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류명춘,이훈재,서동주 경운대학교 산업기술연구소 1998 産業技術硏究論文誌 Vol.1 No.1(A)
The number of databases maintained in the world is increasing rapidly. Many of these databases are huge and are therefore very difficult to manually analyze. To make it feasible to analyze databases, researchers have been developing tools for knowledge discovery in databases. This paper proposed the knowledge discovery system based on rule-based system to efficiently discover knowledge in databases.
산마늘로부터 단리한 kaempferol과 quercetin의 콜레스테롤 저하 활성
이성숙,문서현,이학주,최돈하,조명행 한국목재공학회 2004 목재공학 Vol.32 No.1
식용 임산자원인 산채류를 기능성 식품으로 개발하고자 산마늘을 비롯한 충 13종의 에탄을 조추출물에 대한 콜레스테롤 저하활성을 검정하였다. 즉, 콜레스테롤 생합성 과정 초기에 관여하는 3-hydroxy-3-methylglutaryl coenzyme A reductase(HMG-CoA reductase)와 후기에 관여하는 squalene synthase의 효소 활성을 조사한 결과 산마늘 잎 에탄올 추출물이 두 효소의 활성을 공히 70% 이상 저해하여 활성이 가장 우수한 것으로 나타났다. 그리고 이러한 콜레스테롤 저하활성과 관련이 있는 물질을 탐색하고자 산마늘로부터 물질 단리를 시도하여 디클로로메탄 가용부로부터 kaempferol과 quercetin을 단리하였다. 또한 유전자 레벨에서의 콜레스테롤 저하 활성을 조사하기 위해 단리물질과 분획물을 C100세포(햄스터 유래 HMG-CoA reductase 고발현 세포주)에 각각 5㎍/㎖과 10㎍/㎖로 24시간 처리하여 HMG-CoA reductase와 squalene synthase의 mRNA 발현 정도를 조사하였다. 그 결과 10㎍/㎖로 kaempferol과 quercetin을 처리한 경우 두 효소의 mRNA가 전혀 발현하지 않는 것으로 나타나 유전자 레벨에서의 콜레스테롤 생합성 저해 효과를 확인할 수 있었다. 이상의 결과 산마늘 잎 에탄올 추출물은 콜레스테롤 생합성에 관여하는 HMG-CoA reductase와 squalene synthase의 활성을 저해하며 이러한 활성 저해 효과는 kaempferol과 quercetin에 기인하는 것으로 사료되었다. 특히 kaempferol과 auercetin은 여러식물의 성분으로서 이미 알려진 화합물이지만 콜레스테롤 저하활성이 있는 것으로 밝혀진 것은 이번이 처음으로 금후 이들 물질과 이들 물질을 함유하고 있는 식물 활용에 필요한 자료를 제공하였다고 사료된다.
2단계 발효에 의한 포도식초와 재래식 포도식초의 품질 비교
정용진,이명희,서권일,김주남,이용수 동아시아식생활학회 1998 동아시아식생활학회지 Vol.8 No.4
Grape vinegar(A) and grape onion vinegar(B) added (3% of onion juice) were produced through two stages of fermentation(alcohol fermentation and acetic acid fermentation) to increase the grape's use. Grape wine which contained 5.6% alcohol was produced on the 3rd day of first stage. Then through the second stages, grape vinegar, of which total acidity was 5.37% was produced. The quality of (A) and (B) which was produced through the two stages of fermentation was compared with the traditional grape vinegar(C,D) in the market. The content of sugar in (D) was a little higher such as 5.4 °Brix than others. That of (A) and (B) was 5.13, 4.98 °Brix respectively. The content of remaining alcohol in (C) was high such as 0.23% comparatively, But there was no remaining alcohol in (A) and (B). The content of acetic acid was 4.3~5.3% as a major organic acid of vinegars. The content of tartaric acid was 340.0 in (A), 316.7 in (B), 322.6 in (C) and 391.7㎎% in (D). The content of lactic acid was distinctly high such as 277.4㎎% in (D). There were differences such as 9.2~15.5㎎% in the content of total free amino acids among grape vinegars. (D) contained 15.5㎎% of total free amino acid and (B) also highly such as 12.0㎎%. Potassium was high in grape vinegars. The content of potassium, sodium and copper was higher in (A) than (B).
Efficacy and safety of pharmacotherapy for smoking cessation among pregnant smokers: a meta‐analysis
Myung, S‐,K,Ju, W,Jung, H‐,S,Park, C‐,H,Oh, S‐,W,Seo, HG,Kim, HS Blackwell Publishing Ltd 2012 BJOG Vol.119 No.9
<P><I>Please cite this paper as:</I> Myung S, Ju W, Jung H, Park C, Oh S, Seo H, Kim H, for the Korean Meta‐Analysis (KORMA) Study Group. Efficacy and safety of pharmacotherapy for smoking cessation among pregnant smokers: a meta‐analysis. BJOG 2012;119:1029–1039.</P><P><B>Background </B> The efficacy and safety of pharmacotherapy for smoking cessation among pregnant smokers has not yet been established.</P><P><B>Objective </B> To investigate the efficacy and safety of pharmacotherapy for smoking cessation among pregnant smokers.</P><P><B>Search strategy </B> A search was made of PubMed, Embase and CENTRAL in June 2011.</P><P><B>Selection criteria </B> Randomised controlled trials (RCTs), quasi‐RCTs and retrospective or prospective controlled studies were included.</P><P><B>Data collection and analysis </B> The main analyses were designed to examine the efficacy of pharmacotherapy for smoking cessation among pregnant smokers based on the longest follow‐up data available and from data obtained at the latest available time‐point in pregnancy in each study.</P><P><B>Main results </B> Of 74 articles identified from the databases, seven studies (five RCTs, one quasi‐RCT and one prospective study) involving a total of 1386 pregnant smokers, 732 in the intervention groups and 654 in the control groups, were included in the final analyses. In a fixed‐effects meta‐analysis of all seven studies based on the longest follow‐up data available, pharmacotherapy had a significant effect on smoking cessation (relative risk [RR] 1.80; 95% confidence interval [CI] 1.32–2.44). Subgroup meta‐analysis by type of study design also showed similar findings for RCTs (RR 1.48; 95% CI 1.04–2.09) and other types of studies (RR 3.25; 95% CI 1.65–6.39). The abstinence rate at late pregnancy in the intervention ranged from 7 to 22.6% (mean abstinence rate 13.0%; 95% CI 10.9–15.2%). A few minor adverse effects and serious adverse effects were reported in several studies.</P><P><B>Author’s conclusions </B> This study indicates that there may be clinical evidence to support the use of pharmacotherapy for smoking cessation among pregnant smokers. Further RCTs are needed.</P>
Supplementation of Safflower Seed Powder and Extracts Enhances Bone Metabolism in Rib-Fractured Rats
Seo, Hyun-Ju,Moon, Kwang-Deog,Jeon, Seon-Min,Kim, Jun-Han,Cho, Myung-Sook The Korean Society of Food Science and Nutrition 2003 Preventive Nutrition and Food Science Vol.8 No.1
The current study investigated the effect of Korean safflower (Carthamus tinctorius L.) seed powder and its water and ethanol extracts on bone metabolism during recovery from rib-fracture induced by surgical operation in rats. 10-week-old male Sprague-Dawley rats weighing about 320 g were divided into 9 groups after arrival: 10d control (AIN 76 semi-purified diet), 10d safflower seed powder (10d SS-powder), 10d safflower seed ethanol extract (10d SS-EtOH), 10d safflower seed water extract (10d SS-$H_2O$), 20d control (AIN-76 semi-purified diet), 20d safflower heed powder (20d SS-powder), 20d safflower seed ethanol extract (20d SS-EtOH), 20d safflower seed water extract (20d SS-$H_2O$), and 20d sham-operation (20d sham), The dietary level for all the supplements was 5% based on the raw material weight. The rats were fed the experimental diets for 10 days before the rib fracture operation and for a further 10 or 20 days after the operation. A number 9 rib was fractured surgically and a sham-operation also performed. The rats were then sacrificed on the l0th or 20th day after the operation. The body weight initially decreased after the operation in all the rib-fractured groups, then gradually recovered. The concentrations of plasma osteocalcin were higher in the control group than in all the safflower-supplemented groups 10 and 20 days after the rib-fracture (p < 0.05). The bone-specific ALP (alkaline phosphatase) activity was significantly higher in the SS-EtOH group than in the other groups 20 days after the rib-fracture (p < 0.05). The level of urinary DPD (deoxypridinoline) was significantly higher in the SS-EtOH and SS-$H_2O$ groups than in the other groups 10 days after the rib-fracture. When comparing the PTH (parathyroid hormone) and calcitonin levels, the SS-$H_2O$ group exhibited the highest PTH level among the groups 10 and 20 days after the rib-fracture. Thus, it was concluded that the bone turnover during the fracture-healing period was more rapid in the rats supplemented with safflower seed powder or its fractions than in the control rats. Furthermore, the SS-$H_2O$ fraction was identified as the most effective in stimulating bone remodeling, as bone resorption and bone formation were both significantly increased during fracture healing when compared to the control group.
Proposal of a Novel Lung Fibrosis Scoring System for Post-COVID-19 Lung Fibrosis Patients
( Seo Hee Yang ),( Eun-ju Park ),( Hyung-jun Kim ),( Myung Jin Song ),( Yeon Wook Kim ),( Byung Soo Kwon ),( Sung Yoon Lim ),( Yeon-joo Lee ),( Jong Sun Park ),( Ho Il Yoon ),( Jae Ho Lee ),( Choon-ta 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.0
Background The usefulness of lung ultrasound (LUS) in the initial test for coronavirus disease 2019 (COVID-19) was already known, but ultrasound assessment of pulmonary fibrosis after intensive care for COVID-19 is not elucidated. We aimed to suggest new lung fibrosis scoring system and determine whether they correlate with traditional radiographic findings. Furthermore, we examined the usefulness of hand-held ultrasound at outpatient clinic in the evaluation of pulmonary complications of post- COVID-19 patients after recovery. Methods Severe COVID-19 patients who need for mechanical ventilation in intensive care unit were enrolled prospectively. All patients underwent LUS (GE Vscan Extend™) scans on the day of admission, discharge, and follow-up visit about one month after discharge. If possible, high resolution computed tomography (HRCT) was also taken. In 12 pulmonary zones, the presence or absence of A-line, pleural effusion, lung sliding, and consolidation were observed, and total lung fibrosis score was assigned by giving a score according to the degree of markers that could reflect fibrosis, such as B-lines, pleural thickening, or consolidation. Results We currently enrolled eleven patients, one of whom has died, three are still in the ICU. So far, seven had underwent LUS before discharge and are expected to be followed up at outpatient clinic. The average numbers of B-lines was 2.31 [1.93-2.43]; pleural thickness (mm) 2.11 [1.91-2.34] in the initial stage, and at the stage before discharge, 0.29 [0.14-0.43] in B-lines 2.47 [2.30-2.56] in the pleural thickness, respectively. They will be followed up in an outpatient clinic one month later using a portable handheld ultrasound and the correlation of quantitative assessment by HRCT also analyzed. Conclusions We have presented a novel scoring system for the evaluation of pulmonary fibrosis in post-COVID patients. We suggest that LUS can be considered as the first-line tool in outpatient setting for follow-up of post-COVID lung fibrosis.
S-210 Impact of Hypertension on Insulin Resistance in Asian Population
( Myung Han Hyun ),( Byoung Geol Choi ),( Seung-woon Rha ),( Jin Oh Na ),( Cheol Ung Choi ),( Hong Euy Lim ),( Jin Won Kim ),( Eung Ju Kim ),( Chang Gyu Park ),( Hong Seog Seo ),( Dong Joo Oh ) 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1
Background: Hypertension is a well-known risk factor for cardiovascular and metabolic diseases. However, it is not clear that whether hypertension is associated with increased insulin resistance, especially in Asian population. Methods: We investigated the relationship between hypertension and insulin resistance of 4,983 consecutive patients during a mean follow-up of 2 years. To adjust potential confounders including age, gender, body mass index, diabetes mellitus, hyperlipidemia, chronic kidney disease, lipid profile, and medications, a propensity score matching (PSM) analysis was performed using the logistic regression model. Insulin resistance index based on the homeostatic model assessment-insulin resistance (HOMA-IR). We also compared fasting blood glucose (FBS), glycated hemobglobin (HbA1c), fasting serum insulin (Insulin) between the subset of hypertension and normotension group. Results: After PSM analysis, 1,590 patients (795 hypertension vs 795 normotension) with the mean follow-up duration of 594±266 days were analyzed. Baseline characteristics were similar between the two groups. In paired t-test, hypertension group increased HOMA-IR by 15% significantly (p<0.001). However, normotension group increased HOMA-IR by 3% without significance. In contrast to HOMA-IR, Insulin level was significantly increased in both groups and no significant change in FBS were observed in two groups (Table). Conclusions: In the present study, hypertension is associated with increased insulin resistance in Asian population.