Impact of Interferon-Based Treatment on Quality of Life and Work Related Productivity from the Korean Cohort in the MOSAIC Study

( Sang Hoon Ahn ),( Won Hyeok Choe ),( Yoon Jun Kim ),( Jeong Heo ),( Dorota Latarska-smuga ),( Jiho Kang ),( Seung Woon Paik ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: Chronic Hepatitis C Virus (HCV) infection increases the risk for progressive liver disease, hepatocellular carcinoma and negatively impacts the patient’s quality of life. HCV treatment is evolving with direct acting antivirals but IFN based therapy has been the standard of care for many years and remains available in some countries. The MOSAIC study aims to characterize patients with chronic HCV infection and assess the impact of IFN-containing treatment on health-related quality of life, work related productivity and health care utilization. Methods: MOSAIC is an international prospective multicenter observational study that has been conducted in 20 countries. Consecutive patients with chronic HCV infection were enrolled and those who initiated an IFN based regimen were prospectively followed for 48 weeks. We report results from the Korean cohort Results: 100 patients were enrolled: 86 were treatment naïve and 14 were treatment experienced. 33 patients initiated an IFN based regimen: 6 patients started IFN + RBV, 26 patients started Peg-IFN + RBV, none started Peg-IFN + RBV + DAA and 1 patient received other treatment. Among the treated cohort, demographic and disease characteristics were the following: the mean age was 54.5 years; 14 patients were male. 14 had minimal or no fibrosis, 2 portal fibrosis, 3 bridging fibrosis and 6 patients suffered from cirrhosis. HCV Genotype distribution was as follows: genotype 1: 11; genotype 2: 19 and genotype 3: 3. Table 1 describes the results at baseline and changes over 4, 12 and 48 weeks and end-of-treatment (EOT) for the quality of life and work productivity outcome measures (EQ-5D-5L, HCV-PRO and WPAI). Conclusions: Results from the Korean cohort of the MOSAIC study show a moderate trend for deterioration of health-related quality of life and work productivity associated with IFN based treatment for patients with chronic HCV infection during treatment period. Acknowledgements: The design, study conduct, analysis, and financial support of MOSAIC study were provided by AbbVie. AbbVie participated in the interpretation of data, review, and approval of the content of the abstract. All authors had access to all relevant data and participated in writing, review, and approval of this abstract. Medical writing support was provided by Olivier Van de Steen of Medeor-consulting, funded by AbbVie. Disclosures: Sang Hoon Ahn: served as an advisor and lecturer for Bristol-Myers Squibb, Gilead Sciences, F.Hoffmann-La Roche, Merck, AbbVie, and has received unrestricted grants from Bristol-Myers Squibb, Gilead Sciences, and F. Hoffmann-La Roche for investigator- initiated trials Won Hyeok Choe: Nothing to disclosure Yoon Jun Kim: Nothing to disclosure Jeong Heo: received a grant from GSK; Research support from BMS, and Roche; Advisor for Abbvie, BMS, Gilead Sciences, Pharma Essentia, SillaJen, and Johnson & Johnson. Dorota Latarska-Smuga, Jiho Kang: are employees of AbbVie, Inc. and may hold stock or stock options. Seung Woon Paik: received grant and research support from AbbVie, BMS, Gilead, GSK, Merck, Novartis, and Roche

한의진단명과 진단요건의 표준화 연구 II (표준화 실례) : 2차년도 연구결과 중간 보고

양기상,최선미,최승훈,안규석,박경모,박종현,김성우,신승호,정우열,전병훈,고현,김정범,신상우,김성훈,김동희,권영규,엄현섭,장혜옥 한국한의학연구원 1996 한국한의학연구원논문집 Vol.2 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the second year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows; - differential diagnosis according to condition of body fluid, differentiation of syndromes according to the state of qi and blood, differential diagnosis according to relative excessiveness or deficiency of yin and yang(氣血陰陽津液辨證) - differentiation of diseases according to pathological changes of the viscera and their interrelation - analyzing and differentiating of febrile diseases in accordance with the theory of the six channels(傷寒辨證) The individual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name(異名), notion of diagnosis pattern, index of differentiation of symptoms and signs(辨證指標), the main point of diagnosis, analysis of diagnosis pattern(證候分析), discrimination of diagnosis pattern(證候鑑別), a way of curing a diseases(治法), prescription(處方), herb in common use(常用藥物), diseases appearing the diagnosis pattern(常見疾病), documents(文獻調査). This study was carried out on the basis of the Chinese documents and references.

2003년 국내 중증급성호흡기증후군 진료 현황 및 문제점 분석

이진수,김은실,정문현,백제중,정선화,안주희,최영화,이선희,고철우,김성범,김민자,박승철,기현균,송재훈,최상호,김양수,이상오,조용균,박영훈,정숙인,김연숙,이흥범,손창희,장성희,정희진,김우주 대한감염학회 2004 감염과 화학요법 Vol.36 No.3

목적 : 2002년 말 중국에서 SARS가 발생한 이후 국내에서도 2003년 10월까지 총 3명의 추정환자, 17명의 의심환자가 보고되었다. 향후 추가적인 SARS의 유행이 우려되는 상황에서, 그간의 SARS 환자 진료에 있어서의 실질적인 준비사항, 진료 현황 등에 대한 조사를 통해 문제점을 파악하여, 향후 더 나은 대비가 될 수 있도록 개선점을 제시하고자 하였다. 재료 및 방법 : SARS로 의심되는 환자를 진료 경험이 있는 병원의료진을 대상으로 2003년 10월에 설문조사를 실시하였다. 설문에는 SARS 환자 진료 시의 실질적인 조치, 진료 현황, 병실, 응급실 및 외래에서의 격리 시설과 준비사항, 보건당국의 관리와 지원에 관한 사항을 포함하였다. 결과 : 대상이 되는 22개 병원 중 17개(17/22, 77.2%) 병원이 설문에 응하였다. SARS 환자를 위한 격리실은 응급실, 외래, 일반병실 및 중환자실에서 각각 9개(9/17, 52.9%), 5개(5/17, 29.4%), 15개(15/16, 93.7%), 4개(4/16, 25%) 병원에서 음압처리가 되어있지 않은 일인실 혹은 다인실이 사용되었고, 1개(1/16, 6.3%) 병원에서만 일반병실에서 음압격리실이 운영되었다. 입원환자의 진찰 시 개인보호구의 착용은 거의 모든 의료기관에서 이루어졌다. 보건당국에서 SARS지정병원의 시설 등을 사전에 확인한 곳은 1곳(1/12, 8.3%)이였고, 14개 병원(14/15, 93.3%)에서는 보건당국에 의뢰한 검사결과를 통하 받지 못하였다. 결론 : 의료기관에서 SARS 환자용 격리실뿐만 아니라 기존의 격리실 설비 등이 미흡하였으며, 특히 중환자실 및 외래의 준비가 더욱 부족하였다. 보건당국의 의료기관에 대한 종합적인 지원이 부족하였고, 병원과의 원활한 연계가 잘 이루어지지 않았다. SARS 만이 아닌 격리를 필요로 하는 질환의 적절한 진료를 위해 향후 병원 시설의 정비와 정부차원에서의 보다 구체적이고 실질적인 대책마련이 필요하다. Background : There was an worldwide outbreak of the Severe Acute Respiratory Syndrome (SARS) originated from China in late 2002. During that period three cases of suspected SARS and 17 cases of probable SARS were reported in Korea. With the concerns about the reemergence of SARS-coV transmission, it is important to be prepared for any possibility. So, this study is aimed to analysis the past measures in managing SARS and propose the amendatory plans to improve the preparedness. Materials & Methods : Questionnaires were collected among clinicians with any experience in managing the probable or suspected SARS cases in Oct. 2003. 17 out of 22 hospitals responded to the questionnaire. The contents in the questionnaire were practical activities, personal equipments, response plans, isolation facilities in emergency centers, outpatient clinics, general wards and intensive care units, and relationship with the public health department. Results : The dedicated isolation rooms in emergency centers, outpatient clinics, general wards, and intensive care units were prepared in 9 (9/17, 52.9%), 5 (5/17, 29.4%), 15 (15/16, 93.7%), and 4 (4/16, 25.0%) hospitals, respectively. Except for one hospital that newly made negative pressure room for SARS, single or multi-bed rooms without airborne infection control were used in all the other hospitals. The personal precaution principles were kept quite well in general wards. Before the designation of SARS hospital by the public health department prior evalution to see if the hospital was suitable for managing SARS was conducted in only 1 (1/12, 8.3%) hospital. The results of laboratory diagnosis were reported back in 1 (1/15, 6.6%) hospital. Conclusions : The isolation facilities which can control airborne infection were almost deficient not only for SARS but also for other respiratory transmissible diseases. For the infection control of transmissible diseases including SARS, more investment is needed on medical facilities and comprehensive support from the public health department required.

마우스에 있어서 Olive Oil의 食餌가 免疫反應에 미치는 影響

안영근,박병철,김정훈,이상근,박영길 한국환경독성학회 1991 환경독성보건학회지 Vol.6 No.1

This study was performed to investigate the effect of olive oil diet on the immune response in ICR male mice. Experimental diets of 4 groups were fed ad libitum to the ICR male mice for 27 days. The results of this study were summarized as followings: 1. 10% Olive oil diet group as compared with the control diet group significantly decreased liver weight rate but significantly increased hemagglutination titer (HA), Arthus reaction, delayed type hypersensitivity reaction (DTH), rosette forming cell (RFC), and phagocyte activity. 2. 20% Olive oil diet group as compared with the control diet group significantly increased body weight gain, liver weight rate, and HA but significantly decreased Arthus reaction, DTH, RFC, phagocyte activity, and peripheral circulating white blood cell (WBC). 3. 30% Olive oil diet group as compared with the control diet group significantly increased liver weight rate but significantly decreased body weight gain, Arthus reaction, plaque forming cell (PFC), DTH, RFC, phagocyte activity, and WBC. The results showed that the increase of olive oil doses significantly decreased humoral and cellular immune responses, phagocyte activity, and WBC.

마우스에 있어서 Olive Oil의 食餌가 免疫反應에 미치는 影響

안영근,박병철,김정훈,이상근,박영길 원광대학교 식품약품안전성연구소 1991 食品藥品安全性硏究 Vol.4 No.-

This study was performed to investigate the effect of olive oil diet on the immune response in ICR male mice. Experimental diets of 4 groups were fed ad libitum to the ICR male mice for 27 days. The results of this study were summarized as followings: 1. 10% Olive oil diet group as compared with the control diet group significantly decreased liver weight rate but significantly increased hemagglutination titer (HA), Arthus reaction, delayed type hypersensitivity reaction (DTH), rosette forming cell (RFC), and phagocyte activity. 2. 20% Olive oil diet group as compared with the control diet group significantly increased body weight gain, liver weight rate, and HA but significantly decreased Arthus reaction, DTH, RFC, phagocyte activity, and peripheral circulating white blood cell (WBC). 3. 30% Olive oil diet group as compared with the control diet group significantly increased liver weight rate but significantly decreased body weight gain, Arthus reaction, plaque forming cell (PFC), DTH, RFC, phagocyte activity, and WBC. The results showed that the increase of olive oil doses significantly decreased humoral and cellular immune responses, phagocyte activity, and WBC.

사회서비스형 복지국가전략의 지속가능성

안상훈 서울大學校經濟硏究所 2011 經濟論集 Vol.50 No.3

이 연구는 한국 복지정치 활성화를 통해 현재 진행 중인 복지논쟁을 보다 지속가능한 전략으로 전환시키고자 하는 목적에서 출발한다. 복지국가에 관한 찬반론을 넘어서서 어떤 복지국가전략이 지속가능성이 높은가 하는 방향으로 논의를 돌리고자 하는 것이다. 본론에서는 우선 사회서비스를 보다 강화하는 한국형 생활보장의 논리를 이론적 차원에서 논의한다. 현 시점의 선진자본주의가 당면한 일자리 없는 성장의 국면에서 현금에 비해 사회서비스가 강조되어야 하는 이론적인 이유들이 소개된다. 이러한 이론적 논의에 대한 경험적 측면에서의 분석결과는 크게 두 부분으로 나눠서 제시된다. 우선, 복지자본주의의 세 가지 유형에 관한 경제적·사회적 성과비교를 통해 사회서비스를 강화하는 북유럽형의 전반적 성과가 높다는 점을 보이고 있다. 다음으로는 복지국가의 크기와 구성을 동시에 고려하여 총사회지출, 현금이전지출과 사회서비스지출이 경제적 사회적 성과들이 어떤 관계를 보이는지에 관한 분석을 실시하였다. 그 결과, 사회서비스가 성장침해 효과가 적고 실업을 낮추며 고용, 특히 여성고용을 촉진하는 효과가 분명함을 확인하였다. 요컨대, 사회서비스를 강화하는 전략의 유효성을 확인할 수 있었고 현존하는 복지국가 전략 중에서는 북유럽형이 가장 우수한 성과를 보인다는 점을 알 수 있었다. 그럼에도 불구하고, 통일이나 고령화 속도 등의 상황차이로 인해서 예컨대 '스웨덴 모델' 그 자체를 우리에게 적용하는 것이 불가하며, 성공적인 전략의 원칙과 요소를 수용하여 '한국형' 고유전략을 마련하는 것이 시급하다고 결론을 내리고 있다. This study starts with a reserch object of which intension is to transform current welfare debate of Korea towards a more sustainable direction. As current debate of back-and-white is not useful in the time of welfare political activation, we need to concentrate on the issues like what kind of welfare strategy is more sustainable and economy-friendly. In the part of theoretical discussion, we propose a 'Korean Livelihood Security Model' in which programs of social services are emphasized. As is well known, when the current problem of capitalist market is labor demand shortage, it is argued that we can create more jobs by providing more social services. Empirical findings from two types of analysis commonly support this hypothesis. According to the comparison of three different strategies, the strategy of Nordic countries where social services have developed in addition to cach transfers shows higher performance in economic as well as social indicators. This result is doulble-checked in the correlation analysis where we compared how cash and service are related to the major economic and social indicators. In conclusion, this study suggests that we should not simply copy the Nordic strategy but accept important items of its success. This is due to unique situations Korea facs such as reunification, comparatively too fast ageing phenomenon, etc. All in all, this study ends up with some evidences by which we can confirm our proposal of 'Korean' version of welfare strategy in which social services are more spotlighted.

선택형 컨조인트 분석을 이용한 레스토랑 고객의 효용측정에 관한 연구

안성식;이훈영 경희대학교 산업관계연구소 2009 産硏論叢 Vol.34 No.-

본 연구목적의 선택형 컨조인트 분석방법을 외식업계에 소개하고, 이 방법의 타당성을 전통적인 컨조인트 분석방법과 비교하여 검증하는 데에 있다. 본 연구에서는 전통적인 컨조인트 분석방법과 선택형 컨조인트 분석방법을 비교하기 위하여 레스토랑을 방문한 고객을 대상으로 자료를 수집하고 분석하였다. 전통적인 컨조인트 분석결과와 선택형 컨조인트 분석결과의 예측타당성을 비교하기 위해서 전통적인 컨조인트 분석방법은 16개 카드의 선호순위를 선택형 컨조인트 분석의 예측모형은 선택세트 4를 제시하여 수집한 자료를 이용하였다. 두 모형의 비교는 예측타당성과 시장점유율 예측정확성은 선택세트 5개를 20번 제시하여 수집한 자료를 활용하였다. 분석결과 개별 153명 수준에서 선택세트 5개를 20번 제시한 결과 전통적인 컨조인트 분석방법의 예측타당성은 평균 6.64개(33.22%), 개별수준의 선택형 컨조인트 분석방법의 예측타당성을 살펴보면 평균 8.58개(42.88%)로 전통적인 분석방법 보다 예측력이 더 높은 것으로 나타났다. 시장점유율의 예측타당성을 검정하기 위해 153명이 전체수준에서 선택세트 5개를 20번 제시한 경우 실제선택비율과 전통적인 컨조인트 분석방법에 의한 시장점유율의 차이, 전체수준과 153명 개별수준에서 선택세트 5개를 20번 제시한 결과 선택형 컨조인트 분석방법과의 시장점유율 차이를 살펴보면 차이가 있는 것으로 나타났다. 본 연구결과는 전체수준이 아닌 개별수준에서 선택형 컨조인트 분석을 살펴보았다는 점에서 전통적인 컨조인트 분석과 전체수준에서 살펴본 선택형 컨조인트 분석의 대안으로 권할 수 있다. 선택형 컨조인트 분석방법이 전통적인 컨조인트 분석방법 보다 예측 타당성이나 시장점유율예측 면에서 우월하고, 선택형 컨조인트 분석방법의 장점으로 인하여 레스토랑 선택대안에 대한 정보를 활용한 선택형 컨조인트 분석방법이 외식업계에 확산되어 그 효용성이 더욱 증대하리라 기대한다. The aim of this study is to introduce a choice-based conjoint analysis method to the restaurant industry and to verify its validity by comparing it with the conventional conjoint analysis method. In order to compare both conjoint analysis methods, this study has collected data from restaurant customers. Specifically, in comparing the predictive validity of the results from the conventional conjoint analysis and the choice-based conjoint analysis, 16 cards of preference rankings were presented as the prediction model for the former, while 5 sets of options were presented for the latter. As a result, it is expected that the utility of choice-based conjoint analysis method using the information of restaurant choice alternatives would be expanded to the restaurant industry because of its strong point: it is regarded to be superior to the conventional conjoint analysis in terms of the predictive validity and market share prediction.

고출력 CW Nd:YAG 레이저를 이용한 CSP 1N 박판재 절단시 공정변수의 절단표면특성에 미치는 영향

안동규,김민수,이상훈,유영태,박형준 한국공작기계학회 2004 한국공작기계학회 추계학술대회논문집 Vol.2004 No.-

The objective of this research work is to investigate the influence of process parameters, such as power of laser, travel speed of laser and material thickness, on roughness and striation of the cut surface for the case of cutting of CSP IN sheet using high power Nd:YAG laser with continuous wave (CW). In order to find the practical cutting region and the relationship between process parameters on the roughness and the striation, several laser cutting experiments are carried out. From the results of experiments, the allowable cutting region and an optimal cutting speed for each cutting condition have been obtained to improve the quality of the cut surface. In addition, it has been shown that the surface roughness is related to the number of striation and depth of valley of the cut surface.

부분 치수절단술을 이용한 복잡 치관파절의 치료 : 증례보고

안병덕,김영재,장기택,이상훈,김종철,한세현,김정욱 大韓小兒齒科學會 2008 大韓小兒齒科學會誌 Vol.35 No.2

혼합 치열기 및 초기 영구치열기의 소아,청소년에서 외상에 의한 치관 파절은 빈번하게 발생한다. 치관파절은 치수의 노출 유무에 따라 단순 치관파절,복잡 치관파절로 분류된다. 치수가 노출된 복잡 치관파절의 경우 치수에 대한 고려 및 처치가 필수적인데,초기 영구치열기에는 전치부 치근의 발육이 완전히 이루어지지 않았기 때문에 완성된 치근을 가지는 치아보다 치료가 복잡하다. 치료의 목적은 적절한 치수 치료를 통해 치근의 완성을 도모하는 것으로 이를 위해 직접 치수복조술,부분 치수절단술,치경부 치수절단술의 방법을 이용한다. 이 중 부분 치수절단술은 성공률도 높으며 치경부 치수를 보존하기 때문에 여러 장점을 지니는 치료방법이다. 복잡 치관파절을 주소로 내원한 환자에서 부분 치수절단술을 시행하여 양호한 결과를 나타내어 이를 보고하는 바이다. Traumatic crown fracture in mixed dentition or early permanent dentition is relatively common. Crown fracture is classified into simple or complicated crown fracture by the presence of pulp exposure. The condition of pulp must be considered in treatment of crown fractures with pulp exposure. Treatment of immature crown-fractured incisor with pulp exposure is more complex because of its incomplete root formation. Pulp capping, partial pulpotomy, cervical pulpotomy can be used for continuous root development in immature crown-fractured incisor with pulp exposure. The success rate of partial pulpotomy is very high and there are several advantages of partial pulpotomy because the cell-rich coronal pulp tissue is preserved. This paper reports 2 cases of crown-fractured permanent incisors with pulp exposure that had been treated by partial pulpotomy successfully.

친복지동맹의 복지지위균열에 관한 정치사회학적 비교연구 : 스웨덴의 경험과 한국의 실험 Swedish Experience and Korean Experiment

안상훈 서울대학교 한국사회복지연구회 2003 사회복지연구 Vol.21 No.-

복지국가 발전의 중요한 요인은 그 복지국가의 정책들이 사회성원들의 정치적인 욕구를 어떠한 방식으로 반영하고 있는가의 여부와 관계된다고 할 수 있다. 이러한 인식의 출발점을 가지고 있는 본 연구에서는 주로 탈계급론을 표방하는 최근의 이론적 발전맥락 속에서 복지국가발전을 위한 정치적 동학의 기초적 균열을 확인하고 있다. 본 연구에서는 우선 복지정치균열을 확인하기 위한 이론적 분석틀로서 복지지위의 세 가지 차원에 관한 이론적 제안을 살펴보고 이에 관한 실증적 증거를 확보하고 있다. 복지지위모형의 논리는 스웨덴과 한국 복지정치의 토대가 유사할 수 있다는 가설을 지향하고 있는데, 적어도 LISREL 분석에서 다루어진 변수들과 관련해서는 경험적 증거를 확보할 수 있었다. 이러한 분석결과는 스웨덴과 한국의 친복지적 정권이 시도한 복지정치의 성공과 실패를 가름하려는 시도로 이어진다. 양국의 균열구조가 기초적인 차원에서는 유사한 토대에 근거하고 있다는 실증분석결과에 기대어 양국을 비교한 결과, 스웨덴 복지정치의 성공적 요소들이 우리의 경우에는 결핍되어있다는 결론에 도달하고 있다. 결론적으로 볼 때, 친복지동맹의 지평을 확대할 수 있는 정치적 감수성이 우리에게 절실하다고 할 수 있는 것이다. The basic driving force behind the development of the welfare state are related to how the welfare policies of a society reflect or subsume political needs of the individual. This study starts with the notion of non-class cleavages of the contemporary social scientific perspective and scrutinizes fundamental mechanism of welfare politics. This study firstly suggests using welfare status theory and its tri-dimensional statuses as the theoretical framework with which we explore the puzzles of welfare politics. The theory has been empirically tested by LISREL and proved useful to the applied for both Swedish and Korean welfare politics. On the basis of the empirical results, the latter part of the study concentrates its lenses onto if Korean welfare politics of DJ government has been successful in comparison to that of Sweden. In conclusion, the study shows how much and in what point Korean welfare politics has been doomed to be a failure while Swedish version of pro-welfare politics be a conspicuous success. What is necessary for the future development of Korean welfare politics is the political sensitivity of the pro-welfare elite of the country.