개에서 발생한 기관 허탈의 진단과 관리

이새미,윤기영,서경원,최호정,정성목,송근호,조종기,박성준 忠南大學校 獸醫科大學 附設 動物醫科學硏究所 2012 動物醫科學硏究誌 Vol.19 No.1

A 11-year-old Yorkshire terrier anesthetized for computed tomography. The dog showed cyanosis and syncope during postanesthetic recovery, therefore drug administrated parenterally. Goose-honking was noticed after full recovery. As a result of survey radiography and fluoroscopy, grade 4 tracheal collapse was diagnosed. Prescription for the dog was oral administration of hydrocodone 0.22 mg/kg. theophylline 20 mg/kg, prednisone 0.5 mg/kg, amoxicillin 22 mg/kg and chlorpheniramine 2 mg/kg twice a day for 3 days. A 10-year-old Pomeranian was diagnosed as grade 2 traceal collapse at the local animal hospital 2 years before being referred to the veterinary teaching hospital of Chungnam National University. On physical examination, goose-honking, coughing and intermittent open-mouth breathing. Tracheal narrowing was observed on survey einradiography and fluoroscopy. Oral administration of theophylline 13 mg/kg, enrofloxacin 5 mg/kg, chlropheniramine 0.5 mg/kg twice a day was prescribed for 2 weeks.

대장수술 후에 발생한 급성신부전의 위험인자

이혜미,황창재,김재황,김흥대,박대팔,서일숙,송선옥,김세연,이덕희,지대림 영남대학교 의과대학 2007 Yeungnam University Journal of Medicine Vol.24 No.2

연구 배경 : 급성 신부전은 술 후 발생할 수 있는 합병증 중에서 사망률은 큰 영향을 줄 수 있으므로 이 연구를 통해 위험인자를 알아보려고 한다. 재료 및 방법 : 2004년 1월부터 2006년 12월까지 3년간 영남대학교 의과대학 부속병원에서 대장 수술을 받은 570명의 환자들을 대상으로 하였다. 환자들의 성별과 연령, 미국 마취과학회 신체등급, 동반질환, 수술의 종류, 응급수술의 여부, 수술 시간, 재수술의 여부, 술 중의 투약 상황, 술 후에 자가 통증 조절기에 사용한 약제, 술 중에 저혈압의 유무, 수혈 여부, 술 후 기계적 환기를 시행한 경우를 비교하였다. 결과 : 비교 결과에서 성별과 수술의 종류, 응급 수술의 여부, 개복여부 등에는 유의한 차이를 보이지 않았다. 반면 환자의 나이와 수술 시간, 재수술의 여부, 술중에 이뇨제 등을 사용한 경우, 술 중에 저혈압의 유무, 술 후에 기계적 환기를 시행한 경우 등에는 유의한 차이를 보였다. 결론 : 이상의 결과로 급성신부전의 원인은 어느 한 가지라고 하기 보다는 위험인자에 얼마나 노출되어 있는가가 결정하는 것 같고, 그 원인들이 모여서 상승효과를 내는 것 같다. 그러므로 수술 전부터 많은 위험에 노출된 환자는 술 중 더 적극적인 감시를 시행하여 수술 후의 합병증 발생을 줄이는 노력을 기울여야 하겠다. Background : Acute renal failure is one of the leading causes of postoperative morbidity and mortality. The purpose of this study was to determine the risk factors that are associated with acute renal failure after colorectal surgery. Materials and Methods : Five hundred seventy patients who operated colorectal surgery at the Yeungnam University Medical Center over three years from 2004 to 2006 were enrolled in this study. The effects of gender, age, ASA classification, concomitant disease, surgery type and duration, reoperation, urogenital manipulation, medication, hypotension, hypovolemia, transfusion, and postoperative ventilatory care on the occurrence of acute renal failure after colorectal surgery were studied. Results : The major risk factors of acute renal failure after colorectal surgery were age of patients (P=0.003), ASA classification (P<0.001), concomitant disease (P<0.001), duration of the time surgery (P=0.034), reoperation (P=0.001), use of intraoperative diuretics (P=0.005), use of postoperative diuretics (P<0.001), intraoperative hypotension (P=0.018), intraoperative transfusion (P<0.001), postoperative transfusion (P<0.001), and postoperative ventilatory care (P=0.001). Conclusion : Multiple factors cause synergistic effects on the development of acute renal failure after colorectal surgery. Therefore, efforts to reduce the risk factors associated with acute renal failure are needed. In addition, intensive postoperative care should be provided to all patients.

Alprazolam함유 poly(D,L-lactic acid) microsphere의 제조 및 평가

용철순,오두만,권미라,박새해 영남대학교 약품개발연구소 1996 영남대학교 약품개발연구소 연구업적집 Vol.6 No.-

Poly(D.L-lactic acid)(PLA) microspheres containing alprazolam(APZ) were prepared by a solvent-emulsion evaporation method and their release patterns were invostigated in vitro. Various batches of microspherss with different size and drug content were obtained by changing the ration of APZ to PLA, PLA concentration in the dispersed phase and stirring rate. Rod-like APZ crystals on microsphere surface, which were released rapidly and could act as a loading dose, were observed with increasing drug content. The release rate was increased with increase in drug contents and decresase in the molecular weight of PLA. The release rate of APZ for long-acting injectable delivery system in vitro, which would aid in predicting in vivo release profile, could be controlled by properly optimizing various factors affecting characteristics of microspheres.

FC 1-2 : Immunomodulatory effects of Ul-Jin thermomineral water on Oxazolone-induced atopic dermatitis murine model

( Sae Mi Park ),( Dae Hong Kim ),( Eun Jong Song ),( Kum Hee Jung ),( Jun Young Lee ),( Young Bok Lee ),( Dong Soo Yu ),( Jin Wou Kim ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2

Background: Althoug the therapeutic effect of Balneotherapy for atopic dermatitis is controversial, many atopic patients are visiting thermomineral springs and present clinical improvements. Objectives: The aim of this study is to evaluate the therapeutic effect and the immunologic mechanism of balneotherapy in atopic dermatitis. Methods: Oxazolone-induced atopic dermatitis murine model was used for evaluating the therapeutic effect of balneotherapy with Ul-Jin thermomineral water. Confocal microscopic imaging analysis was performed for lesional expression of IL-4, IL-17, CD4, Foxp3, and TNF-a. Lesional mRNA expression of IL-33, TSLP, and Foxp3 was evaluated by real-time reverse transcriptase polymerase chain reaction method. Histologic evaluation was also performed. Results: Comparing with distilled water balneotherapy group, the lesional expression of IL-4, TNF-a, IL-17 was decreased in mineral water balneotherapy group by confocal microscopic examination. However, Confocal microscopic evaluation of CD4 and Foxp3 showed increase in mineral water balneotherapy. The lesional mRNA levels of IL-33 and TSLP showed reduction in mineral water balneotherapy group, whereas the level of mRNA of Foxp3 increased in mineral water balneotherapy group. Conclusion: These results suggest that balneotherapy can be an effective and safe treatment option in atopic dermatitis.

Preparation and physical properties of polypropylene nanocomposites with dodecylated graphene nanoplatelets

Park, Sae Mi,Kim, Dae Su V.S.P 2017 COMPOSITE INTERFACES -ZEIST- Vol.24 No.4

Pregnancy-associated with type B aortic dissection

( Sae Mi Park ),( Ji-man Heo ),( Ho Yeon Kim ),( Hai-joong Kim ) 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-

The purpose of this study was to report our experience with type B aortic dissection during pregnancy. A 34 year-old multiparous women presented with dyspnea and orthopnea at the 29th weeks of pregnancy. She had a family history of sudden death history of younger brother but her genetic study revealed no evidence of Marfan syndrome or other disorder. Computed tomography angiography demonstrated a dilatation of descending thoracic aorta 35mm and aortic dissection from juxta left subclavian artery level to left common iliac artery level. Pregnancy was continued with beta-blocker therapy to maintain normal blood pressure and betamethasone for fetal lung maturation. A cesarean section was performed at the 29+6 weeks of pregnancy. She and her baby survived the perinatal period and showed no major adverse outcome afterward. She and her baby were followed by outpatient observation; mother had surveillance with computed tomography angiography after delivery. Careful multidisciplinary care throughout the pregnancy and peripartum period are essential for the management of aortic dissection for both the mother and fetus.

P158 : Safety & pain reducing effectiveness of facial subcutaneous injection of Cross-linked dextran and polymethylmethacrylate (PMMA) mixture with lidocaine to the nasolabial folds; single center, double blinded, one-arm, 3weeks follow up study

( Sae Mi Park ),( Dae Hong Kim ),( Eun Jong Song ),( Kum Hee Jung ),( Jun Young Lee ),( Young Bok Lee ),( Jin Wou Kim ),( Dong Soo Yu ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2

Background: In a filler injections, one of patients` main concerns injections pertains to pain and discomfort, especially for the first time patient. Objectives: To evaluate pain at the injection site during and after the injection of Cross-linked dextran and polymethylmethacrylate (PMMA) with lidocaine mixture or the same filler without lidocaine and to evaluate outcomes after 3 weeks. Methods: In a double-blinded, prospective, randomized, split-face design trial, Cross-linked dextran and PMMA mixture with lidocaine was injected in one nasolabial fold(NLF), and the same filler without lidocaine was injected in the contralateral NLF of 14 enrolled patients. Injection site pain was measured using a visual analogue scale at injection (time 0) and 15, 30, 45, and 60 minutes after injection. Patients were asked to return for an evaluation after 3 weeks and to complete a self-assessment questionnaire during the follow-up visit. Results: There was more than 10mm(VAS score) less pain associated with the dermal gel with lidocaine than with the same filler without lidocaine at all time points (p<.001). The greatest difference in pain was recorded at the time of injection, and then the effect gradually declined over the 60-minute period. Both fillers were well tolerated, and there was no difference in outcome after 3 weeks. Conclusion: Studies have shown that lidocaine enhances treatment comfort and optimizes the injection experience while maintaining a similar safety and effectiveness profile.

Isoliquiritigenin in licorice functions as a hepatic protectant by induction of antioxidant genes through extracellular signal-regulated kinase-mediated NF-E2-related factor-2 signaling pathway

Park, Sang Mi,Lee, Jong Rok,Ku, Sae Kwang,Cho, Il Je,Byun, Sung Hui,Kim, Sang Chan,Park, Sook Jahr,Kim, Young Woo SPRINGER VERLAG 2016 EUROPEAN JOURNAL OF NUTRITION Vol.55 No.8

<P>These findings are considered as scientific evidence that isoLQ in licorice has the function of being a hepatic protectant against oxidative damages through ERK-mediated Nrf2 activation.</P>

Angiomyxolipoma of the lower lip: case report

( Sae Mi Park ),( So Min Kim ),( Hyung Jin Hahn ),( Young Bok Lee ),( Dong Soo Yu ),( Jin Wou Kim ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1

Angiomyxolipoma is a rare variant of lipoma, histopathologically characterized by a proliferation of vascular vessels and adipose tissue mixed with myxoid stroma. The anatomic distribution of lipoma is wide with relative sparing of the head, hands, and feet. To date, only 15 cases of angiomyxolipoma were reported in the English-language literature, which have been located mainly in subcutaneous tissues. Only one case of angiomyxolipoma originating within the oral tissue was reported in 2011. In the present case, a 60-year-old man presented with asymptomatic, solitary, 1.0 x 1.5 cm-sized, oval-shaped, erythematous nodule on the lower lip for 3 years. Histopathologic findings revealed mature lipomatous tissue with areas of myxoid stroma containing abundant variable-sized vascular channels. No necrosis, mitoses or hemorrhage was observed. These findings were consistent with angiomyxolipoma. The patient underwent total excision of the lesion. After 5 months of follow-up, no recurrence has been observed. Herein, we report a unique case of angiomyxolipoma affecting the lower lip of a 60-year old male.

Congenital ectodermal dysplasia

( Sae Mi Park ),( Jin Young Choi ),( Hyung Jin Hahn ),( Young Bok Lee ),( Dong Soo Yu ),( Jin Wou Kim ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1

Ectodermal dysplasia denotes large group of inherited disorders that are defined by primary defects in the development of 2 or more tissues, derived from embryonic ectoderm, such as nails, teeth, hair, and sweat glands. The most common form is hypohidrotic ectodermal dysplasia which is characterized by hypohidrosis, hypotrichosis, hypodontia, periorbital hyperpigmentation, and depressed nasal bridge noses. The most frequently affected structure is the hair on various parts of the body including scalp. A 19-year-old male diagnosed with congenital ectodermal dysplasia in childhood visited our clinic to obtain a medical certificate prior to his conscription to military service. The sparse scalp hair and complete absence of axillary hairs, pubic hairs and eyebrows were all supportive to the diagnosis. Closer inspection revealed oligodontia with only three teeth remaining. Periorbital hyperpigmentation, mild frontal bossing, protruberant lips, and a depressed nasal bridge were present along with dry skin caused by hypohidrosis since birth. A skin biopsy obtained from his palm and scalp showed a hypoplasia of the hair and the sebaceous glands, with a decrease in their number, size, and degree of maturation. Taken together with the clinical manifestations, a diagnosis of hypohidrotic ectodermal dysplasia was made. Herein, we report a case of congenital ectodermal dysplasia in a 19-year-old male.