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Zhang Wentao,Zheng Zongtai,Wang Keyi,Mao Weipu,Li Xue,Wang Guangchun,Zhang Yuanyuan,Huang Jianhua,Zhang Ning,Wu Pengfei,Liu Ji,Zhang Haimin,Che Jianping,Peng Bo,Zheng Junhua,Li Wei,Yao Xudong 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Accumulating studies have confirmed that PIWI-interacting RNAs (piRNAs) are considered epigenetic effectors in cancer. We performed piRNA microarray expression analysis on renal cell carcinoma (RCC) tumor tissues and paired normal tissues and performed a series of in vivo and in vitro experiments to explore piRNAs associated with RCC progression and investigate their functional mechanisms. We found that piR-1742 was highly expressed in RCC tumors and that patients with high piR-1742 expression had a poor prognosis. Inhibition of piR-1742 significantly reduced tumor growth in RCC xenograft and organoid models. Mechanistically, piRNA-1742 regulates the stability of USP8 mRNA by binding directly to hnRNPU, which acts as a deubiquitinating enzyme that inhibits the ubiquitination of MUC12 and promotes the development of malignant RCC. Subsequently, nanotherapeutic systems loaded with piRNA-1742 inhibitors were found to effectively inhibit the metastasis and growth of RCC in vivo. Therefore, this study highlights the functional importance of piRNA-related ubiquitination in RCC and demonstrates the development of a related nanotherapeutic system, possibly contributing to the development of therapeutic approaches for RCC.
Terahertz Characteristics of Hydroxygraphene Based on Microfluidic Technology
Boyan Zhang,Siyu Qian,Bo Peng,Bo Su,Zhuang Peng,Hailin Cui,Shengbo Zhang,Cunlin Zhang 한국광학회 2023 Current Optics and Photonics Vol.7 No.4
Hydroxygraphene as a kind of functionalized graphene has important applications in composite, photoelectric and biological materials. In the present study, THz and microfluidic technologies were implemented to study the THz transmission characteristics of hydroxygraphene with different concentrations and residence times in magnetic and electric fields. The results show that the THz transmission intensity decreases with the increase in sample concentration and duration of an applied electric field, while it increases by staying longer in the magnetic field. The phenomenon is analyzed and explained in terms of hydrogen bond, conductivity and scattering characteristics. The results establish a foundation for future research on the THz absorption characteristics of liquid graphene based on microfluidic technology in different external environments. It also provides technical support for the application and development of graphene in THz devices.
Credibilitic Multiperiod Mean Semivariance Portfolio Selection with Transaction Costs
Peng Zhang,Bi-Yu Peng 대한산업공학회 2018 Industrial Engineeering & Management Systems Vol.17 No.3
This paper proposes a credibilitic multiperiod mean-simivariance portfolio selection model with transaction costs, borrowing constraints, threshold constraints and cardinality constraints. In this model, the return rate of asset and the risk are quantified by credibilitic expected value and credibilitic semivariance, respectively. Threshold constraints limit the amount of capital to be invested in each stock and prevent very small investments in any stock. Based on credibilitic theories, the model is transformed into a mix integer dynamic optimization problem with path dependence. The proposed model is approximated to dynamic programming model. A novel discrete iteration method is designed to obtain the optimal portfolio strategy, and is proved linearly convergent. Finally, an example is given to illustrate the behavior of the proposed model and the designed algorithm using real data from the Shanghai Stock Exchange.
Peng He,Shucai Li,Jie Xiao,Qian-qing Zhang,Fei Xu,Jian Zhang 대한토목학회 2018 KSCE JOURNAL OF CIVIL ENGINEERING Vol.22 No.5
Numerous studies on the instability and shear strength of expansive soil slopes have suggested that the fundamental reason forshallow sliding failures is insufficient shear strength caused by repeated dry-wet cycles under low stress. Therefore, this paper studiedthe effects of low stress and dry-wet cycles on the shear strength of expansive soil slopes. A nonlinear curve that can be well fittedusing generalized power functions was observed for the shear strength of expansive soil, and a numerical model with nonlinearlydistributed shear strength taken into consideration was built using FISH. In this way, the dynamic distribution of shear strength as afunction of vertical stress was obtained. Compared to conventional models, the proposed model was more accurate in terms oftheoretical aspects, and the obtained results exhibited improved consistency with the actual mode. In order to improve theapplicability of this model, a mapping model of atmospheric action and engineering design of safety factors of slopes was establishedusing a Gaussian Process Regression (GPR) model, which is suitable for cases characterized by high dimension, small samplepopulation, and nonlinearity. Herein, the numerical calculations were replaced with output responses. In this way, fast prediction ofthe stability of expansive soil slopes in terms of a shallow sliding failure prediction model was achieved. To verify the feasibility ofthe proposed approach, dynamic predictions of shallow sliding failures of expansive soil slopes were carried out for NanyouHighway under different rainfall conditions. Meanwhile, safety factor responses corresponding to different slope design schemeswere also obtained using the proposed model, providing reference for slope stability analysis in expansive soil zones.
Peng Zhang,Vincent, Abhilash,Kumar, Amit,Seal, Sudipta,Hyoung Jin Cho IEEE 2010 IEEE electron device letters Vol.31 No.7
<P>The hydrogen-sensing performance of a nanosensor integrating interdigitated electrodes with a gap of 100 nm and indium-oxide-doped tin dioxide nanoparticles is investigated at room temperature. The nonlinear behavior observed from the I/V curves of the sensor in air atmosphere indicated the presence of a Schottky barrier contact at the electrode/sensing-material interface. The linear I/V response obtained in hydrogen atmosphere suggested that the Schottky barrier height could be modulated in the presence of hydrogen. At a low applied voltage of 0.4 V and 0.09-vol% hydrogen gas exposure, a very large sensitivity of 2300 and a short response time of 127 s were recorded.</P>
Multiperiod Mean Absolute Deviation Uncertain Portfolio Selection
Zhang, Peng Korean Institute of Industrial Engineers 2016 Industrial Engineeering & Management Systems Vol.15 No.1
Multiperiod portfolio selection problem attracts more and more attentions because it is in accordance with the practical investment decision-making problem. However, the existing literature on this field is almost undertaken by regarding security returns as random variables in the framework of probability theory. Different from these works, we assume that security returns are uncertain variables which may be given by the experts, and take absolute deviation as a risk measure in the framework of uncertainty theory. In this paper, a new multiperiod mean absolute deviation uncertain portfolio selection models is presented by taking transaction costs, borrowing constraints and threshold constraints into account, which an optimal investment policy can be generated to help investors not only achieve an optimal return, but also have a good risk control. Threshold constraints limit the amount of capital to be invested in each stock and prevent very small investments in any stock. Based on uncertain theories, the model is converted to a dynamic optimization problem. Because of the transaction costs, the model is a dynamic optimization problem with path dependence. To solve the new model in general cases, the forward dynamic programming method is presented. In addition, a numerical example is also presented to illustrate the modeling idea and the effectiveness of the designed algorithm.
The Admissible Multiperiod Mean Variance Portfolio Selection Problem with Cardinality Constraints
Zhang, Peng,Li, Bing Korean Institute of Industrial Engineers 2017 Industrial Engineeering & Management Systems Vol.16 No.1
Uncertain factors in finical markets make the prediction of future returns and risk of asset much difficult. In this paper, a model,assuming the admissible errors on expected returns and risks of assets, assisted in the multiperiod mean variance portfolio selection problem is built. The model considers transaction costs, upper bound on borrowing risk-free asset constraints, cardinality constraints and threshold constraints. Cardinality constraints limit the number of assets to be held in an efficient portfolio. At the same time, threshold constraints limit the amount of capital to be invested in each stock and prevent very small investments in any stock. Because of these limitations, the proposed model is a mix integer dynamic optimization problem with path dependence. The forward dynamic programming method is designed to obtain the optimal portfolio strategy. Finally, to evaluate the model, our result of a meaning example is compared to the terminal wealth under different constraints.
Antibacterial Constituents from Fruit Bodies of Ascomyce Bulgaria inquinans
Peng Zhang,Xian Li,Ning Li,Jing Xu,Zhan-Lin Li,Yi Wang,Jin-Hui Wang 대한약학회 2005 Archives of Pharmacal Research Vol.28 No.8
Two ergosterins and two triterpenoids were isolated from the dried fruit bodies of Ascomyce Bulgaria inquinans. By means of chemical (hydrolysis) and spectroscopic methods (NMR, EIMS), their structures were established as betuinic acid (1), cerevisterol (2), (24R)ergosta-7, 22Ediene- 3β, 5α, 6β-triol-3-O-palmitate (3) and ursolic acid (4). Compound 3 is a new compound.