응급실에 내원한 환자에서 어지럼증의 원인과 임상양상의 분석

문원식,정경운,위준선,문정미,전병조,김용권,소정일,류진호,허탁,민용일 대한응급의학회 2001 대한응급의학회지 Vol.12 No.3

Background: Recently, The number of patients who have been complaining of the vertigo or dizziness has been increasing due to rapid growth of elderly population and senile disease. The differentiation of dizzy patients is not familiar to most emergency physicians. This study was designed to differentiate true vertigo and to investigate the clinical difference among central vertigo, peripheral vertigo, and other causes of dizziness. Methods: The authors analyzed the cases of 237 dizzy patients who visited the emergency department of Chonnam University Hospital during the recent 2 years. For the base of dizziness, associated past illnesses, severity, nystagmus type, and the causes of central and peripheral vertigo. Results: Female patients were 142(59.9%) and male patients were 95(40.1%). The most common age group was the 6th decade. The origin of dizziness was classified as peripheral cause(25.3%), central cause(32.9%), and others(41.8%). As to nature of the dizziness, the rotatory sense was dominant in peripheral vertigo and the floating sense and blurred vision in central vertigo. Peripheral vertigo was triggered by position change of head and body, and central vertigo by the eye movement. Audiograms I showed that most patients with central vertigo had normal hearing, but 46.7% of thoswith peripheral vertigo had an abnormal hearing disturbance. Nystagmus was more prevalent in peripheral vertigo Conclusion: History taking and physical examination played an important role in the diagnosis of dizzy patients. An important part of the diagnosis of a dizzy patient could be to evaluate the peripheral origin, the central origin and others causes. Because central vertigo may be associated with a significant neurological pathology, spectral radiological studies, including MRI and CT, are mandatory to rule out a devastating brain lesion.

모체 Thyroxine 투여가 태아알코올효과를 가진 흰쥐 대뇌겉질 및 해마에서 NPY함유 신경세포의 생후 발달에 미치는 영향

김복,박상기,박영란,김종중,문정석,김주수,문영민,현영식,천관영,정윤영 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.2

Background and Objectives: Maternal alcohol abuse is considered to be one of the most prominent cause of neurobiological malformations in the postnatal and adult life of the offspring. In this study, we investigated the effects of maternal alcohol drinking on the postnatal development of NPY-containing neuron, and, the influence of thyroxine treatment on the cerebral cortex and hippocampus of pups of alcohol abused mother. Materials and Method: Time-pregnant rats were divided into three groups. Alcohol-fed group A received 35 calories of liquid alcohol diet daily from gestation day 6; control pair-fed group B was fed a liquid diet in dextrin replaced alcohol isocalorically: alcohol + T4 group C received 35 calories liquid alcohol diet and exogenous thyroxine subcutaneously. Results: Group C showed prominent NPY immunoreactivity in the cerebral cortex compared to group A and B at P7. In group C, NPY-containing neurons were widely distributed in the all layers of cerebral cortex after P14. Besides, numerical decrease of NPY-containing neuron as age increases was not found in group C. However, the decrease of NPY-containing neuron was clearly observed in group A compared to group C after P14. In hippocampus, group Band C were appeared similar patterns after P7. Additionally, in group C, NPY immunoreactivity was prominently appeared in CA2 and CA3 at P14 as compared to group B. Conclusions: The present results showed the increase of intensity and number of NPY-containing neurons in cerebral cortex and hippocampus of pups of exogenous T₄ supplemented alcohol-exposed dams as compared to control pair-fed and alcohol-exposed pups at P7. It presumably suggest that NPY-containing neurons might be regulated by the early postnatal growth stimulatory effect of the exogenously supplemented T₄. Therefore, the increase of NPY synthesis caused by maternal administration of exogenous thyroxine may ameliorate fetal alcohol effect, one of the ill effects as a result of the dysthyroid state following maternal alcohol abuse.

외상 후 뇌 지방색전증 1예

문정미,소정일,김용권,류진호,허탁,서정진,민용일 대한응급의학회 2001 대한응급의학회지 Vol.12 No.2

Post-traumatic fat embolism was first reported by Zenker in 1862, Von Bergmann reported the first clinical diagnosis of the fat embolism syndrome in 1873. Fat embolism has been associated with traumatic or non-traumatic disorders. Fat embolization after long bone trauma is probably common as a subclinical event. The diagnosis of fat embolism syndrome is based on the patient's history, is supported by clinical signs of pulmonary, cerebral, and cutaneous dysfunction, and is confirmed by the demonstration of arterial hypoxemia in the abscence of other disorders. Two different mechanisms cause fat to embolize: direct entry of deposit fat into the blood stream and agglutination of endogenous or exogenous plasma fat. MRI can detect a cerebral fat embolism with a higher sensitivity than cerebral CT. We report a case of post-traumatic cerebral fat embolism without pulmonary involvement, and we present a review of the literature. A 16-year girl had a traffic accident and pelvic bone fracture. Forty eight hours later severe trauma become stuporous without a focal neurological deficit. The patient received supportive therapy, and her condition improved throughout her hospital course. She was discharged with good condition after a 30-day hospital stay.

항정신병약물을 처음으로 사용하는 초발 정신증 환자에서 나타나는 체중 및 대사성 지표의 변화 : 후향적 연구

김우진,심주철,공보금,강제욱,문정준,김정은,김민걸,박민경,김성진,김현정,정도운 대한생물치료정신의학회 2011 생물치료정신의학 Vol.17 No.2

Objectives:This study was to identify weight & metabolic changes in first-episode psychotic patients with antipsychotics use and investigate the differences of weight & metabolic changes between first-episode psychotic patients and controls with antipsychotics use. Method:In this retrospective study, twenty eight first-episode psychotic patients and twenty eight controls with schizophrenia, schizoaffective or bipolar disorder defined by DSM-IV criteria were included. Information about demographic and clinical characteristics of the subjects was gathered from the medical records. Also body weight, sBP, dBP, fasting glucose, lipid profile and WBC count were evaluated before and after antipsychotics use. Rogistic regression was conducted to assess factors associated with weight gain. Results:First-episode psychotic patients showed more weight and BMI changes than controls after antipsychotics use, and these changes continue over 12 months. On the other hand, there were no significant factors associated with weight gain. Conclusion:The results of present study suggest that antispychotics is one of the major causes inducing weight gain of psychotic patients and antipsychotics-induced weight gain is more vulnerable to drug-naive first-episode psychotic patients.

SH 파의 균열 산란장 해석 : 근사혜와 엄밀혜의 비교 Comparisons of Approximate and Exact Solutions

정현조,박문철,송성진,Schmerr, Jr., L. W 한국비파괴검사학회 2004 한국비파괴검사학회지 Vol.24 No.4

SH파의 균열 산란장 해석을 위하여 먼저 균열개구변위(COD)를 미지수로 하는 경제적분방정식(BIE)을 수립하였다. 폭 2a의 고립된 2차원 균열(slit)에 임의의 각도로 입사하는 시간조화 평면파에 대하여 COD를 주파수 ka의 함수로 구하였으며, 다른 연구 결과와 잘 일치함을 확인하였다. 초음파 비파괴평가에서 중요한 변수로 취급되는 원거리 산란음장을 두 가지 방법으로 구하였다. 펄스-에코 모드에서 Kirchhoff 근사법과 BIE-COD에 기초한 엄밀해의 결과를 입사각도와 주파수의 함수로 계산하고 서로 비교하였다. SH파가 균열면에 수직으로 입사/반사한 경우 산란음장은 최대가 되고, 두 방법은 정확히 일치하였다. 수직입사에서 멀어질수록 산란진폭은 모두 급격히 감소하며, Kirchhoff 근사법은 엄밀해와 차이를 보였다. 시간 영역의 원거리 산란진폭 거동을 구하기 위하여 대역폭을 갖는 중심주파수 10MHz를 곱하고, 퓨리에 역변환으로 시간영역 신호를 계산하였다. 경사 입사시에 시간영역의 진폭은 좌우 균열 선단에 의해 분리되며, 두 신호 사이의 시간 간격은 균열의 크기와 관련된다. 엄밀해와 비교할 때 Kirchhoff 근사법은 정확한 시간 간격을 제공하나, 동일한 크기의 균열 선단 신호를 제공하는 부정확함이 있다. This paper describes a crack scattering model for SH wave based on the boundary integral equation (BIE) method, where the fundamental unknown is crack opening displacement (COD). When a time harmonic plane wave was incident on a 2-D isolated crack (slit) of width 2a, the COD distributions were numerically calculated as a function of ka. The calculated COD agreed well with results obtained with other methods. The far-field scattering amplitude, which completely characterizes the flaw response, was calculated in two ways. The Kirchhoff approximation and the BIE-COD exact formulation were compared in terms of incidence angle and frequency ka in a pulse-echo mode. Maximum response was obtained for both methods at the specular reflection direction. Away from the specular direction, the Kirchhoff approximation becomes less accurate. The time domain crack response was also calculated using a band-limited spectrum of center frequency 10MHz. At oblique incidence to the crack both methods show the existence of an antisymmetric flash points occurring from the crack edge. The Kirchhoff approximation provides an exact time interval between flash points, although it unrealistically gives the same amplitude.

배회성 거미(Pardosa astrigera) 주안과 부안의 미세구조적 분석

정문진,임도선,문명진 韓國電子顯微鏡學會 2000 Applied microscopy Vol.30 No.1

배회성거미안 별늑대거미의 4쌍의 단안은 앞이마 부분 1열에 전중안, 전측안, 2열에 후중안, 그리고 두흉부의 3열에는 후측안이 각각 1쌍씩 위치하고 있었다. 전중안의 망막을 구성하는 시세포는 두 개의 신경돌기를 가진 전형적인 이극성 신경세포였으며, 나머지 단안인 전측안, 후중안, 후측안은 단극성 신경세포임이 확인되었다. 후중안과 후측안의 감간은 시세포 원형질막의 일부가 미세융모로 변형된 감간체로 되어 었였으며, 망막을 구성하는 시세포들은 하나의 감간 주위에 규칙적으로 색소세포 돌기가 분포하고 있었으나, 전중안과 전측안의 망막내에는 불규칙적으로 시세포와 색소세포들이 분포 하고 있었다. 반사층은 시세포의 감간과 intermediate segment 사이에서 위치하는 불연속적인 구조이며, 주안인 전중안을 제외한 나머지 눈에서 관찰되었다. 전중안과 전측안이 그리고 후중안과 후측안의 크기가 각각 비슷하였으며, 단안을 구성하는 각 구성물의 크기는 각막이 4쌍의 눈에서 모두 비슷하였고, 렌즈, 세포체, 감간은 전중안과 전측안, 후중안과 후측안이 각각 비슷하였으며, 초자체는 후중안이 가장 크고 이어서, 후측안, 전중안, 전측안의 순으로 관찰되었다. The wandering spider, Pardosa astrigera, had four pairs of ocelli that arranged in three rows on the cephalothorax. Along the anterior margin lay a pair of small anterior median (AM) eye flanked on each side by anterior lateral (AL) eye. Two large posterior median (PM) eye was situated on the clypeus behind the anterior row and still more posteriorly was a pair of posterior lateral (PL) eye. The visual cell of retina consisted of cell body, rhabdome, and intermediate segment. Bipolar neuron was found in anterior median eye (principal eye) and unipolar neuron in others (secondary eye). Rhabdome showed that arranged in PMeye and PLeye. But rhabdomes of AMeye and ALeye were irregular in retina. Except AMeye incontinuous tapetum found in ALeye, PMeye, PLeye. Anterior median eye was similar to anterior lateral eye in length and posterior median eye similar to posterior lateral eye. Component size of eye were similar to 4 pairs eye in cornea. Size of lens, cell body, and rhabdome was similar not only anterior median eye and anterior lateral eye but also posterior median eye and posterior lateral eye. Vitreous body was large posterior median eye than others.

淸末 新小說의 敍事構造 硏究

文丁振 중국어문연구회 2001 中國語文論叢 Vol.20 No.-

晩淸時期, 上海的租界是現代城市的縮影. 人們在租界中看到的不是單一的技術世界, 而是全面的立體的新世界. 隨着近代性商業都市的相繼出現, 報刊事業興起. 報刊雜誌發行範圍之廣, 時效之速, 關注者之多的特點, 吸引了一代小說家. 爲了適應報刊雜誌登載的需要, 小說家便自覺地改變了傳統的創作方法, 從而使作品出現了逈異此前小說的新特點. 値得主意的是本文的硏究對象作品都是由幾種統一原則所組織的. 有的作品用第一人稱敍述者的見聞錄形式敍述故事, 給予讀者更大的眞實感. 此時作家雖然基本上持以第一人稱爲中心的敍述形態, 不過在別人所講的故事部分, 而改用第三人稱. 第一稱的敍述者不僅與作家有關聯性, 而且具有以仲介者資格的個別性價値. 有的作品沒有甚마激動人心的故事, 不注重于情節的曲折, 更多地着眼于場景的描寫, 實況的再現, 心理的刻畵. 作家眞實地再現了當代人物和心態. 有的作品裏, 結構的關鍵是人物或者事件. 無論나種原則, 這裏重要的就是在小說中增强사的主觀性和個別性所內在的時空觀念. 作者的風格是多樣化和個性化. 最終支配新小說作品的結構不是傳統的美學, 而是作者的選擇. 所以新小說表現了結構多樣化的特點, 旣有繼承此前小說結構方式的, 又有模倣西方小說結構的, 而更多的是兼收幷蓄中西小說結構藝術的作品.

뇌졸중후 우울증

문석우,서정석,남범우,최진영 건국대학교 의과학연구소 2004 건국의과학학술지 Vol.14 No.-

In recent years, depression is most commonly reported psychiatric condition after stroke, poststroke depression(PSD) has attracted world-wide interest. This review focuses on the major research themes that have emerged. Pooled data from studies, have wide variation in results is due to different criteria for patient selection, different evaluation methods, diagnostic criteria and poststroke intervals, conducted throughout the world have found prevalence rates for from 18% to 65%. The diagnosis of PSD is most appropriately based on a structured mental state exam and DSM-N criteria for depression due to stroke with major depressive-like episode or depressive features. Rarely, poststroke patients may also develop bipolar mood disorder. The treatment of PSD, single antidepressant showing efficacy and electroconvulsive theraphy(ECT) and behavioral therapies have also effective. The progression of recovery following stroke can be altered by treating depression, which has been shown to improve recovery in activities of daily living(ADL) and cognitive impairment and to decreased mortality. The mechanisms underlying the association of stroke and mood disorder are important areas for future investigation.

비병원성 야생효모로부터 알칼리성 단백질분해효소 생산

문정수, 박경서, 공유리, 김수진, 이종수 배재대학교 자연과학연구소 2022 自然科學論文集 Vol.33 No.1

초음파 이송시스템의 진행파 제어에 관한 연구

정상화,신상문,김태호,서호진,박진완 朝鮮大學校 機械技術硏究所 2007 機械技術硏究 Vol.10 No.1

Methods of major transport system used in many industry fields are conveyor belt, magnetic levitation system and indexing system. It is an indispensable device in many fields and especially it is very important in the factory automation. However, the conventional transport system can damage precision optical components by the contact force and destroy the inner structure of semiconductor by the magnetic field. The new transport system for transporting without damage is required and the ultrasonic wave transport system has been proposed to replace the conventional transport system. In this paper. the object transport system using the ultrasonic wave is developed. Traveling waves are generated through the use of the ultrasonic wave generator to two ends of the beam. The modelling equation on steady state response of ultrasonic vibration is expressed through normal mode expansion. Natural frequency of flexural beam is estimated. Transport direction of the object is analyzed according to phase difference and frequency. In addition, it is verified by experiment.