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충남대학교병원 마취발전의 경향에 관한 분석 : 1967년부터 - 1996년까지 from 1967 to 1996
최세진,김상수,정규돈,윤석화,신용섭,손수창,이원형,김혜자,이정은 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.2
To evaluate the specificity and historical trends of the anesthesia in Chungnam National University Hospital, anesthetic experiences of 83,572 in total performed at Chungnam National University Hospital from January 1967 to December 1996 were analyzed statistically and clinically according to age, sex, surgical department, physical status, elective and emergency surgery, premedicants, IV anesthetics, anesthetic methods, inhalational anesthetics, muscle relaxants. The results were as follows : 1. The number of cases has been steadily increased year by year. 2. The ratio of male to female was 52.8% : 47.2%. 3. According to the age, There were 44,905 cases (54%) in the group of 13-45 years. 4. According to the ASA classification of physical status, most of the cases were belonged to the class 1 & 2 (72.5%). 5. The ratio of elective to emergency was 79.4% to 20.6%. 6. Recently, glycopyrrolate has been used increasingly. 7. Thiopental sodium has been mainly used for intravenous induction agent. 8. General anesthesia has been used mainly. 9. Enflurane is the most common inhalational anesthetic agent. but Isoflurane has been used increasingly. 10. Most of muscle relaxants are Pancuronium & Vecuronium(84.5%).
이새미,윤기영,서경원,최호정,정성목,송근호,조종기,박성준 忠南大學校 獸醫科大學 附設 動物醫科學硏究所 2012 動物醫科學硏究誌 Vol.19 No.1
A 11-year-old Yorkshire terrier anesthetized for computed tomography. The dog showed cyanosis and syncope during postanesthetic recovery, therefore drug administrated parenterally. Goose-honking was noticed after full recovery. As a result of survey radiography and fluoroscopy, grade 4 tracheal collapse was diagnosed. Prescription for the dog was oral administration of hydrocodone 0.22 mg/kg. theophylline 20 mg/kg, prednisone 0.5 mg/kg, amoxicillin 22 mg/kg and chlorpheniramine 2 mg/kg twice a day for 3 days. A 10-year-old Pomeranian was diagnosed as grade 2 traceal collapse at the local animal hospital 2 years before being referred to the veterinary teaching hospital of Chungnam National University. On physical examination, goose-honking, coughing and intermittent open-mouth breathing. Tracheal narrowing was observed on survey einradiography and fluoroscopy. Oral administration of theophylline 13 mg/kg, enrofloxacin 5 mg/kg, chlropheniramine 0.5 mg/kg twice a day was prescribed for 2 weeks.
EMLA Cream 도포와 1% Lidocaine 침윤 후 요골동맥천자시 진통정도의 비교
윤석화,황원재,최세진 충남대학교 의과대학 지역사회의학연구소 1995 충남의대잡지 Vol.22 No.2
In a double blind study, the efficacy of topical 5% EMLA cream was compared with that of 1% lidocaine infiltration in the pain-relief and incidence of complication after radial arterial cannulation. Forty three premedicated adults were allocated randomly to two groups to receive EMLA cream and 1% lidocaine infiltration. Following arterial cannulation, pain was assessed by the patient using visual analogue score (VAS) and by a independent observer using four-caregory verbal rating score (VRS). There no significant differences between the EMLA group and 1% lidocaine infiltration group both patient and observer assessments. Compared with lidocaine infiltration group, significantly lower trial numbers of puncture in those recieving EMLA cream group, but no difference of discomfortness of puncture were observed in EMLA cream group.
全泰玉,周原植,金福仁,崔병국,吳世旭 東亞大學校 1980 東亞論叢 Vol.17 No.2
Austenite stainless steel 년 316 has heat treated to austenite structure by heating at 1100℃ for 1hr and suddenly cooling. These specimens has been dealed with aging treatment at 700℃ for 0hr, 2hr, 10hr, and 100hr separately, and then conducted by creep test on the uniaxial state of stress in atmosphere of 600℃. The experimental results are obtained as follows. 1) Creep rupture stain rate has increased by the increasing of aging time. 2) Creep rupture time have had large affect of aging time comparing with 0hr aging specimen and increased by 20%, 40%, and 60% separately for 2hr, 10hr, and 100hr aging specimen. The empirical formulas of creep rupture time "t" as follows. (aging time are in parenthesis) t?=2.297×10? t?=8.810×10? t?=2.951×10? t?=1.178×10? 3) Creep constant "n" has increased, "k" decreased and creep limit increased by increasing the aging time. Then creep strain rate has decreased and increased by increasing the aging time and stress. The empirical formulas as follows. ε?=3.326×10? ε?=1.905×10? ε?=1.347×10? ε?=3.465×10? 4) The creep strain rate multiplied by creep rupture time has constant value according to property of material and belongs to the range of parallel line at logarithmic graph paper. 5) Hardness has increased by the increasing of aging time and intergranular hardness is higher than transgranular hardness. 6) The micro cracks occur from wedge crack and cavitation crack at grain boundary and exist at the surface of specimen and the surface of longitudnal section. 7) High stress and aging specimens have mostly wedge crack. Low stress and nonaging specimens have mostly cavitation crack. 8) Rupture surface of higher stress has shearing fracture of about 45° inclination, and has tendency of fracture by directing perpendicular to the axis for decreasing creep stress and also has same phenomenon for occurrence and propagation of crack.
Midazolam의 백서 기관평활근 이완효과와 Flumazenil의 길항작용
윤석화,신용섭,손수창,이원형,김혜자,최세진 충남대학교 의과대학 지역사회의학연구소 1995 충남의대잡지 Vol.22 No.2
Midazolam have been used widely as adjuvants in both regional and general anesthesia and in high risk patients in the intensive care unit. In the present study we evaluated the effect of midazolam and antagonistic effect of flumazenil on isolated rat tracheal preparations mounted for recording isometric contractile force. Trachea smooth muscle were contracted with acetylcholine (10^-5M, Ach) and potassium chloride (40mM KC1). Midazolam 5x10 exp (-6)M and 5x10 exp (-5)M produced dose-dependent relaxation and flumazenil (3.2 x 10 exp (-7)M), central antagonist of benzodiazepine, pretreatment had no significant change midazolaminduced relaxation. Midazolam probably did not relax airway smooth muscle by activatong central benzodiazepine receptors, as flumazenil did not block the concentration-related relaxation of midazolam. Our study suggests that flumazenil may be used satety for asthmatic patients who have been with midazolam, as flumazenil did not antagonize airway relaxation elicited by midazolam.
Urapidil, Labetalol의 투여가 기관내 삽관시 심혈관계에 미치는 영향
신용섭,윤석화,손수창,이원형,이정은,황원재,김만수,김영주,김혜자,최세진 충남대학교 의과대학 지역사회의학연구소 1994 충남의대잡지 Vol.21 No.2
We have examined the comparative efficacy of small doses of intravenous urapidil and labetalol in blunting hemodynamic response to endotracheal intubation and surgical incision in 30 patients without cardiovascular diseases. After intravenous urapidil 0.2 mg/kg or labetalol 0.2 mg/kg anesthesia was induced with thiopental 5mg/kg. Endotracheal intubation was facilitated by vecuronium 0.15 mg/kg with priming principle and anesthesia was maintained with enflurane and nitrous oxide in oxygen. Systolic, diastolic and mean arterial pressure and heart rate were measured before administration of the drugs, 5 minute after administration, just prior to endotracheal intubation and 1, 3, 5, 10 minute after intubatin. Also the peak blood pressures and heart rate within 10 minutes after surgical incision were measured. Endotracheal intubation and surgical stimulation were associated with significant increases in blood pressures and heart rate in both urapidil and labetalol group. Comparison of the changes in systolic, diastolic, and mean artrial pressures and heart rate between urapidil and labetalol group showed no significant difference except peak systolic pressure after surgical incision. It is concluded that the pressor response to endotracheal intubation and surgical stimulation are not influenced significantly by urapidil 0.2 mg/kg or labetalol 0.2 mg/kg. However, urapidil and labetalol preloading may be similarly effective in the blunting of the increases in blood pressures with larger doses of the durgs during anesthetic induction.
GUIDELINE : Severe influenza treatment guideline
( Won Suk Choi ),( Ji Hyeon Baek ),( Yu Bin Seo ),( Sae Yoon Kee ),( Hye Won Jeong ),( Hee Young Lee ),( Byung Wook Eun ),( Eun Ju Choo ),( Ja Cob Lee ),( Young Keun Kim ),( Joon Young Song ),( Seong 대한내과학회 2014 The Korean Journal of Internal Medicine Vol.29 No.1