calcium and superoxide production in the endothelial cells. Therefore, the anti-inflammatory function of KRGE may be contributed to protecting the endothelial dysfunction in the vascular inflammatory disorders.
Second Trimester Maternal Serum Marker and Adverse Pregnancy Outcome
( Se Eun Cho ),( Yoo Jeong Shin ),( Hyo Jeong Kim ),( Hyun Young Ji ),( Hye Min Kwak ),( Hyun Hwa Cha ),( Suk Joo Choi ),( Soo Young Oh ),( Soo Youn Lee ),( Cheong Rae Roh ),( Jong Hwa Kim ) 대한산부인과학회 2011 Obstetrics & Gynecology Science Vol.54 No.11
Objective The aim of this study is to assess the risk of adverse pregnancy outcome by maternal serum markers in Quad test and to compare the existing cutoff (2.0 MoM) with 95 percentile cutoff generated from our consecutive population in predicting adverse pregnancy outcome. Methods We generated 95 percentile cutoff as our own reference using 3,000 consecutive women who performed Quad test. Except for follow-up loss, fetal aneuploidy and anomaly, 2,598 women were analyzed for the assessment of adverse pregnancy outcome consisted of preeclampsia (PE), preterm birth (<32 weeks), low birth weight and fetal death in utero. Results We confirmed high levels of alpha-fetoprotein (AFP), human chorionic gonadotropin (hCG), and inhibin A are associated with development of PE, preterm birth, and low birth weight. In general, 95 percentile cutoff corresponded similarly with 2.0 MoM except AFP. Combination of serum markers increased the odds ratio for predicting adverse pregnancy outcome. The women with higher level of both AFP and inhibin A (2.0 ≥ MoM) had 9.8 times higher risk for PE, 24.8 times higher risk for preterm birth, and 5.6 times higher risk for low birth weight. The women with higher level of AFP, hCG, and inhibin A had 8.2 times higher risk for PE, 29.4 times higher risk for preterm birth. Notably, negative predictive value of serum markers for PE and preterm birth are over 98% either in alone and in combination. Conclusion Maternal serum makers either in alone and in combination offer valuable information on the risk assessment of adverse pregnancy outcome.
A Multicenter Retrospective Study of Outpatient Intravenous Sedation for Dental Treatments
Se Hwa Jung,Sang Hyun Baik,Hyun Ki Roh,Na Ra Kang,Jae Jung Im,Byung Ha Lee,Jae Yoon Jeon,Kyung Gyun Hwnag,Kwang Sup Shim,Chang Joo Park 大韓顎顔面成形再建外科學會 2009 Maxillofacial Plastic Reconstructive Surgery Vol.31 No.2S
Case Reports : 2 Cases of a Benign Pulmonary Metastasizing Leiomyoma
Eun Joo Lee,Hye Cheol Jeong,Sung Yong Lee,Je Hyeong Kim,Sang Yeub Lee,Chol Shin,Jae Jeong Shim,Kwang Ho In,Kyung Ho Kang,Se Hwa Yoo,Sang Hoon Lee,Han Kyeom Kim,Yu Whan Oh 대한결핵 및 호흡기학회 2009 Tuberculosis and Respiratory Diseases Vol.67 No.6
A benign pulmonary metastasizing leiomyoma is a recognized clinical entity that has been infrequently reported in the medical literature. We report two cases of a benign pulmonary metastasizing leiomyoma. A 35-year-old woman who underwent myomectomy and a cesarean section approximately 6 years earlier visited our hospital for further evaluation of incidentally revealed multiple lung nodules. A diagnostic percutaneuous biopsy was performed. Finally she was diagnosed with a benign metastasizing leiomyoma. The patient then received LH-RH and has been followed up since. The other 44-year-old woman presented after an initial radiology evaluation revealed the presence of multiple, small-sized lung nodules. She underwent a right middle lung wedge resection to confirm the diagnosis. Finally she diagnosed with a benign metastasizing leiomyoma. The multiple lung nodules have been followed up closely.
Henoch-Schonlein 자반증 임상양상으로 나타나 진단이 늦어졌던 웨게너 육아종증
송세빈 ( Se Bin Song ),최혜숙 ( Hye Sook Choi ),김이형 ( Yee Hyung Kim ),최천웅 ( Cheon Woong Choi ),박명재 ( Myung Jae Park ),유지홍 ( Jee Hong Yoo ),강홍모 ( Hong Mo Kang ),김윤화 ( Yoon Hwa Kim ),박주철 ( Joo Cheol Park ) 대한결핵 및 호흡기학회 2007 Tuberculosis and Respiratory Diseases Vol.63 No.6
Wegener`s granulomatosis is a systemic vasculitis of the medium and small arteries, as well as of the venules, arterioles, and occasionally large arteries, and primarily involves the upper and lower respiratory tracts and the kidneys. Renal symptoms of Wegener`s granulomatosis are indistinguishable from those of vasculitis such as Henoch-Schonlein purpura and microscopic polyangiitis. This case, though initially diagnosed as Henoch-Schonlein purpura, was confirmed as Wegener`s granulomatosis from a lung biopsy fifteen years after the initial diagnosis. We report this case with a review of the literature. (Tuberc Respir Dis 2007;63:531-536)