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Lee, Sung Won,Park, Joon Beom,Kim, Hwa Jin,Kim, Hye Young,Lee, Sang Yeob,Chung, Won Tae,Shin, Yoon Kyung,Park, Hwan Tae,Rho, Jee Hyun,Yoo, Young Hyun Elsevier 2018 Biochemical and biophysical research communication Vol.503 No.3
<P><B>Abstract</B></P> <P>Free fatty acids (FFAs) are considered the principal inducers of lipotoxicity, leading to cell dysfunction and/or cell death. Lipotoxicity in Schwann cells (SCs) damages neurons, which may be associated with peripheral neuropathies and axon degeneration. However, the molecular mechanism by which FFAs exert lipotoxicity in SCs remains to be established. In the present study, we demonstrate that palmitate exerts lipotoxicity in SCs through apoptosis and that palmitate-induced lipotoxicity in SCs is mediated through reactive oxygen species (ROS) generation. We observed that the six-transmembrane protein of prostate 2 (STAMP2), which plays a pivotal role in lipid homeostasis, is expressed in SCs. We further demonstrate that palmitate induces lipoapoptosis in SCs through ROS generation-mediated STAMP2 downregulation and that STAMP2 depletion accelerates the palmitate-exerted lipoapoptosis in SCs, indicating that STAMP2 confers on SCs the ability to resist palmitate-induced lipotoxicity. In conclusion, palmitate induces lipoapoptosis in SCs through ROS generation-mediated STAMP2 downregulation. Our findings indicate that ROS and STAMP2 may represent suitable targets for pharmacological interventions targeting lipotoxicity-associated peripheral neuropathies and axon degeneration.</P>
( Lee Sang Yeob ),( Kim Yong Jun ),( Kang San Hyeon ),( Lee Dong Yeol ),( Cho Duk Song ),( Kim Kyong Han ),( Lee Sung Won ),( Chung Won Tae ) 대한내과학회 2011 대한내과학회 추계학술대회 Vol.2011 No.1
The purpose of this study was to compare with uveitis accompanied rheumatic disease and uveitis unaccompanied rheumatic disease in immunosuppressive therapy response. An observational study was conducted of 432 patients diagnosed with uveitis who visited the rheumatologic department to evaluate with rheumatic disease between 2000 and 2009. We divided patients into two groups: uveitis related to rheumatic disease and unrelated to rheumatic disease. All patients were treated and a response to treatment was measured at the end of the observation period. The 432 patients were diagnosed to uveitis, 33 (7.6%) patients had rheumatic diseases related uveitis and 399 (92.4%) patients had uveitis unrelated rheumatic disease. the each group were similar to gender and body mass index. but the mean age at onset of uveitis was younger uveitis with rheumatic disease than uveitis without rheumatic disease(44.06 vs 48.23 years). The rheumatic disease accompanied uveitis was consisted of spondyloarhtropathy (31%), bechet`s disease (27%), rheumatoid arthritis (18%), systemic lupus erythematosus (15%), sjogren`s syndrome (6%) and mixed connective tissue disease (3%). The state of inflammation, ESR and CRP levels in patients with uveitis associated with rheumatic diseases were increased but the ocular complications did not increase in uveitis associated with rheumatic disease. The response of immunosuppressive therapy in patients with uveitis associated with rheumatic diseases was good and was statistically significant (p<0.05). The uveitis accompanied rheumatic disease was better response to immunosuppressive therapy and less frequent complications than uveitisu naccompanied rheumatic disease in early treatment.
Occurrence of Soybean Sleeping Blight Caused by Septogloeum sojae in Korea
( Sung Kee Hong ),( Hyo Won Choi ),( Young Kee Lee ),( Sang Yeob Lee ),( Hong Sik Shim ) 한국균학회 2012 Mycobiology Vol.40 No.4
Sleeping blight was observed on soybean plants grown in Yanggu, Suwon and Geumsan from 2005 to 2011. Symptoms developed on stems and pods of affected soybean plants. Five fungal isolates were obtained from the diseased plants and identified as Septogloeum sojae based on their morphological, cultural and molecular characteristics. Pathogenicity of the fungus was confirmed on soybean plants by artificial inoculation. This is the first report of S. sojae causing sleeping blight in soybean plants in Korea.