자궁내막암 환자에서 복강경하 자궁적출술과 복식 자궁적출술의 비교 연구

김종혁,이상수,김천복,김대연,김용만,김영탁,목정은,남주현 대한부인종양 콜포스코피학회 2003 Journal of Gynecologic Oncology Vol.14 No.4

목적 : 자궁내막암 환자에서 시행된 복강경 수술의 임상적 결과를 평가하고 수술적 지표 및 재발률에 대하여 기존의 개복 수술과 비교하고자 하였다. 연구 방법 : 1997년 8월부터 2003년 11월까지 저자들은 임상적 병기 I기인 79명의 자궁내막암 환자에서 복강경하 자궁적출술과 골반 및 부대동맥 림프절 절제술을 시행하였다. 총 79명의 환자 중, 수술적 병기 I기와 II기로 판명된 74명의 환자를 연구 대상으로 하였다. 대조군으로는 같은 기간 동안에 개복수술을 시행한 환자중 복강경 수술군과 병기가 같은 168예를 선정하였다. 결과 : 평균 수술 기간, 수혈량은 양군에서 비슷하였으며, 평균 재원 기간은 복강경 수술군에서 유의하게 짧았다. 수술전후 및 만성 합병증의 발생은 개복 수술군에서 유의하게 증가되었으며, 획득한 림프절의 수는 복강경 수술군에서 유의하게 더 많았다. 복강경 수술군에서 1예, 개복 수술군에서는 2예에서 재발하였고, 2년 무병 생존률은 복강경 수술군과 개복 수술군에서 각각 97.5%와 98.6%으로 유의한 차이는 관찰되지 않았다. 결론 : 자궁내막암 치료로서 복강경 수술은 기존의 개복술을 대신할 수 있는 안전하고 효과적인 시술 방법이다. 개복 수술과 비교해 볼 때, 재발 및 생존율 면에서 차이가 없었지만, 향후 전향적이고 더 오랜 추적기간을 갖는 연구가 필요하다고 사료된다. Objective : To evaluate the outcomes of laparoscopic surgery and to compare surgical parameters and recurrence rate of these with those of conventional abdominal surgery in patients with endometrial cancer. Methods : From August 1997 to November 2003, we have performed 79 cases of LAVH (laparoscopically assisted vaginal hysterectomy) with or without lymph node dissection. Laparoscopic approach was adapted in patients with FIGO clinical stage I by imaging study. Of the 79 patients, 74 patients who were proved to be surgical stage I and II were enrolled in this comparative study. As a control group, We selected 168 cases for the laparotomy group of the same stages. Results : The mean duration of surgery, the amount of blood transfusion and hemoglobin chamges were similar in both the laparoscory and the convertional alparotomy group. The mean duration of hospital stay was significantly shorter in patients treated by laparoscopic surgery (10.2 vs. 15.5 days). The number of lymph node obtained was significantly higher in the laparoscopy group. Two year recurrence-free survival rates were 97.5% in laparoscopy group and 98.6% in laparotomy group (p=0.763). Conclusion : Laparoscopic surgery for the treatment of early stage endometrial cancer is safe and effective altematives in terms of perioperative complications. Overall and recurrence-free survival did not differ significantly in both groups however long term risk for recurrence and survival has yet to be defined.

Cisplatin에 의한 흰쥐 공장의 alkaline phosphatase 활성변화에 미치는 SOD의 영향

김성목,현성희,전영희,문원진,백두진 한양대학교 의과대학 1995 한양의대 학술지 Vol.15 No.1

Cisplatin has been widely used as an effective anticancer platinum compound. Cisplatin incorporates with intrastrand or interstrand of the DNA and it inhibits the synthesis of the nucleic acid and protein. During the treatment of cancer patients, cisplatin acts on normally proliferating cells, which results in nephrotoxicity, nausea, vomiting, anorexia, bone marrow suppression and inner ear damage. These toxicities are related to oxygen free radicals formation by cisplatin, which inhibits the activity of the catalase and admages the mitochondria. The author has demonstrated the effect of superoxide dismutase(SOD), one of the antioxidant enzymes, on changes of alkaline phosphatase activities in the jejunum of the cisplatin treated rats. A total of 60 healthy Sprague-Dawley rats weighing about 200gm were used as an experimental animals. Cisplatin(6mg/kg) was administered intraperitoneally with pretreatment of 15000unit/kg of SOD or not. The experimental animals are sacrificed at 6 hours, 12 hours, 24 hours and 3 days after the administration of cisplatin. A part of jejunum were obtained and fixed in 10%-neutral formalin at 4℃. The speciments were sectioned 16㎛ thickness in frozen cryostat. The activity of alkaline phosphatase was evaluated histochemically by Gomori's method and incubation time of sections of specimens was 30minutes. The results were as follows. 1. SOD increase the activity of alkaline phosphatase in the epithelium of jejunum of the rat. 2. The activities of alkaline phosphatase of the epithelium of the mucosa decrease in jejunum of 6 hours and 12 hours of cisplatin treated rats. In the 24 hours and 3 days, activities of alkaline phosphatase of the epithelium increase. The atrophied villi are observed in the 12 hours and 24 hours of cisplatin treated group. 3. The activities of alkaline phosphatase increase in 12 hours and 3 days of cisplatin treated group with SOD pretreatment, the activities decrease in 6 hours of cisplatin treated group with SOD pretreatment. The activities of alkaline phosphatase in the 24 hours of cisplatin treated group with SOD pretreatment show a decided decrease over those of control group with SOD pretreatment. The atrophied villi are seen in the 12 hours and 24 hours of cisplatin treated group with SOD pretreatment. 4. The activities of alkaline phosphatase in the cisplatin treated group with SOD pretreatment are higher than those in the cisplatin treated group, except 24 hours of cisplatin treated group. 5. There are very little changes of alkaline phosphatase activities in the lamina propria, submucosa and muscle layer of all groups. Consequently, these results suggests that cisplatin decreases the activity of the alkaline phosphatase and SOD pretreatment decreases the range of the change in alkaline phosphatase activity of jejunum of the cisplatin treated rats.

상악골에 발생한 악성섬유성조직구종의 치험례

이상철,김여갑,류동목,이백수,윤옥병,신민철 大韓顎顔面成形再建外科學會 1998 Maxillofacial Plastic Reconstructive Surgery Vol.20 No.1

간절제술을 시행한 양성 간종양의 임상적 고찰

김도균,이상목,홍성화,오수명,주흥재 경희대학교 1998 慶熙醫學 Vol.14 No.3-4

하계 집중 호우에 따른 강화도 갯벌 퇴적물 내 공극수 성분 변화

목진숙,김성한,조혜연,현정호 한양대학교 이학기술연구소 2007 이학기술논문지 Vol.10 No.-

2007년 7월 10일부터 8월 9일까지 강화도 남단 동검리 갯벌에서 표층 퇴적물 6 cm 이내 화학 성분(CO₂, NH₄^(+), Fe^(2+), SO₄^(2-), HS^(-))의 농도를 측정하였다. 조사 기간 동안 세 차례의 태풍(EWINIAR, BILIS, KAEMI)과 폭우 (110∼202.5 mm)가 있었다. 그로 인해 염분은 7∼21 psu(practical salinity units)의 범위를 보였고, CO₂, NH₄^(+), Fe^(2+), SO₄^(2-), HS^(-)의 농도는 각각 84∼159, 5.52∼16.46, 3.56∼9.69, 160∼461, 0.58∼0.99 mmol m^(-2)의 범위로 나타났으며, 전반적으로 폭우 이후 급격히 감소한 후 다시 회복되는 경향을 보였다. 이러한 결과는 폭우 이후 담수 유입 증가에 따른 희석 효과를 반영하고 있을 뿐만 아니라, 물리적 교란에 의해 혐기성 상태의 분해 산물이 재산화 됨으로써 퇴적물 내 혐기성 조건이 완화되었음을 의미한다. 본 연구 결과는 향후 기상이변에 따른 집중호우가 갯벌 내 생지화학적 과정에 큰 영향을 미칠 수 있음을 지시해 준다. Concentrations of pore water constituents CO₂, NH₄^(+), Fe^(2+), SO₄^(2-), HS^(-) within top 6 cm sediment were measured from 10 July to 9 August 2007 at Donggeom intertidal mudflat of the south Ganghwa in Korea. There was a typhoon (EWINIAR, BILIS, KAEMI) and heavy rainfall (110∼02.5 mm) of three times during the period. Therefore salinity ranged from 7 to 21 psu concentrations of CO₂, NH₄^(+), Fe^(2+), SO₄^(2-), HS^(-) ranged 84∼159 , 5.52∼16.46, 3.56∼9.69, 160∼461 0.58∼0.99 mmol m^(-2), respectively, and constituents were steeply decreased after heavy rainfall and recovered again. These results reflected the dilution effect by the increasing of freshwater discharge after heavy rainfall and implied that physical disturbance led to less anoxic conditions in the sediment by reoxidizing the anoxic decomposition products. This results also implied that the short-term heavy rainfall may have a profound impact on the sediment biogeochemistry.

악성 종양세포주에서 세포독성 물질에 의한 apoptosis의 유발에 관한 연구

김병주,이상목,고석환,윤충,박재훈,장린 경희대학교 1997 慶熙醫學 Vol.13 No.4

바닥판의 모드질량산정에 관한 연구

김장윤,황재승,홍성목 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2(구조계)

Modal mass is essential to analyze structural response under disturbance and to design the vibration control devices used to enhance the serviceability of structure. Modal mass differs from that of analytic mathematical model due to the error generated from analytical assumption and construction. Therefore, the objective of this study is to proposed to calculate the modal mass of structure based on the system identification. And the proposed method is applied to two examples, the single DOF system and the slab of apartment.

전기투석을 이용한 아세트산의 회수

金永穆,金相憲,李炳哲 弘益大學校 産業技術硏究所 2004 産業技術 Vol.14 No.-

This paper studied acetic acid recovery by using mono-polar membrane electrodialysis. Current efficiency, solute recovery efficiency, energy consumption, and mass flux of acetic acid and water flux were measured at various dilute stream acetic acid concentrations, flow rates and current densities. The experiment in this paper indicated that current efficiency, recovery efficiency, and energy consumption increased linearly as the current density increased. The effect of flow rate changes are not critical on the solute flux.

電氣抵抗探針法에 의한 氣泡塔內의 氣泡特性에 관한 硏究

金相烈,金瀅翰,睦演洙 동아대학교 공과대학 부설 한국자원개발연구소 1988 硏究報告 Vol.12 No.1

The bubble behavior in a bubble column was observed, and its size and velocity were determined using two sets of probes measuring the resistance. From the measurement a local gas holdup was also obtained. Since the local gas holdup could be measured, the distribution of bubbles in the radial direction was able to find from the experiment. As a result, a correlation between gas holdup and the operating condition of the column, represented as Reynolds number, and the physical property, expressed as Galilei number, was made from the experimental data.

國際貿易에 따른 環境問題와 韓國經濟의 對應方案

김용진,강상목 釜山敎育大學校 1994 부산교육대학 논문집 Vol.30 No.1