Growth Inhibition of Colon Cancer through Inactivation of STAT3 Pathway by IL-10 and IL-1ra Released from Murine Macrophage

Jin Tae Hong, Dohee Won1, Mi Hee Park, Sun Mi Kown, Miran Jo, Sang-Yoon Nam, Beom Jun Lee, Young Won Yun, Ki-Wan Oh, Sang Bae Han 충북대학교 동물의학연구소 2011 Journal of Biomedical and Translational Research Vol.12 No.4

The objective of this study was to determine the effect of macrophages on growth of human colon cancer cells. The results showed that co-culture of colon cancer cells with macrophages inhibited the growth of colon cancer cells (HCT116 and SW620) depending on the number of macrophages, RAW 264.7 cells, and activated THP-1 cells accompanied by down regulation of pSTAT3 in cancer cells. We also found that expression and release of cancer cell growth inhibitory cytokines, IL-1 receptor antagonist (IL-1ra) and IL-10, was increased in macrophages. Blocking of the STAT3 pathway with specific inhibitor and siRNA of STAT3 abolished the growth of colon cancer cells and expression of IL-1ra and IL-10. In addition, neutralization of IL-1ra and IL-10 with antibodies resulted in reversal of macrophage-induced inhibition of cancer cell growth. These data showed that IL-1ra and IL-10 released from macrophages inhibit growth of colon cancer cells through inhibition of the STAT3 pathway

MWPC 위치검출기의 X-선 천체물리학에의 응용

남욱원,최철성,문신행,강희동 경북대학교 센서기술연구소 1990 센서技術學術大會論文集 Vol.1 No.1

1983 년경 국내에서도 과학탐사 로케트와 인공위성이 발사될 예정에 있으며 이에 따라 X-선 천체물리학을 위한 방사선 센서의 국내 개발이 시급히 요청되는 바이다. 따라서 현재 방사선계측에 많이 이용되고 있는 방사선 센서들 중 국내에서 개발되어온 MWPC위치검출기를 소개하고 인공위성 혹은 과학탐사로케트에 탑재되어 X-선 천체물리학연구에 이용될 경우 연구 개발되어 나가야 할 방향을 제시하고자 한다. Domestic sounding rocket and scientific satellite are scheduled to launch around 1993. The development of radiation sensor is required to observe X-rays coming from celestial bodies by the use of those space vehicleS. In this study we introduce the multi-wire position sensitive detector and the future works of onboard detector for X-ray astrophysics.

원발성 중추신경계 임파종 : 치료 및 생존율 Treatment and Survival Rate

남도현,이상형,김동규,정희원,지제근,왕규창,김현집,최길수,한대희 대한신경외과학회 1993 Journal of Korean neurosurgical society Vol.22 No.3

The authors report on 17 patients having primary central nervous system(CNS) lymphomas between January, 1981 and August, 1992. All patients were treated at Seoul National University Hospital. Only three cases underwent surgery only and fourteen cases underwent surgery and radiation therapy with or without chemotherapy. There were no immunosuppressive patients. Sixteen patients were analyzed for survival studies, because one case was lost during follow-up. The median survival time(MST) was 26 months and one- and two-year survival rates for the 16 patients were 87.5% and 65.6% respectively. The rate of survival was analyzed according to possible prognostic factors ; age and sex, multiplicity and location of tumors, preoperative Karnofsky performance score(KPS), pathological subclassification, type of surgery, preoperative steroid therapy, postoperative adjuvant therapy, extent of radiation, chemotherapy and the degree of response to treatment at three months follow-up. Postoperative adjuvant therapy and the degree of response to the treatment correlated with survival. Fourteen patients who underwent postoperative adjuvant therapy had a median survival time of 63 months. The one- and two-year survival rates were 100% and 75% respectively compared to the MST of 1.5 months with survival rates of 0% and 0% retrospectively for the two patients who did not. A higher long term survival rate was observed in the group with better immediate responses. In nine of 16 patients with complete responses, the MST, one-, and two-year survival rates were 63 months, 100%, and 83% respectively. The authors suggest that preoperative application of steroids may be considered in case of clinically suspected primary CNS lymphomas. It is concluded that after obtaining the tissue diagnosis of primary CNS lymphomas, radiotherapy with or without chemotherapy should be performed until the complete response.

^(131)I 전신스캔 음성 재발 분화 갑상선암에서 EDG PET의 임상적 의의 : ^(99m)Tc-MIBi Scintigraphy와 비교분석

원종철,이성진,이태윤,남궁일성,이시열,김하영,한정희,류진숙,문대혁,안일민 대한내분비학회 2001 Endocrinology and metabolism Vol.16 No.4-5

人體 胃癌 및 胃炎에서의 CEA의 表現에 對한 免疫酵素 組織學的 硏究

元南熙,李大一,白承龍 고려대학교 의과대학 1982 고려대 의대 잡지 Vol.19 No.3

Carcinoembryonic antigen (CEA) isolated from adenocarcinomata of human digestive system and fetal or embryonic gut tissue is one of tumor associated antigens. In recent years, extensive studies to detect CEA in the blood as well as in the tissue of various conditions have been reported. However, characterization of CEA in the tissue of stomach cancer, common malignant tumor in Korea, has rarely been investigated. The author performed peroxidase-antiperoxidase immunohistologic study with anti-CEA antibody to determine the presence of CEA in 51 cases of gastric adenocarcinoma and 18 cases of chronic gastritis. All tissues examined were obtained with endoscopic biopsy, fixed in 10% formalin and embedded in paraffin. The findings were analysed and results obtained are as following. 1. CEA positive reaction to anti-CEA antibody was noted in 45 of the 51 cases with gastric cancer (88.2%). 2. Patterns of positive reaction to anti-CEA antibody of 45 CEA positive adenocarcinomas were focal in 9 cases (20.0%), moderate in 10 cases (22.2%) and diffuse in 26 cases (57.8%). 3. Comparing the pattern of CEA positive reaction with histologic differentiation of cancer cell, the differentiated type showed diffuse linear pattern along membrane the surface and undifferentiated type revealed focal positive pattern in the cytoplasm. 4. Of 18 cases with chronic gastritis, 8 cases of non-specific gastritis and 10 cases of intestinal metaplasia, CEA poistive reaction to anti-CEA antibody was noted in 4 cases at the lesion of intestinal metaplasia. The results obtained above suggest that presence of CEA in gastric cancer is detected 88% of cases, variable in pattern, partly depending on morphologic differentiation, and even exhibit in goblet cells in some intestinal metaplasia which is believed to be a precancerous condition of stomach cancer.

Ba-Ferrite를 이용한 자기 연마재 개발

김희남,송승기,정윤중,윤여권,김희원,조상원,심재환 한국안전학회 2003 한국안전학회지 Vol.18 No.2

The magnetic polishing is the useful method to finish some machinery fabrications by using magnetic power. This method is one of the precision techniques and has an aim for clean technology in the transportation of the pure gas in the clean pipes. The magnetic abrasive polishing method is not so common in the field of machine that it is not known to widely. There are rarely researcher in this field because of non-effectiveness of magnetic abrasive. Therefore, in this paper we deals with the development of the magnetic abrasive with the use of Ba-Ferrite. In this development, abrasive grain WA has been made by using the resin bond fabricated at low temperature. And magnetic abrasive powder was fabricated from the Ba-Ferrite which was crushed into 200 mesh. The XRD analysis result shows that only WA abrasive and Ba-Ferrite crystal peaks were detected, explaining that resin bond was not any more to contribute chemical reaction. From SEM analysis, we found that WA abrasive and Ba-Ferrite were strongly bonding with each other.

압력센서식 수위계측 시스템의 개발과 GIS에의 적용

박찬원,박희석,남현식 강원대학교 산업기술연구소 2005 産業技術硏究 Vol.25 No.B

This peper presents a development of the Data Logger System to transmit the outcome of the waterlevel measuring instrument using the pressure sensor by means of the CDMA network. In or order to set up the real time monitoring the waterlevel measurement system, we have designed the waterlevel sensor, communication terminal and repeater, and data logger. Furthermore, its application for the GIS(Geographical Information System) with management server system and software solutions have also developed to minimize the property damages from the flood disaster which occurs every year in the river.

라오스의 벼 생산 현황과 문제점

이문희,최경진,이정일,정남진,양원하,김제규 한국국제농업개발학회 2001 韓國國際農業開發學會誌 Vol.13 No.4

Rice is the single most important crop in Lao PDR. In the 2000 rice production year, total rice production in the Laos reached 2.2 million tons. This is regarded as sufficient to provide national self-sufficiency. The rice harvested area in 2000 was approximately 719,500ha and represented 80% of cropped land area. Approximately 82% of production was from wet season cropped and 18% was from the irrigated dry season. Grain yield per unit area vary from 1.68 to 4.39 ton/ha in the wet season environment. However, the highest grain yield (4.39 ton/ha) obtained from the dry season irrigated crop. Higher yields and reduced year variation in production can be expected with the further intensification of production systems in the low land environments. However, further imporvements in production will be dependent on higher levels of inputs and further alleviation of some the production constraints.

가상현실을 이용한 뇌졸중 환자의 균형장애 평가와 임상평가 지수와의 상관성 연구

김연희,박지원,정준용,우영근,최종덕,김남균 최신의학사 2003 最新醫學 Vol.46 No.11-12

대학생의 노인에 대한 태도에 관한 연구

이영희,권미경,김남선,김혜원,최미경,이규은,홍윤미 關東大學校 醫科大學 醫科學硏究所 2003 關東醫大學術誌 Vol.7 No.1

The purpose of this study is to identify the perception, the future and images, and prejudice toward old people. And to examine difference the group of gerontological education (educated group) with the non-educated group. 189 students in K university were participated in this study. The educated group was composed 101 students who enrolled liberal arts course that learned this title. Data were collected from May to June, 2002. The results are as follows; 1) Many students perceived the elderly that was started 60~64 years. 2) The perception, the future and images, and prejudice of both groups were some positively. 3) Each variables were not significantly difference. But the mean level of the educated group were more higher. 4) The educated group was found significantly related to the perception and prejudice(r=.303, p=.002). The non-educated group was found significantly related to the perception and the future and image(r=.421, p=.000), the perception and prejudice(r=.321, p=.003), the future, image and prejudice(r=.272, p=.012).