백서 심근경색모델에서 시간경과와 경색의 크기에 따른 심자도의 변화

김미성(Mi Sung Kim),박영선(Young Sun Park),권순길(Sun Gil Kwon),지정훈(Jeong Hoon Ji),신종성(Jong Sung Shin),오광식(Kwang Sik Oh),양용모(Yong Mo Yang),연태진(Tae Jin Youn),김동운(Dong Woon Kim),조명찬(Myeong Chan Cho),이용호(Yong Ho 대한내과학회 2002 대한내과학회지 Vol.62 No.1

N/A Background: Magnetocardiogram (MCG), which records the changes of magnetic fields generated by the heart`s electrical activity, theoritically can provide unique data for clinical application. To date, MCG has been investigated only at a single time point after myocardial infarction (MI) with severe left ventricular dysfunction in rats. The purpose of the present study was to investigate sequential changes of MCG after MI and to evaluate effects of infarct size on MCG. Methods: Acute MI were induced by the permanent ligation of left coronary artery in 22 rats. Magnetic fields were recorded just above a rat with Nb Superconducting Quantum Interference Device (SQUID) gradiometer inside a magnetically shielded room. MCG was measured before and immediately after surgery and it was subsequently recorded at the time points of 1, 4 and 6 hours post operatively. MCG was also measured at 1, 3, 7 and 21 days after surgery. Results: Elevation of ST segment and appearance of pathological Q wave on the MCG were evident immediately after the ligation of coronary artery and persisted to 6 hours after MI. On MCG, ST segment was depressed and T wave was inverted from 1 day after MI. In rats with small-and moderate- sized MI (infarct size〈30%), ST depression returned to near the isoelectric level and Q wave disappeared from 7 days after MI. However, ST depression and Q wave were still present in rats with larger infarct (infarct size≥30%). Conclusion: Evolutional changes of MCG were well-recognized up to 21 days after MI. Furthermore, the infarct size can be expressed by the extent of Q wave and ST segment depression on MCG. Taken together, these data indicate that MCG is a helpful modality for the diagnosis, evaluation of infarct size and follow up after MI.(Korean J Med 62:42-48, 2002)

성악 전공 학생의 가칭 시 음성의 SPR(Singing Power Ratio)에 관한 연구

조성미,정옥란,이상욱 한국음성과학회 2004 음성과학 Vol.11 No.4

This study attempted to provide a spectrum analysis for quantitative evaluation of singing voice quality of singing students rather than the presence or absence of the singer's formant. The regression analysis was used to analyse the relationship between ringing quality, SPR, and SPP of singing voice of college student subjects majoring in music. This study measured singing power ratio (SPR) in 41 singing students. Digital audio recordings were made in sung vowels for acoustic analyses. Each sample was judged by 1 experienced singing teacher and 4 voice pathologists on one semantic bipolar 7-point scales (ringing-dull). The results showed that the SPR and SPP had significant correlations with ringing Quality. The SPR had a significant relationship with ringing quality on singing voice in singing students. The SPR can be an important quantitative measurement for evaluating singing voice quality.

실용음악 전공 학생들의 발성치료 전후 성대 및 음성 특성 비교

황연신,심미란,김철준,최용석,김상연,최찬호,선동일,Hwang, Yeon Shin,Shim, Mi Ran,Kim, Chul Jun,Choi, Yong Suk,Kim, Sang Yeon,Choi, Chan Ho,Sun, Dong Il 대한후두음성언어의학회 2016 대한후두음성언어의학회지 Vol.27 No.2

Background and Objectives : Many students major in applied music singing have various difficulties in phonation when they sing or perform. But the studies about this cause are lack. The purpose of this study is whether singing voice therapy based on vocal music is effective or not to applied music singing students that have difficulties in phonation. Materials and Methods : Singing voice therapy program had been done to 8 students major in applied music singing during 7 weeks. We did laryngeal stroboscope, perceptual, acoustic and aerodynamic examination before and after singing voice therapy to this students. And we studied post examination results have differences or improvements compared to pre examination results. Results : Four male students don't have effective improvement after singing voice therapy but they shows slight improvement in aerodynamic examination values compared to pre examination values. Four female students shows improvement in aerodynamic examination values and pitch range increasing. Above all, one student's vocal nodules disappeared after singing voice therapy. Conclusion : Singing voice therapy based on music singing is very effective to the students major in applied music singing. Above all, their curriculum in applied music singing should include phonation training based on music singing before training perform and technic practices.

Myocardial Protection by Recombinant Soluble P-selectin Glycoprotein Ligand-1 Suppression of Neutrophil and Platelet Interaction Following Ischemia and Reperfusion

Sang Soo Ham,Yoon Young Jang,Jin Ho Song,Hyang Mi Lee,Kwang Joon Kim,Jun Sik Hong,Yong Kyoo Shin 대한생리학회-대한약리학회 2000 The Korean Journal of Physiology & Pharmacology Vol.4 No.6

<P> Polymorphonuclear leukocytes (PMNs) play an important role in myocardial ischemia/reperfusion (MI/R) injury. Moreover, platelets are also important blood cells that can aggravate myocardial ischemic injury. This study was designed to test the effects of PMNs and platelets separately and together in provoking cardiac dysfunction in isolated perfused rat hearts following ischemia and reperfusion. Additional control rat hearts were perfused with 75⁓10<SUP>6</SUP> PMNs, with 75⁓10<SUP>6</SUP> platelets, or with 75⁓10<SUP>6</SUP> PMNs⁢75⁓10<SUP>6</SUP> platelets over a five minute perfusion followed by a 75 min observation period. No significant reduction in coronary flow (CF), left ventricular developed pressure (LVDP), or the first derivative of LVDP (dP/dt max) was observed at the end of the observation period in any non-ischemic group. Similarly, global ischemia (I) for 20 min followed by 45 minutes of reperfusion (R) produced no sustained effects on the final recovery of any of these parameters in any group of hearts perfused in the absence of blood cells. However, I/R hearts perfused with either PMNs or platelets alone exhibited decreases in these variables of 5∼10% (p<0.05 from control). Furthermore, I/R hearts perfused with both PMNs and platelets exhibited decreases of 50 to 60% in all measurements of cardiac function (p<0.01). These dual cell perfused I/R hearts also exhibited marked increases in cardiac myeloperoxidase (MPO) activity indicating a significant PMN infiltration, and enhanced P-selectin expression on the coronary microvascular endothelium. All cardiaodynamic effects as well as PMN accumulation and P-selectin expression were markedly attenuated by a recombinant soluble PSGL-1 which inhibits selectin mediated cell adhesion. These results provide evidence that platelets and PMNs act synergistically in provoking post-reperfusion cardiac dysfunction, and that this may be largely due to cell to cell interactions mediated by P-selectin. These results also demonstrate that a recombinant soluble PSGL-1 reduces myocardial reperfusion injury by platelet and PMNs interaction.

Could cluster of risk factors predict clinical outcome in patients with acute myocardial infarction?

( Sang Mi Park ),( Hong Nyun Kim ),( Se Yong Jang ),( Myung Hwan Bae ),( Dong Heon Yang ),( Hun Sik Park ),( Yongkeun Cho ),( Shung Chull Chae ),( Jang Hoon Lee ) 대한내과학회 2015 대한내과학회 추계학술대회 Vol.2015 No.1

Purpose: Conventional risk factors are differently contributed to short-term prognosis of acute myocardial infarction (AMI); hypertension and diabetes increase adverse outcome, whereas hyperlipidemia, smoking, and obesity paradoxically decrease adverse outcome of post-MI patients. The aim of this study is to assess whether cluster of conventional risk factors, PARADOCS (Pressure of ARtery Abnormality, Diabetes, Obesity, Cholesterol, Smoking) score, would improve the ability to predict major adverse cardiac events (MACEs) in patients with AMI. Methods: Between November 2005 and July 2011, 24,020 patients (17,232 men; mean age=63.0±12.8) with AMI were analyzed from Korean AMI registry. PARADOCS score was calculated as follows; [number of non-paradoxical risk factors (NRF) -number of paradoxical risk factors (PRF)]+3 in which non-paradoxical risk factors are hypertension and diabetes, and paradoxical risk factors are the rest. The 1-year MACEs were defined as death and non-fatal MI. Results: NRF including hypertension and diabetes were present in 49.6% and 27.0%, whereas PRF including hyperlipidemia, smoking, and obesity were present in 12.3%, 43.0%, and 34.6%, respectively. During the follow-up, 1,409 (5.9%) MACEs occurred. PARADOCS score was significantly higher in patients with 1-year MACEs (3.38±1.03 versus 2.81±1.08, p<0.001). In Cox proportional hazards model, PARADOCS score was an independent predictor of 1-year MACEs (hazards ratio 1.26, 95% confidence interval 1.18-1.34; p<0.001) after adjusting for confounding variables. Patients were categorized into 3 groups according to the PARADOCS score; PARADOCSLOW (0-1, n=2,446), PARADOCSMID (2-3, n=14,594), and PARADOCSHIGH (4-5, n= 6,980). Kaplan-Meier survival curve showed that there were significant differences in the 1-year MACEs among three groups including 3.5% in PARADOCSLOW, 8.5% in PARADOCSMID, and 16.4% in PARADOCSHIGH, respectively (long-rank p<0.001). Conclusions: In post-MI patients, conventional risk factors are differently associated with short-term prognosis, and score of these risk factors, PARADOCS score, can provide useful prognostic information to clinicians.

근대적 인간관계의 전사[前史]: 이인직의 <혈의 누>, <귀의 성>을 중심으로

배상미 ( Sang Mi Bae ) 한국문학연구학회 2013 현대문학의 연구 Vol.0 No.51

본 논문은 신소설의 시초 격인 이인직의 두 작품 <귀의 성>과 <혈의 누>에 나타난 가족관계의 변화양상을 살펴보았다. 조선에 유입된 서구의 국가관은 수직적 인간관계로 짜여 있었던 조선 사회를 수평적 인간관계로 재편되도록 만드는 계기가 된다. 근대적 인간관계의 유입은 소설에도 그 흔적을 남기고 있다. <혈의 누>에서 결혼제도는 현재 조국의 부정부패와 구태를 야기한 근본적인 원인이다. 구완서와 옥련은 부모가 정해준 상대와 일찍 결혼하여 성욕 등 본능적 욕구에만 천착하게 만드는 기존의 결혼제도를 개혁하고자 한다. 결혼 당사자들끼리 결혼을 결정하는 새로운 결혼체계의 시도는 그들에게 문명인이 되기 위한 중요한 조건이다. 그러나 이들의 결혼은 사랑을 근거로 하고 있지 않다. <귀의 성>에서 김승지 부부의 관계는 가부장적 부부관계가 아닌 친밀함에 의거한 소통코드로 구성되어있다. 김승지 부인은 김승지가 이 소통체계에 거스르는 행동을 일삼자 그 원인이 되는 길순이를 제거하기에 이른다. 이 결과는 두 사람 사이에 친밀성의 코드가 확고하지 않았기 때문에 발생했다고 볼 수 있다. 부부중심의 결혼관이 성립되어가는 과정을 결혼을 둘러싼 당사자들 사이의 관계변화를 통해 보여주는 <귀의 성>과 수평적인 부부관계와 친밀성을 기반으로 한 의사소통코드를 만들어가는 <혈의 누>는 결혼관계가 가문중심에서 부부중심으로 재편되고, 결혼을 뒷받침하는 토대가 부부간의 공감과 유대로 설정되는 변화를 반영한다. 이것을 서구 근대의 결혼을 뒷받침해주는 낭만적 사랑이 나타나게 될 하나의 전초라고 해석할 수 있을 것이다. 그러나 두 소설에서 근대적 관계망으로의 변화는 남녀 모두에게 동일하게 적용되지 않는다. 남성인물은 가족관계로부터 비교적 자유로운 반면, 여성인물은 가족관계에 강하게 긴박되어있다. 여성은 근대적 교육을 받았다고 하더라도 그 뜻을 펼 적당한 장소를 찾지 못하고, 가족을 자아실현을 할 거의 유일한 공간으로 발견해낸다. This thesis studied the change of family relationship from Lee In-Jik`s novels of Hyeol Ui Nu and Gui Ui Sung. The view of nation from western was a chance to reconstruct human relationship from hierarchical to equal. The flow of modern relationship was found in novels. The feudal marriage was a fundamental reason causing corruptions and conventions. Gu Wan-seo and Kim Ok-ryun wanted to renovate the feudal marriage. They tried to the new system of marriage that was consisted by they decided their own partner not their parent`s will but their own will. It was a important condition to get modernity. However, when they decided to marry, they did not concern the feeling of romantic love between them. In Gui Ui Sung, The relationship of Kim`s couple constructed a communication code based their intimacy not patriarchical relationship. Since Mr. Kim broke the communication code frequently, Mrs. Kim eliminated the cause, Jilsoon. The result showed us that their intimate relationship was not very strong. On the one hand, Hyeol Ui Nu showed that when a couple decided their marriage, their will became more important than their parents`, On the other hand, Gui Ui Sung made comprised couple relationship and communication code based intimacy. These two novels reflected that agents of marriage changed from parents to a couple. It could be interpreted to the sign that would be appeared to romantic love which based on modern western marriage. However, the change of modern relationship in these novels was very different between men and women. The characters of men were relatively free from family, but women were not. Women who learned modern study could not find their own place where worked using their intelligence. Family was only place to achieve their self-realization.

보조자극분자를 이용한 암치료

장미라,윤희령,성인옥,정상원,김용찬,손정희,이혜영,강광일,백상기,김영상 충남대학교 생물공학연구소 2002 생물공학연구지 Vol.8 No.1

Tumor cells express tumor-associated antigen which can be target to the cytotoxic Tlymphocytes. CTL precursor activation requires antigen recognition and cytokine help from Th cells. In this pathway, the cross-presentation mechanism, professional antigen presenting cells first pick up tumor antigen and present the antigen to Th cells. Another pathway is to activate CTL precursor by the direct priming. The tumor cells, however, lack costimulatory signal, which is required for full activation. The lymphocytes recognized specific antigen without costimulatory signal resulted in anergy. Tumor cells engineered to express the costimulatory molecules are better immunogen and induce antitumor immunity. We will discuss the recent progress in tumor therapy using the costimulatory molecules on the basis of the direct priming mechanism.

보문 : Polyethylene Film포장이 포도 Sheridan의 저장력에 미치는 영향

남상영(Sang Young Nam),김경미(Kyoung Mi Kim),박종천(Jong Chun Park),주선종(Seon Jong Joo),정재현(Jai Hyun Jung) 한국식품저장유통학회(구 한국농산물저장유통학회) 1997 한국식품저장유통학회지 Vol.4 No.1

위신경내분비암 1례

김상일,이정은,윤상미,송홍석,이상숙 啓明大學校 醫科大學 1998 계명의대학술지 Vol.17 No.4

저자들은 67세 남자 환자에서 위부분절제술 시행 후 cisplatin와 etoposide의 복합항암화학요법을 실시한 위신경내분비암 1례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. The existence of gastric neuroendocrine carcinomas had been scarcely recognized. When present, the correct diagnosis is seldom made before surgery. The recognition of these tumors can be problematic for the pathologist. Some of these tumors have "small cell" appearance by light microscopic examination, but others only be called "poorly differentiated carcinoma". But tremendous advances in immunohistochemistry in the last 15 years have yielded powerful tools to the pathologist in diagnosing these tumors. We experienced a case of neuroendocrine carcinoma of the stomach. The patient was a 67-year-old male and visited our hospital with epigastric pain. Subtotally resected stomach showed 3.5×4×5cm sized ulcerated tumor that was located at lesser curvature. Final diagnosis was neuroendocrine carcinoma, which stained positively for synaptophysin immunohistochemically. Herein, we report a case of neuroendocrine carcinoma of stomach and review the literature.

Water-soluble Genistin Glycoside Isoflavones Upregulate Antioxidant Metallothionein Expression and Scavenge Free Radicals

Chung, Mi-Ja,Kang, Ah-Young,Jun, Hee-Jin,Kim Sang-Yeon,Moon, Tae-Hwa,Park, Kwan-Hwa,Lee, Sung-Joon 생명자원연구 2005 생명자원연구 Vol.13 No.-