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Kim, Tae Min,Park, Yeon Hee,Lee, Sang-Yoon,Kim, Ji-Hoon,Kim, Dong-Wan,Im, Seock-Ah,Kim, Tae-You,Kim, Chul Woo,Heo, Dae Seog,Bang, Yung-Jue,Chang, Kee-Hyun,Kim, Noe Kyeong American Society of Hematology 2005 Blood Vol.106 No.12
<P>This study was launched to determine the prognostic significance of local tumor invasiveness (LTI) in 114 patients diagnosed with stage IE/IIE extranodal natural killer (NK)/T-cell lymphoma, nasal type (NTCL). LTI was defined as bony invasion or destruction or tumor invasion of the skin. Complete remission (CR), overall survival (OS), and disease-free survival (DFS) were compared between each group according to LTI, Ann Arbor stage, and International Prognostic Index (IPI). LTI was observed in 23 patients. Using multivariate analysis, factors associated with low probability of CR were the presence of LTI (P < .001), the presence of B symptoms (P = .003), and single-modality chemotherapy (P = .045). The presence of LTI (relative risk [RR] = 8.4, 95% confidence interval [CI] 3.9-17.9; P < .001) and high IPI score (RR = 2.8, 95% CI 1.2-6.8; P = .019) were also predictive of OS. The presence of LTI (RR = 7.3, 95% CI 3.2-16.5; P < .001) was an independently significant factor for reduced DFS. Ann Arbor staging system did not predict CR, OS, or DFS but IPI did have predictive power with regard to survival outcome. LTI is the most important prognostic factor in predicting low probability of CR and reduced OS and DFS in nasal stage IE/IIE NTCL.</P>
Kim, Dae-Young,Lee, Keun-Wook,Yun, Tak,Kim, Dong-Wan,Kim, Tae-You,Heo, Dae Seog,Bang, Yung-Jue,Kim, Noe Kyeong National Hellenic Research Foundation 2005 Oncology reports Vol.14 No.1
<P>This study was conducted to assess the efficacy of systemic chemotherapy in patients with brain metastasis from non-small cell lung cancer. Sixty-three consecutive patients who were diagnosed as having non-small cell lung cancer (NSCLC) with synchronous brain metastasis (BM) and had not been previously treated were included in this study. After cranial radiation therapy (RT), all patients in 'the chemotherapy arm' (CTX) were treated with platinum-based combination chemotherapy, and best supportive care was selected for patients in 'the no-chemotherapy arm' (no-CTX). Thirty-one of the 63 patients received systemic chemotherapy. The median age of all patients was 55 years. The performance status of all patients was ECOG grade 1-2. Twenty-two patients had a solitary brain metastasis, 37 patients had more than two masses, and 38 patients had extracranial metastatic lesions. In the CTX arm, a paclitaxel-based combination chemotherapy was administered in 38.7%, gemcitabine-based in 25.8%, and vinorelbine-based in 25.8% as the first-line chemotherapy. Seventeen patients were treated with a second-line chemotherapy, and paclitaxel plus gemcitabine was used in 8 patients. For the first-line and second-line chemotherapies, extracranial overall responses were 36 and 35%, the median response durations were 29.1 weeks (range: 9.1-58.1 weeks) and 30.4 weeks (range: 19.4-44.0 weeks), respectively. 'Progression of the extracranial lesion' (58.1%) was more frequent than an 'aggravation of neurologic status' (19.4%) for the pattern of treatment failure in the first-line chemotherapy. The causes of failure were identical in the second-line chemotherapy. The median survival of the CTX arm was longer than that of the no-CTX arm (58.1 vs. 19.0 weeks, p<0.001). Toxicity in the CTX arm was tolerable. The systemic chemotherapy showed an effectiveness to increase the survival of patients with BM from NSCLC, and extracranial progression was the main cause of chemotherapeutic failure, although consideration for non-randomized methods should be made in this study.</P>
간 및 자궁에 전이된 췌장의 Somatostatinoma
김태유,박영이,임영혁,허대석,방영주,김노경,김선희,김철우 대한내과학회 1993 대한내과학회지 Vol.44 No.5
저자등은 췌장 부위의 종양과 간과 자궁으로의 전이가 있으면서, 일반적인 췌담관계의 악성 종양과는 다른 임상경과를 갖고, 면역 화학적 조직 검사와 혈장 somatostatin의 측정으로 입증된 somatostatinoma 1예를 경험하여 보고하는 바이다. Somatostatinoma, a rare endocrine tumor, is characterized by diarrhea, steatorrhea, diagetes, and cholelithiasis due to excessive production of somatostatin. We report a case of a 32-year-old woman with pancreatic somatostatinoma that methastasized to the liver and uterus. The patient first presented with jaundice and diarrhea, and subsequently ascites and vaginal bleeding. The diagnosis was made by the pathologic examination, immunohistochemistry, and elevated plasma level of somatostatin. The patient was transiently improved with recombinant γ-interferon therapy.
반월형 사구체신염이 병발된 T 림프구 기원의 원발성 간림프종 1 예
김용일,정철원,이현순,김홍빈,박동영,이효석,김성권,소영,김노경,김병관,김선미,이기형,허대석 대한내과학회 1997 대한내과학회지 Vol.53 No.1
The primary lymphoma of the liver is a rare disease. We report a case of primary hepatic T-cell lymphoma associated with crescentic glomerulonephritis. The case, a 53-year-old male was presented with a 2-year history of hepatic mass and a 1-month history of foamy urine, rapidly progressive azotemia, and oliguria. The kidney biopsy revealed diffuse crescentic glomerulonephritis. The result of immunohistochemical study of liver biopsy specimen was consistent with non-Hodgkin's lymphoma in T-cell lineage. Because renal function was deteriorated rapidly and there were signs of volume overload, hemodialyses were performed. Although the patient received 2 cycles of combination chemotherapy with CHOP(cyclophosphamide, vincristine, prednisolone, and doxorubicin), he did not respond and died of sepsis.
김동완,송인성,김철우,김노경,방영주,방수미,임석아,김학균,류민희,허대석 대한소화기학회 1998 대한소화기학회지 Vol.32 No.1
Immunoproliferative small intestinal disease (IPSID) is constituted with a-heavy chain disease (α-HCD) and Mediterranean lymphoma. In contrast to western type of small intestinal lymphoma, the Mediterranean lymphoma is characterized by symptoms such as diarrhea, weight loss, malabsorption, and involvement of the distal duodenum and the upper jejunum. We present a case of the Mediterranean lymphoma. A male patient complained of diarrhea, fever, night sweats and weight loss for a year. An exploratory laparatomy revealed the small intestine to be diffusely thickened with malignant infiltration and to be perforated at one site. Jejunal resection was performed. On histologic examination, we confirmed it as malignant lymphoma of B-cell linage. This is the first case report of the Mediterranean lymphoma in Korea.