간경변 및 간암과 혈청 구리와 아연농도와의 관련성

현명수,서석권,윤능기,이종영,이승훈,이무식,Hyun, Myung-Soo,Suh, Suk-Kwon,Yoon, Nung-Ki,Lee, Jong-Young,Lee, Seoung-Hoon,Lee, Mu-Sik 대한예방의학회 1992 예방의학회지 Vol.25 No.2

현재까지도 완전히 규명되지 못한 간질환과 혈청 구리 및 아연농도와의 관련성을 밝히고, 이들의 진단적 가치를 알아보고자 1990년 10월에서 1991년 8월 사이에 대구시 소재 모 대학병원 내과와 건강진단센터에 내원한 사람들 중에서 무작위로 선정한 정상 63명, 간경변 60명 그리고 간암 33명을 대상으로 일반적 특성을 조사하였고, 체내 일일 변동을 고려하여 공복시 오전 9시에서 11시 사이에 혈액을 채취하여 간기능검사의 생화학적 표지자와 혈청 구리 및 아연농도의 분석에 사용하였다. 혈청 구리의 평균농도는 대조군 $91.97{\pm}4.76{\mu}g/dl$, 간경화군 $106.21{\pm}2.73{\mu}g/dl$ 그리고 간암군 $127.05{\pm}0.77{\mu}g/dl$이었고, 대조군과 간경화군 사이에 통계적으로 유의한 차이는 없었으나, 간경화군과 간암군사이에는 통계적으로 유의한 차이를 보였다(p<0.05). 아연에 있어서는 대조군 $110.82{\pm}7.24{\mu}g/dl$,간경화군 $68.10{\pm}5.43{\mu}g/dl$ 그리고 간암군 $63.78{\pm}2.20{\mu}g/dl$로 나타났고, 간경화군과 간암군 사이에 통계적으로 유의한 차이는 없었으나, 대조군과는 두 군 모두 통계적으로 유의한 차이를 보였다(P<0.05). Cu/Zn비는 세 군 사이에 모두 통계적으로 유의한 차이가 있었다(p<0.05). 간기능검사의 생화학적 표지자들 중에 총 단백, 알부민, ALP 그리고 총 빌리루빈은 세 군 간에 모두 통계적으로 유의한 차이가 있었으나(p<0.05), ALT와 AST의 간경화군과 간암군 간의 차이는 통계적으로 유의하지 않았고, 직접 빌리루빈은 대조군에 대해 간암군에서 통계적으로 유의한 차이가 없었다. 헐청 구리와 아연농도 그리고 Cu/Zn비와 통계적으로 유의한 상관관계를 보인 표지자는 세 군에서 다양하게 나타났다. 다중 로지스틱 회귀분석에서 간경화 및 간암에 대한 odds ratio는 혈청 아연농도만이 각각 0.951, 0.952로 통계적으로 유의하였고(p<0.05), 혈 청 구리 농도와 Cu/Zn비는 통계적인 유의성이 없었다. 세 군에 대한 판별분석에서 구분을 위한 주요변수로 선정된 것은 알부민, ALP, 혈청 아연농도, 나이 그리고 총 빌리루빈이었고, 이를 적용하여 판별한 결과 바른구분의 백분율은 대조군 95.4%, 간경변군 73.4%, 간암군 75.7%로 총 84.0% 였다. 본 연구는 아연이 간질환에 대해 독립적으로도 억제하는 효과가 있을 것이며, 혈청 아연농도의 측정은 간질환의 진단에 유용하게 이용될 수 있을 것임을 시사하고 있다고 생각된다. This study was done to identify the association between serum copper and zinc levels and the cirrhosis and hepatocellular carcinoma(HCC), and to evaluate its diagnostic value on liver diseases. Sixty-three healthy persons, 60 patients with cirrhosis and 33 patients with hepatocellular carcinoma were rendomly selected and investigated for their general characteristics from October 1990 to August 1991. For analysis of the biochemical markers in liver function test and the serum copper and zinc levels, their fasting venous blood were sampled at 9:00 to 11:00 in the morning and centrifuged to separate the serum within one hour. All the samples were immediately analysed for biochemical markers and stored at $-20^{\circ}C$ in polypropylene tubes further copper and zinc analysis. Mean of serum coppper levels was $91.97{\pm}4.76{\mu}g/dl$ in control, $106.21{\pm}2.73{\mu}g/dl$ in cirrhosis and $127.05{\pm}0.77{\mu}g/dl$ in HCC. The value of HCC was statistically significantly higher than that of the control and cirrhosis(p<0.05). Serum zinc levels were $110.82{\pm}7.24{\mu}g/dl$ in control, $68.10{\pm}5.43{\mu}g/dl$ in cirrhosis and $63.78{\pm}2.20{\mu}g/dl$ in HCC. The values of cirrhosis and HCC were statistically significantly lower than that of control(p<0.05). The Cu/Zn ratio was statiatically significantly different among three groups(p<0.05). Test total protein, albumin, ALP and total bilirubin of biochemical markers of liver function were statistically significantly different among three groups(p<0.05). Differences between cirrhosis and HCC for ALT and AST, and between the control and HCC for direct bilirubin were not statistically significant. Biochemical markers statistically significantly correlated with serum copper and zinc levels and Cu/Zn ratio(p<0.05), were variable in three groups. In multiple logistic regression, odds ratio of serum copper level and Cu/Zn ratio had no statistical significance on the cirrhosis and the HCC, but that of serum sinc was statistically significant as 0.951 and 0.952(p<0.05). Serum copper and zinc levels and Cu/Zn ratio were not statistically significantly different between the cirrhosis and HCC. H\Albumin, ALP, zinc, total bilirubin and age among all variables were selected as main variables for three-group discriminant analysis. Percentage of 'grouped' cases correctly classified by these five variables was 98.4 for control, 73.4 for cirrhosis, 75.7 for HCC and 84.0 for all subjects. This study suggests that zinc level is considered to play a role as diagnostic marker on the hepatic disorders and be more useful than serum copper level and Cu/Zn ratio in diagnosis of the liver diseases.

西部慶南에서 發生한 소의 GLOBIDIUM病에 關한 報告

馬点述,박응복,李熙碩,文武洪 진주농과대학 1969 진주농과대학 연구논문집 Vol.- No.8

이번에 慶南 山淸郡에서 調査한 Globidium病發症牛 3例의 觀察에서 다음과 같은 結果를 얻었다. (1) 從來의 全南道 南部海岸地方의 本病發生地域 以外에 西部慶南에서도 Globidium病의 發生이 確認되었다. (2) 重症例에서 皮膚內의 原蟲胞囊의 分布密度는 매우 稠密하고 全身皮膚는 한점 남김없이 胞囊에 占據되어 있어 臨床的으로 瀕死期에 이룬 重態이었다. (3) 臟器, 組織別 胞囊의 分布는 皮膚上皮組織內, 眞皮層, 皮下骨格筋, 口唇腺 및 體淺部淋巴節에 있었다. (4) 皮膚외의 藏器의 組織學的所見은 口唇腺組織의 慢性增殖性炎, 骨格筋의 Zenker氏變性 및 體表淋巴節의 慢性淋巴節炎 이었다. Globiodiosis, cyst-forming protozoan disease which occur in South Africa, Sudan, France, Iberian Peninsula, Mexico and Korea, has been reported as an endemic skin disease in southern coast district of Cholranam-do, Korea. In the course of systemic examination of cattles in western Kyongsangnam-do showing thickend, rugous skin lesion during September, 1968, three cases of bovine Globiodiosis were observed. And in histological examination of the skin and other organs, we found characteristic globidial cysts of about 380-470μin diameter, composed of a thick wall of homogenous, pale blue staining substance lined on its inner surface by a thin ring of cytoplasm which contains two or eight large nuclei and with its inner contents, tiny crescentic bodies. And so, on the pathological studies of these globidial patients some findings were summerized as follows: 1. One of the affected patients exhibited extreme emaciation caused by cachexic condition with dispnea, oculonasal discharge, progressive scleroderma, thickening and fissuring of the skin and a alopecia representing umerous globidial cysts, present on any area of the whole skin. 2. The globidial cysts were distributed through the squamous epithelium of the skin, the dermal layer, the cutaneous skeletal muscle, the labial gland, and the superficial lymphnodes of the body. 3. Histopathological entity of the involved organs was characterized by chronic hyperplastic inflamation in the labial gland, Zenker's degeneration of the skeletal muscle and chronic lymphadenitis accompanying with diffuse reticular cell hyperplasia, multiple focal proliferation of plasma cells and macrophages in the medulally cords, and occupation with reticular cells macrophages and erythrocytes in the distend sinuses.

침전반응법으로 합성한 수산아파타이트 분말의 중금속 흡착 특성 및 폐수중의 유해 금속 제거제로서의 유용성

이무성,나춘기,이미숙,김옥배,김문영,Lee, Mu Seong,Na, Choon Ki,Lee, Mi Suk,Kim, Oak Bae,Kim, Moon Young 대한자원환경지질학회 1995 자원환경지질 Vol.28 No.3

It is well known that hydroxyapatite [$Ca_{10}(PO_4)_6(OH)_2$] have an exchangeability for various heavy metal ions in aqueous solution. To evalute the feasibility of employing the synthetic hydroxyapatites as an eliminatable exchanger for environmentally noxious caions in waste water, the adsorption properties, the removal capacities and the selectivity of the apatites for various cations were investigated in more detailed. The heavy metal cations have been exchanged in calcium part of hydroxyapatite. The order of the degree of amount exchanged of the investigated cations is $Pb^{2+}>Cd^{2+}>Zn^{2+}>Ba^{2+}$. The molar ratios between released $Cd^{2+}$ ions and remeved divalent metal cations in the reacted solution with hydroxyapatite are roughly close to an integer 1.0, suggesting that an ion-exchange reaction could have played a major role in the removal of heavy metals rather then an adsorption effect. The exchangeability of the hydroxyapatite powder of Ca/P molar ratio 1.67, which have specipic surface area of $104.5m^2g^{-1}$, appeared to be better then $237.6{\mu}g$ per g for $Pb^{2+}$ ions. The removal capacity of the heavy metal ions varies directly as particle size of hydroxyapatites. All evidences obtained indicate that the synthesized hydroxyapatite powders by precipitation reaction method can be employed as an effective cation exchanger for eliminating noxious ions in waste water even in some improvemental.

아침형과 저녁형 사람에서 야간의 졸리움, 수행 및 체온의 비교

윤진상,국승희,신일선,신만식,최영,이무석,이형영 大韓睡眠-精神生理學會 1994 수면·정신생리 Vol.1 No.1

Phase I trial and pharmacokinetic study of tanibirumab, a fully human monoclonal antibody to vascular endothelial growth factor receptor 2, in patients with refractory solid tumors

Lee, Su Jin,Lee, Seon Young,Lee, Weon Sup,Yoo, Jin San,Sun, Jong-Mu,Lee, Jeeyun,Park, Se Hoon,Park, Joon Oh,Ahn, Myung-Ju,Lim, Ho Yeong,Kang, Won Ki,Park, Young Suk Springer US 2017 Investigational new drugs Vol.35 No.6

<P><B>Summary</B></P><P><I>Background</I> Tanibirumab is a fully human monoclonal antibody to vascular endothelial growth factor receptor 2 (VEGFR-2). We conducted a first-in-human phase I study of tanibirumab in patients with solid tumors refractory to standard chemotherapy. Primary endpoints were evaluating safety, pharmacokinetics (PKs), estimating maximum-tolerated dose (MTD) and recommended phase II dose (RP2D). <I>Methods</I> We designed our study to escalate tanibirumab at 9 different dose levels with a 3 + 3 method and tanibirumab (1–28 mg/kg) was administered intravenously on D1, 8, 15 in 28-day courses. Dose limiting toxicities (DLTs) were only assessed during the first cycle of treatment and response evaluation was performed every 2 cycles. The effects of tanibirumab on several angiogenic factors were analyzed. <I>Results</I> From October 2011 to September 2013, a total of 26 patients with refractory solid tumors were enrolled. The median age was 58 years (range, 27–75) and 20 patients were male. The most common tumor type was colorectal cancer (<I>N</I> = 19) and seven patients had a history of previous bevacizumab treatment. As hemangioma continued to occur, the final dose level, 28 mg/kg, was not performed. DLTs were not found, and the MTD was confirmed to be 24 mg/kg. Hemangioma was observed in 16 patients (61.5%), but all were grade 1–2 and disappeared after discontinuation of the study drug. Among the 18 patients in the efficacy set, no objective response was observed, but 11 patients showed stable disease. PKs were characterized by dose-dependent linear exposure and the mean trough concentrations exceeded biologically relevant target levels at 12 mg/kg and above. Serum VEGF, soluble VEGFR-2, and PlGF increased at the 4 mg/kg dose level and above. <I>Conclusions</I> Treatment with tanibirumab showed a tolerable toxicity profile and modest clinical efficacy in patients with refractory solid tumors. A phase II trial of tanibirumab is ongoing now.</P><P><B>Electronic supplementary material</B></P><P>The online version of this article (doi:10.1007/s10637-017-0463-y) contains supplementary material, which is available to authorized users.</P>

Integrated design and performance analysis of the KO HCCR TBM for ITER

Lee, Dong Won,Jin, Hyung Gon,Lee, Eo Hwak,Yoon, Jae Sung,Kim, Suk Kwon,Lee, Cheol Woo,Ahn, Mu-Young,Cho, Seungyon Elsevier 2015 Fusion engineering and design Vol.98 No.-

<P><B>Abstract</B></P> <P>To develop tritium breeding technology for a Fusion Reactor, Korea has participated in the Test Blanket Module (TBM) program in ITER. The He Cooled Ceramic Reflector (HCCR) TBM consists of functional components such as First Wall (FW), Breeding Zone (BZ), Side Wall (SW), and Back Manifold (BM) and it was designed based on the separate analyses for each component in 2012. Based on the each component analysis model, the integrated model is prepared and thermal-hydraulic analysis for the HCCR TBM is performed in the present study. The coolant flow distribution from BM and SW to FW and BZ, and resulted structure temperatures are obtained with the integrated model. It is found that the non-uniform flow rate occurs at FW and BZ and it causes excess of the design limit (550°C) at some region. Based on this integrated model, we will perform the design optimization for obtaining uniform flow distribution for satisfying the design requirements.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Integrated analysis is performed with the conventional CFD code (ANSYS-CFX). </LI> <LI> Overall pressure drop and coolant flow scheme are investigated. </LI> <LI> Manifold design is being performed considering flow distribution. </LI> </UL> </P>

한국사람 손바닥문의 생김새

이제만,정민석,정호근,이경종,신동훈,안미선,김도윤,이민석,정구영,정연무,조한범,유상준,박성식 아주대학교 1997 아주의학 Vol.2 No.2

Palm prints have been used for personal identification because they are unique to each individual. Palm prints have also been used for diagnosing genetic disorders and for revealing physical anthropological characteristics, due to their specific appearance characteristic of genetic factors and nationality. Therefore, several analytical methods of palm prints have been developed and applied for the purpose described. However, in the previous reports, the analytical methods of palm prints and the numbers of subjects were insufficient to find Standard values for Korean palm prints. In this study, in order to determine the Standard value for Korean palm prints, we examined palm prints of 3216 Korean adults (2095 males and 1121 females), analyzed the data according to sex and side of hand, and compared with those of foreigners. The results are s follows: 1) The incidence of 7, 9, and 11 of D was 41.8%, 33.5%, and 20.4%, respectively. Comparing the incidences 017, 9, and 11 of D in Koreans with those of foreigners, the Korean belong to the Asians including the Japanese, the Chinese, and the Philippine, however, the Korean was doser to the Blacks and distant from the Whites than the other Asians. 2) The palm prints were classified into the open type in which B terminates at the ulnar border of hand, and the dosed type in which B does not. Open type, 7-5-5 (male 37.6%, female 39.5%) and 9-7-5 (male 23.9%, female 25.5%), was more frequent in female than in male, while dosed type, 11-9-7 (male 9.8%, female 9.1%), was more frequent in male than in female. Also, open type, 7-5-5 (right 28.9%, left 47.6%), was more frequent in left hand than in right hand, while dosed type, 11-9-7 (right 17.1%, left 2.1%), was more frequent in right hand than in left hand. Consequently, open type was more frequent in the weak hand, whereas dosed type was more frequent in strong hand. 3) Because a-b (39.2) and c-d (35.0) were more numerous than b-c (27.8), distance between a and b and between c and d were longer than that between c and d. The long distance of a, b and c, d could be resulted by wide moving range of second finger and fifth finger, respectively. Also, there was a tendency that the palmar ridge counts of right hand was more numerous than those of left hand, which could be resulted by wide moving range of right fingers in the right-handed persons who were more frequent than the left-handed persons. 4) O, in which there was no triradius, and X, in which dermal ridge from a triradius was blocked and terminated at the other dermal ridge, were frequent in C (O 7.8%, × 7.2%) than in D (O 0.1%, × 0.1%) or in B (O 0.4%, X 1.2%). The frequency of 0 and X in C was thought to be related with the location of ein the narrow space between d and b. The narrow space between d and b was known because c-d and b-c was less numerous than a-b. 5) The distances between adjacent triradii were longer in male than in female, however, the palmar ridge counts for a-b, b-c, and c-d were less numerous in male than in female. Consequently, dermal ridges were thought to be thicker in male than in female. The Standard values of Korean palm prints obtained from this study are expected to be used for both diagnosing genetic disorders and for revealing physical anthropological characteristics in Korea. Further studies to clarify the relationship between the palm prints and the power of hand as well as the moving range of fingers are in need.

형광등용 고효율 전자안전기 개발

이무영(Mu Young Lee),이무석(Mu Suk Lee) 영남대학교 정보통신연구소 1996 정보통신연구소논문집 Vol.3 No.1

N/A

특성화고등학교 비장애학생의 장애인식, 장애인권감수성 및 장애수용태도에 관한 연구

이무숙(Mu Suk Lee),정대영(Dae Young Jung) 학습자중심교과교육학회 2020 학습자중심교과교육연구 Vol.20 No.14

본 연구의 목적은 특성화고등학교 비장애학생의 장애인식, 장애인권감수성 및 장애수용태도의 관계와 매개 효과를 알아보는 것이다. 경남 소재 특성화고등학교 7개교의 비장애학생 448명에게 설문지를 배부하였으며, 413부를 본 연구의 자료로 활용하였다. 연구 결과의 해석을 위해 IBM SPSS 25.0을 사용하고, 기술통계분석, 독립표본 T검증, 일원배치 분산분석, 상관분석, 단순회귀 분석, 위계적 회귀분석을 실시하였다. 본 연구의 결과는 다음과 같다. 첫째, 특성화고등학교 비장애학생의 장애인식, 장애인권감수성 및 장애수용태도의 전반적 경향에서 장애인식이 가장 긍정적으로 나타났으며, 장애수용태도, 장애인권감수성 순으로 나타났다. 둘째, 장애인식, 장애인권감수성 및 장애수용태도가 양의 관계, 즉, 서로 정적인 관계에 있으며, 이 세 변인은 서로 정적인 영향을 미치는 것으로 나타났다. 셋째, 장애인식과 장애수용태도 사이에 장애인권감수성이 매개효과가 있는 것으로 나타났다. 본 연구는 장애인식과 장애수용태도에 대한 장애인권감수성의 관계와 매개 역할을 밝혀 장애학생에 대한 인권 침해를 예방하고, 인권친화적인 학교환경을 조성하는데 기초자료를 제공하는데 기초자료를 제공하였다는데 의의가 있다. The objective of this study is to understand the relationships and mediating effects of disability awareness, sensitivity to disability human rights, and disability acceptance attitude targeting the specialized vocational high school students without disabilities. After selecting seven specialzed vocational high schools in gyeongnam were distributed a questionnaire to total 448 students without disabilities, total 413 questionnaires were used for the data of this study. The collected data was analyzed using the IBM SPSS 25.0 for interpreting the results of this study, the descriptive statistical analysis, the independent two samples t-test and one-way ANOVA, the correlation analysis and simple regression analysis, and the hierarchical regression analysis was performed. The results of this study are as follows. First, in the overall trends of disability awareness, sensitivity to disability human rights, and disability acceptance attitude of specializd vocational high school students without disabilities, the disability awareness was the most positive, which was followed by the disability human rights in order. Second, the disability awareness, sensitivity to disability acceptance attitude and the sensitivity to disability human rights, and disability acceptance attitude were in the positive(+) relationships to each other while those three variables had positive effects on each other. Third, the sensitivity to disability human rights had the mediating effects on the relationship between disability awareness and disability acceptance attitude. In the results of this study, the significance of this study is to provide the basic data for preventing the violation of human rights of the students with disabilities and also establishing a human rights-friendly school environment by revealing the relationship and midiating roles of sensitivity to disability human rights in the relationship between disability awareness and disability acceptance attitude.

보문 : 포장방법 및 수분 함량이 곶감의 상온 장기 저장에 미치는 영향

이무호(Mu Ho Lee),이숙희(Suk Hee Lee),박선도(Seon Do Park),최부술(Boo Sull Choi) 한국식품저장유통학회(구 한국농산물저장유통학회) 1995 한국식품저장유통학회지 Vol.2 No.2