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박상호,이상돈,고형대 목포대학교 정보산업연구소 2000 情報産業硏究誌 Vol.8 No.-
현재의 연구지원 관리는 업무능력의 한계와 수시적이고 반복적인 업무처리로 많은 비용낭비요소를 발생시키고 있다. 연구지원 관리 시스템은 연구과제와 관련된 제반 행정절차를 효율적으로 관리하기 위해 프로토타입을 설계하고 구현하였다. 본 논문에서는 연구과제와 관련된 제반 행정절차를 전산화하며 연구지원의 질적 개선을 도모하고자 한다.
Phenylephrine이 토끼 유두근의 수축력과 활동전압에 미치는 영향
이영배,고인송,박종완,엄대용,이상돈 중앙대학교 의과대학 의과학연구소 1989 中央醫大誌 Vol.14 No.1
In order to clarify the receptor types and mechanisms underlying the positive inotropic effect of phenylephrie on the mammalian ventricular myocardium, the action potential, its first derivatives and isometric contraction of the rabbit papillary muscle were recorded using a free transducer and glass capillary microelectronics filled with 3M KCI, and results were analyzed. The results were as follows; l. In normal Tyrode solution, the contractile force was increased with increments of phenylephrine concentration and maximum effect was reached at the stimulation frequency of 1 Hz in 10^-5 M phenylephrine. 2. In 22 mM K^+-Tyrode solution, the maximum rate of rise (Vmax) of action potential, overshoot and the duration oction potential were significantly increased with increments of phenylephrine concentration (10^-6 ~ 10^-4 M). 3. The negative inotropic effect induced by verapamil was reversed by phenylephrine. 4. Phentolamine (3x10^-6 M) shifted the dose response curve for phenylephrine to the right more than propranolol (10^-6 M) did. The above results may be interpreted as follow; The positive inotropic effect of phenylephrine is caused by increase in slow inward current (Ca^2+influx into the myocardial cell), and is mediated through α- and β-adrengergic receptors in the rabbit pailary muscle
위 유문동근 K^+ - 경축에 미치는 Vanadate의 효과
김충수,고인송,엄대용,이상돈 중앙대학교 의과대학 의과학연구소 1988 中央醫大誌 Vol.13 No.3
Effects of vanadate on the spontaneous contraction and the high K^+-induced contracture of guinea pig’s pyloric antral smooth muscles were observed in the various Na^+ and/or Ca^+ of bathing solutions. Following results were obtained; 1. Basal tension and developed tension of the spontaneous activity were increased by vanadate and the membrane potential tended to be depolarized. 2. Phasic contracture increased, tonic contracture decreased as the outside K^+ concentration increased and the both components were increased by vanadate. 3. In the case of absence of K^+ and/or Na^+, the contracture were hardly developed and the spontaneous, rhythmic contraction were sustained. 4. Effects of vanadate on the K^+-contracture and the Ca^2+-sensitivity of the Phasit and tonic components were prominent in the presence of Na^+. The above results suggested that vanadate would increase the voltage-dependent calcium current in smooth muscle cells of the pyloric antrum.
Review : Ionic Conductance(s) in Response to Post-junctional Potentials
( Sang Don Koh ),( Poong Lyul Rhee ) 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2013 Journal of Neurogastroenterology and Motility (JNM Vol.19 No.4
The gastrointestinal motility is regulated by extrinsic and intrinsic neural regulation. Intrinsic neural pathways are controlled by sensory input, inter-neuronal relay and motor output. Enteric motor neurons release many transmitters which affect post-junctional responses. Post-junctional responses can be excitatory and inhibitory depending on neurotransmitters. Excitatory neurotransmitters induce depolarization and contraction. In contrast, inhibitory neurotransmitters hyperpolarize and relaxe the gastrointestinal smooth muscle. Smooth muscle syncytium is composed of smooth muscle cells, interstitial cells of Cajal and platelet- derived growth factor receptor α-positive (PDGFRα+) cells (SIP syncytium). Specific expression of receptors and ion channels in these cells can be affected by neurotransmitters. In recent years, molecular reporter expression techniques are able to study the properties of ion channels and receptors in isolated specialized cells. In this review, we will discuss the mechanisms of ion channels to interpret the post-junctional responses in the gastrointestinal smooth muscles. (J Neurogastroenterol Motil 2013;19:426-432)
Tannic Acid가 가토 동방결절 세포 및 심방근 세포의 전기적 특성에 미치는 효과
高相敦,金基淳 한양대학교 의과대학 1988 한양의대 학술지 Vol.8 No.1
Though several workers have demonstrated that intravenous administration of tannic acid elicits a hypotensive response, little study has been made on the direct actin of tannin on the heart. Therefore the present study was undertaken to investigate direct effects of tannic acid on the sinoatrial node and atrial muscle cells of the rabbit heart by means of conventional microelectrode techniques. A superfusion of sinus node cells with tannic acid (0.1, 0.25, 0.5%) resulted in a concencration-dependent reduction of action potential amplitude (APA) and rate of spontaneous firing (RSF), and V max (maximum upstroke velocity)was also decreased by 0.25% tannic acid but action potential duration (APD) was not altered significantly. Following superfusion of atrial muscle cell respectively with 0.1% tannic acid (pH 5.8) and acid-Tyrode solution (pH5.8),ApA and RSF were generally decreased. The effects on APA and RSF of tannin was far more pronounced than that of acid-Tyrode solution. A significant prolongation of APD was observed only after superfusion of atrial muscle fiber with acid-Tyrode solution. The results of present study suggest that tannic acid can exert direct effects on the sinus node and atrial muscle cells generally decreasing APA and RSF.
Differential expression of nitric oxide synthase in human stomach cancer
Koh, Eunjin,Noh, Sung Hoon,Lee, Young Don,Lee, Hoi Young,Han, Jeung-Whan,Lee, Hyang Woo,Hong, Sungyoul 성균관대학교 약학연구소 1999 成均藥硏論文集 Vol.11 No.-
The level of expression and cellular localization of isoenzymes of nitric oxide synthase (NOS) was detected in human stomach tumor tissues. Tumor tissues showed 70% higher activity of NOS than that of normal tissues (P<0.01). Poorly differentiated adenocarcinoma tend to have higher activity (P<0.05) than well differentiated and moderately differentiated tumor tissues. Aminoguanidine (AG), 2-amino-5,6-dihydro-6-methyl-4H-1,3-thiazine (AMT), N^G-monomethyl-L-arginine (L-NMMA), and N^ω-nitro-L-arginine (L-NNA) inhibited NOS activity in tumor tissues by 18,14,11 and 13%, respectively. The TNF-α mRNA expression was correlated with the inducible NOS(iNOS) level, which was high in adenocarcinomas and low in normal tissues. Tumor tissues showed higher expression of iNOS in gland epithelial cells but the level of eNOS was significantly decreased with an exception of concentrated localization in the proliferation capillary endothelium. These results revealed that isoforms of NOS might contribute differentially to growth and progression of human stomach tumor. ⓒ 1999 Elsevier Science Ireland Ltd. All rights reserved.
수종 항경련제가 고양이 척수 후각 세포의 activity에 미치는 효과
고상돈,신홍기,김기순,김태영 한양대학교 의과대학 1993 한양의대 학술지 Vol.13 No.1
The present study was undertaken to investigate effects of a few anticonvulsants on the dorsal horn cell activities, to elucidate their mechanism of action and to examine whether these anticonvulsants have spinal and/or supraspinal actions. Spontaneous activities and the responses of wide dynamic range (WDR) cells to mechanical stimulations and graded electrical stimulations of the afferent nerve were extracellulary recorded in the normal and spinal cats before and after the intravenous administration of diphenylhydantoin (15-30mg/kg, DPH), carbamazepine (15-30mg/kg, CBZ) and valproic acid (15-30mg/kg, VA). Also studied were the effects of picrotoxin and strychnine on the anticonvulsant-induced changes in the dorsal horn cell activities. All the anticonvulsants tested inhibited dose-dependently the response of WDR cell to afferent signals. The resposes of WDR cell to pinch and C-fiber stimulation were more strongly inhibited than those to brush and A-fiber stimulation. Strychnine (0.5mg/kg), not picrotoxin (0.5mg/kg) strongly blocked an inhibitory effect of DPH on all the reponses of WDR cells except C-fiber response. In the spinal animal, approximately two-third of DPH-induced inhibition was maintained. The anticonvulsants also markedly inhibited spontaneous activities of the cat spinal neurons. These results lead to the conclusion that in the lumbar segment of the cats spinal cord most of anticonvulsant-induced inhibitions of the responses of WDR cell to afferent signals were mediated through glycine receptors at both the spinal and supraspinal sites.