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New stilbenoid with inhibitory activity on viral neuraminidases from Erythrina addisoniae
( Phi Hung Nguyen ),( Min Kyun Na ),( Trong Tuan Dao ),( Derek Tantoh Ndinteh ),( Joseph Tanyi Mbafor ),( Jae Young Park ),( Hyeon Sook Cheong ),( Won Keun Oh ) 영남대학교 약품개발연구소 2011 영남대학교 약품개발연구소 연구업적집 Vol.21 No.-
Nguyen, Phi-Hung,Zhao, Bing-Tian,Ali, Md Yousof,Choi, Jae-Sue,Rhyu, Dong-Young,Min, Byung-Sun,Woo, Mi-Hee American Chemical Society and American Society of 2015 Journal of natural products Vol.78 No.1
<P>As part of an ongoing search for new antidiabetic agents from medicinal plants, three new (<B>2</B>, <B>4</B>, and <B>5</B>) and two known selaginellin derivatives (<B>1</B> and <B>3</B>) were isolated from a methanol extract of <I>Selaginella tamariscina</I>. The structures of the new compounds were determined by spectroscopic data analysis. All isolates showed strong glucose uptake stimulatory effects in 3T3-L1 adipocyte cells at a concentration of 5 μM. Furthermore, these compounds were found to possess inhibitory effects on PTP1B enzyme activity with IC<SUB>50</SUB> values ranging from 4.6 ± 0.1 to 21.6 ± 1.5 μM. Compound <B>2</B> showed the greatest potency, with an IC<SUB>50</SUB> value of 4.6 ± 0.1 μM, when compared with the positive control (ursolic acid, IC<SUB>50</SUB> = 3.5 ± 0.1 μM). Therefore, these selaginellin derivatives may have value as new lead compounds for the development of agents against type 2 diabetes.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jnprdf/2015/jnprdf.2015.78.issue-1/np5005856/production/images/medium/np-2014-005856_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/np5005856'>ACS Electronic Supporting Info</A></P>
NGUYEN, Phu Ha,NGUYEN, Phi-Hung,TSAI, Jung-Fa,NGUYEN, Thanh Tam,HO, Van Nguyen,DAO, Trong-Khoi Korea Distribution Science Association 2020 The Journal of Asian Finance, Economics and Busine Vol.7 No.12
In accordance with huge demand for capital to meet the expansion of steel production, there are more and more steel companies who have officially listed their stocks in HOSE and HNX. One of the key issues in successful initial public offerings and seasonal offerings for these companies is how to make stocks of steel companies become more attractive in the eyes of investors. The purpose of this research is to analyze the determinants of share prices of listed steel companies in Vietnam. This study utilized macro-economic variables, ratios and indicators representing characteristics of steel industry collected from Quarter 1/2006 to Quarter 4/2019 in association with the panel data and the feasible generalized least square (FGLS) model to evaluate the degree of these factors on the share prices. The results of the research show that ROE, Cons_rate, and CO2_rate are three main factors affecting the share prices of listed steel companies. Among which, ROE and Cons_rate have a positive effect, while CO2_rate has a negative effect on the share prices of listed steel companies. It also confirms the relationship between the environmental factor, construction industry factor and the stock prices. This lays foundations for recommendations for the future policies towards environmental protection and sustainable development.
Phi-Hung Nguyen,Bing Tian Zhao,이정형,김영호,민병선,우미희 대한화학회 2014 Bulletin of the Korean Chemical Society Vol.35 No.6
In the course of our program to search for antithrombotic and anti-inflammatory agents from plants, twelve phenolics (1–12) were isolated from the stems of Parthenocissus tricuspidata. Their structures were elucidated on the basis of spectroscopic (1D and 2D NMR, and MS) data analyses, and comparison with published data. At the concentration of 100 μg/mL, compounds 2, 4, 6 and 10 possessed potential effects on anti-blood coagulation, with inhibitory percentage of 216, 174, 148 and 225%, respectively; while aspirin used as positive control showed 181% inhibition at the same concentration. Furthermore, the anti-inflammatory activity of isolated compounds (1–12) was investigated on lipopolysaccharide (LPS)-induced murine macrophage cells (RAW264.7). Compounds 2, 4 and 6 also potential inhibited the production of nitric oxide, with IC50 values of 11.9 ± 0.3, 2.9 ± 0.2 and 29.0 ± 0.6 μM, respectively. Celastrol, the positive control used, gave an IC50 value of 1.0 ± 0.1 μM.
NGUYEN, Phi-Hung,TSAI, Jung-Fa,NGUYEN, Hong-Phuc,NGUYEN, Viet-Trang,DAO, Trong-Khoi Korea Distribution Science Association 2020 The Journal of Asian Finance, Economics and Busine Vol.7 No.12
The COVID 19 pandemic has led to a new global recession and is still causing a lot of issues because of the delays in the employment of people. This scenario has severe consequences for many countries' labor markets in the world. This problem's complexity and importance requires an integrated method of subjective and objective evaluation rather than intuitive decisions. This research aims to investigate sustainable indexes for assessing the unemployment problem by using a Multi-Criteria Decision-Making Model (MCDM). Grey theory and Decision Making Trial and Evaluation Laboratory (GDEMATEL) are deployed to transform the experts' opinions into quantitative data. The analysis based on 20 crucial criteria is employed to determine the weights of sustainability of unemployment problems. The results revealed that the top ten of determinants are Economic growth, Industrialization, Foreign direct investment, Real GDP per capita, Education level, Trade Openness, Capacity Utilization Rate, Urbanization, Employability skills, Education system expansion, which have the most significant effects on the unemployment rate under COVID 19 impacts. Furthermore, GDEMATEL could effectively assess the sustainable indicators for unemployment problems in "deep and wide" aspects. The study proposes the Grey MCDM model, contributes to the literature, provides future research directions, and helps policymakers and researchers achieve the best solutions to the unemployment problems under "economic shocks."
Nguyen, Phi-Hung,Dung, Vu Viet,Zhao, Bing Tian,Kim, Young Ho,Min, Byung Sun,Woo, Mi Hee Pharmaceutical Society of Korea 2014 Archives of Pharmacal Research Vol.37 No.11
<P>A phytochemical study of the grains of S. bicolor, resulting in the isolation of twelve flavonoid glycosides 1-12. Their chemical structures were elucidated on the basis of spectroscopic (1D and 2D NMR) and MS data analyses. All compounds were tested on thrombin time (TT) assay and α-glucosidase assay in order to assess their inhibitory effects on blood coagulation and α-glucosidase enzyme. At the concentration of 500 μg/mL, compounds 3, 4, 7 and 10 possessed the potential effects on blood coagulation with inhibitory percentage of 197, 152, 120 and 158 %, respectively, whereas aspirin, which used as a positive control, indicated 181 and 138 % inhibition at 500 and 375 μg/mL, respectively. Furthermore, compounds 3, 4, 7, 9 and 10 also displayed strong inhibitory effects on α-glucosidase enzyme, with 85.2, 55.7, 43.9, 52.7 and 65.2 % inhibition at 100 μg/mL, respectively, whereas acarbose, as a positive control, possessed only 38.7 % at the same concentration. Taken together, our data suggest that S. bicolor and its flavonoid-enrich extracts could be considered as supplemental and or functional foods having beneficial effects against blood coagulation-induced ischemia, possibly thromboembolism disease, as well as diabetes.</P>
Nguyen, Phi-Hung,Yang, Jun-Li,Uddin, Mohammad N.,Park, So-Lim,Lim, Seong-Il,Jung, Da-Woon,Williams, Darren R.,Oh, Won-Keun American Chemical Society and American Society of 2013 Journal of natural products Vol.76 No.11
<P>As part of our ongoing search for new antidiabetic agents from medicinal plants, we found that a methanol extract of <I>Morinda citrifolia</I> showed potential stimulatory effects on glucose uptake in 3T3-L1 adipocyte cells. Bioassay-guided fractionation of this active extract yielded two new lignans (<B>1</B> and <B>2</B>) and three new neolignans (<B>9</B>, <B>10</B>, and <B>14</B>), as well as 10 known compounds (<B>3</B>–<B>8</B>, <B>11</B>–<B>13</B>, and <B>15</B>). The absolute configurations of compounds <B>9</B>, <B>10</B>, and <B>14</B> were determined by ECD spectra analysis. Compounds <B>3</B>, <B>6</B>, <B>7</B>, and <B>15</B> showed inhibitory effects on PTP1B enzyme with IC<SUB>50</SUB> values of 21.86 ± 0.48, 15.01 ± 0.20, 16.82 ± 0.42, and 4.12 ± 0.09 μM, respectively. Furthermore, compounds <B>3</B>, <B>6</B>, <B>7</B>, and <B>15</B> showed strong stimulatory effects on 2-NBDG uptake in 3T3-L1 adipocyte cells. This study indicated the potential of compounds <B>3</B>, <B>6</B>, <B>7</B>, and <B>15</B> as lead molecules for antidiabetic agents.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jnprdf/2013/jnprdf.2013.76.issue-11/np400533h/production/images/medium/np-2013-00533h_0002.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/np400533h'>ACS Electronic Supporting Info</A></P>
Phi-Hung NGUYEN,Jung-Fa TSAI,Thanh-Tam NGUYEN,Thi-Giang NGUYEN,Dang-Duong VU 한국유통과학회 2020 The Journal of Asian Finance, Economics and Busine Vol.7 No.11
Real estate markets play an essential role in the economic development of both developed and developing countries. Investment decisions in private real estate demand the consideration of several qualitative and quantitative criteria. Especially in Vietnam, demand for housing, apartments are rising which has resulted because of the migration from rural to urban areas. This study aims to determine the influencing factors of the real estate purchasing behavior and then recommend a grey Multi-Criteria Decision Making (MCDM) support model to evaluate real estate alternatives based on a numerical example in Vietnam. A set of essential criteria are identified based on experts’ opinion, and the proposed determinants are initial investment, maintenance cost, prestige location, distance to interesting places, parking lot, public transportation, property condition, total area size, number of rooms, and neighbors. The subjective weights were obtained by using the Decision-Making Trial and Evaluation Laboratory (DEMATEL) model, and the Grey Relational Analysis (GRA) technique is employed to prioritize and rank real estate alternatives. The results reveal that this approach can be useful to make purchasing decisions for many kinds of real estate property under uncertain business environments. These findings indicate that the presented hybrid model has advantages in granting flexibility to the preferences of decision makers.
Nguyen, Phi-Hung,Zhao, Bing Tian,Lee, Jeong Hyung,Kim, Young Ho,Min, Byung Sun,Woo, Mi Hee Korean Chemical Society 2014 Bulletin of the Korean Chemical Society Vol.35 No.6
In the course of our program to search for antithrombotic and anti-inflammatory agents from plants, twelve phenolics (1-12) were isolated from the stems of Parthenocissus tricuspidata. Their structures were elucidated on the basis of spectroscopic (1D and 2D NMR, and MS) data analyses, and comparison with published data. At the concentration of $100{\mu}g/ml$, compounds 2, 4, 6 and 10 possessed potential effects on anti-blood coagulation, with inhibitory percentage of 216, 174, 148 and 225%, respectively; while aspirin used as positive control showed 181% inhibition at the same concentration. Furthermore, the anti-inflammatory activity of isolated compounds (1-12) was investigated on lipopolysaccharide (LPS)-induced murine macrophage cells (RAW264.7). Compounds 2, 4 and 6 also potential inhibited the production of nitric oxide, with $IC_{50}$ values of $11.9{\pm}0.3$, $2.9{\pm}0.2$ and $29.0{\pm}0.6{\mu}M$, respectively. Celastrol, the positive control used, gave an $IC_{50}$ value of $1.0{\pm}0.1{\mu}M$.
NGUYEN, Phi-Hung,TSAI, Jung-Fa,KUMAR G, Venkata Ajay,HU, Yi-Chung Korea Distribution Science Association 2020 The Journal of Asian Finance, Economics and Busine Vol.7 No.7
Multi-criteria stock selection is a critical issue for effective investment since the improper stock investment might cause many problems affecting investors negatively. Investors need a range of financial indicators while they are choosing the optimal set of stocks to invest. This study aims to rank the stock of agriculture companies indexed on the Vietnam Stock Exchange Market. The data of 13 agriculture companies during the 2016-2019 periods was analyzed by analytical hierarchy process (AHP) integrated with grey relational analysis (GRA), multi-objective optimization ratio analysis (MOORA), and technique for order performance by similarity to ideal solution (TOPSIS). The AHP method is employed to determine the weights of the proposed financial ratios, and GRA, TOPSIS, and MOORA approaches are used to obtain final ranking. The results indicated that HSL is the top stock with the highest rank and GRA, MOORA, and TOPSIS rankings have strong correlation values between 0.78-1. The findings suggest that the integrated model could be implemented effectively to specific analysis of industries such as oil and gas, textiles, food, and electronics in future research. Further, other techniques like COPRAS, KEMIRA, and EDAS could be employed to evaluate the financial performance of other companies to solve investment problems.