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노진혁,이병진,조옥자,박시룡 대한피부과학회 2003 大韓皮膚科學會誌 Vol.41 No.7
Angiosarcoma is a rare malignant tumor of endothelial cell origin. Histopathologically, varied differentiation may be observed even within the same tumor. Epithelioid angiosarcoma is one subset of poorly differentiated angiosarcoma which is a rare variant. We report a case of epithelioid angiosarcoma of the scalp in a 59-year-old man. The patient had a painful solitary, 2×3 cm sized, dome-shaped, firm, erythematous to purplish nodule with crust on the vertex of the scalp. Histopathologically, the tumor was chiefly composed of solid sheets of atypical epithelioid cells with prominent eosinophilic cytoplasm, a large vesicular nuclei, and occasional intracytoplasmic vacuoles. Well to moderately differentiated areas with irregular vascular channel-like structures lined by atypical hyperchromatic endothelial cells were also seen in the peripheral areas of the tumor. Immunohistochemically, the tumor cells were positive with CD31 which is sensitive marker of endothelial cell. (Korean J Dermatol 2003;41(7) : 971~973)
태아 피부의 발육과정에서 저분자량 케라틴(K8/18)의 발현
고유수 ( Yoo Soo Ko ),조옥자 ( Ok Ja Joh ),이재승 ( Jai Seung Lee ),송계용 ( Kye Yong Song ) 대한피부과학회 2007 대한피부과학회지 Vol.45 No.10
Background: The epidermis and adnexal epithelium might express different types of keratin (K) during fetal development. Objective: The objective is to observe the distribution of K8/18 in the skin of fetuses and to find out the distinction of expressions of K8/18 during fetal development. Methods: Immunohistochemical analysis was applied to the skin of the scalp and sole of 42 fetuses ranging from 10 to 39 weeks of gestation. Immunohistochemical staining with monoclonal antibodies with CAM5.2 using LSAB kit against K8/18 was conducted. Results: In the skin of the scalp, K8/18 was expressed in the periderm and basal layer of epidermis from the 10th week to the 31st week of fetal gestation. K8/18 was expressed in the hair germ, bulge and basal cells of fetal the infundibulum and sebaceous glands. Root sheath cells were weakly positive but matrix cells were negative. The expression of K8/18 was negative in the basal layer of the sole. Merkel cells, which are located in the basal layer and upper dermis, were positive from the 12th week of gestation. Terminal eccrine ducts and acinar cells were positive after the 20th week of gestation. Conclusion: K8/18 in the skin of the scalp and sole of fetuses were expressed in different ways. The expression of K8/18 in the basal cells of the sole were negative while basal cells of the epidermis of the scalp were positive transiently from the 12th to the 31st week of gestation. Early hair germ cells and bulge cells were expressed strongly in hair follicles. Terminal eccrine ducts and acini were expressed strongly in the eccrine gland. Merkel cells located in the basal layer and papillary dermis also express K8/18. (Korean J Dermatol 2007;45(10):1013∼1019)
이나영,이병진,조옥자,박시룡 대한피부과학회 2003 大韓皮膚科學會誌 Vol.41 No.4
Mastocytosis is a heterogenous group of disorders characterized by abnormal growth and accumulation of mast cells in one or more organ systems. Urticaria pigmentosa represents the most common form of cutaneous rnastocytosis in children and adults. We report a case of adult-onset urticaria pigmentosa in a 53-year-old man. The patient had pruritic multiple scattered well-demarcated brownish macules and papules on whole body for 4 years. Histopathologic examination showed diffuse and perivascular infiltration of Iymphocytes and cuboidal mast cells in the upper dermis. Any sign or symptom of systemic involvement was not detected. (Korean J Dermatol 2003;41(4) : 509~512)
이나영,노진혁,조옥자,박시룡,송계용 대한피부과학회 2003 大韓皮膚科學會誌 Vol.41 No.7
Trichoblastoma is a benign cutaneous neoplasm that consists of follicular germinative cells. We report a case cf trichoblastoma in a 58-year-old man. The tumor was presented as a solitary symmetrical shaped pedunculated 5.0×4.0×2.0cm sized multilobular tumor on right lower leg for 2 years. Histopathologic examination showed well circumscribed dermal tumor composed of multilobular tumor islands of palisaded basaloid epithelial cells. The tumoral lobules were concentrically surrounded by hyalinized collagen bundles with fibroblasts. The overall architecture was reminiscent of hair bulbs. Cytokeratin 14 stain showed positive reaction, but cytokeratin 10 stain showed negative reaction. The tumor was completely excised with clear margin. No sign of recurrence has been noted until 9 months later. (Korean J Dermatol 2003;41(7) : 968~970)
최희봉 ( Hee Bong Choi ),조옥자 ( Ok Ja Joh ),박시룡 ( See Ryoug Park ),김낙인 ( Nack In Kim ) 대한피부과학회 2006 대한피부과학회지 Vol.44 No.9
Background: Bowen`s disease, also known as squamous intraepidermal carcinoma, is a pre-malignant skin tumor with a potential to progress to an invasive carcinoma. Objective: The purpose of this study was to investigate the clinical and histopathological characteristics of Bowen`s disease. Methods: A total of 45 patients with Bowen`s disease were enrolled in this study. The hospital charts and histopathological slides from 1994 to 2005 were reviewed retrospectively at Seoul Veterans Hospital. Results: There were thirty-seven cases (82%) of single lesions and eight cases (18%) of multiple lesions. Thirty cases (81%) of solitary Bowen`s disease were located in non sun-exposed areas. These included the trunk, extremities and genital area in decreasing order. Seven cases (19%) of solitary Bowen`s disease occurred on sun-exposed areas including the face and the dorsum of the hand in decreasing order. Analysis of the clinical character of Bowen`s disease was performed and results were as follows: the most common type was patch (20 cases; 44%), plaque (14 cases; 31%) and pigmented lesions (12 cases: 27%). Analysis of the histopathological character of Bowen`s disease was performed and results were as follows: the most common type was irregular (18 cases; 46%), psoriasiform (11 cases; 28%) and verrucous, atrophic type in decreasing order. Of 18 cases where surgical removal was performed, there were 2 case (11%) of recurrence. Of 16 cases where cryotherapy treatment was administered, there were 3 cases of recurrence. And of 4 cases where CO2 laser therapy was used, there was 1 case (25%) of recurrence, in 2 cases where multiple or large-sized lesions were observed, clinical recovery processes were monitored after applying isotretinoin and 5-FU combined therapy, as well as surgical removal and cryotherapy combined therapy. Conclusion: In Bowen`s disease among Koreans, there were many distinctive clinical and histopathological features compared to those of non-Korean cases. (Korean J Dermatol 2006;44(9):1058~1064)
Surgical Treatment of Lip Hypertrophy Secondary to Port-wine Stain
( Hyun Chul Shim ),( Mihn Sook Jue ),( Eun Jung Kim ),( Ok Ja Joh ),( Hyang Joon Park ) 대한피부과학회 2013 大韓皮膚科學會誌 Vol.51 No.1
Background: Port-wine stain (PWS) is a congenital capillary malformations characterized by ectasia of capillaries and venules. These vascular channels progress gradually to hyperplasia of soft and hard tissues, manifested as hypertrophy of involved structures. Especially, when these lesions involve the lip, macrocheilia may develop with time. Usually vascular-specific laser treatment is used for PWS, however with no favorable effect with soft-tissue hypertrophy. Therefore, surgical treatment may be necessary in such cases. Objective: The subjects were 9 patients who had PWS with lip hypertrophy, who were aged from 9 to 65 years. Methods: The patients underwent cheiloplasty which include making an incision horizontally on a labial mucosa of the lip, and dissection of hypertrophied soft tissue in the front and back of the orbicularis oris muscle. Results: Of the 9 patients, only 2 had postoperative complication such as mild chewing of the labial mucosa. After a minor revision surgery, these symptoms disappeared. Good to excellent results were achieved in all patients during the final postoperative cosmetic evaluation. Conclusion: Surgical correction is appropriate for treatment of three-dimensional tissue deformity such as lip hypertrophy with good cosmetic results and minimal complications. (Korean J Dermatol 2013;51(1):28∼31)