정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

경북 지역의 지하수 수질에 관한 연구 3 : 용도별 지하수 수질의 특성 The Characterisrics of Groundwater by Used Types

한성욱,양득석,김복조 경운대학교 산업기술연구소 2002 産業技術硏究論文誌 Vol.5 No.1(B)

We investigated the contamination of groundwater in Gyeongbuk region about 180 points by used types and by rock types. From the view point of used types, the obtained results were as follows; The concentration of nitrate nitrogen was highest for agriculture used as 5.3mg/l and was medium for life used as 4.2mg/l while faculty used was lowest as 1.8mg/l. In case of chloride ion, the concentration was highest for agriculture use as 39.9mg/l and was medium for faculty used as 34.8mg/l, while life used was lowest as 23.5mg/l. In case of 359mg/l. In case of the concentration of pH and COD, it showed that the relationship with used types was not so good.

白鼠에 있어서 肝吸蟲感染에 대한 獲得抵抗에 관한 硏究

趙星煥,朱炅煥,林漢鍾 고려대학교 의과대학 1984 고려대 의대 잡지 Vol.21 No.3

The development of acquired resistance in clonorchiasis was studied in rats experimentally infected with Chonorchis sinesis. The induction of acquired resistance was attempted by first exposing adult rats to 15 or 50 metacercariae of C. sinesis from naturally infected Pseudorasbara parva and then treated with praziquantel prior being challenged. The reinfection was performed at 1, 2, 4, and 8 weeks after elimination of flukes. Worm recovery rates and growth of the worms obtained from rats necropsied at 4 weeks after reinfection were compared to those of control group. End point titers of rat's serun were studied by ELISA at the time of reinfection and morphological findings of bile ducts were also studied by the light microscope. In other experiments, rats were infected repeatedly with 5 or 10 metscercariae at 1 week interval for 5 times. Animals were kills 4 weeks after the last exposure and the results were compared to a single infection of 25 or 50 metacercariae. Worm collection was failed in rats challenged with 50 metacercariae at 1 or 2 weeks after treatment. Worm recovery rates were 3.5 and 20.0% in rats reinfected at 4 and 8 weeks respectively after treatment, while 41.5% in control rats. In other experiment, 15.6%, 18.3% and 33.3% in worm recovery rates were obtained in rats, challenged with reinfections at 2, 4, and 8 weeks respectively after treatment of these rats initially infected with 15 metacercariae. Recovery rates were 50.0% in control group. Worm racovered in this experiment were found retarded in growth compared to control group. High end point antibody titers of the rat serum at the time of reinfections were presented by ELISA and it seemed too suppress maturation of the worms. Histopathological recovery of the bile ducts were not remarkable until 4 weeks after treatment and it may be contributed to reinfection as an another protecting factor. Multiple low dose repeated infection showed lower recovery rates compared to high dose single infection. Worm recovery rates of animals infected 5 times with 5 metacercariae were 11.0% and single infection on 25 were 53.0%. That of animals infected 5 times with 10 metacercariae was 13.0% compared to 41.5% of single infection of 50 metacercariae. In conclusion, the data presented in this study indicate that during the course of infection by C. sinesis acquired resistance is induced by preceding infection although complete protection may not be elicited.

Dioxin류의 반응에 대한 분자궤도함수론적 연구 : dibenzo-p-dioxin, 2,7-dichlorodibenzo-p-dioxin, dibenzofuran, 2,8-dichlorodibenzofuran 중심으로

한성욱,이길준,김복조 경운대학교 산업기술연구소 2001 産業技術硏究論文誌 Vol.3 No.2(B)

Molecular orbital studies for dibenzo-p-dioxin, 2,7-dichlorodibenzo-p-dioxin, dibenzofuran and 2,8-dichlorodibenzofuran were carried out by semiempirical PM3 method. Reaction sites for nucleophilic, electrophilic and radical reaction of dioxins were predicted and discussed by MO studies. The values of approximated superdelocalizability were 0.7802, 0.2686, 0.3104, 0.1982 for the above dioxins, respectively. And reported rate constant for the reaction of dioxins with OH radical (Eitzer et. al.. Environ, Sci. Technol. 1989, 23, 1389) was well correlated with approximated superdelocalizability.

경북 지역의 지하수 수질에 관한 연구 4 : 암반 종류에 따른 지하수 수질 특성 The Characterisrics of Groundwater by Rock Types

한성욱,이동섭,김복조 경운대학교 산업기술연구소 2002 産業技術硏究論文誌 Vol.5 No.1(B)

We investigated the contamination of groundwater in Gyeongbuk region about 180 points by rock types. From the view point of rock types, the obtained results were as follows; The mean depth of rock types were decreased as follows sedimentary > gneiss > granite > granodiorite. In case of pH, the difference of value was small. While, the concentration of COD showed that it's concentration was increased as the mean depth was increased. In the region of granite, sedimentary and gneiss, the value of nitrate nitrogen was 3.5mg/l, 3.3mg/l and 1.7mg/l, respectively. In case of chloride ion, the concentration was highest for granite as 30.5mg/l and was medium for sedimentary and gneiss as 29.8mg/l and 26.9mg/l, respectively. while granodiorite was lowest as 8.97mg/l. The EC values were as follows; In the region of granite, sedimentary, gneiss and granodiorite, the value of EC was 444mg/l, 430mg/l, 390mg/l and 242mg/l, respectively.

Ellipticine과 그 이성질체들에 대한 분자궤도함수론적 연구

한성욱,이길준,김복조 경운대학교 산업기술연구소 2002 産業技術硏究論文誌 Vol.5 No.1(B)

Molecular orbital studies were carried out for the ellipticine and its isomers, known as having antitumor activity and cytotocity, by semiemperical PM3. Electrostatic potential studies have shown that the most reactive site of proton attacks was the nitrogen atom in carbazol ring. The net charge of the nitrogen was linearly correlated with the basicity of the isomers. We have predict the antitumor activity of the isomer by the basis of the dipole moment [suggested by Barone et.al. J. Mole. Stru.(Theochem) (1992), 253, 319]. And we have suggested that frontier orbital theory is valuable to explain for the formation of covalent adducts. These results may suggest clues that the method how to interpretate the mechanism of action for ellipticine and how to design new drugs.

Effect of Plant Growth Regulators on Clonal Production through Basal Stem Explant Cultures of a Phalaenopsis Hybrid

Jo,Man-Hyun,Ham,In-ki,Park,Sang-kyu,Seo,Gwan-Seok,Han,Gyu-Heung,Woo,In-Shik 한국자원식물학회 2003 Plant Resources Vol.6 No.2

This study was conducted to develop the clonal propagation technique through in vitro culture using basal stem explants in Phalaenopsis hybrid grown in vitro. The highest frequency of protocorm-like body (PLB) formation was obtained when basal stem explants were cultured on VW medium containing 30g/L sucrose, 500 mg/L activated charcoal, 150 ml/L coconut water, 1 mg/L NAA, 5 mg/L 2iP and 2.5g/L gel rite. PLBs transferred to Hyponex medium were regenerated to plantlets. Plantlets transferred to plastic pots containing spagnum moss were developed and successfully acclimatized under greenhouse. The flower was bloomingly opened in plants regenerated from basal stem explants. The flower was not different from both mother plant and plant induced through clonal propagation of Phalaenopsis hybrid.

보안위협 모니터링을 위한 AI 데이터셋 구성방안 연구

한상현, 조인준 배재대학교 공학연구소 2021 공학논문집 Vol.23 No.1

Cyber-attacks are evolving into a form of a long-term continuous attack by forming a dense group. However, there are cases of being defenseless against hacking attacks due to the lack of information on vulnerabilities exposed to security threats. In addition, organizations and companies with limited assets and response capabilities are often unable to take action due to the lack of measures to respond to such attacks. To solve this problem, we create a shared dataset by collecting various vulnerability information that has been disclosed, and after learning AI, we intend to present information on security vulnerabilities and effective detection and response methods for hacking attacks targeting vulnerabilities. 사이버 공격은 치밀하게 집단을 구성하여 장기간 지속적인 공격을 하는 형태로 진화하고 있다. 하지만 보안위협에 노출된 취약점들에 대한 정보 부재로 해킹공격에 무방비로 당하는 사례도 발생하고 있다. 또한 자산 및 대응역량이 제한된 기관 및 기업들은 이러한 공격에 대응할 수 있는 방안 부재로 조치를 할 수 없는 경우가 상당히 많다. 이러한 문제점을 해결하기 위해 공개되어있는 각종 취약점 정보들을 모아 공유 데이터셋을 만들어 AI 학습 후 보안취약점에 대한 정보와 취약점을 노린 해킹공격에 대한 효과적인 탐지와 대응하는 방안을 제시하고자 한다.

간세포암의 고주파 열치료 후 천자침 경로를 통한 전이 1례

조영완,박석주,진한영,김준영,이재익,강명주,박정하,윤정희,박성재,지삼룡,이연재,이상혁,설상영 인제대학교 2006 仁濟醫學 Vol.27 No.-

Radiofrequency ablation(RFA), as a form of minimally invasive therapy for hepatocellular carcinoma, has become an important treatment modality. Because of limitation of surgery, RFA has become standard therapy for hepatocellular carcinoma in some situations. But there are some complications of RFA such as bleeding, infection, hematoma, adjacent organ thermal damage including intestinal perforation, needle track seeding, and so on. There are few reports in the literature that systematically evaluate the incidence of needle tract seeding and its associated risk factors. And only 2 cases of needle tract seeding of hepatocellular carcinoma after RFA were reported in Korea. We report a case of needle tract seeding of hepatocellular carcinoma after RFA.

빈발재발성 미세변화 신증후군환아에서 발생한 다발성 뇌경색증

조성옥,한헌석,차상훈,이경희,박범수,하태선,채수안 충북대학교 의과대학 충북대학교 의학연구소 1995 忠北醫大學術誌 Vol.5 No.2

신증후군에서는 동맥 및 정맥의 혈전에 의한 혈전색전증의 위험이 높다. 이는 혈 중 응고인자 Ⅰ, Ⅱ, Ⅶ, Ⅷ, Ⅹ등의 증가와 뇨소실로 인한 antithrombin Ⅲ의 감소, 섬유소 용해계의 변화, 혈소판 응집력의 증가에 기인하며 그 외 스테로이드 투여, 이뇨제 투여, 저체액 상태도 관여한다고 생각하나 이런 과응고현상에 대한 정확한 병태생리는 규명되고 있지 않다. 저자들은 내원 21개원 전 처음 신증후군 증상을 보였고 신장 조직 검사상 미세변화 신증후군으로 진단을 받고 스테로이드와 면역 억제제를 사용하였으나 6개월에 3-4회의 재발을 보이던 중 내원 1달 전 보호자 자의로 모든 약물 복용을 중단한 채로 지내다가 고열과 반혼수 상태를 보여 내원한 7세 남아에서 다발성 뇌경객증을 발견하였기에 문헌 고찰과 함께 보고하는 바이다. The risk of thromboembolism by arterial or venous thrombosis is high in the nephrotic syndrome. This may be due to the increased serum concentrations of the factor Ⅰ, Ⅱ, Ⅶ, Ⅷ, Ⅹ etc, decrease of antithrombin Ⅲ due to urinary loss, the change of thrombolytic system, increase in the platelet aggregation capacity, the use of steroid, diuretics, and hypovolemic state. But, the pathophysiology of this hypercoagulable state has not been clear. A 7-year- old boy had been diagnosed as having frequently relapsing minimal change nephrotic syndrome, 21 months ago. In spite of the administration of prednisolone and cytoxan, he had presented recurrent proteinuria in the frequency of 3-4 times per 6 months. From 1 month prior to visiting emergency room, his parents discontinued his medications, therefore, he showed fever and semicomatous mental status. In brain MRI study, multiple cerebral infarcts were noted. So, the authors report a case of multiple cerebral infarcts in a patient with frequently relapsing minimal change nephrotic syndrome with a brief review of related literature.