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Levofloxacin과 Torsades de Pointes
권세아 ( Se Ah Kwon ),김철홍 ( Cheol Hong Kim ),송원준 ( Won Jun Song ),구자경 ( Ja Kyung Koo ),이순재 ( Soon Jae Lee ),박지영 ( Ji Young Park ),현인규 ( In Gyu Hyun ),고장휴 ( Jang Hyu Ko ),김현수 ( Hyun Soo Kim ) 대한결핵 및 호흡기학회 2010 Tuberculosis and Respiratory Diseases Vol.69 No.6
Torsades de pointes associated with a prolonged QT interval is a life-threatening arrhythmia, which may be induced by any of the following: drugs, electrolyte imbalances, severe bradycardia and intracranial hemorrhage. Torsades de pointes is characterized by beat-to-beat variations in the QRS complexes in any ECG leads with rates of 200~250 per minute. Fluoroquinolones are widely used and well tolerated antibacterial agents. However, prolongation of the QT interval leads rarely to Torsades de pointes as a significant adverse effect. So, it should be used with caution in high-risk patients for developing Torsades de pointes. We report one case of 67-year old man with contact burns who experienced Torsades de pointes, which probably resulted from the use of levofloxacin, and no further episode occurred after its withdrawal.
인공호흡기 적용환자에서 폐쇄형 기도흡인 전·후 과환기와 과산소 적용의 효과
신현주,김정아,권은옥,노화경,김미영,노진숙,권영옥,권정아,손희경,김세현,서미희,김선영,이영진,남지현,우정희,김명애 병원간호사회 2006 임상간호연구 Vol.12 No.2
Purpose: The purpose of this study was to identify the effects of hyperventilation and hyperoxygenation before and after endotracheal suctioning using closed-suction system on mechanically ventilated patients. Method: We selected 20 patients who were mechanically ventilated and randomly assigned into 4 groups according to the type of treatments using repeated measure. We applied 3 types of treatment, hyperventilation, hyperoxygenation, hyperventilation+hyperoxygenation, and no treatment and measured physiologic effects-SpO_(2), HR and, mena BP. Result: There were no significant differences between the group with no treatment and the group with hyperventilation, before and after endotracheal suctioning using closed-suction system(SpO_(2)(p=.693), HR(p=.970) and mean BP(p=.638)). There were no significant differences between the group with no treatment and the group with hyperoxygenation before and after endotracheal suctioning using closed-suction system(SpO_(2)(p=.693), HR(p=.970) and mean BP(p=.638)). There were no significant differences between the group with no treatment and the group with hyperventilation hyperoxygenation before and after endotracheal suctioning using closed-suction system(SpO_(2)(p=.693), HR(P=.970) and mean BP(P=.638)). Conclusion: As the results, all of the methods, hyperventilation, hyperoxygenation, and hyperventilation hyperoxygenation can be used when nurses apply endotracheal suctioning using closed-suction systems. In case of hypoxemic patients, hyperoxygenation is recommended for prevention of deoxygenation due to endotracheal suctioning using closed-suction systems.
Kwon, Kitae,Park, See-Hyoung,Han, Byung Seok,Oh, Sae Woong,Lee, Seung Eun,Yoo, Ju Ah,Park, Se Jung,Kim, Jangsoon,Kim, Ji Woong,Cho, Jae Youl,Lee, Jongsung MDPI 2018 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.19 No.9
<P>Urban particulate matter (UPM) exerts negative effects on various human organs. Transient receptor potential vanilloid 1 (TRPV1) is a polymodal sensory transducer that can be activated by multiple noxious stimuli. This study aimed to explore the effects of the UPM 1648a on the expression of TRPV1, and its regulatory mechanisms in HaCaT cells. UPM enhanced TRPV 1 promoter-luciferase reporter activity. UPM also increased expression of the TRPV 1 gene as evidenced by increased mRNA and protein levels of TRPV 1. In addition, elucidation of the underlying mechanism behind the UPM-mediated effects on TRPV 1 expression revealed that UPM can upregulate expression of the TRPV1 gene by activating activator protein-1 (AP-1) and nuclear factor kappa B (NF-κB). The UPM treatment also altered Ca<SUP>2+</SUP> influx and cell proliferation, as well as production of interleukin-8 (IL-8), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β). In addition, these UPM-induced effects were attenuated by SB203580 and ammonium pyrrolidinedithiocarbamate (PDTC). However, SP600125 and PD98059 did not alter the UPM-induced effects. Taken together, these findings indicate that UPM upregulates expression of the TRPV 1 gene, which is mediated by the p38 mitogen-activated protein kinase (MAPK) and NF-κB signaling pathways and suggest that UPM is a potential irritant that can induce skin processes such as aging and inflammatory responses.</P>
Se Youn Choi,Inho Kim,김남중,Seung-Ah Lee,Youn-Ak Choi,Ji-Yeon Bae,Ji Hyun Kwon,Pyoeng Gyun Choe,박완범,Sung-Soo Yoon,Seonyang Park,Byoung Kook Kim,Myoung-Don Oh 대한혈액학회 2011 Blood Research Vol.46 No.4
Background :The aim of this study is to investigate the hematological manifestations of human immunodeficiency virus (HIV) infection, the risk factors for cytopenia, and the effect of highly active anti-retroviral therapy (HAART) on cytopenia. Methods :Medical records of patients treated for HIV at the Seoul National University Hospital from January 2005 to March 2010 were retrospectively reviewed. To determine the impact of HIV itself, we excluded HIV patients who had other conditions that could have resulted in hematological manifestations. Multiple logistic regression analyses were performed to identify risk factors for cytopenia. Results :A total of 621 cases were investigated, and after exclusion, data of 472 patients were analyzed. The frequency of cytopenia was anemia, 3.0% (14/472); neutropenia, 10.0% (47/472); thrombocytopenia, 2.4% (12/472); lymphopenia, 25.7% (121/470); isolated cytopenia, 11.2% (53/472); and bicytopenia, 2.1% (10/472). The leading risk factor for cytopenia identified by multivariate logistic regression methods was AIDS status at initial presentation. After HAART, cytopenia was reversed in the majority of patients (thrombocytopenia, 100%; neutropenia, 91.1%; and anemia, 84.6%). Conclusion :This study isolated the impact of HIV infection alone on hematologic manifestations and confirmed that these changes were reversible by HAART. Control of the HIV infection will have the main role in the management of hematological manifestations of the virus.
Kwon, Ji Eun,Jeong, Hae Jin,Kim, So Jin,Jang, Se Hyeon,Lee, Kyung Ha,Seong, Kyeong Ah Elsevier 2017 Harmful algae Vol.68 No.-
<P><B>Abstract</B></P> <P>Heterotrophic nanoflagellates are ubiquitous and known to be major predators of bacteria. The feeding of free-living heterotrophic nanoflagellates on phytoplankton is poorly understood, although these two components usually co-exist. To investigate the feeding and ecological roles of major heterotrophic nanoflagellates <I>Katablepharis</I> spp., the feeding ability of <I>Katablepharis japonica</I> on bacteria and phytoplankton species and the type of the prey that <I>K. japonica</I> can feed on were explored. Furthermore, the growth and ingestion rates of <I>K. japonica</I> on the dinoflagellate <I>Akashiwo sanguinea</I>—a suitable algal prey item—heterotrophic bacteria, and the cyanobacteria <I>Synechococcus</I> sp., as a function of prey concentration were determined. Among the prey tested, <I>K. japonica</I> ingested heterotrophic bacteria, <I>Synechococcus</I> sp., the prasinophyte <I>Pyramimonas</I> sp., the cryptophytes <I>Rhodomonas salina</I> and <I>Teleaulax</I> sp., the raphidophytes <I>Heterosigma akashiwo</I> and <I>Chattonella ovata</I>, the dinoflagellates <I>Heterocapsa rotundata, Amphidinium carterae, Prorocentrum donghaiense</I>, <I>Alexandrium minutum</I>, <I>Cochlodinium polykrikoides</I>, <I>Gymnodinium catenatum</I>, <I>A. sanguinea</I>, <I>Coolia malayensis</I>, and the ciliate <I>Mesodinium rubrum</I>, however, it did not feed on the dinoflagellates <I>Alexandrium catenella</I>, <I>Gambierdiscus caribaeus</I>, <I>Heterocapsa triquetra, Lingulodinium polyedra</I>, <I>Prorocentrum cordatum</I>, <I>P. micans,</I> and <I>Scrippsiella acuminata</I> and the diatom <I>Skeletonema costatum</I>. Many <I>K. japonica</I> cells attacked and ingested a prey cell together after pecking and rupturing the surface of the prey cell and then uptaking the materials that emerged from the ruptured cell surface. Cells of <I>A. sanguinea</I> supported positive growth of <I>K. japonica</I>, but neither heterotrophic bacteria nor <I>Synechococcus</I> sp. supported growth. The maximum specific growth rate of <I>K. japonica</I> on <I>A. sanguinea</I> was 1.01 d<SUP>−1</SUP>. In addition, the maximum ingestion rate of <I>K. japonica</I> for <I>A. sanguinea</I> was 0.13ngC predator<SUP>−1</SUP>d<SUP>−1</SUP> (0.06 cells predator<SUP>−1</SUP>d<SUP>−1</SUP>). The maximum ingestion rate of <I>K. japonica</I> for heterotrophic bacteria was 0.019ngC predator<SUP>−1</SUP>d<SUP>−1</SUP> (266 bacteria predator<SUP>−1</SUP>d<SUP>−1</SUP>), and the highest ingestion rate of <I>K. japonica</I> for <I>Synechococcus</I> sp. at the given prey concentrations of up to ca. 10<SUP>7</SUP> cells ml<SUP>−1</SUP> was 0.01ngC predator<SUP>−1</SUP>d<SUP>−1</SUP> (48 <I>Synechococcus</I> predator<SUP>−1</SUP>d<SUP>−1</SUP>). The maximum daily carbon acquisition from <I>A. sanguinea</I>, heterotrophic bacteria, and <I>Synechococcus</I> sp. were 307, 43, and 22%, respectively, of the body carbon of the predator. Thus, low ingestion rates of <I>K. japonica</I> on heterotrophic bacteria and <I>Synechococcus</I> sp. may be responsible for the lack of growth. The results of the present study clearly show that <I>K. japonica</I> is a predator of diverse phytoplankton, including toxic or harmful algae, and may also affect the dynamics of red tides caused by these prey species.</P> <P><B>Highlights</B></P> <P> <UL> <LI> <I>K. japonica</I> is a predator of toxic or harmful dinoflagellates and raphidophytes. </LI> <LI> <I>K. japonica</I> cells pecked the surface of the prey cell and then ingested prey materials. </LI> <LI> The maximum specific growth rate of <I>K. japonica</I> on <I>A. sanguinea</I> was 1.01 d<SUP>−1</SUP>. </LI> <LI> Bacteria did not support positive growth of <I>K. japonica</I> due to its low ingestion rates. </LI> <LI> <I>K. japonica</I> could be an effective predator on <I>A. sanguinea</I>. </LI> </UL> </P>
Kim, Se-Young,Park, Min-Jung,Kwon, Jeong-Eun,Choi, Si-Young,Seo, Hyeon-Beom,Jung, Kyung Ah,Choi, Jeong-Won,Baek, Jin-Ah,Lee, Han Hee,Lee, Bo-In,Park, Sung-Hwan,Cho, Mi-La Elsevier 2018 IMMUNOLOGY LETTERS Vol.201 No.-
<P><B>Abstract</B></P> <P>Inflammatory bowel disease (IBD) is caused by chronic inflammation of the gastrointestinal tract. The pathogenesis of IBD remains unclear. The inflammation is associated with activation of T helper (Th) lymphocytes and chronic production of inflammatory cytokines. Ro60 suppresses the expression of tumor necrosis factor α, interleukin (IL)-6, and interferon α by inhibiting Alu transcription; control of Ro60 mRNA expression may thus be therapeutically useful. However, few studies have evaluated the anti-inflammatory activity of Ro60. The Ro60 level is decreased in IBD patients; we thus hypothesized that Ro60 was involved in the development of this autoimmune disease. We subjected mice with dextran sodium sulfate (DSS)-induced colitis to gene therapy using a vector that overexpressed Ro60 threefold. We scored IBD progression by repeatedly weighing the mice. Ro60 ameliorated colitis severity and reduced the levels of tumor necrosis factor α, IL-6, IL-17, IL-8, and vascular endothelial growth factor. Ro60 overexpression decreased the levels of α-smooth muscle actin (a marker of activated myofibroblasts) and type I collagen. The anti-inflammatory and anti-fibrotic activities of Ro60 ameliorated the severity of DSS-induced colitis in mice by repressing inflammation, fibrosis, angiogenesis, and the production of reactive oxygen species.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Overexpression of Ro60 delivered using recombinant DNA ameliorates DSS induced colitis severity. </LI> <LI> Ro60 reduces the levels of IL-6 and TNF-α proinflammatory cytokines in vitro and in vivo. </LI> <LI> Ro60 inhibits the expression of markers of oxidative stress, fibrosis and cell death in colonic tissue. </LI> </UL> </P>