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        • Potential Therapeutic Targets for the Primary Gallbladder Carcinoma: Estrogen Receptors

          Zhang,,Ling-Qiang,Zhang,,Xiu-De,Xu,,Jia,Wan,,Yong,Qu,,Kai,Zhang,,Jing-Yao,Wang,,Zhi-Xin,Wei,,Ji-Chao,Meng,,Fan-Di,Tai,,Ming-Hui,Zhou,,Lei,Liu,,Chang Asian Pacific Organization for Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.4

          Gallbladder carcinoma, the most frequent malignant neoplasm of the biliary tract system, has always been considered to feature late clinical presentation and diagnosis, limited treatment options and an extremely poor prognosis. In recent years, while the incidence of gallbladder cancer has appeared to be on the increase, the available treatment methods have not greatly improved survival of the affected patients. Thus, exploring new therapeutic targets for this devastating disease is an urgent matter at present. Epidemical studies have demonstrated that the incidence of gallbladder carcinoma exhibits a distinct gender bias, affecting females two to three times more than males, pointing to crucial roles of estrogen. It is well known that estrogen acts on target tissues by binding to estrogen receptors (ERs), which are mainly divided into three subtypes, $ER{\alpha}$, $ER{\beta}$ and $ER{\gamma}$. $ER{\alpha}$ and $ER{\beta}$ appear to have overlapping but also unique even opposite biological effects. As important pathogenic mediators, ERs have been considered to relate to several kinds of tumors. In gallbladder carcinoma tissue, ERs have been shown to be positively expressed, and ERs expression levels are associated with differentiation and prognosis of this cancer. Nevertheless, the exact mechanisms of estrogen inducing growth of gallbladder carcinoma remain poorly understood. On the base of the current investigations, we deduce that estrogen participates in promotion of gallbladder carcinoma by influencing the formation of gallstones, stimulating angiogenesis, and promoting abnormal proliferation. Since ERs mediate the carcinogenic actions of estrogen in gallbladder, and therapy targeting ERs may provide new directions for gallbladder carcinoma. Therefore, it should be stressed that ERs are potential therapeutic targets for gallbladder carcinoma.

        • SCIESCOPUSKCI등재

          Optimization of Submerged Fermentation Medium for Matrine Production by Aspergillus terreus, an Endophytic Fungus Harboring Seeds of Sophora flavescens, Using Response Surface Methodology

          Zhang,,Qiang,Li,,Yujuan,Xu,,Fangxue,Zheng,,Mengmeng,Xi,,Xiaozhi,Zhang,,Xuelan,Han,,Chunchao The Korean Society of Mycology 2017 Mycobiology Vol.45 No.2

          Different endophytes isolated from the seeds of Sophora flavescens were tested for their ability to produce matrine production. Response surface methodology (RSM) was applied to optimize the medium components for the endophytic fungus. Results indicated that endophyte Aspergillus terreus had the ability to produce matrine. The single factor tests demonstrated that potato starch was the best carbon source and the combination of peptone and $NH_4NO_3$ was the optimal nitrogen source for A. terreus. The model of RSM predicted to gain the maximal matrine production at $20.67{\mu}g/L$, when the potato starch was 160.68 g/L, peptone was 24.96 g/L and $NH_4NO_3$ was 2.11 g/L. When cultured in the optimal medium, the matrine yield was an average of $20.63{\pm}0.11{\mu}g/L$, which was consistent with the model prediction. This study offered an alternative source for the matrine production by endophytic fungus fermentation and may have far-reaching prospect and value.

        • KCI등재SCOPUS

          A Dynamic Modeling Approach to Simulate Groundwater Discharges into a Tunnel from Typical Heterogenous Geological Media During Continuing Excavation

          Qiang,Xia,Mo,Xu,Han,Zhang,Qiang,Zhang,Xian-xuan,Xiao 대한토목학회 2018 KSCE JOURNAL OF CIVIL ENGINEERING Vol.22 No.1

          Most of the analytical and numerical models of tunnel groundwater inflow ignore the excavation process, leading to inaccurate prediction of discharge rate. A dynamic modeling approach was introduced by redevelopment of MODFLOW to simulate the change of groundwater flow step by step in accord with tunnel excavation. The drilling tunnel was conceptualized as a changing boundary condition, which was modeled by dividing the drilling process into a series of successive steps. The impact of permeability heterogeneity on groundwater flow was studied through a comparison between a homogeneous hydraulic conductivity case and a synthetic heterogeneous one. It was found that the discharge rate at drilling front kept stable in the homogeneous case, resulting in a linear increase in the total discharge rate, similar to the analytical solution by Perrochet (2005). In contrast, the front and total discharge rate were influenced significantly by the variability of permeability in the heterogeneous case. The time-dependent discharge rate at a given place was subject to an exponential decay for both cases with the maximum inflow occuring at the beginning of excavation. The relationship between discharge rate and hydraulic properties was further investigated in a high-K zone. It revealed that maximum discharge rate was proportional to hydraulic conductivity (K) and specific storage (Ss). The decaying rate of discharge was time-dependent and also proportional to the value of K and Ss. The water budget analysis demonstrated that water released from storage of the high-K zone was the major source of tunnel discharge at early times.

        • Possible Epithelial Ovarian Cancer Association with HPV18 or HPV33 Infection

          Zhang,,Pei-Pei,Zhou,,Lei,Cao,,Jia-Shi,Li,,Yi-Ping,Zeng,,Zhi,Sun,,Ni,Shen,,Li,Zhu,,Hao-Yue,Ruan,,Yang,Zha,,Wen-Ting,Wang,,Xin-Yu,Zhang,,Ke-Qiang,Zhang,,Ran Asian Pacific Organization for Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.6

          The present study was conducted to investigate the prevalence of HPV infection in epithelial ovarian cancer (EOC) in Hunan province. DNA samples were collected from paraffin embedded ovarian tissue from 322 patients with EOC, 99 with ovarian benign tumors and 199 normal persons. The polymerase chain reaction and direct sequencing were used to identify the HPV types in the samples. The relationship between the infection of human papillomavirus (HPV) and the epithelial ovarian carcinoma (EOC) was investigated combined with clinical data. The prevalence of HPV18 and HPV33 in EOC group and benign group was higher than in the normal group. HPV18 and HPV33 may play a role in the development of both EOC and ovarian benign tumor and may participate in the development of EOC with traditional risk factors, family history and abortion, possibly exerting synergistic effects.

        • Design of Course-Keeping Controller for a Ship Based on Backstepping and Neural Networks

          Qiang,ZHANG,Na,JIANG,Yancai,HU,Dewei,PAN 국제이네비해양경제학회 2017 International Journal of e-Navigation and Maritime Vol.7 No.1

          Due to the existence of uncertainties and the unknown time variant environmental disturbances for ship course nonlinear control system, the ship course adaptive neural network robust course-keeping controller is designed by combining the backstepping technique. The neural networks (NNs) are employed for the compensating of the nonlinear term of the nonlinear ship course-keeping control system. The designed adaptive laws are designed to estimate the weights of NNs and the bounds of unknown environmental disturbances. The first order commander are introduced to solve the problem of repeating differential operations in the traditional backstepping design method, which let the designed controller easier to implement in navigation practice and structure simplicity. Theoretically, it indicates that the proposed controller can track the setting course in arbitrary expected accuracy, while keeping all control signals in the ship course control closed-loop system are uniformly ultimately bounded. Finally, the training ship of Dalian Maritime University is taken for example; simulation results illustrated the effectiveness and the robustness of the proposed controller.

        • KCI등재

          Power Cable Ampacity and Influential Factors Analysis under Operation

          ( Qiang Tong ), ( Jianping Qi ), ( Yanling Wang ), ( Likai Liang ), ( Xiangxing Meng ), ( Qiang Zhang ) 한국정보처리학회 2018 Journal of information processing systems Vol.14 No.5

          With the increasing of urban electricity demand, making the most use of the power cable carrying capacity has become an important task in power grid system. Contrary to the rated ampacity obtained under extremely conservative conditions, this paper presents the various steady value of cable ampacity by using the changing surrounding parameters under operation, which is based on cable ampacity calculation equation under the IEC-60287 standard. To some degree, the cable ampacity analysis of actual surroundings improves the transmission capacity of cables. This paper reveals the factors that influence cable ampacity such as insulating layer thickness, allowable long-term conductor temperature, the ambient temperature, soil thermal resistance coefficient, and so on, then gives the class of the influence of these parameters on the ampacity, which plays a great role in accurately calculating the real-time ampacity and improving the utilization rate of cable in the complex external environment condition. Furthermore, the transient thermal rating of the cable is analyzed in this paper, and temperature variation of the conductor under different overload conditions is discussed, which provides effective information for the operation and control of the system.

        • KCI등재SCOPUS

          Effects of Copper Oxide and Carbon Nanotubes on Thermal Stability of Silicone Rubber Nanocomposites

          Qiang,Zhang,Lu,Bai,Junping,Zheng 한국고분자학회 2016 폴리머 Vol.40 No.2

          Silicone rubber (SR) filled with carbon nanotubes (CNTs), copper oxide (CuO) and CuO modified CNTs (CuO-CNTs) were prepared to detect the effects of these additives on thermal stability of SR by thermogravimetric analysis and tensile testing before and after aging. Flynn-Wall-Ozawa method was also employed to analyze the thermal degradation kinetics. The results indicated that all the additives could increase the initial thermal degradation temperature and thermal oxidative aging properties of SR and a synergistic effect was found in CuO-CNTs/SR. Meanwhile, activation energies of SR filled with additives increased significantly relative to neat SR and found to be optimal for CuO-CNTs/SR with activation energy increasing to 231.29, 121.68 kJ·mol-1 larger than that of blank sample. It is because that CNTs and CuO could promote each other to capture the free radicals generated by thermal oxidative reaction of the methyl side groups and thereby terminate the process.

        • SCIESCOPUSKCI등재

          CORROSION BEHAVIOR OF NI-BASE ALLOYS IN SUPERCRITICAL WATER

          Zhang,,Qiang,Tang,,Rui,Li,,Cong,Luo,,Xin,Long,,Chongsheng,Yin,,Kaiju Korean Nuclear Society 2009 Nuclear Engineering and Technology Vol.41 No.1

          Corrosion of nickel-base alloys (Hastelloy C-276, Inconel 625, and Inconel X-750) in $500^{\circ}C$, 25MPa supercritical water (with 10 wppb oxygen) was investigated to evaluate the suitability of these alloys for use in supercritical water reactors. Oxide scales formed on the samples were characterized by gravimetry, scanning electron microscopy/energy dispersive spectroscopy, X-ray diffraction, and X-ray photoelectron spectroscopy. The results indicate that, during the 1000h exposure, a dense spinel oxide layer, mainly consisting of a fine Cr-rich inner layer ($NiCr_{2}O_{4}$) underneath a coarse Fe-rich outer layer ($NiFe_{2}O_{4}$), developed on each alloy. Besides general corrosion, nodular corrosion occurred on alloy 625 possibly resulting from local attack of ${\gamma}$" clusters in the matrix. The mass gains for all alloys were small, while alloy X -750 exhibited the highest oxidation rate, probably due to the absence of Mo.

        • KCI등재SCOPUS

          Facile Preparation of Mechanical Reinforced and Biocompatible Silk Gels

          Qiang,Zhang,Guocong,Han,Chen,Lu,Qiusheng,Wang,Xiufang,Li,Zuwei,Luo,Renchuan,You,Shuqin,Yan 한국섬유공학회 2019 Fibers and polymers Vol.20 No.4

          Nontoxic and controllable way to fabricate silk fibroin (SF) gel with high mechanical properties is of critical important to biomaterial in tissue engineering. Electrochemically triggered electrophoretic migration and electric charge of the silk molecules both contributed to SF microspheres and electronic gel (e-gel) formation by sol-gel transition. In this study, a novel silk pH e-gel with higher mechanical property was prepared by combining low-voltage electric fields with isoelectric point (pI) adjustment. This green process was mild and friendly without chemical crosslinker. Compressive modulus of the silk pH e-gel was up to 70 MPa that was significantly higher than that of SF gelation spontaneously. Furthermore, analysis of molecule conformation of the silk pH-e-gel demonstrated that most of random coil structures transformed into α-helix and a little β-sheet structures during this process. The silk pH e-gel was loaded with rhodamine B and showed an obvious sustainable release profile. Accumulation releasing amounts was approximately 60 % at day 9. Cytocompatibility of the silk pH-e-gel was evaluated by epithelial cell. The results showed that the gels could support the cell growth and proliferation in vitro. Finally, gel biodegradation was assessed by protease XIV. After biodegradation for 28 days, remaining weight of the gel was about 20.23±2.59 wt%, indicating its good biodegradability. This novel process was established successfully by combining low voltage field with pH-control, which provided an alternative material for regenerative medicine.

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