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정명아,서유승,양진수,박준섭,윤진훈,이중건,이준승,이영규,김동희,조성범,주종은 대한신장학회 2002 Kidney Research and Clinical Practice Vol.21 No.2
Pelvic actinomycosis is a chronic granulomatous suppurative disease caused by an anaerobic grampositive organism Actinomyces israelii. It is com-monly associated with an intrauterine device(IUD) and can mimick pelvic or intra-abdominal malignant neoplasm. Ureteral obstruction leading to hydronephrosis is a rare complication of tubo-ovarian abscess. We experienced a case of hydronephrosis as a complication of pelvic actinomycotic abscess. The patient was a 46-year-old women presenting with fever and right flank pain. Leukocytosis and pyuria were present and a hydronephrosis was diagnosed by intravenous pyelography. Ultrasonography and a computerised tomography revealed a mass in right adnexum compressing the right ureter. Removal of retroperitoneal abscess and salphingo-oophorectomy were done and the diagnosis of actinomycosis was made by pathologic finding of resected mass. Postoperatively, the patient was treated with second-generation cephalosporin successfully. (Korean J Nephrol 2002;21(2):337-340)
소화성궤양 환자에서 저용량 clarithromycin 3제요법의 Helicobacter pylori 제균효과
정명아 ( Myeong A Cheong ),김태헌 ( Tae Hun Kim ),박영숙 ( Young Sook Park ),이진혁 ( Jin Hyuk Lee ),주연호 ( Yeon Ho Joo ),최일주 ( Il Ju Choi ) 대한소화기학회 2002 대한소화기학회 춘계학술대회 Vol.2002 No.-
<목적> 우리나라에서는 H. pylori의 첫 치료로 PPI, amoxacillin과 clarithromycin의 3제요법이 추천되고 있다. Clarithromycin의 용량은 500mg을 하루 2회 복용하는 것이 추천되나, 250mg을 하루 2회 복용하는 저용량 Clarithromycin 3제요법의 H. pylori 제균 효과에 대하여는 아직 논란이 있는 실정이다. Omeprazole을 사용한 3제요법에 대한 국내의 보고에서 clarithromycin
알칼리성 과황산칼륨 산화법을 이용한 해수와 담수에서의 총질소 총인 동시 분석방법에 대한 연구
정진아 ( Jeong Jin A ),박청길 ( Park Cheong Gil ),김동명 ( Kim Dong Myeong ) 한국물환경학회 2003 한국물환경학회지 Vol.19 No.3
It is necessary to develop a standard method for determination of total nitrogen (T-N) and total phosphorous (T-P) in seawater because the T-N and the T-P have been adopted in marine water quality standards since 2001. Precision and recovery of the simultaneous determination of T-N and T-P by alkaline persulfate oxidation in seawater and freshwater were assessed. Relative standard deviation and recovery of eleven seawater and freshwater standards of known nitrogen concentration were ±1.59∼±6.45% and 93.0∼100.6%, respectively. Relative standard deviation and recovery of eleven seawater and freshwater standards of known phosphorus concentration were ±0.62∼±4.95% and 96.0-1 00.8%, respectively. Relative standard deviation of five samples of seawater collected from Nakdong estuary and five samples of freshwater collected from Nakdong river were ±3.14∼±5.52% for nitrogen and ±3.98∼±6.67% for phosphorus. We can find that this method has a good precision and recovery below the acceptance limits for total nitrogen and total phosphorus in analyzing seawater and freshwater samples.
류마티스관절 활막세포에서의 Receptor Activator of NF-kB Ling (RANKL)의 발현 및 파골세포 생성
주영실 ( Yeong Shil Joo ),정명아 ( Myeong A Cheong ),신동혁 ( Dong Hyuk Sheen ),임미경 ( Mi Kyoung Lim ),심승철 ( Seung Cheol Shim ),정덕환 ( Duke Whan Chung ) 대한류마티스학회 2003 대한류마티스학회지 Vol.10 No.4
Objective: A number of soluble factors which play important role in the pathophysiology of rheumatoid synovitis are also known to be involved in osteoclast differentiation and activation through RANKL (Receptor activator of NF-κB ligand). To investigate the importance of RANKL in the pathogenesis of bone erosion in rheumatoid arthritis (RA) patients, we analyzed the expression of RANKL and Osteoprotegerin (OPG) and examined the formation of osteoclasts in rheumatoid synovial fibroblasts under the influence of various osteotropic factors. Methods: Primary culture synoviocytes or fibroblast-like synoviocytes isolated from synovial tissues of 8 RA patients were cultured and treated with IL-1β (2 ng/ml), TNF-α(2 ng/ml), INF-γ (1000 /ml), IL-15 (10 ng/ml), IL-12 (10 ng/ml), dexamethasone (10(-9) M), PMA (10 ng/ml) or 1,25 (OH)2D3 (10(-9) M) for 18 hours. Expression RANKL or OPG mRNA was measured by semiquantitative RT-PCR within linear amplification condition. TRAP (+) MNC (tartrate resistant acid phosphatase-positive multinucleated cell) formation was induced from primary culture synoviocytes or in coculture system of synovial fibroblasts with PBMCs in the presence of M-CSF and 1,25 (OH)2D3. Results: 1. The intensity of base-line expression was different from patient to patient. Primary culture synoviocytes and synovial fibroblasts express RANKL and OPG mRNA with decreasing intensity when they are passaged. 2. Expresssion of RANKL mRNA was significantly increased by 1,25 (OH)2D3 and IL-1β (158.8±21% and 197.2±17% of controls, p<0.05 and p<0.005, respectively), while decreased significantly by dexamethasone (25.6±4.6% of controls, p<0.005). Expression of RANKL mRNA was significantly increased by IL-1β and decreased by dexamethasone, in a dose- and time-dependant manner. 3. TRAP (+) MNCs are formed from primary culture synoviocytes or in coculture system of synovial fibroblasts and PBMC in the presence of M-CSF and 1,25 (OH)2D3. Dexamethasone clearly inhibited TRAP (+) MNCs formation from synovial cells. Conclusion: The regulatory mechanism for the expression of RANKL or OPG in rheumatoid synoviocytes might be different from that in bone marrow cells. Modulating the expression of these molecules could have potential therapeutic implication targeting bone destruction in RA.
Inhibition of Osteoclast formation from cultured synovial cells by Dexamethasone
( Yeong Shil Joo ),( Myeong A. Cheong ),( Jae Il Park ),( Min Ju Kang ),( Byoung Joon Kim ),( Kyu Jeung Ahn ),( Sung Woon Kim ),( Jin Woo Kim ),( Yeong Seol Kim ),( Young Kil Choi ) 대한내과학회 2001 대한내과학회 추계학술대회 Vol.61 No.-