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Dendritic Cell Dysfunction in Patients with End-stage Renal Disease
Kim, Ji Ung,Kim, Miyeon,Kim, Sinae,Nguyen, Tam Thanh,Kim, Eunhye,Lee, Siyoung,Kim, Soohyun,Kim, Hyunwoo 한국조명·전기설비학회 2017 한국조명·전기설비학회 학술대회논문집 Vol. No.
<P>End-stage renal disease (ESRD) with immune disorder involves complex interactions between the innate and adaptive immune responses. ESRD is associated with various alterations in immune function such as a reduction in polymorphonuclear leukocyte bactericidal activity, a suppression of lymphocyte proliferative response to stimuli, and a malfunction of cell-mediated immunity at the molecular level. ESRD also increases patients' propensity for infections and malignancies as well as causing a diminished response to vaccination. Several factors influence the immunodeficiency in patients with ESRD, including uremic toxins, malnutrition, chronic inflammation, and the therapeutic dialysis modality. The alteration of T-cell function in ESRD has been considered to be a major factor underlying the impaired adaptive cellular immunity in these patients. However, cumulative evidence has suggested that the immune defect in ESRD can be caused by an Ag-presenting dendritic cell (DC) dysfunction in addition to a T-cell defect. It has been reported that ESRD has a deleterious effect on DCs both in terms of their number and function, although the precise mechanism by which DC function becomes altered in these patients is unclear. In this review, we discuss the effects of ESRD on the number and function of DCs and propose a possible molecular mechanism for DC dysfunction. We also address therapeutic approaches to improve immune function by optimally activating DCs in patients with ESRD.</P>
증례 : 신장 ; 판코니 증후군을 동반한 간질성 신염 포도막염 증후군 1예
김미연 ( Miyeon Kim ),김현우 ( Hyun Woo Kim ),김지영 ( Ji Young Kim ),정진호 ( Jinho Jeong ),박은정 ( Eun Jung Park ),김진석 ( Jinseok Kim ),김소미 ( So Mi Kim ) 대한내과학회 2015 대한내과학회지 Vol.88 No.6
본 증례에서는 간질성 신염으로 진단되어 스테로이드 치료 후 호전된 중년여성에서 판코니 증후군 양상의 세뇨관장애 및 포도막염이 발생하여 간질성 신염 포도막염 증후군으로 재진단하고, 스테로이드로 치료한 1예를 경험하여 문헌고찰과 함께 보고하는 바이다. Tubulointerstitial nephritis and uveitis (TINU) syndrome is a rare disease that comprises 4.7% of acute interstitial nephritis. With reno-ocular manifestations, TINU syndrome is accompanied by symptoms such as fever, fatigue, malaise, anorexia, vomiting, and arthralgia. TINU syndrome is reported mainly in children or adolescent girls, and it is rare in adults. Although TINU syndrome can present with multiple renal tubular defects, Fanconi syndrome characterized by generalized impairment of proximal tubular function, leading to renal glucosuria, hyperuricosuria, hyperphosphaturia, proximal renal tubular acidosis, and kaliuresis leading to hypokalemia, has rarely been described. We report a case of TINU syndrome with Fanconi syndrome in a 46-year-old HLA B27-positive Korean woman. (Korean J Med 2015;88:711-714)
Ionizing irradiation to Helicoverpa armigera (Lepidoptera: Noctuidae) as a quarantine treatment
Miyeon Jang,Junheon Kim,Sin Ae Jang,Jeongmin Kim,Yeon Jeong Lee,Eunsik Shin,Chung Gyoo Park 한국응용곤충학회 2015 한국응용곤충학회 학술대회논문집 Vol.2015 No.10
Rapid growth in trade of agricultural products has increased the risk of introduction of exotic pests into new area. In order to fulfill quarantine obligations, several treatments are in practice: fumigation with methyl bromide (MB), application of extreme temperatures, controlled atmospheres, and combinations of them. Although MB was most effective and widely applied for quarantine treatment, its use was banned by the Montreal Protocol. Ionizing irradiation phytosanitary treatments – gamma radiation, electron beam, and X-ray are being used as an alternative to MB currently. For applying ionizing irradiation as a quarantine treatment, there is a research protocol which should be followed, International Standards for Phytosanitary Measure 18 [ISPM #18] and Phytosanitary Treatment Regulation of Korea (Notice 2014-35). We have evaluated the effect of gamma radiation, electron beam, and X-ray on H. armigera as quarantine treatments. In this presentation, ISPM #18 and Notice 2014-35 will be talked with the example of H. armigera.
Genome wide analysis of rice blast pathogen, Magnaporthe oryzae, in Korea
Yoonhee KIM,Hyejeong KIM,Jinsoo KIM,Miyeon JEONG,Soyoung PARK,Suyoung KIM,Jongsun Park,Soonok KIM,Yong-Hwan LEE,Seong Sook HAN,Jae Hwan ROH,Woobong CHOI 한국작물학회 2007 한국작물학회 학술발표대회 논문집 Vol.2007 No.11
Magnaporthe oryzae is a causal pathogen of the rice blast, the most destructive disease of rice worldwide. This ascomycete fungus has been intensively studied as a model organism in plant-pathogen interactions. Recently, the genome sequence of M. oryzae 70-15 was published by International Rice Blast Consortium. This led us to investigate comparative and functional analysis of this pathogen at genome-wide level. As a first step, sequencing project of M. oryzae Korean strain KJ201 was launched to face practical interests on diversity of plant pathogens. We constructed a fosmid library with a copy number controllable pCC1 vector. Over 13,000 end reads from 6637 fosmid clones were generated and anchored on genome sequence of the strain 70-15. Currently, 9,793 end reads, in which 2.684, clones with both ends and 1,757 clones with on end matched, are aligned to the sequence of strain 70-15. In the next step, shotgun sequencing of fosmid clones was conducted for fine scale comparative analysis of chromosome 7 that is well defined in genome sequencing of 70-15. Totally 119 fosmid clones were pooled in region and analyzed. For reasonable intra-species comparison in genome of M. oryzae, two strains, KJ201 and Guy11, were chosen for whole genome shotgun sequencing analysis with GS454 FLX system. About 8X genome coverage sequences were obtained for each strain and being merged for comparative analysis. Genome information of other strains is being also available from China and Japanese research groups and could be joined together for extended comparative analysis and the results give more detail in genome diversity in species level.
Attraction of Athetis dissimilis to the pheromone components of Euzophera batangensis
Jeongmin Kim,Junheon Kim,Sin Ae Jang,Miyeon Jang,Yeon Jeong Lee,Young Sik Cho,Bong Kyu Byun,Chung Gyoo Park 한국응용곤충학회 2015 한국응용곤충학회 학술대회논문집 Vol.2015 No.10
Athetis dissimilis (Hampson) (Lepidoptera: Noctuidae) [뒷흰날개담색밤나방] was attracted to pheromone traps for Euzophera batangesis (Lepidoprera Pyrimidae) [밤알락명나방], when occurrence of E. batangesis was monitored in sweet persimmon orchard with its pheromone, (Z)-9-tetradecenol (Z9-14OH), (Z9,E12)-9,12-teradecadienol (Z9,E12-14OH) and their mixture. With the components, we monitored the seasonal occurrence of A. dissimilis, tested response of the moth to single or mixed components, and compared efficacy of three different types of traps. A. dissimilis was trapped on May 14 for the first time. First occurrence peak was observed during June 4-24 and second peak during August 20 – September 10. A. dissimilis was attracted to single component of Z9-14OH and Z9,E12-14OH and to their mixture at Jinju, Sancheong, and Sacheon. In trap efficacy tests, delta traps with white color caught most number of the moths significantly at Sacheon. However, at Sancheong, there was no statistical difference among the traps, although funnel trap caught most number of A. dissimilis. Pest status of A. dissimilis is not known eg. whether it is a pest of persimmon or other fruits. However, with Z9-14OH, E9,E12-14OH and their mixture, it is expected to be monitored and controlled.
Lee, Siyoung,Kim, Eunsom,Jhun, Hyunjhung,Hong, Jaewoo,Kwak, Areum,Jo, Seunghyun,Bae, Suyoung,Lee, Jongho,Kim, Busun,Lee, Jungmin,Youn, Sulah,Kim, Somi,Kim, Miyeon,Kim, Hyunwoo,Lee, Youngmin,Choi, Dong American Society for Biochemistry and Molecular Bi 2016 The Journal of biological chemistry Vol.291 No.28
<P>Although it has been established that diabetes increases susceptibility to infections, the role of insulin (INS) in the immune response is unknown. Here, we investigated the immunological function of INS. Proinsulin dimer (pINSd) was a potent immune stimulus that induced inflammatory cytokines, but mature INS was unable to induce an immune response. An affinity-purified rabbit polyclonal antibody raised against mature IL-1α recognized IL-1α and pINS but failed to detect mature INS and IL-1β. Analysis of the pINS sequence revealed the existence of an INS/IL-1α motif in the C-peptide of pINS. Surprisingly, the INS/IL-1α motif was recognized by monoclonal antibody raised against IL-1α. Deleting the INS/IL-1α motif in pINSd and IL-1α changed their activities. To investigate the pINSd receptor, the reconstitution of IL-1 receptor 1 (IL-1R1) in Wish cells restored pINSd activity that was reversed by an IL-1R antagonist. These data suggested that pINSd needs IL-1R1 for inflammatory cytokine induction. Mouse embryo fibroblast cells of IL-1R1-deficient mice further confirmed that pINSd promotes immune responses through IL-1R1.</P>
Miyeon Jang,Junheon Kim,Yoon-A Joo,Sin Ae Jang,Chung Gyoo Park 한국응용곤충학회 2015 한국응용곤충학회 학술대회논문집 Vol.2015 No.04
Helicoverpa armigera is a serious polyphagous pest inflicting losses to various kinds of food crops. Among dis-infestation methods, methyl bromide (MeBr) has been widely used in quarantine treatments. However, after regulation as ozone depleting substance, MeBr is restricted in use. Phytosanitary irradiation has been suggested as an useful alternative to MeBr. In this study, H. armigera adults were irradiated with 400 Gy which was decided as a critical dose to the adults by the preliminary experiments. The irradiated females and males were mated reciprocally with fresh ones. Some of the both sexes were subjected to comet assay to determine the degree of DNA damage by gamma ray irradiation. There was no significant difference in fecundity among mates. However the irradiation significantly affected hatchability of F1 eggs. No F1 eggs hatched in the mate of treated female (TF) x treated male (TM). Hatchability of F1 eggs from TF x UM (untreated male) and UF x TM mates were 0.3% and 1.1%, respectively. A few larvae from UF x TM mate developed up to adults. Comet assay indicated that gamma-ray irradiation is efficient in damaging male's DNA than female's which may be the cause of dramatic decrease in F1 hatchability.