저장 온도 및 상대습도가 비타민 정제 중 지용성 비타민 함량의 변화에 미치는 영향

김동섭,이재황,김세곤,이동언,박석준,이진희,이강표,최성원,백무열 경희대학교식량자원개발연구소 2007 硏究論文集 Vol.26 No.1

당뇨병과 동반된 화농성 간농양의 임상상 및 예후인자

오은숙,강무일,이원영,오기원,임동준,이소영,이정민,고승현,김성래,안유배,손현식,윤건호,차봉연,이광우,손호영,강성구 대한당뇨병학회 2000 임상당뇨병 Vol.1 No.1

연구배경: 감염질환은 혈관질환과 함께 당뇨병의 중요한 사망원인의 하나이며, 혈당조절이 불량할수록 감염 빈도가 증가됨은 잘 알려져 있다. 간농양의 발생이 있어서도 당뇨병은 중요한 기저질환 중의 하나이다. 일반적으로 간농양의 가장 흔한 원인균은 Escherichi coli라고 알려져 있으나, 최근 당뇨병을 가진 간농양 환자에서 Klesiella pneumoniae의 검출이 증가되고 있다. 또 최근 연구에 의하면 K.pneumonie가 간농양의 가장 흔한 원인균이며, K. pneumoniae에 의한 간농양은 K.pneumoniae 이외의 균주에 의한 간농양보다 당뇨병과 밀접히 관련되어 있다고 보고된 바 있다. 이에 저자들은 간농양 환자를 대상으로 당뇨병환자의 빈도를 알아보고, 그 원인균 및 특징을 비당뇨병 환자들의 경우와 비교해 보고자 하였다. 방법: 1992년 1월부터 1999년 6월까지 방사선학적 검사 혹은 수술에 의해 간농양이 확인되거나, 경피적 천자나 수술을 통한 배농액 배양, 혹은 혈액 검사에서 원인균이 증명된 182명의 환자를 대상으로 후향적 임상고찰을 실시하였다. 결과: 화농성 농양을 가진 167명의 환자(남:94명, 여:73명)중 당뇨병을 가진 환자는 54명 (남:30명, 여:24명)으로 32.3%를 차지하였다. 환자의 평균나이는 당뇨군에서 62.1 ± 13.4세, 비당뇨군에서는 55.1 ±15.5세로 당뇨군에서 높았으며(p=0.0021), 남녀간의 평균나이 비교 시 두 군 모두 여성의 나이가 의미있게 높았다. 비당뇨군에 비하여 당뇨군의 경우 저알부민혈증의 빈도와 aspartate transaminase가 증가되어있었다. 원인균주는 K. pneumoniae (당뇨군54%, 비당뇨군 39.1%), E. coli(당뇨군 17.5%, 비당뇨군 18.8%), Pseudomonas aeruginosa, Streptococcus viridans, Enterococcus 순이었으며 두 군간의 의미는 차이는 없었으나 K. pneumoniae의 경우 다른 균종에 비해 단독감염의 빈도가 높았다(82.8%). 사망률은 당뇨군에서 16.7%, 비당뇨군에서 7.1%로 당뇨군에서 의미있게 높았으며(p=0.019), 당뇨군에서의 사망환자는 모두 패혈증이 동반되어 있었다. 당뇨환자의 사망군은 생존군에 비해 당뇨병 이환기간이 길고 혼합감염의 빈도가 높았다(p=0.046). 검사실 소견에서는 총 빌리루빈 및 알카리성 포스파타제의 증가가 관찰되어 있었다. 결론: E. coli가 간농양의 주된 원인균이라는 기존 보고와는 달리 당뇨군과 비당뇨군 모두 K. pneumoniae가 간농양의 주된 원인균이었다. 또한 당뇨 유병기간이 길고 당뇨조절이 불량한 환자에서 혼합감염이며 총 빌리루빈 및 알카리성 포스파타제의 증가등과 같은 위험인자가 존재할 경우 사망률이 증가될 수 있으므로 이들 군에서는 적극적인 치료가 필요할 것으로 사료된다. Background: Liver abscesses are commonly associated with underlying disease, particularly diabete mellitus. The number of the liver abscesses caused by Klebslella pneumoniae in diabetic patient has been increased in Korea nowadays. This study was conducted to clarify the clinical presentation and prognostic factors of pyogenic liver abscesses, especially in diabetic patients and to determine the proportion of K. pneunomiae as a pathogen in liver abscess in Korea. Methods: Medical records of 167 patients treated for pyogenic liver abscess from January, 1992 through June, 1999 were reviewed retrospectively in detail. Major Pathogenic organism, clinical manifestations, prognostic factors, the importance of diabetes mellilus as an underlying disease and its effect on clinical features and prognosis were analyzed. Results: Among 167 cases of pyogenic liver abscess, underlying diabetes mellitus was present in 32.3%. The mean age of patients was 62.7 13.4 years in diabetic liver abscess group and 55.1 15.5 years in non-diabetic liver abscess group. Most liver abscesses were cryptogenic in origin or secondary to the billary tree diseases. The clinical presentations among the two groups were not significantly different. When compared to patients without diabetes, patients with diabetes had significantly higher proportions of hypoalbuminemia and elevated aspartate transaminase level. The most common organism of the pyogenic abscess was K. pneumoniae in both groups. Percutaneous drainage of the abscess with appropriate antibiotics was the most commonly used therapeutic modality in liver abscess. The mortality rate of diabetic liver abscess is 16.1 % and 7.1% in nondiabetic liver abscess. Complications, especially septicemla, were found more frequently in patients with diabetes than in patients without diabetes (64.8% vs 28.3%, septicemia : 31.5% vs 9.7%). The factors influencing mortality in the diabetic liver abscess were disease duration, mixed infection, presence of septicemia, elevated bilirubin and alkaline phosphatase. Conclusions: In contrast to prior report that the E. coli was the most common pathogen in liver abscess, we found that K. pneumoniae was the most common organism cultured in liver abscess. Diabetic patients have more complications and higher mortality than patients without diabetes. Early detection and proper treatment are needed to improve the outcome for diabetic patient with liver abscess.

化學發癌 物質의 發癌 能力에 關한 反應性 指數의 理論的 硏究

李一峯,宋寧大,林周相,崔茂悅,朴柄珏 嶺南大學校 基礎科學硏究所 1990 基礎科學硏究 Vol.10 No.-

There are many theoretical indices for chemical carcinogenicity. Among the various indices, the LUMO electron density and approximate superdelocalizability have taken to compared and discussed for the carcinogenicity of PAHs, aromatic amines and Azo-compounds. The sum of LUMO electron density of the trans-butadiene type 1, 2, 4 positions in a molecule has been known to be in more agreement with the observed values than those of approximate superdelocalizability. It is suggested that any trans-butadiene type 1, 2, 4 positions play an importmant role in the elucidation of mechanism of chemical carcinogenesis.

수평면 회전식 풍력발전기에 대한 유체역학적 해석

이상무 동양대학교 2001 동양대학교 논문집 Vol.7 No.1

This paper discusses the horizontally rotating wind power generator.Quasi static analysis are applied to evaluate its performance.Translational velocity, which varies on the distance from the rotation center, is assumed constant to apply the fluid dynamic lift and drag coefficients.The analysis shows that the horizontally rotating wind power generator is effective in low rotation speed.In high rotation, the reverse torque reduces the total effective torque.It is recommended to give efforts to reduce the reverse torque for the acceptable performance of the horizontally rotatting type generator.

신체화장애 환자의 스트레스 대처방식 및 심리적 특성

이주연,이무석,윤진상,양종철,문지웅,정해원,은성종 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.6

Objectives : The purpose of this study was to investigate the stress coping strategies and psychological charactehstics, such as combined psychopathology and tendency of symptom interpretation, in patients with somatization disorder. Methods : Thirty patients meeting the criteria of DSM-IV somatization disorder were compared with thirty controls. We evaluated the subjects using Symptom Checklist-90-Revised (SCL-90-R), Somato-Sensory Amplification Scale (SSAS), Symptom Interpretation Questionnaire (SIQ), and The Ways of Stress Coping Questionnaire (SCQ). Independent t-test and Pearson correlation analysis were used. Results : From the results of SCL-90-R subscales, the scores of somatization, obsession-compulsion, depression, anxiety, and psychoticism were significantly higher in patients with somatization disorder than nonnal controls. Somatization disorder patients had greater amplification of physical sensation in SSAS and significantly higher score in physical interpretation of SIQ compared with psychological or environmental interpretation, In the SCQ of somatization disorder patients, we observed generallylower levels of total coping scores than the control group and significant positive correlation between passive coping style of SCQ and psychological interpretation of SIQ. Conclusion : These results show that patients with somatization disorder have various psychopathology, greater amplification of physical sensation, physical interpretation tendency of symptoms, and insufficient copying strategy.

SHS법에 의한 TiC-Al₂O₃계 세라믹스의 합성 및 소결특성

이형복,김성수,편무실,최덕배 明知大學校 産業技術硏究所 1991 産業技術硏究所論文集 Vol.10 No.-

TiC-Al₂O₃ system powders were prepared by the self-propagating high temperature synthesis method from the mixture of metal titanium, carbon and alumina powder, Powder and sintering characterization of TiC-Al₂O₃ system were investigated. TiC-15wt% Al₂O₃ compacts sintered by hoy-pressing under the pressure of 20MPa at 1850 for 90 minutes showed 3-point bending strength of 724Mpa, ?? of ??????, hardness of 2450㎏/㎟ and relative density of 97%. The combustion mode of combustion wave showed steady-state up to 15wt% Al₂O₃, spin above 20wt% Al₂O₃ also combustion velocity was decreased with increasing of Al₂O₃ contents.

위 MALT 림프종에서 다발성 림프절 전이로 오인된 동시성 림프절 결핵 1예

김성은,김규종,김도현,송준영,문대성,장리라,유찬희,문원,박무인,박선자,김영옥 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.2

28세 남자가 내시경적 점막절제술을 통해 저등급 위MALT 림프종으로 진단되었다. 병기설정을 위해 18F-FDG PET 검사를 시행하였고 우측 쇄골상부, 우측상/하부 기관주위, AP window 부위에 강한 섭취가 관찰되어 전이성 림프절로 판단하였다. 그러나, 우측 쇄골상부 림프절에서 시행한 절제생검에서 만성육아종성염증소견이 관찰되었고 조직의 결핵 중합효소연쇄반응에서도 양성 반응을 보였다. 2개월간 항결핵제의 사용 후 시행한 추적 컴퓨터단층촬영 검사에서 림프절 크기의 감소를 보여 최종적으로 위 MALT 림프종에서 광범위 림프절 전이로 오인된 동시성 림프절 결핵으로 진단되었다. A 28-year-old man was diagnosed as gastric MALT lymphoma in diagnostic EMR (endoscopic mucosal resection). He subsequently underwent an 18F-FDG PET. 18F-FDG PET showed intense multifocal uptake in right supraclavicular, right upper and lower paratracheal, and AP window areas that was considered radiologically to represent widespread metastatic lymphadenopathy. Excisional biopsy of a supraclavicular lymph node, however, revealed chronic granulomatous lymphadenitis with a positive reaction of Tb-nested PCR. After antituberculosis treatment for 2 months, a follow-up CT scan showed complete resolution of the lesions. Intense 18F-FDG uptake could be due to an infectious process such as synchronous tuberculous lymphadenitis. Therefore, this could mimic a malignant condition such as lymphoma with extensive lymph node metastasis due to a false-positive finding, which may lead to a misdiagnosis.

정신과 환자에 수반된 신체 질환

李相求,韓弘武,張煥一 최신의학사 1975 最新醫學 Vol.18 No.11

While working with the psychiatric patients, Psychiatrists often find cases that need treatments for physical as well as psychiatric illness. In this regard, One hundred and seventy seven patients admitted to the Neuro-Psychiatric Ward of Kyung-Hee Univ. Hospital during the period of the year 1974, through, were studied and the following results were obtained. 1) Out of 177 neuropsychiatric patients, 105 patients were found to have accompanying physical illness. (59.32% of the patients) 2) Out of 105 patients who had accompanying physical illness, 31 were found to have occured during the hospitalizations, 59 were not aware of the physical illness at the time of admission, and 15 knew of the existence of the physical illness at the time of admission. 3) Classification of the physical illnesses reveald 20 cases (19%) of E. N. T. diseases, 17 cases (16. 2%) of skin diseasea, and 10 cases (9.5 %) each of respiratory and eye diseases respectively. 4) Eleven patients for whom treatment of physical illness was considered as more urgent than that of psychiatric illness were transfered to other departments. 5) Eight patients (7.6% of total physical illnesses) were considered to have contagious diseases. 6) Mean duration of hospitalization of the group with physical illness was 45 days, whereas the group without physical illness was 23 days. 7) Among the patients with accompaning physical illness, male outnumbered female at the rate of 72 to 33. 8) No significant difference was found in the eductional level between the two groups of patients. 9) Mean age of the patients with accmpanying physical illness was 34 years old and that of the patients without accompanying physical illness was 30 years old. The authors hope this report to be not only a warning to illegitimate negligence of physical aspect of health in psychiatric practice, but also a preliminary data for further studies of physical illnesses associated with psychiatric illnesses; the influence of physical illness on psychiatric illness, other reciprocal interrelationship between physical and psychiatric illness or it's therapeutic implications.

工業廢水處理에 攪拌槽와 振動吸着塔의 活用에 關한 硏究

李承務,李勝撥 연세대학교 대학원 1976 延世論叢 Vol.13 No.2

Mass transfer coefficients for the external and internal transport were determined for adsorption of alkyl benzene sulfonate, one of the refractory organic pollutants, on the loca granular activated carbon in the agitating vessel and oscillating cylinder which is, so calledl resonant bubble contactor. The experimental results were correlated with characteristic dimensionless groups of system parameter, and then showed that the film transport coefficient in the oscillating cylinder was increased approximately three times that in the agitated vessel. Other experimental results showed that intraparticle mass transport coefficient was proportional to the square root of time in the initial period of adsorption. Finally, the experimental results were suite fit with the theoretically derived equation on the assumption of film and pore diffusion.

이온교환법에 의한 수은이온의 흡착에 관한 연구

李承務,崔光鎬 연세대학교 대학원 1980 延世論叢 Vol.16 No.2

This investigation on the adsorption of Hg (II) to chelating resin in the fixed bed ion exchange column was carried out to obtain the mass transfer coefficient, and showed by the equilibrium experiment in batch system, that this process was approached to an irreversible reaction, in dilute solution ranging from 1.25×10-7 mol/ml to 1×10-6 mol/ml. Under the irreversible liquid film mass transfer model, kLs was subsequently not only independent of both initial concentration of Hg (II) and amounts of resins, but also proportional to the 0.25 power of the velocity, thereby expressed as following equation; kLS= 0.34 U0.25 This study also brought about another worthwhile conclusion that the irreversible liquid-film mass transfer model in adsorption of Hg (II) would be valid by compared with Selke and Dryden's experimental results, using dimensionless analysis between Reynolds number and j-factor.