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RISS 인기검색어
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- 저자 : ( Sarah Yoon ) (검색결과 49 건)
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Yoon, Sarah So-Jung,Lee, Kyung-Hoon Architectural Institute of Korea 2010 Architectural research Vol.12 No.2
The main objective of this study is to investigate the perception, recognition and response of innovative/ self-initiated play and its correlation to play space and play environment understood by children in their middle childhood years. Play, play theory, and the acceptance of play have an important role in child development. In recent years, play and the importance of innovative/ self-initiated play have been associated with a number of important societal issues. The impact of play and/or lack of play during the developmental stages of childhood directly influence a child's ability to mature and adapt into society. In order to investigate the overall perceptions of play and play space among the average child in their middle childhood, a questionnaire survey was distributed and analyzed using SSPS 15.0. This survey was conducted within the site specific context of South Korea. Interestingly enough, the differences in the responses can be organized into three main categories: age, gender and housing type. In result different directions for further study and research for future play spaces and play environments that support innovated/ self-initiated play have been suggested.
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Rethinking Political Correctness in the Age of #MeToo: Philip Roth’s The Human Stain
( Sarah Yoon ) 미국소설학회(구 한국호손학회) 2019 미국소설 Vol.26 No.1
In January 2018, Philip Roth said about the #MeToo movement in an interview with The New York Times, “none of the more extreme conduct I have been reading about in the newspapers lately has astonished me” (McGrath). At the height of the #MeToo movement, which had indicted media and business tycoons, as well as political leaders, Roth said that his lifelong novelistic concern in “depicting these men each as he is, each as he behaves, aroused, stimulated, hungry in the grip of carnal fervor” had meant that he had confronted the “hard facts” of such male lustful drives (McGrath). This paper rereads The Human Stain, in which Roth criticizes the effects of political correctness in the enclosed institution of academia, to comment on the perspective of human existence as “inevitably stained” (Roth 242). In rereading the tragic dimensions of the novel, this paper seeks to grapple with the effects of political correctness and the limitations of public opinion (represented through the academic institution, including the flawed feminist scholar Delphine Roux) on the lives of characters like Coleman Silk and Faunia Farley.
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Between Patriarchy and Neoliberalism : Cho Namju’s 82-nyŏnsaeng Kim Chiyŏng
SARAH YOON 계명대학교 한국학연구원 2020 Acta Koreana Vol.23 No.1
Cho Namju’s 82-nyŏnsaeng Kim Chiyŏng is a 2016 bestselling Korean novel that has received international attention. Having achieved immense popularity in Korea, the novel has become a centerpiece of recent feminist discussions in Korea through its exposure of contradictions in and between the patriarchal regime and a neoliberal society. This article explores the tensions and contradictions of these two models of social organization and their uneasy alliance in this novel, particularly in the narrated experiences of young mothers.
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Sarah Sojung Yoon,Kyung-Hoon Lee 대한건축학회 2010 Architectural research Vol.12 No.2
The main objective of this study is to investigate the perception, recognition and response of innovative/ self-initiated play and its correlation to play space and play environment understood by children in their middle childhood years. Play, play theory, and the acceptance of play have an important role in child development. In recent years, play and the importance of innovative/ self-initiated play have been associated with a number of important societal issues. The impact of play and/or lack of play during the developmental stages of childhood directly influence a child’s ability to mature and adapt into society. In order to investigate the overall perceptions of play and play space among the average child in their middle childhood, a questionnaire survey was distributed and analyzed using SSPS 15.0. This survey was conducted within the site specific context of South Korea. Interestingly enough, the differences in the responses can be organized into three main categories: age, gender and housing type. In result different directions for further study and research for future play spaces and play environments that support innovated/ self-initiated play have been suggested.
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Yoon, Sarah,Shin, Boram,Woo, Hyun Goo Korean Society for Molecular and Cellular Biology 2021 Molecules and cells Vol.44 No.8
Cyclase-associated protein 2 (CAP2) has been addressed as a candidate biomarker in various cancer types. Previously, we have shown that CAP2 is expressed during multi-step hepatocarcinogenesis; however, its underlying mechanisms in liver cancer cells are not fully elucidated yet. Here, we demonstrated that endoplasmic reticulum (ER) stress induced CAP2 expression, and which promoted migration and invasion of liver cancer cells. We also found that the ER stress-induced CAP2 expression is mediated through activation of protein kinase C epsilon (PKCε) and the promotor binding of activating transcription factor 2 (ATF2). In addition, we further demonstrated that CAP2 expression promoted epithelial-mesenchymal transition (EMT) through activation of Rac1 and ERK. In conclusion, we suggest that ER stress induces CAP2 expression promoting EMT in liver cancer cells. Our results shed light on the novel functions of CAP2 in the metastatic process of liver cancer cells.
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Effects of HMGB-1 Overexpression on Cell-Cycle Progression in MCF-7 Cells
Yoon Sarah,Yoon Byung Koo,배덕수,Choi Doo Seok,Lee Jin Young 대한의학회 2004 Journal of Korean medical science Vol.19 No.3
High mobility group-1 (HMGB-1) enhances the DNA interactions and possesses a transcriptional activation potential for several families of sequence-specific transcrip-tional activators. In order to examine the effect of HMGB-1 on the cell cycle progres-sion in MCF-7 cells, the HMGB-1 expression vector was transfected into synchronized MCF-7 cells, and the effect of HMGB-1 overexpression on the cell cycle was exam-ined. The HMGB-1 protein level in the transfected cells increased 4.87-fold compared to the non-transfected cells. There were few changes in the cell cycle phase distri-bution after HMGB-1 overexpression in the MCF-7 cells. Following the estrogen treat-ment, the cell cycle progressed in both the HMGB-1 overexpressed MCF-7 and the mock-treated cells. However, a larger proportion of HMGB-1 overexpressing MCF-7 cells progressed to the either S or G2 phase than the mock-treated cells. The mRNA levels of the cell cycle regulators changed after being treated with estrogen in both the HMGB-1 overexpressing MCF-7 and the mock-treated cells, but the changes in the expression level of the cell cycle regulator genes were more prominent in the HMGB-1 overexpressing MCF-7 cells than in the mock-treated cells. In conclusion, HMGB-1 overexpression itself does not alter the MCF-7 cell cycle progression, but the addition of estrogen to the HMGB-1 overexpressing MCF-7 cells appears to accel-erate the cell cycle progression.
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Sang Yoon Lee,Bokyung Kim,Sarah Yoon,Yeon Joo Kim,Tian Liu,Joo Hong Woo,Yong-Joon Chwae,Eun-hye Joe,주일로 생화학분자생물학회 2010 Experimental and molecular medicine Vol.42 No.9
In brain tissue, astrocytes play defensive roles in central nervous system integrity by mediating immune responses against pathological conditions. Type I phosphatidylinositol 4-phosphate 5-kinase α (PIP5Kα) that is responsible for production of phosphatidylinositol 4,5-bisphosphate (PI[4,5]P2) regulates many important cell functions at the cell surface. Here, we have examined whether PIP5Kα is associated with astrocyte inflammatory responses. Gangliosides are releasable from damaged cell membranes of neurons and capable of inducing inflammatory responses. We found that treatment of primary cultured astrocytes with gangliosides significantly enhanced PIP5KαmRNA and protein expression levels. PI(4,5)P2 imaging using a fluorescent tubby (R332H) expression as a PI(4,5)P2-specific probe showed that ganglioside treatment increased PI(4,5)P2 level. Interestingly,microRNA-based PIP5Kα knockdown strongly reduced ganglioside-induced transcription of proinflammatory cytokines IL-1β and TNFα. PIP5Kα knockdown also suppressed ganglioside-induced phosphorylation and nuclear translocation of NF-κB and the degradation of IκB-α, indicating that PIP5Kα knockdown interfered with the ganglioside-activated NF-κB signaling. Together, these results suggest that PIP5Kαis a novel inflammatory mediator that undergoes upregulation and contributes to immune responses by facilitating NF-κB activation in ganglioside-stimulated astrocytes.
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급성 뇌경색증에서 Transcranial Doppler의 진단적 가치에 관한 연구
윤세라,이기재,김호균 인제대학교 1999 仁濟醫學 Vol.20 No.1S
Transcranial doppler(TCD)의 두개내 혈관협착, 특히 다발성 협착의 진단의 적용에 대해서 알아보았다. 현재 관용적으로 쓰이고 있는 TCD상의 혈류속도의 증가만을 기준으로 하였을 때와 혈류속도외에 혈류의 형태학적인 변화, 측부 순환의 양상, 혈류속도의 감소, 좌우 비대칭성 등의 다양한 진단 지표를 고려하였을 때의 결과를 뇌혈관촬영술과의 상관관계에 비추어 비교하여 보았다. 두개내의 다발성 혈관협착의 빈발성과 그에 따른 복잡한 혈류양상 때문에 혈류속도 외에 다양한 진단 지표를 동시에 고려하였을 때가 TCD의 민감도, 특이도, 및 정확도를 증가시켜 TCD의 진단적 가치를 높임을 알 수 있었다. Objectives: The purpose of this study is to evaluate the usefulness of morphologic changes and collateral flow patterns in addition to velocity criteria using transcranial doppler(TCD) in detection of intracranial vascular stenosis, especially in cases of multiple stenoses. Methods and Materials : Medical records, angiography, and TCD findings were reviewed in 86 patients with acute cerebral infarction who underwent both cerebral angiography and TCD examination. Angiography was performed after TCD within a week. Angiography and TCD were interpreted blindly by neurologist and neuroradiologist. TCD was interpreted, using the velocity criteria according to the previous normal data of Yonsei medical collage, and to the morphologic changes and collateral flow patterns, retrospectively. Results: Total 373 sites of patients, who had good windows of TCD at intracranial portion of carotid siphon(siphon), proximal portion of middle cerebral artery(M1), and basilar artery were evaluated. Total 67 sites(46 patients) of stenoses were found 28 sites of M1, 30 sites of siphon, and 9 sites of basilar artery, Fifty eight of 67 sites had more than one site of intracranial stenosis. Among them, 43 sites had multiple stenoses within a vascular territory proximally and distally. When we used mean velocity as a sole parameter of diagnostic criteria, the overall sensitivity, specificity, and accuracy of TCD in detection of the stenosis at M1, siphon. and basilar artery were 19.4%, 85.0%, and 79.4%, respectively. When abnormal flow waveforms, collateral flow patterns, and decreased MV were considered together, they were improved to 55.2%, 91.1%, and 78.8%, respectively. When these parameters were considered in patients with multiple stenoses, one of the most confusing factor of diagnosis, false negative ramie was decreased markedly. The sensitivity was increased to 53.5%, close to that wish single stenosis (58.3%), resulting in better correlation with angiography and TCD examination. Conclusion: Owing to the high frequency of multiple stenoses and iris complex flow pat terns in intracranial stenosis, TCD may not be effective screening test for intracranial vascular stenosis if increased mean velocity is used as a sole criteria. So it seems to be better in detection of intracranial vascular stenosis that variable parameters such as changes in flow waveforms, collateral flow patterns, decreased mean velocity, and asymmetry index are considered simultaneously.
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