http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
( Eun Hye Lee ),( Eun Young Kim ),( Yun Ho Roh ),( Ah Young Leem ),( Joo Han Song ),( Song Yee Kim ),( Kyung Soo Chung ),( Ji Ye Jung ),( Young Ae Kang ),( Young Sam Kim ),( Joon Chang ),( Moo Suk Par 대한결핵 및 호흡기학회 2017 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.124 No.0
Background: Solid malignancies are associated with the development of Pneumocystis jirovecii pneumonia (PJP). This study aimed to evaluate the risk factors for PJP among patients with lung cancer. Methods: This retrospective case-control study compared patients who had lung cancer with PJP (n = 112) or without PJP (n = 336) at Severance Hospital between January 2013 and December 2016. The patients were matched according to age, sex, histopathology, and stage. PJP was considered present when the patient had (i) positive PCR or direct immunofluorescence results for pneumocystis, (ii) clinical symptoms and radiological abnormalities that were consistent with a pneumonic process, and (iii) received targeted PJP treatment. Results: The development of PJP was associated with radiotherapy (RTx), concurrent chemoradiotherapy (CCRTx), lymphopenia, and prolonged high-dose steroid therapy (20 mg of prednisolone equivalent per day for ≥3 weeks). Multivariate analysis revealed independent associations with prolonged high-dose steroid therapy (odds ratio [OR]: 2.02, 95% confidence interval [CI]: 1.07-3.80; p=0.029) and CCRTx (OR: 1.77, 95% CI: 0.99-3.16; p=0.054). Steroid use was frequently related to RTx pneumonitis or esophagitis (29 patients, 43.3%) and cancer infiltration symptoms (24 patients, 35.8%). Sixty-nine of the 112 patients with PJP (61.6%) died during their PJP treatment. Conclusion: Prolonged high-dose steroid therapy and CCRTx were risk factors for PJP development among patients with lung cancer. Clinicians should consider PJP prophylaxis for those high-risk patients.