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Tie2 is tied at the cell-cell contacts and to extracellular matrix by Angiopoietin-1
Shigetomo Fukuhara,Keisuke Sako,Kazuomi Noda,Kaori Nagao,Koichi Miura,Naoki Mochizuki 생화학분자생물학회 2009 Experimental and molecular medicine Vol.41 No.3
Angiopoietin-1 (Ang1) binds to and activates Tie2 receptor tyrosine kinase. Ang1-Tie2 signal has been proposed to exhibit two opposite roles in the controlling blood vessels. One is vascular stabilization and the other is vascular angiogenesis. There has been no answer to the question as to how Tie2 induces two opposite responses to the same ligand. Our group and Dr. Alitalo’s group have demonstrated that trans-associated Tie2 at cell-cell contacts and extracellular matrix (ECM)-anchored Tie2 play distinct roles in the endothelial cells. The complex formation depends on the presence or absence of cell-cell adhesion. Here, we review how Ang1-Tie2 signal regulates vascular maintenance and angiogenesis. We further point to the unanswered questions that must be clarified to extend our knowledge of vascular biology and to progress basic knowledge to the treatment of the diseases in which Ang1-Tie2-mediated signal is central. Angiopoietin-1 (Ang1) binds to and activates Tie2 receptor tyrosine kinase. Ang1-Tie2 signal has been proposed to exhibit two opposite roles in the controlling blood vessels. One is vascular stabilization and the other is vascular angiogenesis. There has been no answer to the question as to how Tie2 induces two opposite responses to the same ligand. Our group and Dr. Alitalo’s group have demonstrated that trans-associated Tie2 at cell-cell contacts and extracellular matrix (ECM)-anchored Tie2 play distinct roles in the endothelial cells. The complex formation depends on the presence or absence of cell-cell adhesion. Here, we review how Ang1-Tie2 signal regulates vascular maintenance and angiogenesis. We further point to the unanswered questions that must be clarified to extend our knowledge of vascular biology and to progress basic knowledge to the treatment of the diseases in which Ang1-Tie2-mediated signal is central.
Noble gas studies of lunar meteorites MIL 090034, MIL 090036, and MIL 090070
Jisun Park,Keisuke Nagao,Jisu Choi,Jong Min Baek,Changkun Park,Jong Ik Lee,Mi Jung Lee,Laurence E. Nyquist,Gregory F. Herzog,Brent D. Turrin,Akira Yamaguchi,Michael K. Weisberg,Naoki Shirai,Mitsuru Eb 대한지질학회 2018 대한지질학회 학술대회 Vol.2018 No.10
남극 드레이크 해협 피닉스 해령 P3구역 축부 해저현무암: K-Ar 연대측정과 지구과학
이종익,허순도,이미정,김규중,Keisuke Nagao 한국해양과학기술원 2003 Ocean and Polar Research Vol.25 No.1
The axial seamount basalts in the P3 segment of the Phoenix Ridge were obtained from dredging and the K-Ar age determination and whole-rock geochemical analyses have been done for understanding their origin. The K-Ar ages for PR2 basalts sampled from 1,000 m below sea level are 2.6 - 2.2 Ma and those for PR3 basalts from 800 m are 1.6-1.5 Ma. The younger ages towards the crest of the seamount indicate that this submarine volcano has been grown by central eruptions. The youngest age of about 1.5 Ma for PR3 basalts corresponds to the final eruption period of this volcano. The seamount basalts contain small amounts of normative quartz and olivine. They have transitional geochemical nature between alkaline- and subalkaline-series basalts. Trace and rare earth elements compositions of the seamount basalts are very similar to those of ocean island basalts (OIB), and indicate that this seamount has been formed by a hotspot activity, not in association with a seafloor spreading. The melting degree from the source has decreased with time, and finally the volcanic activity has stopped when the basaltic magma reached mild alkaline composition.