Porokeratosis ptychotropica: dermoscopic features

( Myeong Hyeon Yang ),( Seol Hwa Seong ),( Ji Yun Jang ),( Min Soo Jang ),( Kee Suck Suh ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1

Porokeratosis is a disorder of keratinization characterized by one or more atrophic macules or patches surrounded by a distinctive hyperkeratotic ridge-like border called a cornoid lamella. Numerous variants of porokeratosis have been described including porokeratosis ptychotropica (PP), a rare variant that is localized to gluteal folds of the buttocks, often simulating other inflammatory skin diseases. PP is first described by Lucker et al in 1995 using the Greek words ptyche (fold) and trope (a turning) to depict the flexural distribution. A 44-year-old male presented with a solitary grayish, well-demarcated, hypertrophic and infiltrative verrucous plaque with satellite papules on the left buttock. On dermoscopy, sharply demarcated and surrounded by a hyperpigmented border with whitish hyperkeratotic scale and brownish globules linearly arranged along the periphery were seen. And brownish to purplish diffuse structureless areas and scanty brownish globules were seen in the central area. Histologic findings showed epidermal hyperkeratosis, parakeratosis with multiple cornoid lamellae, some dyskeratotic keratinocytes, and focal degenerative change of basal layer. Also, upper dermis shows marked melanin incontinence. The diagnosis of PP was made. The lesion was removed through surgical excision. Herein, we report atypical presentation of PP and dermoscopic findings as a complement to clinical examination in the diagnosis of PP.

Performance and energy efficiency verification of bench scale bio-electrochemical anaerobic digestion

( Hyeon-myeong Yang ),( Ji-hwan Cha ),( Min-ji Kim ),( Byeong-chang Park ),( Hang-bae Jun ) 한국폐기물자원순환학회 2022 ISSE 초록집 Vol.2022 No.-

Municipal solid waste(MSW) have been continuously increased as urbanization progresses rapidly. The highest proportion of MSW is food waste, and the importance of recycling food wastes is increasing. Recycling methods of food waste are feedstuff, composting and biogasification. Among them, biogasification, a carbon-neutral recycling method, is attracting attention. However, biogasification, that is, anaerobic digestion(AD), needs to improve the low process stability and organic matter decomposition rate, etc., and bioelectrochemical anaerobic digestion(BEAD) can improve the above problems by supplying a small amount of voltage. But, most of the experiments on BEAD were conducted on the lab scale, and the performance verification on a larger scale was not performed. Therefore, this study tried to perform performance verification of BEAD on bench scale. The reactor was composed of AD and BEAD reactors. Working volume of both reactors is 100 L. BEAD reactor was composed of a main reactor and a small reactor including electrodes, and both reactors were connected. The operation was performed under the conditions; organic load rate of 4 kg/㎥/d, HRT of 20 days, and temperature of 35°C. Additional, a voltage of 0.4 V was supplied to the BEAD. The results of the experiment showed that the average amount of organic removal was 5,800 mg-COD/L and the average amount of methane generation was 35 L/d higher than that of AD. In addition, the energy efficiency of BEAD was calculated by comparing BEAD and AD, and the average was 290%. Therefore, in this study, it was confirmed that the rapid organic removal and methane generation were performed even when BEAD was applied at the bench scale, and effective energy recovery was achieved by a small amount of voltage supply.

A case of eczema herpeticum in mycosis fungoides

( Myeong Hyeon Yang ),( Seol Hwa Seong ),( Ji Yun Jang ),( Min Soo Jang ),( Kee Suck Suh ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1

Eczema herpeticum (EH), also known as Kaposi's varicelliform eruption, is characterized by disseminated papulovesicular eruption caused by a herpes simplex virus infection superimposed on a pre-existing dermatosis. The eruption usually occurs in individuals with atopic dermatitis or other pre-existing dermatosis such as Darier's disease, pemphigus foliaceus, and ichthyosis vulgaris. Mycosis fungoides (MF) is the most frequent manifestation of cutaneous T cell lymphoma but its cause and pathophysiology remain unclear. Herpes virus infection occurs not uncommonly in MF patients. However, only a few MF patients with EH have been described. A 58-year-old male presented with erythematous patches and plaques on the face. Two years ago, he was diagnosed with MF stage IIA and he had been receiving treatment including oral retinoid and ultraviolet A-1 therapy. Because the patient suffered from severe pruritus and his lesions had worsened, he was started to treat with topical imiquimod 5% cream 3 times weekly. After applying topical imiquimod 12 times, painful edematous plaques developed on his face. After 3 days, grouped vesicles and erosions developed in the erythematous areas of the face. Tzanck’s smear from a vesicle on his face showed multinucleated giant cells. The diagnosis of EH was thus made. The patient was treated with valacyclovir (3,000 mg/day) for 7 days and the lesion was completely resolved. Herein, we report a case of EH in MF.

P224 Association of lichen planus and hepatitis C virus infection in the Busan, Korea

( Myeong Hyeon Yang ),( Ji Yun Jang ),( Joon Hee Kim ),( Kang Hoon Lee ),( Hyun Hwangbo ),( Min Soo Jang ),( Kee Suck Suh ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2

<div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div> Background: Lichen planus (LP) is a chronic inflammatory mucocutaneous disease and its association with hepatitis C virus (HCV) infection has been suggested in many studies. But reported prevalence of HCV infection in patients with LP tends to appear wide international variable between 0 and 70%. Objectives: The purpose of this study is to assess the prevalence of HCV infection in patients with LP in Busan, Korea and association between the two diseases. Methods: We reviewed medical records of 65 patients of LP, who lived in Busan, at our department of dermatology from May 1992 to April 2016. We investigated medical history, clinical, and laboratory findings including anti-HCV antibody and HCV RNA via reverse transcription-polymerase chain reaction (RT-PCR) for evaluation of HCV infection and liver function test (LFT). Results: Six patients (9.2%) were positive for anti-HCV antibody and all of them were confirmed with RT-PCR. Percentage of HCV infection among 65 patients of LP in this study was higher than that among adult in Busan (1.1%). Two patients (3.1%) were positive for hepatitis B surface antigen. Abnormal values in LFT were observed in 16 patients (24.6%) and liver diseases were observed in 7 patients (10.8%). Other associated diseases were hypertension, diabetes mellitus, and cardiac disease. Conclusion: LP is associated with HCV infection and it would be necessary to investigate HCV infection and liver disease in the LP patients.

[P277] Superficial mycoses caused by Cladophialophora boppii

( Myeong Hyeon Yang ),( Ji Yun Jang ),( Joon Hee Kim ),( Hyun Hwangbo ),( Min Soo Jang ),( Kee Suck Suh ),( Young Kwon Kim ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1

Cladophialophora boppii is black yeast-like fungus that is not commonly encountered in human infections. However, in recent years, dematiaceous molds have been described as significant human pathogens, causing an extended range of diseases, particularly in immunosuppressed patients. There have been few reports of subcutaneous and deep-seated infections of C. boppii, but its superficial infection has not yet been reported. A 59-year-old woman presented with asymptomatic blackish pigmented macules on the both toe webs that had developed 2 years ago. KOH microscopy showed branched chains of elongated oval conida extending from hyphae. Macroscopic view of colony isolated from skin lesions after culture on Sabouraud agar for 2 weeks showed olivaceous to blackish colony with velvety texture. The histologic findings showed hyphae and spores on the cornified layer of the epidermis with Periodic acid Schiff staining. Also, increased melanin in epidermis and dermis was stained positively with the Fontana-Masson staining. The sequence of ITS-1 regions amplified by PCR was found to be identical to that of C. boppii and the diagnosis of superficial mycoses caused by C. boppii was made. The patient was treated with terbinafine 250 mg/day for 4 weeks and the skin lesion was partially improved. Herein, we report the first case of a superficial mycoses caused by the black yeast-like fungus, C. boppii in an woman without evidence of immunodeficiency.

FC 1-7 Immunohistochemical evaluation of MMPs, TRPV, and CD117 in granulomatous rosacea compared with non-granulomatous rosacea

( Myeong Hyeon Yang ),( Ji Yun Jang ),( Joon Hee Kim ),( Kang Hoon Lee ),( Hyun Hwangbo ),( Min Soo Jang ),( Kee Suck Suh ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2

Background: Granulomatous rosacea (GR) is a variant of rosacea. Ultraviolet radiation (UVR) is considered to be etiologically related to GR, but its pathogenesis still remains unclear. Although, recent studies suggested that transient receptor potential vanilloid (TRPV) and mast cells are involved in the pathogenesis of rosacea, their role in each variants of rosacea such as GR has not been reported. Objectives: To investigate immunohistochemical expression of MMP-1, -9, TRPV, and CD117 in the GR compared with the non-granulomatous rosacea (NGR) and to test the hypothesis that immunohistochemical expressions of GR would relate with UVR. Methods: Biopsy samples were obtained from 11 patients of GR and 11 patients of NGR. For the analysis, subjects in two groups were age-matched. The sections were stained using hematoxylin and eosin, and antibodies MMP-1, -9, TRPV, and CD117. And expression of antibodies was evaluated with a semi-quantitative scale. Results: The expression of MMP-1, -9, and TRPV was significantly increased in GR lesions compared with NGR lesions (p < 0.05), especially at the center of granulomas. CD117 expression was increased in GR lesions, although difference between the two groups was not statistically significant. Conclusion: We suggest that, in GR lesions, TRPV is associated significantly with granuloma formation as well as MMP-1, -9 in relation to UVR exposure, and mast cells may play an important role in this process.

[P424] Epithelioid blue nevus: Dermoscopic features

( Myeong Hyeon Yang ),( Ji Yun Jang ),( Joon Hee Kim ),( Hyun Hwangbo ),( Min Soo Jang ),( Kee Suck Suh ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1

Epithelioid blue nevus (EBN) is a rare but distinctive histologic variant of blue nevus that has been described in patients with Carney complex, an autosomal-dominant multiple neoplasia syndrome. Clinically, EBN is typically characterized as small (less than 1 cm), darkly pigmented, dome-shaped nodules or, less commonly, as macules on the skin or mucosa. Recently, cases of EBN have been reported in patients without Carney complex. On histologic findings, variably pigmented, large epithelioid melanocytes with vesicular nuclei and a small number of melanophages that are sometimes associated with a few pigmented, spindle, and dendritic cells can be seen. A 40-year-old male presented with a solitary steel bluish well demarcated 6 x 4 mm sized nodule with central umbilication on the left arm without any clinical evidence of Carney complex. On dermoscopy, oval shaped, diffuse structureless area with steel-blue pigmentation and a central round dimple with whitish rim were seen. In the absence of any other dermoscopic structures, a clinical diagnosis of blue nevus was established. Histologic findings showed a wedge shaped symmetrical structure composed of heavily pigmented cells involving the dermis. On higher magnification, epithelioid melanocytes with large cytoplasm and abundant melanin within their cytoplasm were seen. The diagnosis of EBN was made. Herein, we report a case of EBN for whom dermoscopy was used as a helpful diagnostic tool.

플라이휠용 소형 고속 BLDC 전동기의 열 및 구조 해석

양현명(Hyeon-myeong Yang),권병일(Byung-il Kwon) 대한전기학회 2018 대한전기학회 학술대회 논문집 Vol.2018 No.-

서프보드용 고속 BLDC 전동기의 개발

양현명(Hyeon-myeong Yang),채진(Zhen Cai),권병일(Byung-il Kwon) 대한전기학회 2019 대한전기학회 학술대회 논문집 Vol.2019 No.7

보조 미생물전기화학적 혐기성소화조가 고부하 운전에 미치는 영향

양현명 ( Hyeon-myeong Yang ),전항배 ( Hang-bae Jun ) 한국물환경학회 2020 한국물환경학회·대한상하수도학회 공동 춘계학술발표회 Vol.2020 No.-

최근 혐기성 소화조에 전극을 결합한 미생물 전기화학적 혐기성 소화조(BEAD)는 start-up 단계에서 소화조의 빠른 안정화와 혐기성 소화조의 주요 저해 인자인 VFAs를 빠르게 처리하여 보다 높은 유기물부하에서도 안정적인 운전이 가능하다고 알려져 있으며 미량의 전압공급이 소화조 내의 전자전달 효율을 향상시켜 미생물 종 변화를 유도할 뿐만 아니라 bulk 및 bio-film의 microorganism활성도를 증가시키는 것이 다양한 연구에서 증명되었다. 그러나 이러한 BEAD의 적용을 위해서는 1)전극의 설치를 위한 기존 AD 반응조의 운전조건 파괴, 2)장기운전을 위한 전극의 내구성 및 유지 관리성 확보의 어려움, 3)경제성과 효율성을 겸비한 재질의 선정 등 경제적인 손실로부터의 극복방안이 필요하다. 다양한 선행연구에서 BEAD반응조에 지속적인 전압공급을 통한 운전보다는 전처리 및 후처리로써의 적용, 비상시 성능회복을 위한 적용, 높은 유기물 부하에서 운전의 안정성 확보를 위한 적용 등 적절한 BEAD반응조 운전을 통한 경제적 이익을 확보하는 것이 효과적이라고 하였다. 따라서 본 연구에서는 auxiliary bio-electrochemical reactor(ABER)의 운전을 통한 유기성 폐기물의 처리에 대한 영향을 평가하였다. 본 연구에서 AD와 BEAD 반응기는 교반기가 장착된 유효용량 20L의 아크릴 반응조를 사용하였으며 ABER의 경우 유효용량 0.8L의 아크릴 반응조를 사용하였다. BEAD와 ABER의 electrodes surface area/working volume은 각 4.2, 13.5m²/m³이며 음식물 탈리액을 기질로 사용하여 OLR을 단계적으로 증가시키며 운전하였다. AD와 ABER는 펌프를 이용하여 순환시켜 주었다. AD와 BEAD운전에서 BEAD의 경우 AD보다 빠른 안정화와 메탄발생이 가능함을 보였다. 그러나 6kg-COD/m³·d의 유기물 부하에서 AD의 경우 VFAs축적으로 인한 Alk. 및 pH저하가 발생하였고 이에 따라 COD제거율 및 CH4발생량 또한 감소하였다. 이때 ABER을 통한 전압의 공급을 통해 AD+ABER반응조의 pH와 Alk.가 안정적으로 유지되었으며 COD 제거율과 CH4발생량 또한 회복됨을 확인하였다. 다시 ABER의 운전을 중지하였을 때 유기물 제거효율은 다시 감소하였으며 pH와 Alk.또한 감소하였다. 이후 ABER의 재운전을 통해 소화조의 안정적인 운전이 가능하였으며 이후 10kg-COD/m³·d의 유기물 부하에서도 BEAD와 유사한 COD제거효율을 나타내며 안정적인 운전이 가능하였다. 이는 ABER을 통한 간접적인 전압공급이 VFAs의 빠른 제거를 통해 전체 반응조를 안정적으로 유지함에 기여하였음을 나타낸다. 직접 전압이 공급된 BEAD반응조는 높은 OLR에서도 안정적인 COD제거가 가능하였다. 반면에 AD는 8kg-COD/m³·d에서 VFAs 축적 및 pH, Alk.의 저하로 COD제거율 및 메탄 발생량이 급격히 감소하였다. ABER을 통한 간접적인 전압의 공급을 통해 AD+ABER반응조의 pH와 Alk.를 회복함을 확인하였으며 이를 통해 COD제거율 및 메탄발생량이 향상되었다. 따라서 ABER의 적용가능성을 확인하였으며, ABER의 간헐적인 운전을 통해 비상시 소화조의 안정화유지가 가능함을 확인하였다.