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Protein-protein Interaction Networks: from Interactions to Networks
Cho, Sa-Yeon,Park, Sung-Goo,Lee, Do-Hee,Park, Byoung-Chul Korean Society for Biochemistry and Molecular Biol 2004 Journal of biochemistry and molecular biology Vol.37 No.1
The goal of interaction proteomics that studies the protein-protein interactions of all expressed proteins is to understand biological processes that are strictly regulated by these interactions. The availability of entire genome sequences of many organisms and high-throughput analysis tools has led scientists to study the entire proteome (Pandey and Mann, 2000). There are various high-throughput methods for detecting protein interactions such as yeast two-hybrid approach and mass spectrometry to produce vast amounts of data that can be utilized to decipher protein functions in complicated biological networks. In this review, we discuss recent developments in analytical methods for large-scale protein interactions and the future direction of interaction proteomics.
Cho, Sa-Yeon Korean Chemical Society 2005 Bulletin of the Korean Chemical Society Vol.26 No.11
Angiogenesis is tightly regulated by a variety of angiogenic activators and inhibitors. Disruption of the balanced angiogenesis leads to the progress of diseases such as cancer, rheumatoid arthritis, and diabetic blindness. Even though a number of proteins involved in angiogenesis have been identified so far, more protein factors remain to be identified due to complexity of the process. Here I report that pituitary tumor-transforming gene (PTTG) induces migration and tube formation of human umbilical vein endothelial cells (HUVECs). High levels of both vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) are detected in conditioned medium obtained from cells transfected with PTTG expression plasmid. Taken together, these results suggest that PTTG is an angiogenic factor that induces production of both VEGF and bFGF.
Rapid Dissemination of Newly Introduced Plasmodium vivax Genotypes in South Korea
Kim, Yeon-Joo,Kim, Jung-Yeon,Lee, Eun-Gyu,Lee, Byeong-Chul,Cho, Shin-Hyung,Yu, Jae-Ran,Rhie, Ho-Gun,Choi, Yien-Kyoung,Lee, Ho-Sa,Lee, Joo-Shil,Kim, Tong-Soo,Choi, Kyung-Mi,Park, Mi-Hyun American Society of Tropical Medicine and Hygiene 2010 The American journal of tropical medicine and hygi Vol.82 No.3
<P>Reemerged Plasmodium vivax malaria in South Korea has not yet been eradicated despite continuous governmental efforts. It has rather become an endemic disease. Our study aimed to determine the genetic diversity in P. vivax merozoite surface protein-1 (PvMSP-1) and circumsporozoite protein (PvCSP) genes over an extended period after its reemergence to its current status. Sequence analysis of PvMSP-1 gene sequences from the 632 P. vivax isolates during 1996-2007 indicates that most isolates recently obtained were different from isolates obtained in the initial reemergence period. There was initially only one subtype (recombinant) present but its subtypes have varied since 2000; six MSP-1 subtypes were recently found. A similar variation was observed by CSP gene analysis; a new CSP subtype was found. Understanding genetic variation patterns of the parasite may help to analyze trends and assess extent of endemic malaria in South Korea.</P>
Change of Refraction while Viewing through the Periphery of Spectacle Lens
Byeon-Yeon Moon,Jong Hwan Sa,Dong-Sik Yu,Sang-Yeob Kim,Hyun Gug Cho 대한시과학회 2018 대한시과학회지 Vol.20 No.2
목적: 안경렌즈의 주변부를 통해서 주시할 때 발생하는 굴절의 변화를 살펴보았다. 방법: 렌즈의 주변부를 통해 봤을 때 굴절력의 변화를 측정하기 위해 렌즈미터의 렌즈 받침부(lens support)로부터 25mm아래에 있는 회전축을 중심으로 주시각도만큼 렌즈가 기울어진 상태에서 렌즈미터로 굴절력을 측정하였으며, 광학중심부와 주변부에서 측정한 굴절력과 비교하였다. 또한 주시각도에 따른 두께의 변화와 정점간 거리의 변화가 굴절에 미치는 영향을 살펴보았다. 결과: 주시각도가 커짐에 따라 시선이 지나가는 렌즈의 두께는 증가하지만 교정굴절력에 큰 영향을 미칠 정도는 아니었다. 주시각도가 증가하면 정점간 거리도 증가하게 되며 추가 (-)굴절력이 필요하다. 주시각도가 30゜이내일 때 추가 굴절력은 –0.1D이하이다. 주시각도가 증가할 때 최소굴절력(구면굴절력)은 기준굴절력과 대체로 큰 차이가 없었다. 원주굴절력은 주시각도 10゜정도까지는 거의 발생되지 않았으나 주시각도가 증가함에 따라 증가하는 경향을 보였다. 결론: 주변시에서 비점수차 등의 수차에 의한 굴절력의 변화는 렌즈의 사용 환경과 취급에서 고려되어야 할 것이다. Purpose : The purpose of this study was to investigate the change of refraction while viewing through the periphery of spectacle lens. Methods : In order to measure the change of refractive power while viewing through the periphery of the lens, the refractive power was measured with a digital lensmeter when the lens was tilted by gaze angle around a rotation axis which was 25 mm below from the lens support of lensmeter, and compared with refractive powers measured at the optical center and periphery. The effects of the refraction caused by the changes of lens thickness and vertex distance according to the gaze angle were also examined. Results : The thickness of a lens at a point of gaze was increased with the increase of the gaze angle, but not so much as to affect the correction power. As the gaze angle increased, the vertex distance increased and additional (-) correction power was required. At the gaze angles within 30゜, the additional power was less than -0.1D. In most cases, as the gaze angle increased, the minimum refractive power (spherical power) was not significantly different from the reference refractive power. Cylindrical power was hardly observed up to about 10゜, but increased with increasing the gaze angle. Conclusions : The change of refractive power caused by aberrations such as astigmatism in the peripheral vision should be considered in the use environment and handling of lenses.
천연정유 Cajuput (Melaleuca cajeputi) 유래 Benzaldehyde의 살초활성
이사은(Sa-Eun Lee),윤미선(Mi-Sun Yun),연보람(Bo-Ram Yeon),최정섭(Jung-Sup Choi),조남규(Nam-Kyu Cho),황기환(Ki-Hwan Hwang),王海英(Hai-Ying Wang),김성문(Songmun Kim) 韓國雜草學會 2010 Weed&Turfgrass Science Vol.30 No.3
본 연구의 목적은 정유에 함유되어 있는 살초활성물질을 탐색하여 제초제 개발을 위한 선도 화합물을 발굴하는데 있었다. Amyris(Amyris balsamifera), cajuput(Melaleuca cajeputi), geranium(Pelargonium graveolens), lavender(Lavendula spp.), mandarin(Citrus reticulata), pine(Pinus spp.) 및 rosemary(Rosmarius officinale) 정유에 대한 살초력을 유채(Brassica napus)를 대상으로 in vitro에서 수행한 결과, cajuput 정유의 살초력이 가장 높았다(GR50 값, 425㎍ g-1). Cajuput 정유에 함유되어 있는 주된 생리활성물질들은 eucalyptol 37,2%, a-terpineol 11.6%, benzaldehyde 5.2%, linalool 4.1%, a-pinene 2.5%, β-pinene 2.4%이었으며, 이들 생리활성물질의 살초력(GR50 값)은 각각 2,731, 500, 50, 372, 4,363, 4,671㎍ g⁻¹이었다. Benzaldehyde의 살초력은 기 보고된 eucalyptol(1,8-cineole)과 a-pinene보다 높았으므로 향후 새로운 제초제 개발을 위한 선도화합물로 활용될 수 있을 것이라 판단된다. Cajuput 정유와 이에 함유되어 있는 가장 높은 살초력을 보였던 benzaldehyde를 80㎏ ha-1 토양처리하였을 때에는 그 어떠한 살초효과도 관찰할 수 없었으나, 경엽처리 하였을 때에는 화본과잡초인 수수, 돌피, 바랭이는 100% 고사되었다. 그러나 살초효과는 20㎏ ha-1 이하에서는 전혀 나타나지 않았는데 이 는 cajuput 정유와 benzaldehyde의 높은 휘발성 때문인 것으로 추론된다. 본 연구의 결과 cajuput 정유의 살초효과는 높은 약량에서만 나타났으므로 약량저감을 위한 처리시기 재설정과 살초력을 높일 수 있는 제형개발이 요구된다. The objective of this study was to find herbicidal compounds from seven different plant essential oils such as amyris (Amyris balsamifera), cajuput (Melaleuca cajeputi), geranium (Pelargonium graveolens), lavender (Lavendula spp.), mandarin (Citrus reticulata), pine (Pinus spp.) and rosemary (Rosmarius officinale), and determine their herbicidal activities. The in vitro herbicidal activity of cajuput essential oil was the highest among six essential oils (GR50 value, 425 ug g-1) and major chemical component in cajuput essential oil were eucalyptol (37.2%), a-terpineol (11.6%), benzaldehyde (5.2%) linalool (4.1%), a-pinene (2.5%) and β-pinene (2.4%), and their GR50 value were 2,731, 500, 50, 372, 4,363, and 4,671 μg g-1, respectively. Soil application of cajuput essential oil and benzaldehyde did not show any herbicidal activity at 80㎏ ha-1. When cajuput essential oil was applied to foliar at 80㎏ ha-1. narrow-leaved plants such as sorghum (Sorghum bicolar), barnyardgrass (Echinochloa crus-galli), and southern crabgrass (Digitaria ciliaris) were killed 100%, however, broad-leaved plants indian jointvetch (Aeschynomeme indica), velvet leaf (Abutilon theophrasti), cocklebur (Xanthium strumarium), Japanese morningglory (Calystegia japonica) were not killed, indicating the cajuput essential oil was effective to control narrow-leaved plants. Herbicidal activities of benzaldehyde at 80 ㎏ ha-1, to those plants were 20, 60 and 95%, respectively. Overall data showed that the herbicidal activity of cajuput essential oil was in part due to benzaldehyde.