녹음 구어 제시가 중도정신지체 성인여성의 목욕 능력 개선에 미치는 효과

鄭如意,陳明聰,陳政見 대구대학교 특수교육재활과학연구소 2006 再活科學硏究 Vol.24 No.2

1. This study aimed to explore the effect of recorded auditory prompts on helping an adult with profound mental retardation to take bath independently. 「A-B-C-A-C」design, a kind of single-subject experiment was adopted. Three phases, baseline phase, intervention phase(B): auditory prompt, and intervention phase(C): recorded auditory prompt were included. A female with profound mental retardation participated in the experiment. It took over seven months to finishing the intervention. The results of the experiment indicated that auditory prompts, whether human auditory prompt or recorded prompt, could help the client to take bath more independently. The families of the client also regarded recorded auditory prompt was a feasible solution. Based on the result, there were some suggestions for the further research. 본 연구의 목적은 녹음 구어 제시를 이용해서 극 중도 지능장애 성인 여성 스스로 목욕 동작을 완성 할 수 있도록 도와주는 효과에 대한 연구입니다. 본 연구에 사용하는 연구법은 ⌜A-B-A-C-A-C⌟역 설계이다. 기선기의(A)개입一(B)인공구어제시 개입二(C)녹음 구어 제시로 나누어졌다. 실험기간은 모두 7개월 반이었다. 연구결과는 피 실험자가 스스로 목욕할 때와 비교했을 때 인공구어 제시와 녹음구어 제시는 모두 피 실험자가 목욕 동작을 완성 하는 데에 효과가 있는 것으로 나타났다. 이 외에도 녹음 구어 제시는 피 실험자 가족들도 받아들일 수 있다. 본 연구 결과에 근거해서 연구자들은 미래 응용과 연구에 대한 건의도 제출하였다.

骈赋非骈文辨

Ye You Ming 한국중국산문학회 2013 중국산문연구집간 Vol.3 No.-

변부는 운문이고 순문학작품으로 묘사와 서정에만 쓰이는 작가의 서정의지의 문학형식이라 말할 수 있다. 변부는 사부로부터 발전해 온 것이다. 그래서 변문은 즉 일반적인 문장으로 그 주된 부분은 응용문이고, 작가가 사회적 교류를 하고 의견을 발표하는 중요한 수단이다. 변문은 고대산문에서 발전해 온 것이다. 그것들의 공통점은 둘 다 변우라는 수사수법을 사용하여 만들어졌다는 것이다. 하지만 그것들은 체제 구조와 행문 구식상 많은 다른 점이 존재한다. 변부는“주객의 대화를 서술하여 음악의 앞 머리을 이끄는 것(述客主以首引)”이 가능 하지만 변문은 사용하지 않는다. 변부의 결미는 여러 가지를 혼용해서 사용할 수 있지만(혹은 “頌”, “系”, “歌”, “重”, “訊”, “詩”등이라고 칭한다) 변문은 일반적으로 사용하지 않는다. 변부는 사육구 외에도 오칠언시구와 騷體句가 있을 수 있다. 변문은 일반적으로 사육구만 사용할 뿐 오칠언시구와 騷體句는 거의 사용하지 않는다. 따라서 변부와 변문은 두 가지의 완전히 다른 문체로, 그것들이 모두 변우 수사수법을 사용한다고 해서 동일한 유형의 문체로 바라보거나 함께 다루어서는 안된다.

siRNA-mediated Silencing of Notch-1 Enhances Docetaxel Induced Mitotic Arrest and Apoptosis in PCa Cells

Ye, Qi-Fa,Zhang, Yi-Chuan,Peng, Xiao-Qing,Long, Zhi,Ming, Ying-Zi,He, Le-Ye Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.6

Purpose: Notch is an important signaling pathway that regulates cell fate, stem cell maintenance and the initiation of differentiation in many tissues. It has been reported that activation of Notch-1 contributes to tumorigenesis. However, whether Notch signaling might have a role in chemoresistance of prostate cancer is unclear. This study aimed to investigate the effects of Notch-1 silencing on the sensitivity of prostate cancer cells to docetaxel treatment. Methods: siRNA against Notch-1 was transfected into PC-3 prostate cancer cells. Proliferation, apoptosis and cell cycle distribution were examined in the presence or absence of docetaxel by MTT and flow cytometry. Expression of $p21^{waf1/cip1}$ and Akt as well as activation of Akt in PC-3 cells were detected by Western blot and Real-time PCR. Results: Silencing of Notch-1 promoted docetaxel induced cell growth inhibition, apoptosis and cell cycle arrest in PC-3 cells. In addition, these effects were associated with increased $p21^{waf1/cip1}$ expression and decreased Akt expression and activation in PC-3 cells. Conclusion: Notch-1 promotes chemoresistance of prostate cancer and could be a potential therapeutic target.

종족 축제와 종족 연극의 연구

엽명생 ( Ming Sheng Ye ) 한양대학교 동아시아문화연구소 (구 한양대학교 한국학연구소) 2012 동아시아 문화연구 Vol.51 No.-

통상 학계에서 주목하는 연극으로, 문인과 선비, 고관과 귀인이 감상하는 예술극과 교통이 발달하고 경제가 번영한 도시에서의 오락극 및 향촌 사원 축제나 정기 시골장에서 상업성 극단이 연출하는 신과 인간이 함께 즐기는 연극을 들 수 있다. 그 연출 주체는 혹은 전문 직업극단의 예인이거나 혹은 문인으로 다소 훈련을 통해 소질을 갖춘 아마추어 배우이거나 혹은 농사를 지으며 때로 극단 활동을 하는 반 직업 배우다. 학자들은 극예술 자체에만 주로 관심을 기울인다. 그러나 일부 산간의 외진 곳에서는 여전히 오직 전적으로 종족의 제사에만 쓰이는 제사연극이 전승되고 있다. 공연의 조직은 종족의 어른이 담당하고, 배우는 종족 내 농가 자제들이 맡는다. 이는 대도시와 시골에서 유행하는 연극 양상과 크게 다르다. 그 공연은 종족의 연례 제사 때에 특별하게 이루어진다. 이런 제사 연극은 사회적으로 잘 알려져 있지 않아 아직 문화계 및 학계의 충분한 주의가 기울여지지 않고 있다. 복건성정화현 화양 촌의 종족연극은 바로 그 전형적인 예로 볼 수 있다. 그 종족 연극의 발견은 중국 고대 농업 사회에서 연극이 종족제사에서 차지하는 역할과 위상을 밝히고, 종족제사와 연극의 상호 의존 관계를 이해하는데 의미를 지니며, 고대 연극이 민간 종족 제사 의식 활동 가운데서 변천을 거듭하면서 전승되어 온 자연스런 양상을 보여 준다는 데 의의가 있다. 오늘날 고대 연극이 민간에 유전되고 존속되는 사회적 원인을 이해하고 탐구할 수 있는 기회를 제공할 뿐만 아니라, 중국 민간 연극사 연구에도 오래되었으면서도 살아있는 참조 물을 제공하는 셈이다. Generally, the operas studied by the academia are the "elegant" ones appreciated by the gentry, the entertaining ones played in the theatre of the metropolitan cities, and the ritual ones to amuse both gods and human beings performed in the temple stages of the villages and market places. The performers in these operas are professional actors of the theatrical troupe, well trained but semi-professional literati, and amateurs consist of farmer-actors. In the past, most scholars only paid attention to the operas that could be categorized as performing arts. But, in the remote mountain areas, there still exist one special ritual opera dedicates to the worship of lineage ancestors. The organizer is the head of the lineage, and the performers all come from the same lineage. As a specific ritual performance for annual ancestor worship, it is quite different from the popular operas in the cities and villages. Such kind of ritual opera is seldom noticed by the people, and ignored by the scholars. The lineage opera in Heyang village of Zhenghe County, Fujian is a typical example of it. The significance of the discovery lies in the new light it shed on the role and status operas had in ancestor worship in ancient agricultural China, the interdependent relationship of ancestor worship and operas, and the original form and development of traditional opera in the ritual of lineage. Thus, it also helps us to study the popularization of traditional opera in the folk societies and the social background for its development, providing a useful and fresh reference for the research of the history of Chinese opera.

MiR-221 promotes trastuzumab-resistance and metastasis in HER2-positive breast cancers by targeting PTEN?

( Xing Ming Ye ),( Wen Dong Bai ),( Hua Yu Zhu ),( Xiao Zhang ),( Ying Chen ),( Lei Wang ),( An Gang Yang ),( Jing Zh Ao ),( Lin Tao Jia ) 생화학분자생물학회 2014 BMB Reports Vol.47 No.5

HER2-overexpressing breast cancers are characterized byfrequent distant metastasis and often develop resistance aftershort-term effective treatment with the monoclonal antibodydrug, trastuzumab. Here, we found that the oncogenic miRNA,miR-221, inhibited apoptosis, induced trastuzumab resistanceand promoted metastasis of HER2-positive breast cancers. Thetumor suppressor PTEN was identified as a miR-221 target;overexpression of PTEN abrogated the aforementionedmiR-221-induced malignant phenotypes of the cells. Thesefindings indicate that miR-221 may promote trastuzumabresistance and metastasis of HER2-positive breast cancers bytargeting PTEN, suggesting its role as a potential biomarker forprogression and poor prognosis, and as a novel target fortrastuzumab-combined treatment of breast cancers.[BMB Reports 2014; 47(5): 268-273]

중서문화적역향발전여중국현대문학

엽자명 ( Zi Ming Ye ) 한국중국학회 2000 國際中國學硏究 Vol.3 No.-

N/A

Multivariate Analysis of the Prognosis of 37 Chondrosarcoma Patients

Yang, Zheng-Ming,Tao, Hui-Min,Ye, Zhao-Ming,Li, Wei-Xu,Lin, Nong,Yang, Di-Sheng Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.4

Objective: The current study aimedto screen for possible factors which affect prognosis of chondrosarcoma. Methods: Thirty seven cases were selected and analyzed statistically. The patients received surgical treatment at our hospital between December 2005 and March 2008. All of them had complete follow-up data. The survival rates were calculated by univariate analysis using the Kaplan-Meier method and tested by Log-rank. ${\chi}^2$ or Fisher exact tests were carried out for the numeration data. The significant indexes after univariate analysis were then analyzed by multivariate analysis using COX regression model. Based on the literature, factors of gender, age, disease course, tumor location, Enneking grades, surgical approaches, distant metastasis and local recurrence were examined. Results: Univariate analysis showed that there were significant differences in Enneking grades, surgical approaches and distant metastasis related to the patients' 3-year survival rate after surgery (P<0.001). No significant difference was not found in gender, age, disease course, tumor location or local recurrence (P>0.05). Multivariate analysis showed that Enneking grade (P=0.007) and surgical approaches (P=0.010) were independent factors affecting the prognosis of chondrosarcoma, but distant metastasis was not (P=0.942). Conclusion: Enneking grades, surgical approaches and distant metastasis are risk factors for prognosis of chondrosarcoma, among which the former two are independent factors.

Effects of dietary valine:lysine ratio on the performance, amino acid composition of tissues and mRNA expression of genes involved in branched-chain amino acid metabolism of weaned piglets

Ye Tong Xu,Xiao Kang Ma,Chun Lin Wang,Ming Feng Yuan,Xiang Shu Piao 아세아·태평양축산학회 2018 Animal Bioscience Vol.31 No.1

Objective: The goal of this study was to investigate the effects of dietary standard ileal digestible (SID) valine:lysine ratios on performance, intestinal morphology, amino acids of liver and muscle, plasma indices and mRNA expression of branched-chain amino acid (BCAA) metabolism enzymes. Methods: A total of 144 crossbred pigs (Duroc×Landrace×Large White) weaned at 28±4 days of age (8.79±0.02 kg body weight) were randomly allotted to 1 of 4 diets formulated to provide SID valine:lysine ratios of 50%, 60%, 70%, or 80%. Each diet was fed to 6 pens of pigs with 6 pigs per pen (3 gilts and 3 barrows) for 28 days. Results: Average daily gain increased quadratically (p<0.05), the villous height of the duodenum, jejunum and ileum increased linearly (p<0.05) as the SID valine:lysine ratio increased. The concentrations of plasma α-keto isovaleric and valine increased linearly (p<0.05), plasma aspartate, asparagine and cysteine decreased (p<0.05) as the SID valine:lysine ratio increased. An increase in SID lysine:valine levels increased mRNA expression levels of mitochondrial BCAA transaminase and branched-chain α-keto acid dehydrogenase in the longissimus dorsi muscle (p<0.05). Conclusion: Using a quadratic model, a SID valine:lysine ratio of 68% was shown to maximize the growth of weaned pigs which is slightly higher than the level recommended by the National Research Council [6].

Chemerin reverses the malignant phenotype and induces differentiation of human hepatoma SMMC7721 cells

Ming Li,Pengcheng Sun,Kaikai Dong,Ye Xin,Aslee TaiLulu,Qinyu Li,Jing Sun,Min Peng,Ping Shi 대한약학회 2021 Archives of Pharmacal Research Vol.44 No.2

Chemerin exhibits an inhibitory eff ect on hepatocellularcarcinoma; however, the underlying mechanismis unclear. Here, low chemerin expression was confi rmedin samples of liver cancer patients and hepatoma cells. Chemerin altered hepatoma cell morphology but had noeff ect on normal hepatocytes. Chemerin inhibited proliferationof several human hepatoma cell lines. Real-time PCRdetection of hepatocellular carcinoma markers showed thatmRNA levels of albumin and A-type gamma-glutamyltransferase increased whereas those of alpha-fetoprotein,alkaline phosphatase, B-type gamma-glutamyl transferase,insulin-like growth factor II, and human telomerase reversetranscriptase decreased in chemerin-treated SMMC7721cells. Western blotting revealed that chemerin up-regulatedalbumin and vimentin expressions, and downregulated alpha-fetoprotein expression. Phosphorylated STAT3 wassignifi cantly up-regulated, whereas phosphorylated ERKand AKT were signifi cantly downregulated by chemerin. Chemerin decreased phosphorylated ERK and AKT expressionand the cell proliferation induced by PI3K activator 740Y-P but could not signifi cantly alter phosphorylated STAT3expression and the cell growth induced by STAT3 inhibitorNSC74859. In conclusion, chemerin reversed the malignantphenotype and induced SMMC7721 cell diff erentiation byinhibiting MAPK/ERK and PI3K/AKT signaling; growthinhibition by chemerin is not directly related to the JAK/STAT signaling pathway. Our study provides novel evidencethat chemerin could be utilized for liver cancer treatment.

Genome‑wide identification and expression analysis of the StSWEET family genes in potato (Solanum tuberosum L.)

Ming Li,Haijuan Xie,Miaomiao He,Wang Su,Yongzhi Yang,Jian Wang,Guangji Ye,Yun Zhou 한국유전학회 2020 Genes & Genomics Vol.42 No.2

Background The sugar will eventually be exported transporter (SWEET) family is a novel type of membrane-embedded sugar transporter that contains seven transmembrane helices with two MtN3/saliva domains. The SWEET family plays crucial roles in multiple processes, including carbohydrate transportation, development, environmental adaptability and host–pathogen interactions. Although SWEET genes, especially those involved in response to biotic stresses, have been extensively characterized in many plants, they have not yet been studied in potato. Objective The identification of StSWEET genes provides important candidates for further functional analysis and lays the foundation for the production of good quality and high yield potatoes through molecular breeding. Methods In this study, StSWEET genes were identified using a genome-wide search method. A comprehensive analysis of StSWEET family through bioinformatics methods, such as phylogenetic tree, gene structure and promoter prediction analysis. The expression profiles of StSWEET genes in different potato tissues and under P. infestans attack and sugar stress were studied using quantitative real-time polymerase chain reaction (qRT-PCR). Results Phylogenetic analysis classified 33 StSWEET genes into four groups containing 12, 5, 12 and 4 genes. Furthermore, the gene structures and conserved motifs found that the StSWEET genes are very conservative during evolution. The chromosomal localization pattern showed that the distribution and density of the StSWEETs on 10 potato chromosomes were uneven and basically clustered. Predictive promoter analysis indicated that StSWEET proteins are associated with cell growth, development, secondary metabolism, and response to biotic and abiotic stresses. Finally, the expression patterns of the StSWEET genes in different tissues and the induction of P. infestans and the process of the sugar stress were investigated to obtain the tissue-specific and stress-responsive candidates. Conclusion This study systematically identifies the SWEET gene family in potato at the genome-wide level, providing important candidates for further functional analysis and contributing to a better understanding of the molecular basis of development and tolerance in potato.