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우상효 慶北大學校 齒科大學 1996 慶北齒大論文集 Vol.13 No.-
치주조직 재생에 중요한 역할을 미치는 성장인자의 여러 가지 적용방법 중 탈회된 치근면에 성장인자를 도포시 성장인자 함유매개체로서 탈회된 치근면의 효과와 성자인자의 유리기간을 알아보고자 본 실험을 실시하였다. 교정치료를 목적으로 내원한 환자의 소구치 부위의 정상 치은을 절제하여 치은섬유아세포를 분리, 배양하였고, 중정도의 치주질환에 이환되어 발치된 치아를 철저히 치근활택술을 시행후 시편을 제작하였다. 치근면 처치를 하지 않은 시편을 대조군으로, 구연산과 테트라사이클린으로 탈회시킨 시편을 실험군으로 하여 각 군을 100ng/ml PDGF-BB에 5분간 침수시킨 후 각 시편에 치은섬유아세포를 접종 후 6시간, 24시간, 48시간, 72시간 배양하여 각 절편의 단위면적당 부착세포수와 증식세포수를 측정하였다. 또한 탈회된 치근면에서 성장인자의 유리기간을 측정하기 위한 용출액을 이용한 세포배양은 위의 방법으로 시편제작후 치근면 처치를 하지 않고 배양액에 5분간 침수시킨 군과 200ng/ml PDGF-BB에 침수시킨 군을 대조군으로, 테트라사이클린과 구연산으로 치근면 처치후 200ng/ml PDGF-BB에 5분간 침수시킨 군을 실험군으로 하였다. 침수 후 각 시편을 다시 1ml 배양액에 넣고, 1일, 2일, 4일, 6일, 8일째 배양액을 채취하여, 72시간 배양후 증식 세포수를 측정하여 다음의 결과를 얻었다. 세포의 부착, 증식에 관한 실험에서 부착, 증식 모두에서 치근면 탈회후 PDGF-BB 적용군이 치근면 탈회없이 적용시보다 많은 부착과 증식을 보였으며, 모든 군에서 통계학적으로 유의한 차이(P<0.01)를 보였고, 구연산과 테트라사이클린 상호간 비교에서는 부착과 증식 모두에서 테트라사이클린 처리군이 더 많은 부착과 증식을 보였으며, 통계학적으로 유의한 차이(P<0.01, 0.05)를 보였다. 용출액을 이용한 성장인자 유리기간 측정에서도 탈회후 PDGF-BB 도포한 군의 용출액에서 더 많은 세포증식을 보였고, 통계학적으로 6일째 용출액까지 유의한 차이 (P<0.01, 0.05)를 보였으며, 이의 결과로 미루어 탈회된 치근면에 도포된 PDGF-BB의 유리기간은 6일정도로 생각되며, 역시 탈회 물질 상호간의 비교에서 테트라사이클린으로 치근면 탈회후 PDGF-BB를 도포한 군이 구연산 처리후 PDGF-BB를 도포한 군보다 우수한 효과를 보였다 It is known that growth factors function as potent biologic mediators regulating numbrous activities of wound healing via cell proliferation, migration and extracellular matrix formation and they also promote periodontal regeneration. But, method of growth factor application is controversial yet. So purpose of this study is to evaluate the effect of demineralized root surface as one of method of growth factor application. The ginigival fibroblasts were primary cultured and fifth or sixth subpassages were used in these experiments. In first experiment, root surface blocks demineralized with 100mg/ml tetracycline for 5 minutes and pH 1 citric acid for 3 minutes(experimental groups) and non-deminerilized root surface blocks (control groups) were placed in 100ng/ml PDGF-BB for 5 minutes. Then the cells were seeded on each root surface blocks and cultured for 6, 24, 48, 72 hours. In second experiment, root surface blocks deminerlized with tetracycline and citric acid and non-demineralized root surface blocks were placed in 200ng/ml PDGF-BB for 5 minutes and another non-demineralized root surface blocks were placed in DMEM without PDGF-BB. At 1, 2, 4, 6, 8 days, the cells were seeded in 24-well plate and using of each eluent, cultured for 72 hours. The results of the four determinants were presented as mean and S.D.. The results were as follows: The attachment and proliferation of human gingival fibroblast on root surface were more increased when PDGF-BB was applicated on root surface demineralized with tetracycline or citric acide than non-demineralized root surface. And, in comparision tetracycline with citric acid, there were more attachment and proliferation of human gingival fibroblast on root surface demineralized with tetracyclin than citric acid, and proliferation of human gingival fibroblast on demineralized root surface was increased time dependently 1 day to 3 days. In second experiment using eluent, proliferation of human gingival fibroblast was more increased to 6 days when human gingival fibroblast was cultrured in eluent that PDGF-BB was applicated on demineralized root surface than two control groups, and degree of proliferation was decreased time dependently 1 day to 6 days. Proliferation of human gingival fibroblast on demineralized root surface was increased time dependently 1day to 3day. In second experiment using eluent proliferation was cultured in eluent that PDGF-BB was applicated on demineralized root surface than two control groups, and degree of proliferation was decreased time dependently 1day to 6days. proliferation of human gingival fibroblast cultured in eluent without PDGF-BB was constant 1 day to 6 days. After 6 days, degree of proliferation of human gingival fibroblast was similar in four groups. This means that release duration of PDGF-BB from demineralized root surface is 6 days. And in comparision tetracycline with citric acid, there was more proliferation of human gingival fibroblast in tetracycline-treated group than citric acid. In conclusion, demineralized root surface as primary site for PDGF-BB application, especially demineralized with tetracycline has important roles in attachment and proliferation of human gingival fibroblast, and may be useful clinical applications in periodontal regenerative procedures.
부정적 정서자극에 대한 타액 알파-아밀라제의 반응 특성
우정민,이상호,임효덕,김상헌,송경은,박정란,이승재 大韓神經精神醫學會 2008 신경정신의학 Vol.47 No.5
Objectives : The aim of this study is to understand the characteristics of salivary a-amylase reactivity (sAA), as a biological maker of stress, by viewing negative affective pictures. Methods : Forty six normal healthy subjects participated in this study. Prior to the experiment, the participants completed baseline psychological assessment including trait-dependent anxiety scales. On experiment, saliva samples were collected one time before and three times after exposure to 5-min stressor consisting 20 negative affective pictures. The state-related scales were measured before and just after exposure to stressor to assess the subjects' state anxiety. Results : Overall, sAA was significantly decreased over time with the increase of negative affect score and state-anxiety. The Anxiety Scale Inventory scores were negatively correlated with the baseline as well as the other following sAA levels (all ps<.05) while the scores of the state-related scales were related not with the baselin but with the other followings. The baseline level of sAA was significantly lower in the higher susceptible group (change of Negative Affect score ?2, N=19) then in the lower counterpart (<2, N=27) in comparison between them (mean : 46.6 vs. 76.5 U/mL, P=.024). After the exposure, the means of sAA levels significantly decreased over time in the lower susceptible group, whereas did not in the higher one (mean : - 1.7 vs. -23.0U/mL, p=.031). Conclusion : These findings suggest that the baseline level of sAA and its reactivity depend on individual trait of anxiety as well as state of reactivity to affective stress.
여성 요도증후군에서 Terazocin의 효과에 대한 연구
우승효,신관희,한광희,정원일,이형래,이상철,김용태,김원재 충북대학교 의학연구소 2000 忠北醫大學術誌 Vol.10 No.2
연구목적: 여성 요도증후군을 보이는 환자에서 교감신경차단제인 terazocin을 복용한 후 치료 효과에 대한 각 증상의 변화와 부작용을 알아보고자 하였다. 대상 및 방법: 1997년부터 1999년까지 충북대학교병원 비뇨기과에 내원한 35명의 여성 중 요검사 및 요배양 검사, 그리고 다른 이학적 검사에서 이상이 없는 요도증후군 환자를 대상으로 간질성방광염 증상점수(ICSS)를 terazocin (3mg/day for 3 months) 투여 전후에 조사하였고, 치료 후 3개월과 1년에 Likert scale 점수를 조사하였다. 결과: ICSS는 비치료군은 18.3±5.9점, 치료군은 16.5±6.8점으로 두군간의 차이는 없는 것으로 나타났다(p=0.52). 치료군은 치료 후 3개월에 시행한 ICSS가 9.9±7.8점으로 치료 전에 비해 현격히 증상이 호전되는 것으로 나타났다(p=0.0001). 특히 3개월에 시행한 Likert scale에서는 주간 및 야간빈뇨, 절박뇨, 배뇨통의 횟수 및 강도, 그리고 전체적인 증상정도에서 40-70% 가량 호전된 것으로 밝혀졌으며 이는 1년 후에도 증상의 호전이 지속되는 것으로 나타났다. 비치료군에서의 1년 후 Likert scale은 6명 중 2명이 전체적인 증상의 호전이 있는 것으로 나타났다. 결론: Terazocin은 환자의 약 70%가량에서 증상의 호전을 가져왔고, 비치료군에서도 환자의 33%가 저절로 증상이 좋아진 것으로 보아 Terazocin은 여성 요도증후군에서 분명히 효과가 있으나 증상이 심할 경우 보조적인 치료로 이용되는 것이 바람직할 것으로 사료된다. Purpose: We performed to assess the effects and complications of terazocin in women with chronic female urethral syndrome. Materials and Methods : Thirty-five women with chronic female urethral syndrome were studied from March 1997 to August 1999. The subjects exhibited normal findings without the pyuria and bacteriuria in urinalysis and urine culture and were invested the interstitial symptom score(ICSS). 29 subjects of them took a terazocin 1-4 mg/day for 3 months. They were reevaluated for the ICSS and Likert scale after 3 months and for Likert scale after 1 year. Results: The ICSS before treatment were showed 18.3±5.9 in the untreated patient group and 16.5±6.8 in the treated patient group, and no statistically difference between both patient groups(p=0.52). In the treated patient group, the ICSS after treatment were showed 9.9±7.8, significant difference between before and after treatment(p=0.0001). The Likert scale was showed at 3 months after treatment that frequency, nocturia, urgency, pain frequency, pain intensity, daily activities, and overall symptoms were improved in 65.5%, 55.2%, 24.1%, 41.4%, 41.4%, 70%, 70%, and 70% of 29 subjects, each other. Overall symptom score assessed at 1 year were showed that 3 subjects was aggravated. In untreated patient group, 2 of 6 was improved in overall symptom score. Conclusion: Terazocin was effective above 70% in the treated group, and symptoms were improved spontaneously in a third of the untreated group. So, we thought that terazocin would be useful as supportive treatment in period of severe symptoms.
표정인식을 위한 PCA와 템플릿 정합을 사용한 얼굴 요소 추출
우효정, 이슬기, 김동우, 류성필, 안재형 충북대학교 산업과학기술연구소 2013 산업과학기술연구 논문집 Vol.27 No.2
This paper proposed an extracting algorithm of human facial components for the recognition of facial expressions. First face image is acquired using the Haar-like feature mask from an input image. The face image is divided into two images. One is the upper image including eye and eyebrow. The other is the lower image including mouth and jaw. The extraction of facial components, such as eye and mouth, begins getting eye image and mouth image. Then eigenfaces are produced by the PCA training process with learning images. An eigeneye and an eigenmouth are produced from eigenfaces. Result eye image is obtained by template matching the upper image with the eigeneye, and the mouth image is obtained by template matching the lower image with the eigenmouth. The simulation results show that the proposed method has superior extraction ratio than previous method.
윤성우,이지영,하경호,이수경,한나,배효근,박선자 고신대학교 의과대학 2010 고신대학교 의과대학 학술지 Vol.25 No.2
Limy bile is a rare condition characterized by excessive precipitation of calcium carbonate in the gallbladder or bile duct. Recently we experienced two cases with obstructive jaundice in which limy bile in the common bile duct but not in the gallbladder for one case, and in the common bile duct and intra hepatic duct but not in the gallbladder for another case. The patients were treated by endoscopic sphincterotomy. Here, we report the cases and review the literature.
李相孝,박상희,金在宇 연세대학교 산업기술연구소 1977 논문집 Vol.7 No.1
This paper deals with an efficient algorithm for generating the complete test set of every fault in combinational logic circuit, and fault detection and diagnosis technique based on Boolean Difference and Partial Boolean Difference. This study is mainly concerned with nonredundant combinational logic circuits. The type of fault is either stuck-at-o or stuck-at-1, i.e. at the input of a gate or at the output of a gate. The combinational logic circuits show a fault when the describing conditions correspond with the combinational logic circuits, for detecting S-A-O, or S-A-1, the method of generating test patterns is proposed, and the detection of fault at the circuit is attempted.
노후된 잔교식의 항만구조물의 신뢰성에 기초한 안전성 및 내하력평가
조효남,김성훈,노홍식,임종권,이우근 한양대학교 공학기술연구소 1995 공학기술논문집 Vol.4 No.1
This study is intended to propose a reliability based approach to safety assessment and berth-capacity rating of aged wharf structures based on measured data acquired from an extensive dynamic field load testing against berth impact of real ships. The study comprises the essential part of a project for assessing actual berth-capacity of deteriorated and damaged dolphin structures at the Onsan oil refinery wharf currently operated for the berth of oil refinery ships of 20,000 DWT.
천추 갈색종양(Brown tumor)으로 발현된 부갑상선 기능항진증 1예
홍우정,구본정,이재민,한상우,이효진,나소영,노흥규,김영건,송민호 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2
부갑상선 기능항진증에 의한 골병변으로 갈색종양이 있다. 갈색종양은 주로 장골을 침범하고 척추골에서의 발생은 매우 드물다. 국내의 보고에서 갈색종양의 장골 침범은 있었으나, 척추골에서의 발생은 보고된바 없다 .저자들은 부갑상선 기능항진증으로 인하여 척추골의 천추에 발생된 갈색종양 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. The bony involvement in primary hyperparathyroidism present as browm tumor or osteitis fibrosa cystica and lead to pathologic fracture. Brown tumor commonly involve long bone such as femur, tibia, fibula, humerus, and radius. Brown tumor of axial skeleton is a rare entity. Previously reported case that involve axial skeleton still not present. We report a 47-year-old male patient that he has a hyperparathyroidism presenting as brown tumor involving sacrum.
오상우,김윤희,고효선,이상열,노승호 圓光大學校 醫科學硏究所 2008 圓光醫科學 Vol.23 No.2
배경: 본 연구는 SCL-90-R에서 9개 증상차원의 요인구조가 어떻게 나타나는지를 알아보는 데 목적이 있다. 방법: SAS 프로그램을 이용하여 정신과적 장애로 진단받은 환자 188명이 수행한 SCL-90-R 자료의 요인구조를 분석하였다. 결과: 요인분석 결과 SCL-90-R의 9개 증상차원은 단일요인으로 나타났다. 결론: SCL-90-R의 요인분석 결과 단일 요인 모형이 탐색되었다. 추후 연구에서는 SCL-90-R의 9개 척도에 대한 확인적 요인분석이 필요할 것으로 생각된다. Background: To find of this study was to find exploratory factor analysis of the nine scales of the Symptom Checklist-90-Revision(SCL-90-R). Methods: This study was investigated the factor structures of nine scales of the SCL-90-R in 188 patients with psychiatric disorders using SAS 8.02 software. Results: The factor structure showed that the factor structures of nine scales of the SCL-90-R had one factor. Conclusion: The factor structures showed that the factor structures of the SCL-90-R had one factor. Further research is nedeed about confirmatory factor analysis of the nine scales of the SCL-90-R.