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관리 회계시스템과 Legacy 시스템 간의 EIS 기반의 인터페이스 모델
한삼용 ( Samyong Han ),김진형 ( Jinhyung Kim ) 한국정보처리학회 2007 한국정보처리학회 학술대회논문집 Vol.14 No.1
RTE(Real Time Enterprise)라는 경영 기법이 21 세기에 대두 되면서 많은 기업들이 환경을 구축하기 시작 하고, 보험사들도 ERP 구축을 통하여 RTE 환경을 이루고자 노력하고 있다. 본 논문에서는 한국 보험사에 구축된 사례를 바탕으로 관리 회계 관점에서의 ERP 와 Legacy 시스템간의 인터페이스를 분석하였다. 이를 통해 유지 보수 단계의 문제점과 시스템 자원 이용의 비효율성 및 시스템 확장에 대한 요구 사항을 쉽게 수용 할 수 없는 구조로 구축 되었음을 알 수 있었다. 이에 대한 해결책으로써 Data Hub 신설 및 코드 항목의 독립 등을 포함한 효과적인 모델을 제시 하며, 그 결과로 Disk 이용을 26 % 절약 하고, 유지 보수의 용이성 및 시스템 확정의 용이성을 확보 할 수 있다.
김삼용,길준영,전의건 충남대학교 의과대학 지역사회의학연구소 1991 충남의대잡지 Vol.18 No.2
A retrospective analysis of clinical data of 32 cases of aplastic anemia diagnosed at Chungnam National University Hospital from August 1985 to July 1991 was done. 1) The highest incidence of aplastic anemia was seen in the third decade and 25 cases of patients (78.2%) were below 40 years of age. The incidence decreased in older age groups. 2) Exposure to possible toxic agents were seen in 6 cases(18.8%), among which benzene was related in 2 cases(6.3 % ), herb drug in 2 cases(6.3 % ), acute viral hepatitis(type B) in 1 case(3.1 % ), antifungal agent in 1 case(3.1 % ). 3) Initially all patients were treated with oxymetholone with or without prednisolone and supportive care. Eleven(37.9 %) out of twenty-nine patients showed responses(CR: 17.2%, PR: 20.6%). Nine out of the eighteen patiens who did not respond to androgen therapy were treated with antilymphocyte globulin (ALG) plus methylprednisolone. Two patients(22.2 %) out of 9 showed complete responses. 4) Overall responses of present series of patients was 44.8 % (androgen± prenisolone therapy: 37.9%, ALG+ methylprednisolone: 6.9%). The actuarial survival of all patients at 72 months was 83.4%. The median survical rate of severe aplastic anemia(32 months) was similiar to that of moderate aplastic anemia(37 months). 5) Factors associated with favourable survival were male sex and presence of etiological factor. Since the prognosis of aplastic anemia in Korea is quite favorable, randomized controlled study would be needed to define the therapeutic roles of bone marrow transplantation of immunosuppressive therapy in patients with severe aplastic anemia in Korea.
항암제 처리한 백혈병 세포주에서의 Apoptosis 발현
김삼용,윤소현,김현수,김종숙,윤환중,김진경,조덕연 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1
The bcl-2 proto-oncogene encodes a 26 kD protein that promotes cell survival by blocking apoptosis. The bax protein is a member of the bcl-2 familly, now known to form heterodimers with the bcl-2 protein. The ratio of bax to bcl-2 is be critical in determining the fate of the cell in response to stimuli that can induce apoptosis. Extract of Pulsatilla Koreana (SB-31) showed promising antitumor activity in vitro with Topo I inhibitory action. In the present study, the relationship between apoptosis and the apoptosis related proteins, bcl-2 and bax were investigated in human leukemic cell lines HL-60, U-937 and CEM-CM3. All anticancer drugs(adriamycin, etoposide, camptothecin, SB-31) induced extensive apoptosis in HL-60, U-937 cells and CEM-CM3 cells. The expression of bcl-2 and bax protein were determined in cell lines by western blotting before and after incubation with anticancer drugs at different time points. 1) In HL-60 or U-937 cell lines, down regulation of bcl-2 and up-regulation of bax were found after incubation with ADR, VP-16 or camptothecin. 2) In HL-60 or U-937 cell lines, no significant change in bcl-2 or bax protein expression resulted after incubation with SB-31. 3) In CEM-CM3 cells, virtually no change was noted in bcl-2/bax expression after incubation with ADR, VP-16, camptothecin or SB-31. It is suggested that different leukemic cell lines use different pathways of apoptosis activation and a given cell may utilize different pathways of apoptosis activation in response to different cytotoxic agents.