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진행성 전신경화증 환자에서 식도관련증상과 식도 운동성과의 상호관계
송인성(I S Song),최규완(K W Choi),김정룡(C Y Kim),정영화(Y H Chung),이풍렬(P L Rhee),정현채(H C Jung),송영욱(Y W Song),이효석(H S Lee),윤용범(Y B Yoon) 대한소화기학회 1988 대한소화기학회지 Vol.20 No.3
N/A To investigate the correlation of esophageal symptoms w ith esophageal manometric parameters in patients with progressive systemic sclerosis (PSS) we tested esophageal motility in 10 patients with PSS who were admitted to Seoul National University Hospital from Feb. 1988 to Aug. 1988 and in 5 normal subjects, and we analyzed every parameters. The results were as follows: 1) 4 patients with esophageal symptoms showed marked decrease of lower esophageal sphincter pressure (LESP) (9.I+4.4 mmHg vs 27.9+8.5 mmHg; p< 0.005) while 6 patients having no esophageal symptoms showed normal LESP (29.4+4.0 mmHg vs 27.9+8.5 mmHg). 2) Normally propagating peristaltic waves were not found in the lower esophageal bodies of 4 patients who had esophagea] symptoms. On the other hand, among 6 patients without symptoms, 3 patients showed no propagating peristaltic waves while the other 3 patients showed normally propagating peristaltic waves in the lower esophagus. 3) The amplitudes of contraction waves at upper esophageal body of patients with esophageal symptoms were decreased compared with those of patients who had no esophageal symptom. (29.0+6.1 mmHg vs 21.0+4.4 mmHg; p<0.05) 4) In cases not showing normally propagating peristaltic waves, nonpropagating, hroad-based, low-amplitude contractions were found at the lower esophageal body. In conclusion, LESP is the esophageal manornetric parameter vhich seemed to be the most closely correlated with esophagea) symptoms in patients with PSS. And PSS seems to influence the upper esophageal contraction. Our data also indicates that esophageal manometry may be useful in the early detection of esophageal involvement in patients with PSS.
Spectral tomographic analysis of Bremsstrahlung X-rays generated in a laser-produced plasma
Rhee, Y.J.,Nam, S.M.,Peebles, J.,Sawada, H.,Wei, M.,Vaisseau, X.,Sasaki, T.,Giuffrida, L.,Hulin, S.,Vauzour, B.,Santos, J.J.,Batani, D.,McLean, H.S.,Patel, P.K.,Li, Y.T.,Yuan, D.W.,Zhang, K.,Zhong, J. Cambridge University Press 2016 Laser and particle beams Vol.34 No.4
<B>Abstract</B><P>A new approach is proposed to analyze Bremsstrahlung X-rays that are emitted from laser-produced plasmas (LPP) and are measured by a stack type spectrometer. This new method is based on a spectral tomographic reconstruction concept with the variational principle for optimization, without referring to the electron energy distribution of a plasma. This approach is applied to the analysis of some experimental data obtained at a few major laser facilities to demonstrate the applicability of the method. Slope temperatures of X-rays from LPP are determined with a two-temperature model, showing different spectral characteristics of X-rays depending on laser properties used in the experiments.</P>
Do Opioid Receptors Play a Role in Blood Pressure Regulation?
Rhee, H.M.,Holaday, J.W.,Long, J.B.,Gaumann, M.D.,Yaksh, T.L.,Tyce, G.M.,Dixon, W.R.,Chang, A.P.,Mastrianni, J.A.,Mosqueda-Garcia, R.,Kunos, G. The Korean Society of Pharmacology 1988 대한약리학잡지 Vol.24 No.2
The potential role of endogenous opioid peptides (EOPS) in cardiovascular regulation has only recently been entertained. EOPS have been localized in brain, spinal cord, autonomic ganglia, particularly the adrenal gland, and many other peripheral tissues. There are at least five major types of opioid receptors; namely ${\mu},\;{\delta},\;k,\;{\sigma},\;and\;{\varepsilon}$ and Experimental evidence indicates that cardiovascular actions of the peptide are mediated primarily by ${\mu},\;{\delta}$ and k receptors, and that these receptor types may be allosterically coupled. In anesthetized rabbits met-enkephalin decreased blood pressure and heart rate, which closely paralleled a reduction in sympathetic discharge. Naloxone, but not naloxone methobromide, antagonized these effects, which suggests a central site of action of met-enkephalin. A number of autonomic agents, particularly adrenergic ${\alpha}$-and, ${\beta}-agonists$ and antagonists modify the cardiovascular actions of met-enkephalin. Experiments in reserpine-treated and adrenalectomized rats provide no evidence of sympathetic nervous system involvement in the pressor responses to intravenous injection of opioid peptides, but rather suggest a direct peripheral action. Finally, activation of a beta-endorphinergic pathway projecting from the arcuate nucleus to the nucleus tractos solitarii in rats can cause naloxone reversible hypotension and bradycardia. There is evidence to implicate this pathway in antihypertensive drug action and in the modulation of baroreflex activity.
Pyrrolic molecular rotors acting as viscosity sensors with high fluorescence contrast
Lee, S. C.,Heo, J.,Ryu, J. W.,Lee, C. L.,Kim, S.,Tae, J. S.,Rhee, B. O.,Kim, S. W.,Kwon, O. P. Royal Society of Chemistry 2016 Chemical communications Vol.52 No.94
<P>New pyrrolic viscosity sensors exhibit one order of magnitude higher fluorescence contrast compared to that of the conventional phenolic analogues due to the viscosity-sensitive rotation of the asymmetric pyrrole group and successfully demonstrate mapping of intracellular viscosity by fluorescence lifetime imaging microscopy.</P>
Rhee, Y. H.,Jang, J·H,Rogers, P. L. 충남대학교 생물공학연구소 1993 생물공학연구지 Vol.3 No.-
Production of copoiymer consisting of 3-hydroxybutyrate and 3-hydroxyvalerate [poly(3HB-co-3HV)] by fed-batch culture of Alcaligenes sp. SH-69 was investigated using glucose as a sole carbon sourece. Synthesis of poly(3HB-co-3HV) during the polymer accumulation stage was favored under dissolved oxygen tension at 20% and C/N ratio (mol glucose/mol ammonium) of 23.1. When conditions were optimal, 36 g liter ^-1 of poly(3HB-co-3HV) containing 3.0mol% of 3HV was produced. Decreasing C/N ratio resulted in an increase of 3HV fraction in the copolymer to a maximum level of 6.3 mol%.
Unraveling the Biological Roles of Reactive Oxygen Species
Murphy, Michael P.,Holmgren, A.,Larsson, N.G.,Halliwell, B.,Chang, Christopher J.,Kalyanaraman, B.,Rhee, S.,Thornalley, Paul J.,Partridge, L.,Gems, D.,Nystrom, T.,Belousov, V.,Schumacker, Paul T.,Wint Cell Press 2011 Cell metabolism Vol.13 No.4
Reactive oxygen species are not only harmful agents that cause oxidative damage in pathologies, they also have important roles as regulatory agents in a range of biological phenomena. The relatively recent development of this more nuanced view presents a challenge to the biomedical research community on how best to assess the significance of reactive oxygen species and oxidative damage in biological systems. Considerable progress is being made in addressing these issues, and here we survey some recent developments for those contemplating research in this area.
( J. H. Park ),( P. L. Rhee ),( J. H. Lee ),( Y. H. Kim ),( J. J. Kim ),( S. W. Paik ),( J. C. Rhee ) 대한소화관운동학회 2005 대한소화관운동학회 춘계학술대회 Vol.16 No.-
<Background> Some IBS patients have more diarrhea than constipation. However the physiological mechanism responsible for diarrhea is not clear. In this study, we have attempted to ascertain putative alterations in the secretory responses of colonic epithe