외상 후 뇌 지방색전증 1예

문정미,소정일,김용권,류진호,허탁,서정진,민용일 대한응급의학회 2001 대한응급의학회지 Vol.12 No.2

Post-traumatic fat embolism was first reported by Zenker in 1862, Von Bergmann reported the first clinical diagnosis of the fat embolism syndrome in 1873. Fat embolism has been associated with traumatic or non-traumatic disorders. Fat embolization after long bone trauma is probably common as a subclinical event. The diagnosis of fat embolism syndrome is based on the patient's history, is supported by clinical signs of pulmonary, cerebral, and cutaneous dysfunction, and is confirmed by the demonstration of arterial hypoxemia in the abscence of other disorders. Two different mechanisms cause fat to embolize: direct entry of deposit fat into the blood stream and agglutination of endogenous or exogenous plasma fat. MRI can detect a cerebral fat embolism with a higher sensitivity than cerebral CT. We report a case of post-traumatic cerebral fat embolism without pulmonary involvement, and we present a review of the literature. A 16-year girl had a traffic accident and pelvic bone fracture. Forty eight hours later severe trauma become stuporous without a focal neurological deficit. The patient received supportive therapy, and her condition improved throughout her hospital course. She was discharged with good condition after a 30-day hospital stay.

溫州蜜柑 夏·秋枝의 發生 및 生長에 미치는 c-MH의 效果

文斗吉,許英珍,韓海龍 濟州大學校 亞熱帶農業硏究所 1986 亞熱帶農業硏究 Vol.3 No.-

溫州蜜柑(Citrus unshiu)에 있어서 夏·秋枝 發生의 化學的 抑制 方法을 探索하는 一環으로 c-MH(maleic hydrazide의 choline鹽)의 利用可能性을 檢討한 結果를 要約하면 다음과 같다. 1. 橋本早生 幼木을 供試하여 6月 中旬부터 9月 初旬에 걸쳐 時期 및 濃度別로 1回 處理한 c-MH의 效果는; 1) 夏枝의 生長은 遲延되었으나 頂芽優勢現象이 없어져 新稍發生數는 오히려 增加되었으며 가지별 生長 특히 잎의 生長이 抑制되었고 심한 경우에는 쐐기 모양의 奇形葉이 出現되었다. 2) c-MH 處理에 依한 夏枝의 生長抑制 效果는 7月 處理區에서 그리고 250ppm 以上의 濃度에서 觀察되었다. 3) 秋枝發生은 1,000ppm 以上의 濃度 1回 處理로 充分히 抑制되었다. 2. 興津早生 結實樹에서 8月 下旬에 이미 發生된 夏枝를 除去한 後 2,000ppm을 1∼2回 處理한 結果; 1) 無處理區는 除去後 얼마 안있어 新梢가 많이 發生되었으나 處理區는 많은 눈이 形成되었지만 가지의 生長은 볼 수 없었다. 2) 處理 當年度 果實은 c-MH 處理에 의해 果汁의 糖度가 增加되었고 酸含量은 減少되는 傾向을 보였다. 3) 2回 處理區는 翌年의 春枝發生이 遲延되었을 뿐만 아니라 發育이 심히 抑制된 가지에서 쐐기모양의 奇形葉이 叢生하였다. 4) 그러나 顯微鏡으로 觀察한 잎의 橫斷面 細胞의 크기는 奇形葉과 正常葉 사이에 差異가 없었다. 5) 處理 다음 해에는 開花時期가 遲連되었고 着花數도 減少되었다. 6) 2回 處理區의 翌年度 果實은 發育이 抑制되었고 果梗部가 突出하였으며 果皮가 두껍고, 거칠은 奇形果의 發生이 많았다. 그러나 1回 處理區는 無處理區와 같았다. 3. 米澤溫州와 宮川早生의 結實樹를 供試하여 7月 下旬부터 10日 間隔으로 500PPM의 C-MH를 2∼3回 그리고 8月 下旬 1,000ppm 1回 處理로 夏·秋枝 發生을 充分히 抑制할 수 있었다. 果實의 發育과 果汁 成分에 미치는 c-MH의 效果는 試驗年度와 供試品種 에 따라 달랐다. The chemical control of summer and autumn shoots in Satsuma mandarin (Citrus unshiu) was examined using the foliar application of the choline salt of maleic hydrazide(c-MH). The results obtained are summarized as follows: 1. The effects of the concentrations and the dates of application were investigated in two-year old tress of 'Hashimoto Early'. 1) While the occurrence of summer shoot was delayed by c-MH, many buds were stimulated to grow afterwards. The growth of individual shoots, especially leaves, was conspicuously retarded. 2) The growth of summer shoot was affected by the application of 250ppm or higher in July. 3) The occurrence of autumn shoot was completely inhibited by an application of 1,000ppm or higher in late August. 2. Fruiting trees of 'Okitsu Early' were sprayed once or twice with 2,000ppm c-MH in late August after artificial removal of summer-shoots. 1) Regrowth of new buds in the current season was totally restricted by c-MH. 2) Juice Brix of the fruit in the current season seemed to be increased by c-MH, while acid content decreased. 3) Double sprays of 2,000ppm resulted in the delayed sprouting and the rosette-type shoots with underdeveloped wedge-shaped leaves in the following spring. 4) No differences in cell size were recognized under an optical microscope between the normal and the underdeveloped leaves. 5) Flowering was also delayed and the number of flowers was reduced by c-MH. 6) Abnormal fruits with protruded stem-end and thickened rough peel resulted from the double sprays of 2,000ppm in the end of the previous growing season, but not from the single spray. 3. It was demonstrated in fruiting trees of 'Miyagawa Early' and 'Yonesawa' Satsuma mandarin that the occurrence of summer flush could be inhibited by 2∼3 sprays of 500ppm c-MH during the period from late July to mid August and that of autumn flush by a spray of 1,000ppm in late August. The effects of c-MH on the fruit development and juice quality varied with years and orchards.

마우스 골수 소핵 시험에 의한 디젤분진, HgCl_(2) 및 Pb(Ac)_2의 유전독성효과

허문영,최성규,유기선,손동헌 江原大學校 附設 環境硏究所 1989 環境硏究 Vol.6 No.-

The clastogenic effects of the diesel emission particle extrace(DEPE), mercuric chloride and lead acetate were examined by the mouse bone marrow micronucleus test. DEPE had a potent clastogenic effect by intraperitoneal injection with dose-response between 100 and 300mg/kg b.w.. Mercuric chloride and lead acetate also gave a clastogenic effects but mercuric chloride only had a dose-response between 1 and 3mg/kg b.w.. When DEPE was administrated with mercuric shloride or lead acetate, the frequency of micronucleated cells was slight but not significant incresase in comparision to a single treatment with DEPE alone.

제주 차귀도 연안해역 미생물 분포 및 이화학적 특성

문영건,김만철,이준백,송춘복,여인규,김종만,박근태,손홍주,최우봉,허문수 한국환경과학회 2006 한국환경과학회지 Vol.15 No.3

방사선 조사가 배양된 조골세포의 apoptosis와 세포주기의 변화 및 석회화 결절 형성에 미치는 영향에 관한 연구

이영미,최항문,허민석,이삼선,최순철,박태원 대한구강악안면방사선학회 2000 Imaging Science in Dentistry Vol.30 No.3

Purpose : The study was aimed to detect the induction of apoptosis, cell cycle arrest and calcified nodule formation after irradiation on primarily cultured osteoblasts. Materials and Methods : Using rat calvarial osteoblasts, the effects of irradiation on apoptosis, cell cycle arrest, and calcified nodule formation were studied. The single irradiation of 10 and 20 Gy was done with 5.38 Gy/min dose rate using the 137Cs cell irradiator at 4th and 14th day of culture. Apoptosis induction and cell cycle arrest were assayed by the flowcytomtry at 1,2,3, and 4 days after irradiation. The formation of calcified nodules was observed by alizarin red staining at 1,3,10,14 days after irradiation at 4th day of culture, and at 1,4,5 days after irradiation at 14th day of culture. Results : Apoptosis was not induced by 10 or 20 Gy independent of irradiation and culture period. Irradiation did not induced Gl arrest in post-irradiated ostedblasts. After irradiation at 4th-day of culture, G2 arrest was induced but it was not statistically significant after irradiation at 14th-day of culture. In the case of irradiated cells at 4th day of culture, calcified nodules were not formed and at 14th-day of culture after irradiation, calcified nodule formation did not affected. Conclusion : Taken together, these results suggest that Irradiation at the dose of 10-20 Gy would not affect apoptosis induction of osteoblasts. Cell cycle and calcified nodule formation were influenced by the level of differentiation of osteblasts. (Korean J Oral Maxillofac Radiol 2000; 30: 189-198)

연속식 오존처리공정을 이용한 낙동강 상수원수의 정수처리 효과

임영성,강관호,이홍재,서동철,박문수,허종수,조주식 한국환경농학회 2002 한국환경농학회지 Vol.21 No.3

낙동강 상수원수를 대상으로 연속적 오존처리에서 오존주업농도에 따른 유기물 분해 특성을 조사하기 위하여 오존처리에 의한 DOC성분변화, UV254/DOC의 변화와 소비오존에 따른 DOC 제거효율을 조사한 결과는 다음과 같다. 유입원수의 수질변화에 따라 다소 차이는 있었으나 전반적으로 오존주입농도가 증가할수록 DOC 처리효율도 증가되었다. 오존처리에 따른 DOC 성분변화는 전오존을 3 mg/L농도로 처리시 TDOC, ADOC, A&BDOC 및 NRDOC는 각각0.6, 0.2, 0.1 및 1.0 mg/L 정도 오존처리에 의하여 감소되었으나 BDOC는 0.8 mg/L 증가하였다. UV254/DOC의 분율은 오존주입농도를 1, 3 및 5 mg/L 처리하였을 때 전오존의 경우는 각각 0.048, 0.044 및 0.037 이였고, 후오존의 경우는 각각 0.018, 0.015 및 0.012로 나타나 오존주입농도가 증가할수록 감소하는 경향을 보였다. 초기 DOC mg당 소비되는 오존량에 대한 DOC 제거율은 전오존과 후오존처리의 초기 DOC에 대한 소비오존량이 각각 약 1.5와 2.3일 때 각자 25%와 32%로서 최대의 DOC 처리효율을 나타내었다. 낙동강 상수원수에 전오존을 처리할 경우 오존주입량은 초기 DOC mg당 소비된 오존이 1.5 mg 이내의 농도가 되도록 주입하고, 후오존은 유입수인 모래여과수의 초기 DOC mg당 소비된 오존이 2.3 mg이내의 농도가 되도록 조절하여 주입하면 적당할 것으로 생각되었다. This study was carried out to evaluate the pollutant removal efficiencies of the advanced drinking water treatment using ozonation process. For raw water. Nakdong River was used. By conducting continuous ozonation experiments, the following results were obtained. Efficiency of water treatment was enhanced with increase in ozone dosage. When ozone dosage of 3 mg/L was used, preozonation of raw water reduced TDOC, ADOC, A&BDOC and NRDOC as much as 0.6 mg/L, 0.2 mg/L, 0.1 mg/L and 1.0 mg/L, respectively. On the other hand, content of BDOC Increased at the level of 0.8 mg/L. Ratio of UV254 absorbance to DOC content by the preozonation with 1, 3 and 5 mg/L dosage were 0.048, 0.044 and 0.037, respectively. In case of postozonation, it were 0.018, 0.015 and 0.012, respectively. When the ratios of consumpted ozone content to 1 mg of initial DOC were 1.5 and 2.3 in preozonation and postozonation treatment, respectively, the highest DOC removal rates of 25% and 32% were obtained by the continuous ozonation.

관상동맥내 스텐트 삽입후 발생한 관상동맥류 2례

제인수,허민영,문치숙,이재호,정수룡,조길현,이영민,김대경,김두일,김동수 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.3

Coronary artery aneurysms are detected with increasing frequency because of the routine use of coronary angiography in the diagnosis and management of coronary artery disease. Although some coronary artery aneurysms are congenital or inflammatory, most are atherosclerotic. The prognosis of atherosclerotic coronary artery aneurysm may depend on the morphology of the aneurysm or the presence of coexisting obstructive disease. Coronary artery aneurysms have been also reported to occur after ballon angioplasty, directional athrectomy, laser angioplasty, and stent implantation with a frequency of 2% to 4%. The long-term outcome of post-intervention coronary artery aneurysm is unknown. We report two cases of the development of a coronary aneurysm 6 months after stent implantation as a treatment of severe obsructive coronary artery disease.

활성화 항원 CD30의 발현과 그 기능

조경신,허영문,남상윤 전주대학교 1999 論文集 Vol.24 No.2

CD30 is a member of the tumour necrosis factor receptor(TNFR) superfamily, and was originally recognized on Reed-Sternberg cells of Hodgkin's disease and, subsequently, on neoplastic cells of non-Hodgkin's disease and normal activated T, B, NK cells and macrophages. Several studies on CD30 expression of malignant cells suggest that CD30 may define relevant subgroups within the main tumor or lymphoma categories. Despite many controversial reports, it is noteworthy that CD30 is expressed solely on Th2 cells but not on Th1 cells after complete differentiation, because, so far, any specific markers of Thl or Th2 cells have not been demonstrated. Expression and its maintenance of CD30 is also dependent upon IL 4 which is a pivotal cytokine for Th2 differentiation and downregulated by FNv, a Thl type cytokine. These observations implicate that CD30 may regulate Th2 cell differentiation or proliferation. At the clonal level, CD30 was revealed to promote Th2 differentiation. Various functions of CD30 from in vitro studies have been described: induction of cell proliferation, apoptosis and cytokine production, inhibition of cell cytotoxicity, enhancement of B cell growth and Ig secretion, induction of NF-KB activation and induction of HIV expression in chronically infected T cells. Although the function of CD30 in vivo is largely unknown, several exciting findings are emerging from recent studies. Mice deficient in CD30 showed a mild impairment in thymic negative selection. Recently, it has been suggested that CD30 protects the body from autoimmunity by limiting the proliferative potential of autoreactive cytotoxic T cells. Taken together, CD30 studies may provide important knowledge for elucidation of the immunopathogenesis of and development of therapeutic regimen of AIDS, autoimmunity and other Th2-related diseases.

통풍성 관절염의 임상적 고찰

윤채중,정승문,김영학,김동규,허광식,김태원,배학연,정종훈,이승일,김평남 朝鮮大學校 附設 醫學硏究所 1997 The Medical Journal of Chosun University Vol.22 No.2

통풍은 Purine 대사의 이상으로 발생하는 질환으로, 고뇨산혈증인 사람의 전부가 통풍으로 발현되지 않고 증상의 출현 양상이 다양하여 진단과 치료에 주의가 필요하며, 조기에 적절한 조치를 한다면 충분히 조절이 가능한 질환이다. 본대학 내과학교실에서는 통풍으로 치료한 32명의 환자에서 임상양상, 병력과 검사소견을 분석하여 다음과 같음 결과를 얻었다. 1. 32명 모두 남자이며, 최초 발병 시기는 24세에서 72세로 평균 43.8±11.9세이었으며, 30대에서 40대까지가 19명(59.4%)으로 대부분을 차지하였다. 내원 당시 나이는 27세에서 75세까지로 평균 52.3±10.4세였으며, 내원시 까지 평균 유병기간은 8.5±6.8년으로 나타났다. 2. 동반 질환으로는 고지혈증 12례, 신장질환 10례, 고혈압 12례, 비만 8례, 당뇨 2례 등이었다. 3. 이환된 관절은 단관절 침범이 19례(59.4%), 다관절 침범이 13례 이었으며, 최초 이한된 관절은 족무지 중족골지골 관절로 19례(59.4%)로 가장 많았고, 통풍 결절은 20례(62.5%)에서 관찰되었으며, 유병기간이 10년 이상된 12례중 11례 (91.7%)에서 결절이 관찰되었다. 4. 평균 혈중 요산치는 9.17±1.75 ㎎/dl이었으며, 8.0 ㎎/dl에서 9.9 ㎎/dl 사이가 19명으로 전체의 59.4%를 차지하였다. Objective: The gout is a heterogeneous group of diseases resulting from tissue deposition of monosodium urate or uric acid crystals from extracellular fluids supersaturated with respect to this end product of human purine metabolism. The clinical manifestations are such as hyperuricemia, gouty arthritis, gouty nephropathy, uric acid nephrolithiasis. We analyze of clinical manifestations and associated factors in gout. Method: We have reviewed the medical records, radiologic findings and clinical results of thirty-two patients admitted at our department from April 1996 to July 1997. Result: 1) All patients were male. The mean age at initial attack was 43.8 years old, ranging from 24 to 72 years old. 2) The mean level of serum uric acid was 9.17mg/dl on admission. 3) The first metatarsopharyngeal joint was involved in 19 cases (59.4%). Tophus was observed in 20 cases (62.5%). 4) Hyperuricemia was associated with hypertension, obesity, nephrolithiasis and hyperlipidemia.

6-(3,4-디클로로페닐)아미노-7-클로로-5,8-퀴놀린디온의 항진균작용 및 안전성 평가

윤여표,김동현,이병무,허문영,정해문,강혜영,최정아,김도희,유충규 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1

6-(3.4-Dichlorophenyl)amino-7-chloro-5.8-quinolinedione (RCK50) was tested for antifungal activities in mice systemically infected with Candida albicans. The therapeutic potential of RCK50 was also assessed in comparison with ketoconazole. RCK50 had ED_50 0.22±0.01 ㎎/㎏. Ketoconazole as a positive control had ED_50 6.00±1.70 ㎎/㎏. Intraperitoneally administered RCK50 at the ED_50 for 7 days and 14 days reduced Candida albicans colony count in the kidneys and liver. And administered RCK50 at the ED_50 for 14 days improved survival rates. The genotoxicities of RCK50 had been evaluated. RCK50 was negative in Ames test with Salmonella typhimurium and chromosomal aberration test in CHL cells. RCK50 did not show any clastogenic effect in mouse peripheral blood and was negative in mouse micronucleus assay. These results indicate that RCK50 has no genotoxic potential under these experimental conditions. Acute oral toxicity studies of RCK50 were carried out in ICR mice of both sexes. RCK50 did not show acute oral toxicities and LD_50 values were over 2.850 ㎎/㎏ in ICR mice.