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김웅흠,김우택,이창연,김동욱,박성기,장무환 동국대학교 경주대학 1993 東國論集 Vol.12 No.-
Hemolytic uremic syndrome is characterized by Coombs-negative microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure in infant and children. At present, E. coli 0157 : H7 and other verotoxin-producing E. coli(VTEC) seem to be a major cause of this illness. The majority of patients have a prodrome of bloody diarrhea, and acute renal failure develops several days to weeks later. Although an optimal treatment remains unknown, the general management of hypertention and renal failure with early and frequent dialysis is the mainatay of treatment, and intravenous administration of immunoglobulin G is like to be effective. We experienced a case composed of bloody diarrhea, seizures, coma, and anuria in 1 year old girl who was diagnosed as HUS and recovered renal function completely with slight impairment of cognitive ability and behavioral function. We presented this case with a review of literatures.
혈중납이 흰쥐의 Microsomal Cytochrome P-450 Monooxygenase 활성도에 미치는 영향
박기현,장성근,윤영안,김기웅,박종안 순천향대학교 1993 논문집 Vol.16 No.3
In rats treated with lead nitrate and/or red ginseng extract mixture we observed a change in the level of hepatic cytochrome P-450 and electron transport system for P-450 dependent reaction, and content of Zincprotoporphyrin(ZPP) and Hemoglobin(Hb) in whole blood. The content of cytochrome P-450 and ?? , and the activity of ECHEase, AHHase and NADPH-cytochrome C(p-450) reductase were slowly decreased according to the dosage of lead nitrate. On the other hand, the activity of ?? reductase was increased according to the dosage of lead nitrate, but in case of treatment with red ginseng mixture, this enzyme activity was slightly decreased. In whole blood, the content of hemoglobin and ZPP were not shown any critival change but lead content increased according to dosage of lead nitrate. These results suggest that content and activity of cytochrome P-450-dependent monoxygenase may be dependent on specificity of substrates, and the acute exposure of lead nitrate and red ginseng extract mixture was not affected any biological significance.
장섬유강화 고분자 복합판의 프레스 성형에 있어서 니트라인에 관한 연구
조선형,이국웅,안종윤,윤성운 한국공작기계학회 2001 한국생산제조학회지 Vol.10 No.2
In recent years, compression molding of lone fiber-reinforced thermoplastics has been increased in commercial aspects. In the process of compression molding of composites, the flow analysis must he developed in order to accurately predict the finished part properties as a function of the molding process parameters. In this model FRTP is assumed to be nonisothermal fluid, which has different viscosities in extensional and in shear. For verification of the model, the formation of a knit line in the L-shaped parts is compared with that of experiments results. In this paper we will discuss the effects of extensional & shears viscosity ratio ξ and slip parameter α on the other mold fill-ing parameters
조선형,안종윤,이국웅,윤성운 한국공작기계학회 2001 한국생산제조학회지 Vol.10 No.2
During a compression molding process of Unidirectional Fiber Reinforced Thermoplastic Composites, control of filling patterns in mold and distribution of fiber is needed to predict the effects of molding parameters on the flow characteristics. To obtain an excellent product and decide optimum molding conditions, it is important to know the relationship between molding conditions and viscosity. In this study, the anisotropic viscosity of the Unidirectional Fiber-Reinforced Polymeric Composites is measured by using the parallel plastometer. The model for flow state has been simulated by using the viscosity. The composites is treated as an incompressible New-tonian fluid. The effects of longitudinal transverse viscosity ratio A and slip parameter α on buldging phenomenon and mold filling patterns, are also discussed.
韓國 自生 범부채(Belamcanda chinensis (L.) DC.)의 種子發芽에 關한 硏究
朴潤点,劉成吾,崔權雄,鄭然玉 한국화훼연구회 1995 화훼연구 Vol.4 No.1
These studies were carried out to investigate the seed germination of Belamcanda chinensis (L.) DC. The results obtained are as follows : 1.Optimum temperature of seed germination was 25℃, and the seed germination rate was raised to 92% by 20/30℃ alternative temperature treatment. 2.Under the condition of moist low temperature storage, the germination rate was 53% at 42 days after sowing, but showed the germination rate of 11% at same period with dry low temperature storage. 3.The germination rate was higher in the light condition than in the dark condition. 4.The germination rate was higher when the seed coat was removed than when the seed coat was not removed or the seed coat was stratificated. 5.The germination rate was 80% with 100ppm GA3 treatment, and 76% wihh soaking treatment of 1% KOH solution for 24 hours.
( Sang Woong Youn ),( Byung Soo Kim ),( Minsu Kim ),( Dae Young Yu ),( Youngdoe Kim ),( Kwang Joong Kim ),( Jee-Ho Choi ),( Sang Wook Son ),( Eun-So Lee ),( Young Suck Ro ),( Young Lip Park ),( YoungJ 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.2
Background: Postmarketing surveillance is conducted to establish drug safety and effectiveness under real practice. Objectives: To validate ustekinumab’s effectiveness and safety in the treatment of adult Korean patients with plaque psoriasis under real practice. Methods: This was a prospective, observational, and multi-center study. The study subjects were aged 18 years and above, who were administered ustekinumab for treating plaque psoriasis. Results: The study included 977 patients; 66.9% were male, with a mean±standard deviation of BSA(%) of 27.0±18.3 and mean PASI of 18.1±9.7. The effectiveness analysis included 581 patients who had at least one follow-up assessment and met treatment criteria per local label and reimbursement guidelines; of these patients, 287 had effectiveness data for visit 6. The timing of visit 6 occurred at 53.7±2.1, weeks; at visit 6 91.6%, 51.2%, and 9.4% achieved PASI75, PASI90, and PASI100 responses, respectively. Adverse events (AEs) occurred in 11.5% yielding an incidence rate of 21.5/100 patient-years (PYs). Serious AEs occurred in 0.8% with an incidence rate of 1.2/100 PYs. The estimated 1-year drug retention rate was 87.7%. Multiple logistic regression analyses showed that higher baseline PASI score and no prior biologic exposure were significant predictors for PASI90 response at visit 6. Conclusion: Ustekinumab is effective and safe, with high drug retention in the treatment of adult Korean patients with plaque psoriasis in real-world practice.