Priority-based Unequal Error Protection Scheme of Data partitioned H.264 video with Hierarchical QAM

( Chen Rui ),( Wu Minghu ),( Yang Jie ),( Rui Xiongli ) 한국인터넷정보학회 2014 KSII Transactions on Internet and Information Syst Vol.8 No.11

In this paper, we propose a priority-based unequal error protection scheme of data partitioned H.264/AVC video with hierarchical quadrature amplitude modulation. In order to map data with higher priority onto the most significant bits of QAM constellation points, a priority sorting method categorizes different data partitions according to the unequal importance factor of encoded video data in one group of pictures by evaluated the average distortion. Then we propose a hierarchical quadrature amplitude modulation arrangement with adaptive constellation distances, which takes into account the unequal importance of encoded video data and the channel status. Simulation results show that the proposed scheme improves the received video quality by about 2 dB in PSNR comparing with the state-of-the-art unequal error protection scheme, and outperforms EEP scheme by up to 5 dB when the average channel SNR is low.

Parecoxib: an Enhancer of Radiation Therapy for Colorectal Cancer

Xiong, Wei,Li, Wen-Hui,Jiang, Yong-Xin,Liu, Shan,Ai, Yi-Qin,Liu, Rong,Chang, Li,Zhang, Ming,Wang, Xiao-Li,Bai, Han,Wang, Hong,Zheng, Rui,Tan, Jing Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.2

Background: To study the effect of parecoxib, a novel cyclooxygenase-2 selective inhibitor, on the radiation response of colorectal cancer (CRC) cells and its underlying mechanisms. Materials and Methods: Both in vitro colony formation and apoptosis assays as well as in vivo mouse xenograft experiments were used to explore the radiosensitizing effects of parecoxib in human HCT116 and HT29 CRC cells. Results: Parecoxib sensitized CRC cells to radiation in vitro with a sensitivity enhancement ratio of 1.32 for HCT116 cells and 1.15 for HT29 cells at a surviving fraction of 0.37. This effect was partially attributable to enhanced apoptosis induction by parecoxib combined with radiation, as illustrated using an in vitro apoptosis assays. Parecoxib augmented the tumor response of HCT116 xenografts to radiation, achieving growth delay more than 20 days and an enhancement factor of 1.53. In accordance with the in vitro results, parecoxib combined with radiation resulted in less proliferation and more apoptosis in tumors than radiation alone. Radiation monotherapy decreased microvessel density (MVD) and microvessel intensity (MVI), but increased the hypoxia level in xenografts. Parecoxib did not affect MVD, but it increased MVI and attenuated hypoxia. Conclusions: Parecoxib can effectively enhance radiation sensitivity in CRC cells through direct effects on tumor cells and indirect effects on tumor vasculature.

A Reference-calibration Method for Tenderness Perception Using Psychophysical Models

Rui Xiong,이영승,Jean-François Meullenet 한국식품과학회 2010 Food Science and Biotechnology Vol.19 No.6

A main advantage of the reference-calibration method is the use of the standard references with the scale values to establish the relationship between sensory and instrumental data which is then used to predict sensory attributes of unknown samples. This study was conducted to predict tenderness perception using instrumental methods through a reference-calibrated model. Chicken breast fillets deboned at 9 different times were cooked and instrumentally tested by a compression test. The fillets were also evaluated by 7 trained panelists. Three different psychophysical models were employed to correlate reference scores with the peak forces and to predict tenderness. The results showed that the Stevens and Beidler models fitted well the peak forces to the reference scores. After calibration, the models were used to predict tenderness scores for all the fillets. This study implied that references could be used to calibrate not only panelists but also instruments for predicting tenderness perception.

Dimethyl Sulfoxide Suppresses Mouse 4T1 Breast Cancer Growth by Modulating Tumor-Associated Macrophage Differentiation

Rui Deng,Shi-min Wang,Tao Yin,Ting-hong Ye,Guo-bo Shen, Ling Li,Jing-yi Zhao,Ya-xiong Sang,Xiao-gang Duan,Yu-Quan Wei 한국유방암학회 2014 Journal of breast cancer Vol.17 No.1

Purpose: The universal organic solvent dimethyl sulfoxide (DMSO)can be used as a differentiation inducer of many cancer cells andhas been widely used as a solvent in laboratories. However, itseffects on breast cancer cells are not well understood. The aimof this study is to investigate the effect and associated mechanismsof DMSO on mouse breast cancer. Methods: We appliedDMSO to observe the effect on tumors in a mouse breast cancermodel. Tumor-associated macrophages (TAMs) were tested byflow cytometry. Ex vivo tumor microenvironment was imitated by4T1 cultured cell conditioned medium. Enzyme-linked immunosorbentassays were performed to detect interleukin (IL)-10 andIL-12 expression in medium. To investigate the cytotoxicity ofDMSO on TAMs, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide (MTT) assays were performed. Results: We foundthat DMSO produced tumor retardation when injected into mouseperitoneal cavities in a certain concentration range (0.5–1.0 mg/g). Furthermore, as detected by flow cytometry, TAM subtypeswere found to be transformed. We further imitated a tumor microenvironmentin vitro by using 4T1 cultured cell conditionedmedium. Similarly, by using low concentration DMSO (1.0%–2.0% v/v), TAMs were induced to polarize to the classically activatedmacrophage (M1-type) and inhibited from polarizing intothe alternatively activated macrophage (M2-type) in the conditionedmedium. IL-10 expression in tumors was reduced, whileIL-12 was increased compared with the control. Furthermore, wereported that 2.0% (v/v) DMSO could lead to cytotoxicity in peritonealmacrophages after 48 hours in MTT assays. Conclusion:Our findings suggest that DMSO could exert antitumor effects in4T1 cancer-bearing mice by reversing TAM orientation and polarizationfrom M2- to M1-type TAMs. These data may providenovel insight into studying breast cancer immunotherapy.

Single-cell RNA sequencing reveals B cell–related molecular biomarkers for Alzheimer’s disease

Xiong Liu-Lin,Xue Lu-Lu,Du Ruo-Lan,Niu Rui-Ze,Chen Li,Chen Jie,Hu Qiao,Tan Ya-Xin,Shang Hui-Fang,Liu Jia,Yu Chang-Yin,Wang Ting-Hua 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-

In recent years, biomarkers have been integrated into the diagnostic process and have become increasingly indispensable for obtaining knowledge of the neurodegenerative processes in Alzheimer’s disease (AD). Peripheral blood mononuclear cells (PBMCs) in human blood have been reported to participate in a variety of neurodegenerative activities. Here, a single-cell RNA sequencing analysis of PBMCs from 4 AD patients (2 in the early stage, 2 in the late stage) and 2 normal controls was performed to explore the differential cell subpopulations in PBMCs of AD patients. A significant decrease in B cells was detected in the blood of AD patients. Furthermore, we further examined PBMCs from 43 AD patients and 41 normal subjects by fluorescence activated cell sorting (FACS), and combined with correlation analysis, we found that the reduction in B cells was closely correlated with the patients’ Clinical Dementia Rating (CDR) scores. To confirm the role of B cells in AD progression, functional experiments were performed in early-stage AD mice in which fibrous plaques were beginning to appear; the results demonstrated that B cell depletion in the early stage of AD markedly accelerated and aggravated cognitive dysfunction and augmented the Aβ burden in AD mice. Importantly, the experiments revealed 18 genes that were specifically upregulated and 7 genes that were specifically downregulated in B cells as the disease progressed, and several of these genes exhibited close correlation with AD. These findings identified possible B cell-based AD severity, which are anticipated to be conducive to the clinical identification of AD progression.

Partial gasification of coal in a fluidized bed reactor: Comparison of a laboratory and pilot scale reactors

Rui Xiao,Laihong Shen,Mingyao Zhang,Baosheng Jin,Yuanquan Xiong,Yufeng Duan,Zhaoping Zhong,Xiaoping Chen,Yaji Huang,Hongcang Zhou 한국화학공학회 2007 Korean Journal of Chemical Engineering Vol.24 No.1

Predictive and Prognostic Roles of Ribonucleotide Reductase M1 in Patients with Pancreatic Cancer Treated with Gemcitabine: A Meta-analysis

Zhang, Xiong,Jin, Fen-Shu,Zhang, Li-Guo,Chen, Rui-Xue,Zhao, Jin-Hui,Wang, Yan-Nan,Wang, En-Fu,Jiang, Zhen-Dong Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.7

Increasing scientific evidence suggests that ribonucleotide reductase M1 (RRM1) may be a powerful predictor of survival in patients with pancreatic cancer treated with adjuvant gemcitabine-based chemotherapy after operative resection, but many existing studies have yielded inconclusive results. This meta-analysis aimed to assess the prognostic role of RRM1 in predicting survival in patients with pancreatic cancer treated with gemcitabine. An extensive literature search for relevant studies was conducted on PubMed, Embase, Web of Science, Cochrane Library, and CBM databases from their inception through May 1st, 2013. This meta-analysis was performed using the STATA 12.0 software and crude hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated. Eight clinical studies were included in this meta-analysis with a total of 665 pancreatic cancer patients treated with adjuvant gemcitabine-based chemotherapy, including 373 patients in the high RRM1 expression group and 292 patients in the low RRM1 expression group. Our meta-analysis revealed that high RRM1 expression was associated with improved overall survival (OS) of pancreatic cancer patients (HR=1.56, 95%CI=0.95-2.17, P<0.001). High RRM1 expression also was linked to longer disease-free survival (DFS) than low RRM1 expression (HR=1.37, 95%CI=0.25-2.48, P=0.016). In conclusion, our meta-analysis suggests that high RRM1 expression may be associated with improved OS and DFS of pancreatic cancer patients treated with adjuvant gemcitabine-based chemotherapy. Detection of RRM1 expression may be a promising biomarker for gemcitabine response and prognosis in pancreatic cancer patients.

Effect of Zanthoxylum alkylamides on glucose metabolism in streptozotocin‑induced diabetic Sprague–Dawley rats

Wang Rui,You Yu-ming,Liu Xiong 한국응용생명화학회 2021 Applied Biological Chemistry (Appl Biol Chem) Vol.64 No.1

This research aimed at investigating the hypoglycemic effect of Zanthoxylum alkylamides and whether TRPV1 receptor could participate in the glucose metabolism by using streptozotocin-induced diabetic rat model. The results showed that the blood glucose measured in the Zanthoxylum alkylamides treated group (ALK) showed significantly lower values than that in the model group (Model). Significant improvements in the oral glucose tolerance as well as plasma insulin and hepatic glycogen were also observed in the ALK group, when compared to the model group. However, the improving effects of Zanthoxylum alkylamides on glucose metabolism disorder in diabetic rats were markedly inhibited by capsazepine as the TRPV1 receptor antagonist. In addition, there were significant differences in the levels of mRNA and protein of phosphoenolpyruvate carboxylase (PEPCK), gucose-6-phosphatase (G6Pase), glucokinase (GK) and cannabinoid receptor l (CB1) in the livers of the ALK group compared to model group. Meanwhile, ALK group also exhibited a remarkable increase in the pancreatic-duodenal homeobox 1 (PDX-1), glucose transporter 2 (GLUT 2), GK levels and a significant decrease in the expression levels of CB1 in the pancreas, while the presence of capsazepine would affected the expression of these genes. These findings indicate that Zanthoxylum alkylamides could ameliorate the glucose metabolism disorder in diabetic rats. Furthermore, the TRPV1 receptor could participate in regulating the expressions of genes and proteins related to glucose metabolism and insulin secretion in the liver and pancreas, and takes a role in the hypoglycemic process of Zanthoxylum alkylamides.

2D-MELPP: A two dimensional matrix exponential based extension of locality preserving projections for dimensional reduction

Zixun Xiong,Minghua Wan,Rui Xue,Guowei Yang 한국인터넷정보학회 2022 KSII Transactions on Internet and Information Syst Vol.16 No.9

Two dimensional locality preserving projections (2D-LPP) is an improved algorithm of 2D image to solve the small sample size (SSS) problems which locality preserving projections (LPP) meets. It’s able to find the low dimension manifold mapping that not only preserves local information but also detects manifold embedded in original data spaces. However, 2D-LPP is simple and elegant. So, inspired by the comparison experiments between two dimensional linear discriminant analysis (2D-LDA) and linear discriminant analysis (LDA) which indicated that matrix based methods don’t always perform better even when training samples are limited, we surmise 2D-LPP may meet the same limitation as 2D-LDA and propose a novel matrix exponential method to enhance the performance of 2D-LPP. 2D-MELPP is equivalent to employing distance diffusion mapping to transform original images into a new space, and margins between labels are broadened, which is beneficial for solving classification problems. Nonetheless, the computational time complexity of 2D-MELPP is extremely high. In this paper, we replace some of matrix multiplications with multiple multiplications to save the memory cost and provide an efficient way for solving 2D-MELPP. We test it on public databases: random 3D data set, ORL, AR face database and Polyu Palmprint database and compare it with other 2D methods like 2D-LDA, 2D-LPP and 1D methods like LPP and exponential locality preserving projections (ELPP), finding it outperforms than others in recognition accuracy. We also compare different dimensions of projection vector and record the cost time on the ORL, AR face database and Polyu Palmprint database. The experiment results above proves that our advanced algorithm has a better performance on 3 independent public databases.

Research on Influencing Factors of Chinese Mobile Communication Customers’ Switching Intention by Mobile Number Portability

Miao Miao,Jia Jia,Rui Tingting,Xiong Fangping,Li haibo 보안공학연구지원센터 2016 International Journal of Future Generation Communi Vol.9 No.4

In order to explore the Influencing Factors of Switching Intention by Mobile Number Portability .We build up a structural equation model for Chinese mobile customers’ influence factors on MNP intention. Including competitive attraction, subjective norm, and policy perception, customer satisfaction, switching barriers, network quality, awareness rates, perceived service quality, usage habits and switching cost. According to empirical analysis, we find that customers with different perceive levels in MNP polices have significant differences in switching intention. And through the analysis and comparison, we find that the influence factors and the path coefficients of the customers’ switching intention are also different when they have different perceive levels in MNP policy.