자가면역성 갑상선질환에서의 백반증 및 원형탈모증

서무규,이재태 慶北大學校 醫科大學 1991 慶北醫大誌 Vol.32 No.2

We studied the association of vitiligo, alopecia areata with autoimmune thyroid disease Vitiligo, alopecia areata, vitiligo with alopecia areata were found in 21 out of 283 patients(7.4%) with autoimmune thyroid disease, 6 out of 223 patients(2.7%) with nonautoimmune thyroid disease. These results suggest stron association of vitiligo & alopecia areata, and autoimmune thyroid disease(p<0.01). The prevalence of vitiligo was similar to that of alopecia areata in autoimmune thyroid disease(3.5% vs. 3.2%). Two patients had vitiligo with alopecia areata. Witiligo in autoimmune thyroid disease was most frequently found on leg and alopecia areata in autoimmune thyroid disease was almost found on temporal area of scalp.

農業科學技術開發 및 普及의 投資效果分析

徐東均,鄭武男,閔勝奎 韓國農業政策學會 1994 농업경영정책연구 Vol.21 No.2

Acetylsalicylic Acid, Dipyridamolel, Nifedipine의 병용치료로 호전된 청피반성 혈관염 1례

서무규,윤기상,성열오 동국대학교 경주대학 1996 東國論集 Vol.15 No.-

청피반성 혈관염은 만성 재발성 피부혈관병증으로 난치성으로 알려져 있다. 최근 혈전치료제인 acetylsalicylic acid 및 dipyridamole과 혈관확장제인 nifedipine의 병용요법으로 만족할만한 치료효과를 보였다는 보고가 있다. 이에 저자들은 19세 여자에서 임상증상, 병리조직학적 및 직접면역형광검사 소견으로 청피반성 혈관염으로 진단하고 상기 3가지 약제를 병용투여하여 병변의 호전을 보인 1예를 경험하고 문헌고찰과 함께 보고한다. We report a case of livedo vasculitis in a 19-year-old female, who showed multiple, recurrent, O.2-2.Ocm sized, erythematous punched-out ulcers on both ankles and dorsa of feet for 3 years. Histopathologic findings showed granulation tissue, hemorrhage, perivascular inflammatory cell infilteration in upper dermis. Direct immunofluorescent studies showed C3 deposit in dermal vessel wall. Therapy was undertaken with acetylsalicylic acid, dipyridamole, and nifedipine daily, resulting in almost complete resolution of the skin lesion for about 1 month after treatment.

일가족에 발생한 Microsporum canis 감염증

서무규,성열오,윤기상,하경임 동국대학교 경주대학 1996 東國論集 Vol.15 No.-

Microsporum (M.)canis 감염은 애완용으로 기르는 고양이나 개가 주된 감염원이며 두부 백선, 안면백선 및 체부 백선 등의 피부질환을 일으킨다. 특히 M. canis 가족감염예는 M. canis 감염증중 비교적 드물다. 저자들은 전형적인 임상 및 균학적 양상을 보인 고양이로부터 감염된 M. canis 가족예를 경험하고 문헌고찰과 함께 보고한다. Microsporum canis Infections Occurring in a Family Departments of Dermatology & Clinical Pathology, College of Medicine, Dongguk University Moo Kyu Suh M.D., Yeol Oh Sung M.D., Ki Seong Yoon M.D., Gyoung Yim Ha M.D." We report a case of Microsporum (M.) canis infections occurring in a family. The mother, a son and a daughter had multiple, wen defined, round, scaly erythematous patches on the scalp & face, face & trunk, and face & chest respectively. Culture from skin lesion of patients and an infected kitten on Sabouraud dextrose agar showed M. canis. After 15 days to one month administration of itraconazole, the lesins healed leaving a slight hypopigmentation.

위암세포에 의한 종양침윤 림프구의 면역반응 억제기전에 관한 연구

박정규,송규상,서광선,최정목,배진선,장일성,윤완희,노승무,조은경,백태현 大韓免疫學會 1995 大韓免疫學會誌 Vol.17 No.3

Tumor-infiltrating lymphocytes ('1°ILs) interact most closely with tumor cells and thus are more likely to reflect tumor host interactions accurately. But it is unknown whether such T cells are nonspecific inflammatory cells or a subset of specific host immune responses. In this study, there was no clear correlation between the infiltration of T lymphocytes in stomach cancer and the overexpression of c-ErbB-2 or increasing class I MHC expression on tumor cells. A positive correlation was seen between the presence of TILs in the tumor and tumors with diploidy by flow cytometric DNA analysis. The proliferative responses of Ills stimulated with IL-2, anti-CD3 mAb, or both were examined. When compared to normal mucosal-associated lymphoid tissue lymphocytes, the proliferative response of TILs to high dose IL-2 was minimal. A similarly poor response to anti-CD3 mAb plus IL-2 was also observed. The freshly isolated TILs exhibit reduced ability to proliferate in response to IL-2, anti-CD3 mAb or both. The microenvironment of the tumor suppresses the proliferative capacity of the TILs. The mechanism of this suppression remains unknown. It could be mediated by suppressor cells, by soluble substances within the tumor, or both. To examine this question, supernatants of stomach cancer cells (SNSNU-1) were tested for the presence of immunosuppressive factors. Human peripheral blood T-cells and tumor-draining lymph node lymphocytes (TDLNL) were incubated for 3 days with SNSNU-1 and then assessed for proliferative responses to PMA, anti-CD28 mAb, or both and for the inducibility to express IFN- r or IL-4 mRNA to PMA. Peripheral blood T-cells pretreated with SNSNU-1 were unable to proliferate in response to PMA, anti-CD28 mAb or both. SNSNU-1 also produces inhibitory activities of TDLNL proliferative response to PMA or anti-CD28 mAb and PMA (49%, 52%, respectively). In contrast, culture supernatants obtained from HEp-2, K562 or Daudi showed normal proliferative responsiveness of peripheral blood T-cells and TDLNL by PMA, anti-CD28 mAb or both.

안면부 종창을 동반한 Henoch-Scho¨nlein 자반증 1례

이재휘,서무규,임문환,박성기,김태우,이창연 동국대학교 경주대학 1991 東國論集 Vol.10 No.-

We experienced a case of Henoch-Scho‥nlein purpura with are manifestation of facial swelling in a 7-year-old boy.

피지선 모반에서 발생한 유두상 한선종 1예

성열오,서무규,문형도,박기흠,이창우,이경섭 동국대학교 경주대학 1993 東國論集 Vol.12 No.-

Syringoadenoma papilliferum occurs as a solitary lesion appearing usually on the scalp. It's origin is not definitely known, and about one-third of cases are associted with nevus sebaseous. We describe a case of syringoadenoma papillferum associated with nevus sebaseous in a 29 year-old female who had developed bean sized verrucotic nodules on the Rt. temporal area of the scalp since 6 years after removal of nevus sebaceous. Histopathologic findings showed hyperkeratosis, acanthosis and villi that projected into a cystic lumen. And the villi were surrounded by two cell layers.

대학생의 노인복지에 대한 인식도

차병준,김무룡,김기열,차경미,김귀희,김현실,서인선,임상규,이순자,위광복,남철현 慶山大學校 保健福祉硏究所 1999 保健福祉硏究 Vol.2 No.-

The purpose of this study is to grasp the change of consciousness of young people in order to seek new approach of policy for aged era. 1,200 students attending collages and universities in three small or medium sized cities were inquired for 2 months, from October 1 to November 30, 1996. The result is as follows. 1. The characteristic of the respondents of this survey is that they include 72.1% of women, 40.4% of people aged between 20 to 21, and 49.1% of people who do not have any religion. Those who are from big cities and those who are form farming villages or fishing village occupy equally 40.2%, those who reside in that cities for a long period 49.0%, and those who live with their family 60.9%. 2. The family feature of the subject is that 31.5% of them are those whose father is the age of 55 and more than 55, 10% of them are those whose mothers age is so, 33.1% of them have 5 family members, 29.5% of them have the family income of 1,000,000 to 1,490,000 won, 83.9% of them are from middle class, 47.7% of them are the people whose grand parents have passed away, 70.4% of them live apart from their grand parents, and 60.9% of them are second child. 3. 64.0% of males, 70% of respondents who are aged over 24, 58.1% of respondents who are from rural communities, 62.4% of respondents who live in rural area, and 58.3% of respondents who live alone, prefer to live with grand parents, marked higher rate than other groups. The groups whose father and mother are the age of more than 55 marked higher rate of 55.9% and 58% each than any other groups(p<0.05). The groups whose family member is less than three, whose grand parents both have passed away in middle class, who live with their grand parents, and who are second children, give more positive answers than any other groups. 4. Those who are older, who are buddhists, who are from rural area or live in rural area, whose family is small, whose family income is small, who are from lower class and whose grand parents are still alive, shows preference to support their parents after marriage. 5. Females(89.4%), those who are from small or medium sized cities(89%), who live with their family(85.6%), whose father is the age of 55 and more than 55, whose mother is the age of 54 and less than 54, whose family member is 6, who are from middle class, whose grandparents are still alive and who are the eldest child in their family, give more response that they prefer to live apart from their children in their old age than any other groups. 6. What elderly people need most right now is past time(42.3%), and the respondents whose age is 20 to 21, who are buddhists, who are from middle sized cities and live alone, whose parents are the age of more than 55, who have small family income, who live with their grand parents and who are second children show higher level than any other groups. 7. 76.8% of respondents answer that they do not need their parent's fortune, marked still higher rate than the opposite answer. Those who are older, who are buddhists, who are from big cities, who reside in rural area, who live alone and have smaller family, who are in bad family economic conditions and who live with grand parents present higher rate of positive response. 8. 59.3% of respondents reply that they think about death from time to time, and those who are female, who are in the age of 20 to 21, who are christian, who live with their family, whose siblings or other family members offer their education expenses show higher rate than any other groups. 9. 92.3% of respondents answer that the budget for welfare facility for elderly people is very small. The younger the respondents are and the worse economic condition they have among those who live in big cities, the more answered that. 10. 50% of respondents think social security should provide for their old age, and 42.8% of them believe they themselves provide against it. The respondence that social security ought provide for it appeared more among those whose age are over 24, who are female, who reside in rural area, who are christian, who are in bad economic condition, and who ever used medical institutions in recent one month, marked higher level than other groups. 11. The adequate time of retirement is 59.97±5.60 for public officers, the highest and 59.28±6.35 for teachers, the next. 12. 35.2% of respondents reply that the adequate budget for the old age after their retirement at the age of 60 is 220 million won, showed the highest level of respondence. 13. The factors which affect on the old people in the charged welfare facilities are sex(p<0.01), the type of housing(p<0.05) and whole family income(p<0.05). 14. The factors which affect on remarriage are sex(p<0.05) and religion(p<0.05). For varying old population and expanded welfare service for them, government and relevant authority should give more attention to secure the budget, establish effective plans to expand various program and the facilities for elderly people in order that elderly people spend the rest of life time more happily and more fruitfully. To do that, each college and university should open Health courses, and educate and inform about health and welfare.

콘크리트의 壓縮强度에 미치는 굵은 골재 크기의 영향에 관한 基礎的 硏究

윤석천,박서규,남재현,김무한 충남대학교 공업교육연구소 1985 論文集 Vol.8 No.1

The purpose of this study is to research an effect of aggregate size on the compressive strength of concrete. Tests were, therefore, made in sixteen classes of concrete : maximum aggregate sizes of 5, 10, 20, 30^mm with water cement rations of 40% and 60% and with AEA°cement rations of 0.00% and 0.03% for each maximum aggregate size. The results of this experiment are showing the fellowing tendency. 1. Generally, with the range of this experiment program, the smaller maximum aggregate size becomes, the higher the compressive strength of concrete gets. 2. The decreasing tate of the compressive strength of concrete gets higher in lean mix concrete than in rich mix concrete at each age. 3. The compressive strength of concrete is developed faster with not only the increase of maximum aggregate size but also the decrease of water cement ratio. And it shows that the rate of the compressive strength development is higher in AE concrete in spite of water cement ratio.

Molecular Phylogenetics of Exophiala Species Isolated from Korea

( Moo Kyu Suh ),( Ho Chung Lee ),( Dong Min Kim ),( Gyoung Yim Ha ),( Jong Soo Choi ) 대한피부과학회 2012 Annals of Dermatology Vol.24 No.3

Background: Recently, identification of fungi have been supplemented by molecular tools, such as ribosomal internal transcribed spacer (ITS) sequence analysis, According to these tools, morphological Exophiala species was newly introduced or redefined. Objective: This study was designed to investigate the phylogenetics based on ribosomal ITS sequence analysis from clinical Exophiala species isolated in Korea. Methods: The strains of Exophiala species were 4 clinical isolates of phaeohyphomycosis agents kept in the department of dermatology, Dongguk University Medical Center (DUMC), Gyeongju, Korea. The DNAs of total 5 strains of Exophiala species were extracted by bead-beating method, Polymerase chain reaction of ITS region using the primer pairs ITS1-ITS4, was done and phylogenetic tree contributed from sequences of ITS region from 5 Korean isolates including E, dermatitidis CBS 109154 and comparative related strains deposited in GenBank. Results: The strains of Exophiala species were 3 strains of E. dermatitidis, 1 strain of E. jeanselmei and 1 strain of Exophiala new species. Among the 3 subtypes (type A, B, C) of E. jeanselmei, E. jeanselmei DUMC 9901 belonged to type B. Of the 2 main types of E. dermatitidis (type A, B) and 3 subtypes of E. dermatitidis type A (A0, A1 and A2), two strains (E. dermatitidis CBS 709.95, E. dermatitidis CBS 109154) belonged to A0 subtypes, 1 strain (E. dermatitidis DUMC 9902) A1 subtype, respectively. Conclusion: Phylogenetic analysis of ITS region sequence provided useful information not only for new species identification but for the subtyping and origin of Exophiala species.