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Chung, Sarah,Lee, Sang Cheon,Sung, Dae Dong,Kim, Chulhee,Kim, Wantae,Park, Sung Bae 東亞大學校附設基礎科學硏究所 1997 基礎科學硏究論文集 Vol.14 No.1
An organic-inorganic bybrid sol-gel matrix was used as host for tridodecylmethylammonium chloride(TDMAC), which is an ionophare for chloride. The sol-gel precursor was prepared by the reaction of triethoxysilane with 1, 4butanediol. On mixing with TDMAC, the sol-state precureor alowly gelled, to give a TDMAC-containting membrane.
( Sarah Chung ),( Jin Young Jeong ),( Yoon Kyung Chang ),( Dae Eun Choi ),( Ki Ryang Na ),( Beom Jin Lim ),( Kang Wook Lee ) 대한내과학회 2016 The Korean Journal of Internal Medicine Vol.31 No.2
Background/Aims: There has been controversy about the role of Toll-like receptor 2 (TLR2) in renal injury following ureteric obstruction. Although inhibition of the renin angiotensin system (RAS) reduces TLR2 expression in mice, the exact relationship between TLR2 and RAS is not known. The aim of this study was to determine whether the RAS modulates TLR2. Methods: We used 8-week-old male wild type (WT) and TLR2-knockout (KO) mice on a C57Bl/6 background. Unilateral ureteral obstruction (UUO) was induced by complete ligation of the left ureter. Angiotensin (Ang) II (1,000 ng/kg/ min) and the direct renin inhibitor aliskiren (25 mg/kg/day) were administrated to mice using an osmotic minipump. Molecular and histologic evaluations were performed. Results: Ang II infusion increased mRNA expression of TLR2 in WT mouse kidneys (p < 0.05). The expression of renin mRNA in TLR2-KO UUO kidneys was significantly higher than that in WT UUO kidneys (p < 0.05). There were no differences in tissue injury score or mRNA expression of monocyte chemotactic protein 1 (MCP-1), osteopontin (OPN), or transforming growth factor (TGF-β) between TLR2-KO UUO and WT UUO kidneys. However, aliskiren decreased the tissue injury score and mRNA expression of TLR2, MCP-1, OPN, and TGF-β in WT UUO kidneys (p < 0.05). Aliskiren-treated TLR2-KO UUO kidneys showed less kidney injury than aliskiren-treated WT UUO kidneys. Conclusions: TLR2 deletion induced activation of the RAS in UUO kidneys. Moreover, inhibition of both RAS and TLR2 had an additive ameliorative effect on UUO injury of the kidney.
( Sarah Chung ),( Jin Young Jeong ),( Ye Jin Kim ),( Dae Eun Choi ),( Yoon Kyung Chang ),( Ki Ryang Na ),( Kang Wook Lee ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Although Toll-like receptor 2(TLR2) may play an important role, inhibition of TLR2 has not shown consistent results of amelioration in renal infi ammation of obstructed kidney. There have been some reports that renin angiotensin system (RAS) may affect the activation of TLR signaling. However, there was few study for the relationship between RAS and renal TLR2 activation in experimental unilateral ureteral obstruction(UUO). Methods: Male wild type and TLR2 knokout(KO) mice backgrounded C57BL/6 were divided into the 8 groups; 1)Sham, 2)Angiotensin II(Ang II)+ Sham, 3)AngII+TLR2 KO, 4)Aliskiren+Sham, 5)Aliskiren+TLR2 KO, 6)UUO only 7)TLR2 KO UUO, and 8)Aliskiren + TLR2 KO UUO. We performed realtime RT PCR and immunohistochemistry for molecular study and H&E stain and Masson trichrome (MT) stain for histologic examination of kidneys. Results: Ang II increased the renal mRNA expression of TLR2 in wild type mice (p <0.05). Ang II-infused TLR2 KO mice kidney showed signifi cantly lower mRNA expressions of osteopontin(OPN) and TGF-ß compared to those of Ang II-infused wild type mice. In TLR2 KO UUO kidneys, there were no differences of MCP-1, OPN and TGF-ß mRNA expressions and renal histology compared with UUO kidneys of wild type mice(p < 0.05, p < 0.05, respectively). The renal renin mRNA expression in TLR2 KO UUO was signifi cantly higher than that of UUO kidneys of wild type mice (p < 0.05). Renin inhibition by aliskiren decreased the mRNA expressions of MCP-1, OPN and TGF-ß, all of which were upregulated in TLR2 KO UUO kidneys (all, p < 0.05). Aliskiren also signifi cantly reduced renal tissue injury score (p < 0.05). Conclusions: Inhibition of RAS attenuates renal infi ammation in TLR2 KO UUO kidneys. It is speculated that RAS may modulate renal TLR2 activation in experimental unilateral ureteral obstruction.
정세라,박성배 인제대학교 1996 仁濟論叢 Vol.12 No.1
비고리 polyether들인 O-S podand들을 Ag+- 선택성 막 전극을 만드는데 막의 활성 요소로 사용하였다. 포단드에 기초를 둔 이 전극들은 Cd2+, Cu2+, Pb2+를 포함한 다른 중금속 이온들에 비해 Ag+에 대한 뛰어난 선택성을 보인다. 또한, 알카리와 알카리 토금속에 대해서도 선택성이 좋음이 관찰 되어 졌다. 이런 센서 체계(sensor systems)들의 반응 기울기(rerponse slopes), pH 효과 및 반응 시간(response time)을 정적 모드(static mode)를 통해 연구했다. Ag+- 선택성은 호스트-게스트(host-guests) 결합후 호스트 분자의 지방족 말단기들(aromatic end groups) 사이의 π-π 쌓임 상호작용(π-π stacking interaction)뿐만 아니라 호스트 분자들과 게스트 이온들 사이의 "soft-soft" 상호작용에 의해 설명 되어 진다. O-S type podands were used as membrane active components to prepare Ag+-selective membrane electrodes. The podand-based electrodes exhibited considerable selectivity toward Ag+ over other heavy metal ions including Cd2+ Cu2+, and Pb2+. Also, good selectivity over alkali and alkali earth metal ions were observed. Response slopes, pH effects, and response time were studied in static mode. The Ag+-selectivity was explained by "soft-soft" interaction between the guest ion and the host molecules as well as the π-π stacking interaction between aromatic end groups of the host molecules after the host-guest binding.
Coronary Artery Dose-Volume Parameters Predict Risk of Calcification After Radiation Therapy
Sarah A. Milgrom,Bibin Varghese,Gregory W. Gladish,Andrew D. Choi,Wenli Dong,Zarana S. Patel,Caroline C. Chung,Arvind Rao,Chelsea C. Pinnix,Jillian R. Gunther,Bouthaina S. Dabaja,Steven H. Lin,Karen E 한국심초음파학회 2019 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.27 No.4
BACKGROUND: Radiation exposure increases the risk of coronary artery disease (CAD). We explored the association of CAD with coronary artery dose-volume parameters in patients treated with 3D-planned radiation therapy (RT). METHODS: Patients who received thoracic RT and were evaluated by cardiac computed tomography ≥ 1 year later were included. Demographic data and cardiac risk factors were retrospectively collected. Dosimetric data (mean heart dose, dmax, dmean, V50 - V5) were collected for the whole heart and for each coronary artery. A coronary artery calcium (CAC) Agatston score was calculated on a per-coronary basis and as a total score. Multivariable generalized linear mixed models were generated. The predicted probabilities were used for receiver operating characteristic analyses. RESULTS: Twenty patients with a median age of 53 years at the time of RT were included. Nine patients (45%) had ≥ 3/6 conventional cardiac risk factors. Patients received RT for breast cancer (10, 50%), lung cancer (6, 30%), or lymphoma/myeloma (4, 20%) with a median dose of 60 Gy. CAC scans were performed a median of 32 months after RT. CAC score was significantly associated with radiation dose and presence of diabetes. In a multivariable model adjusted for diabetes, segmental coronary artery dosimetric parameters (dmax, dmean, V50, V40 V30, V20, V10, and V5) were significantly associated with CAC score > 0. V50 had the highest area under the ROC curve (0.89, 95% confidence interval, 0.80-0.97). CONCLUSIONS: Coronary artery radiation exposure is strongly correlated with subsequent segmental CAC score. Coronary calcification may occur soon after RT and in individuals with conventional cardiac risk factors.
Diekman Sarah,Chung Tae 대한응급의학회 2023 Clinical and Experimental Emergency Medicine Vol.10 No.1
The novel SARS-CoV-2 emerged in 2019, and the global COVID-19 pandemic continues into 2022. It has been known that a subset of patients develops chronic, debilitating symptoms after otherwise complete recovery from acute infection of COVID-19. Multiple terms have been used to describe this constellation of symptoms, including long COVID, long-haul COVID, and post-acute sequelae of SARS-CoV-2 syndrome (PASC). PASC is broadly defined as a wide range of new, returning, or ongoing symptoms at least four weeks after infection. Those patients are often seen in emergency departments after acute COVID-19 infection, but their symptoms are not adequately managed because the underlying pathophysiology of PASC is not well understood. Among patients with PASC, postural orthostatic tachycardic syndrome (POTS) has been increasingly recognized. POTS is one of the most common forms of autonomic dysfunction and defined by a sustained orthostatic tachycardia during active standing or head-up tilt test in the absence of orthostatic hypotension or other cardiopulmonary diseases. Because POTS is a treatable condition, it is important to recognize POTS among PASC patients. Herein, we reviewed the current literature on POTS and dysautonomia in PASC in order to better understand the overlap and distinction between these pathologies.
Seonhong Hwang,Chung-Ying Tsai,Sarah R Bass,Alicia M Koontz 한국재활복지공학회 2014 한국재활복지공학회 학술대회논문집 Vol.2014 No.11
The purpose of this study was to quantify the repeatability and reliability of the upper limb joint angles from eight subjects simultaneously measured by the Kinect and Vicon during wheelchair transfer. Shoulder, elbow, wrist joint, and trunk angles were calculated. The Kinect showed excellent correlation with the Vicon on the time series angle curve (r > 0.61). The shoulder abduction-adduction angle of leading arm and trunk angles were satisfied with ICC values over 0.81. Except for the maximum and minimum angles of leading arm"s elbow joint and those of trunk angles, all other variables had larger ICC differences than 0.1 between two systems. Good correlation of the Kinect with the Vicon and good reliability and validity of the Kinect seemed to indicate a potential application of the Kinect system for practical use at home or in clinics as a low-cost virtual coaching system for upper body motion correction during transfer.