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만성 C형 간염 환자에서 페그인터페론 알파2a와 리바비린 병합 치료중 발생한 벨마비 1예
김일환,장제혁,유충헌,최규남,고정해,김윤정,서광원,김지현,박성재,박은택,이연재,이상혁,설상영 인제대학교 2008 仁濟醫學 Vol.29 No.-
페그인터페론과 리바비린 병합요법은 만성 C형 간염의 일차 치료법이다. 저자들은 만성 C형 간염 환자에서 페그인터페론 과 리바비린 병합 요법 중에 발생한 벨마비 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. 환자는 5년 전부터 만성 C형 간염을 앓아온 48세 남자이며, PEG-IFN α-2a 135μgm 피하주사 주1회와 하루 1200㎎의 리바비린을 투여하였다. 치료시작 후 9개월째 환자는 오른쪽 안면의 근력약화를 호소하였으며 벨마비로 진단되었다. 페그인터페론과 리바비린 병합요법을 지속하면서 관찰하였다. 환자의 벨마비는 페그인터페론 치료를 중단하지 않았음에도 3개월후 증상이 회복되고 이후 벨마비 재발 없이 현재 경과관찰 중이다. 만성 C형 간염에서 페그인터페론과 리바비린 병합 요법시 벨마비의 발생 가능성을 염두에 두어야 하겠다. A Case of Bell's Palsy Associated with Combination Therapy of Pegylated Interferon Alfa-2a (PEG-IFN) and Ribavirin for Chronic Hepatitis C Virus Infection Pegylated interferon alfa(PEG-IFN α) and ribavirin therapy is the first line treatment for chronic hepatitis C. Mild complications of the therapy are common, but more serious complications are rare. We report here a case of Bell's palsy that occurred in a patient with chronic hepatitis C virus infection during combination therapy of PEG-IFN α-2a and ribavirin. The patient was 49-year-old man with chronic hepatitis C (genotype 1b) for 8 years. He had compensated liver cirrhosis with splenomegaly. Therapy with PEG-IFN α- 2a 135mcg/week and ribavirin 1200mg/day was initiated. After 9 months of the therapy, the patient showed a loss of muscular tone on the right side of his face. A diagnosis of Bell's palsy was made. The Bell's palsy resolved over 3 months despite continuation of the combination therapy.
Adenocarcinoma of Unknown Primary Site
( Seo Young Song ),( Won Seog Kim ),( Hye Ran Lee ),( Hyun Sik Jung ),( Sung Yong Oh ),( Ji Hyang Kim ),( Ki Hyun Kim ),( Eun Mi Nam ),( Chul Won Jung ),( Sung Soo Yoon ),( Young Hyuck Im ) 대한내과학회 2002 The Korean Journal of Internal Medicine Vol.17 No.4
Background: Metastatic cancer of unknown primary site occupies 0.5~10% of all diagnosed cancer patients and includes various tumors with diverse responses to systemic chemotherapy. Adenocarcinoma of unknown primary site (ACUPS), the most common subtype, h
A case of basal cell carcinoma with ductal differentiation
( Sung Jin Park ),( Min Seok Ham ),( Ji Hyuck Hong ),( Dae Yeon Kim ),( Soo Hong Seo ),( Young Chul Kye ),( Hyo Hyun Ahn ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1
Basal cell carcinoma (BCC) is the most common skin cancer, which mainly occurs on sun exposed areas of the head and neck. There are many clinical, histological subtypes of BCC although these subtypes share some common characteristics. BCCs can be clinically divided into nodular, pigmented, sclerosing, superficial and fibroepithelioma form. From histologic point of view, it can be classified as two groups: undifferentiated and differentiated. Neoplastic cells of BCC mainly differentiate toward follicular germinative cells, although there are other types such as BCCs which differentiate toward sebaceous, follicular, eccrine and appocrine apparatus. A 59-year-old woman presented with asymptomatic bluish black colored waxy plaque on her left parietal scalp area. She had no significant medical history. The lesion first appeared 16 months ago, increasing size without any symptom, and it was diagnosed as BCC with skin biopsy. The histopathology showed nodules and micronodules of basaloid cells, and unusually, had certain basaloid cells in deeper dermis showing ductal differentiation with mildly vacuolated cytoplasm developing duct-like structures. This suggests that BCC differentiated onto ductal apparatus. Herein, we report a rare case of BCC with ductal differentiation.
Effect of Spoofing on Unmanned Aerial Vehicle using Counterfeited GPS Signal
Seo, Seong-Hun,Lee, Byung-Hyun,Im, Sung-Hyuck,Jee, Gyu-In The Institute of Positioning 2015 Journal of Positioning, Navigation, and Timing Vol.4 No.2
Global Navigation Satellite System (GNSS) including Global Positioning System (GPS) is an important element for navigation of both the military and civil Unmanned Aerial Vehicle (UAV). Contrary to the military UAVs, the civil UAVs use the civil signals which are unencrypted, unauthenticated and predictable. Therefore if the civil signals are counterfeited, the civil UAV’s position can be manipulated and the appropriate movement of the civil UAV to the target point is not achieved. In this paper, spoofing on the autonomous navigation UAV is implemented through field experiments. Although the demanded conditions for appropriate spoofing attack exists, satisfying the conditions is restricted in real environments. So, the Way-point of the UAV is assumed to be known for experiments and assessments. Under the circumstances, GPS spoofing signal is generated based on the Software-based GNSS signal generator. The signal is emitted to the target UAV using the antenna of the spoofer and the effect of the signal is analyzed and evaluated. In conclusion, taking the UAV to the target point is hardly feasible. To implement the spoofing as expectation, the position and guidance system of the UAV has to be known. Additionally, the GPS receiver on the UAV could be checked whether it appropriately tracks the spoofing signal or not. However, the effect of the spoofing signal on the autonomous UAV has been verified and assessed through the experimental results. Spoofing signal affects the navigation system of the UAV so that the UAV goes off course or shows an abnormal operation.
A novel case of acute radiodermatitis possibly induced by carbon ion radiotherapy
( Sung Jin Park ),( Min Seok Ham ),( Ji Hyuck Hong ),( Dae Yeon Kim ),( Soo Hong Seo ),( Young Chul Kye ),( Hyo Hyun Ahn ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1
Radiation dermatitis is defined as skin changes after radiation exposure, which mostly follow certain predictable course dictated by radiation dose, timing, and affected individual cells. Acute radiation dermatitis is mostly characterized as mild erythema and edema which occurs hours after exposure, whereas chronic radiodermatitis occurs after months to years, leading to skin fibrosis and atrophy. Conventional radiation therapy utilizes ionizing radiation, especially known as X-rays and Gamma rays. However, recent studies regarding the other categories of ionizing radiation is actively ongoing. Among them, carbon ion radiation therapy using particle beams is cutting edge issue. A 43-year-old man presented with mild pricky erythematous swelling on left forehead, first appearing 3 days ago. Diagnosed with palate cancer extending to skull base a year before, he was treated with carbon ion radiation therapy (16 times, 64Gy) 9 months ago at Japan. We took a skin biopsy, which turned out to be mild spongiosis with perivascular, periadnexal lymphocytic infiltration. Under the clinical diagnosis of radiodermatitis, patient got no further treatment. Unlike common course of acute radiodermatitis which appears 2-24 hours following exposure, the patient experienced relatively long latency period of 9 months. Proper patient notification regarding adverse dermatological outcome is therefore necessary for whom receiving carbon ion therapy.
2010 해남, 평창, 원주지역 갈대 등 야초류의 이용실태와 사료가치 평가
서성(Sung Seo),한대덕(Dae Duk Han),장선식(Sun Sik Jang),김원호(Won Ho Kim),정민웅(Min Woong Jung),최진혁(Jin Hyuck Choi),김진숙(Jin Sook Kim),김하영(Ha Young Kim),이종경(Joung Kyong Lee) 한국초지조사료학회 2012 한국초지조사료학회지 Vol.32 No.1
본 연구는 부존 조사료자원 이용으로 수입사료를 줄이고 사료비를 절감하고자 2010년도에 전남 해남(간척지), 강원 평창(강변), 원주(섬강변), 전남 영광(와탄강변) 등 4개 지역에서 갈대와 억새 등 야초 자생지를 탐색하고, 수확·이용실태 조사와 함께 사료가치를 분석하였다. 전남 해남 해남목장 내 갈대(Phragmites communis) 위주의 야초 자생지는 300 ha로 예년에는 2회 곤포작업하여 연간 사일리지로 2,300~2,500톤(ha당 8톤)을 생산하였으나 2010년도는 1회 곤포조제로 사일리지 2,000톤(ha당 7톤)을 생산하였다. 유통가격은 롤 당 53천원으로 ㎏당 110원이었다. 곤포는 전량 자가소비하며, 외부 작업단에 롤 당 26천원의 작업비를 지불하였다. 연간 조수입은 2억 2,260만원이며, 소득은 1억원 수준(345천원/ha)이었다. 초장 150 ㎝의 갈대는 조단백질 8.4%, 상대사료가치 71.9 (건초 5등급), 건물 소화율 60.1%로 사료가치는 볏짚에 비해 약간 나은 것으로 평가되었다. 갈대 사일리지의 사료가치와 유기산 함량은 동일 지역에서 동일한 재료로 사일리지를 조제하더라도 수확시기에 따라 차이가 컸으며(CP 4.7~6.4%, RFV 62.2~78.9, 건물 소화율 41.9~53.9%), 갈대 사일리지의 품질은 수단그라스에 비해 불량하였다. 강원 평창 강변 자생갈대의 사료가치는 초장이 79, 117, 121, 142㎝로 생육이 진행됨에 따라 낮아져, 조단백질은 각각 13.9%에서 7.6%로, 상대사료가치는 90.7 (건초 3등급)에서 76.1 (건초 4등급)로, 건물 소화율은 72.9%에서 54.7%로 감소하였다. 원주 섬강 주변 야초류는 곤포수확 작업에 어려움이 있었으며, 초장 130 cm의 갈대는 조단백질 8.5%, 상대사료가치 82.3 (건초 4등급), 건물 소화율 70.2%로 사료가치는 높았으며, 220㎝의 성숙한 갈대는 조단백질 10.2%, 상대사료가치 65.1 (건초 5등급), 건물 소화율 48.9%로 볏짚 대비 조금 나은 것으로 평가되었다. 전남영광지역에서는 와탄천 주변에 자생하는 갈대를 수거 이용하고자 시도하였으나 경제성이 없어 중단하였다. 이상의 결과를 종합하여볼 때, 갈대, 억새 등 야초류는 현 상태에서 최대한 수거·이용하되, 사료가치를 유지하고 가축 기호성이 양호한 시기에 수확하는 것이 중요하며, 최소한 볏짚과 비슷하거나 그 이상의 사료가치를 기대하기 위해서는 7월 중순 이전(늦어도 7월까지)에 수확·이용하는 것이 권장된다. This study was carried out in 2010 to investigate the utilization and forage quality of native grasses, such as Phragmites communis which might reduce the cost of feeding domestic cattle. The regions surveyed were the Haenam ranch in Haenam, Pyeongchang, Wonju, and Yeonggwang. In Haenam, yearly silage production harvested from 300 ha was 2,000 MT (7 MT/ha). All of those round bale silages were self-consumed in that region, and marketing price was 50,000 55,000 won per roll (110 won/㎏). Phragmites communis of 150 ㎝ in length contained 8.4% crude protein (CP) with relative feed value (RFV) 71.9 and 60.1% in vitro dry matter digestibility (IVDMD), which was somewhat more favorable than forage quality of rice straw. The silage quality of Phragmites communis varied greatly by the time of harvest (CP 4.7 6.4%, RFV 62.2 78.9, and IVDMD 41.9 53.9%), even with the same district and of the same original forage materials. Generally, the quality of Phragmites communis silage of was poorer than that of sorghum * sudangrass hybrid. In Pyeongchang, forage quality of Phragmites communis was decreased from 13.9% to 7.6% in CP, 90.7 to 76.1 in RFV, and 72.9% to 54.7% in IVDMD, as plant was getting mature, from 79 ㎝ to 117 ㎝, 121 ㎝ or to 142 ㎝ in length. In Wonju, the quality values of Phragmites communis of 130 ㎝ in length were 8.5% CP, 82.3 RFV and 70.2% IVDMD, while those of matured grasses of 220 ㎝ in length were lower (10.2% CP, 65.1 RFV and 48.9% IVDMD), but this was a little more favorable than quality of rice straw. In Yeonggwang, feeding Phragmites communis was tried in a Hanwoo feed, but stopped due to low profitability. In conclusion, the overall quality of most native grasses including Phragmites communis in this survey was poor. Therefore, we recommend that Phragmites communis and native grasses should be harvested on June or July to obtain richer forage quality in forage values than rice straw.