한국인 정신분열병 환자의 HLA-DQA1,HLA-DQB1 HLA-DRB1 대립유전자 빈도

신규성,이민수,김영리,김영태,조윤정 대한신경정신의학회 2000 신경정신의학 Vol.39 No.4

연구목적: 저자들은 PCR-SSOP 방법으로 한국인 정신분열병 환자에서 HLA-DQA1, HLA-DQB1 및 HLA- DRB1과 정신분열병의 감수성과의 상관성을 밝히고자 하였다. 방법: DSM-IV 에 의거하여 정신분열병으로 진단된 환자군 128명과 정상대조군 160명에 대해 polymerase chain reaction-sequence specifc oligonucleotide probes(PCR-SSOP) 방법을 이용하여 HLA-DQA1, HLA-DQB1, HLA-DRB1 대립유전자의 빈도를 분석하였다. 결과: HLA-DQB1□04는 환자군에서 14.6%로 정상대조군의 8.2%보다 높은 빈도를 보였고 (p=0.028), HLA-DRB1□14는 환자군에서 11.8%로 정상대조군으 5.5%보다 높았으며 (p=0.01), HLA-DRB□15는 환자군에서 2.0%로 정상대조군의 7.1%보다 낮은 빈도를 보였고(p=0.007), HLA-DRB□16은 환자군에서 1.6%로 정상대조군의 4.8%에 비해 유의하게 낮았다(p=0.043). 결론: 한국인 정신분열병 환자에서 HLA-DQB1□04와 HLA-DRB1□14S는 질병 발생의 감수성 인자로 작용을 하고, HLA-DRB1□15와 HLA-DRB1□16은 방어적인 역할을 할 수 있다고 할 수 있으나, 다른 인종에 관한 외국의 연구자들의 결과와는 상이한 양상을 보였다. Objectives: The aim of this study was to investigate the correlation between HLA-DQA1,HLA-DQB1 and HLA-DRB! alleles and disease susceptibility in Korean schizophrenic patients. Methods: HLA-DQA1, HLA-DQB1, and HLA-DRB! allele typing were performed using polymerase chain reaction-sequence specific oligonucleotide probes(PCR-SSOP) method in 128 Korean schizophrenic patients diagnosed by DSM-IV criteria, who were not blood-related, and 160 normal blood bank donors. Results: The HLA-DQB1□04 allele frequency was 14.6% in schizophrenic patients, which was significantly higher than that of normal controls which was 8.2%(p=0.028). HLA-DRB1□14 allele frequency was 11.8% in patients, which was also more frequent than that of normal controls which was 5.5%(p=0.01). HLA-DRB1□15 allele frequency was 2.0% in patients, which was significantly lower than that of normal controls which was 7.1%(p=0.007) and HLA-DRB1□16 allele frequency was 1.6% in patients, which was also lower than that of normal controls which was 4.8%(p=0.043). Conclusion: Schizophrenia in Korea had positive correlation with HLA-DQB1□04 and HLA-DRB1□14, and negative correlation with HLA-DRB1□15 and HLA-DRB1□16. These findings support the association of the HLA-DQB1 and HLA-DRB1 with schizophrenia in Korean population, which was different from other study results in other different ethnic groups.

혈청 HBsAg 양성인 사구체신염의 임상상 및 신조직 소견

신영태,구영선,강민규,황평주,김종학,이강욱,서광선 충남대학교 의과대학 지역사회의학연구소 1999 충남의대잡지 Vol.26 No.1

Hepatitis-B-associated glomerulonephritis is one of the immunologically mediated disorders associated with chronic Hepatitis B virus(HBV) infection. The frequency of HBsAg infection has been high in East Asia and it is one of the most important etiologic factors of the secondary glomerulonephritis. We reviewed the clinical and pathologic features of 29 patients with glomerulonephritis and HBs antigenemia, who were admitted to Chungnam National University Hospital from January 1988 to Febuary 1999. The results were as follows : 1) The average age of the patients was 33.8±10.4(mean±SD) and male to female ratio was 3.8. Proteinuria was present in 27 patients(93%), hematuria in 20 patients(69%) and hypertension in 17 patients(59%). Two patients(7%) manifested with renal insufficiency and 8 patients(28%) with nephrotic syndrome. 2) Renal pathology revealed membranous nephropathy(41%), membranoproliferative glomerulonephritis(21%), mesangial proliferative glomeulonephritis(21%), minimal change nephritis (14%) and focal segmental glomerulonephritis(3%). 3) The pathologic findings of liver were chronic active hepatitis(68%), chronic persistent hepatitis(38%) and liver cirrhosis(8%). 4) During the follow-up period(average:49.4 months), 7 patients(68%) presented persistent proteinuria, 5 patients(21%) progressed to renal failure and 2 patients(8%) resolved clinically. 5) The treatment was done with prednisolone to 3 patients, and with alpha-interferon to 3 patients. One patient treated with prednisolone resolved clinically, but this resolution did not coincide with disappearance of the hepatitis B antigens.

전신성 홍반성 낭창의 임상적 고찰

신영태,김종학,장윤경,양종오,구영선,강민규,황평주,나기량,이강욱,서광선 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

The epidemiology, diagnostic criteria, clinical features, symptoms and signs laboratory findings, kidney pathology, and clinicopathologic correlation of systemic lupus erythematosus(SLE) were analyzed. The 63 patients studied were managed at the Department of Internal medicine, CNUH, from January 1983 to December 1997. Kidney biopsy was performed in 53 patients out of 63 patients with SLE. The results were as follows: 1. The ratio of male to female was 1:26. They were 12 to 71 years old and mean age was 32.1 years old. The peak age incidence was 4th decades(30%). 2. The most frequent chief complaint on admission was generalized edema. Most patients complain two or more symptoms. 3. Immunologic and renal disorders were the most frequently observed in the ARA criteria of SLE. And the positive ANA, hematologic disorder, malar rash, and arthritis, were observed in order of frequency. 4. Among the 53 patients with renal biopsy, 30 patients revealed class Ⅳ lupus nephritis(56%), class II in 12 patients(23%), class V in 8 patients(15%) and class III in 2 patients(6%). 5. The cases of lupus nephritis represented as nephrotic syndrome were high in the class IV with 68% and class V with 86%. 6. Of 30 patients who can be followed up, 5 patients resulted in death(17 % of mortality). They "were 14 to 57 years old and mean age was 28 years old. Follow up duration were from 1 month to 6 years and 3 months, and mean duration was 1 year and 1 month, but 3 cases 7. The causes of death were as follows: Two cases were due to seizure and coma resulted from CNS involvement. One was sepsis due to miliary the & pneumonia. One was dilated cardiomyopathy and heart failure due to cardiac ac involvement. And the other one was sepsis and acute renal failure resulted from cellulitis. 8. Prednisolone was used in all patients basically, and methyl-prednisolone pulse therapy, antimalarials and alkylating agents were used in some cases. In the cases of combined therapy, the activity of SLE was well controlled.

최근 5년간 피부외과술로 치료받은 환자의 분석 : 1994. 1∼1998. 12

신정현,강민정,조소연,황규광,함정희 梨花女子大學校 醫科大學 醫科學硏究所 2000 EMJ (Ewha medical journal) Vol.23 No.2

연구 목적 : 1990년대 이후 국외 및 국내에서 피부외과의 영역이 넓어지고 있으나 현재 국내에서 시행되고 있는 피부외과적 수술에 대한 통계는 아직 보고되지 않아 그 현황이 잘 파악되지 않고 있다. 이에 저자들은 본교실 미용피부외과 클리닉에 내원하여 수술을 받은 환자 1,075명을 대상으로 통계적 분석을 시행하여 피부외과 환자의 분포, 경향을 파악하여 향후 발전의 토대로 삼고자 한다. 방법: 1994년 1월부터 1998년 12월까지 5년간 이화여자대학교 의과대학 부속 동대문병원 피부과 미용피부외과 클리닉에 내원하여 수술을 받은 환자 1,075명을 대상으로 성별, 연령별, 주거지역별 분포와 진단명 및 수술의 종류에 대하여 통계적 분석하였다. 결과: 1) 남녀비는 1 : 2.4였고, 연령은 10개월부터 87세까지로 다양하였으나 20, 30대가 66.0%로 가장 많고 평균연령은 남자 30.6세, 여자 30.2세였다. 환자의 주거지역별 분포는 서울시가 75%로 가장 많았고 서울시내 지역구별의 차이는 크지 않았다. 2) 환자 1명이 두 가지 이상의 질환을 가질 때 각 질환을 개개로 간주하여 총 1.354예의 질환을 수술하였으며 반흔(39.8%), 색소성 질환(30.8%), 악성/양성종양(21.2%), 기타질환(8.2%) 순이었다. 3) 수술은 총 2,334회 시행되었고 그 종류별 빈도는 화학박피수술 가장 많아 846예(36.2%)이었고 다음으로 냉동외과술 650예(27.8%), CO_2 레이저 255예(10.9%), 기계박피술 209예(8.9%), 외과적 절제술 113예(4.8%), Mohs 미세도식수술 61예(2.6%), 혈관응고술 50예(2.1%), 피판재건술 48예(2.0%)이었으며 그 외 모발이식 15예, 표피이식 13예, 자가지방이식 2예 등이 있었다. 4) 각 반흔의 종류에 따라 분류하면, 여드름반흔은 화학박피술(72.7%), CO_2 레이저(11.9%) 및 기계박피술(9.7%)로, 위축성반흔은 기계박피술(37.3%). CO_2 레이저(27.8%) 및 펀치상향술(11.9%)로, 비후성반흔은 냉동외과술(28.2%), 기계박피술(24.2%) 및 CO_2 레이저(22.7%)로 치료하였다. 5) 악성종양 및 일부 양성종양에 Mohs 미세도식수술을 시행하였으며 재건술로 총 61예 중 피판재건술을 시행한 예가 가장 많아 45.9%이었고, 단순봉합이 36.1%, 복합봉합은 18.0% 이었다. 결론: 피부외과적 수술환자는 여자가 남자보다 2.4배 많았으나 남자의 비율이 증가추세에 있고 남녀 모두 평균 연령은 30대였다. 수술질환은 반흔과 색소성 질환이 가장 많아 미용적인 관심이 매우 높음을 알 수 있었고 연도별 유의한 차이는 없었다 총 2,334회 수술 중 화학박피술, 냉동외과술이 50% 이상을 차지하였고 반흔의 종류에 따라 선호되는 수술이 달랐다. 악성종양은 모두 Mohs 미세도식 수술하였으며 주로 국소 피판술로 재건하였다. 이상의 분석으로 피부외과적 수술환자의 분포, 대상질환, 수술방법 등을 빈도별로 파악할 수 있었으며, 향후 각 질환별 혹은 수술별로 세분하여 수술성과 및 만족도 조사를 시행함으로써 피부외과 분야 및 본 크리닉의 발전 방향을 설정하는 가늠자 역할을 할 것으로 기대한다. Background : The field of dermatologic surgery has seen trementdous developments in the past few years. Objective : Our purpose was to discuss current statistical data on the dermatologic patients treated by surgical methods at our institute. Methods : We analyzed 2,334 cases of surgeries performed on 1,075 patients at the Department of Dermatology of Ewha Womans University Tongdaemun Hospital during a period of 5 years (1994. 1 - 1998. 12). Results & Conclusion : The results are summarized as folows: 1) Of the 2,334 cases of surgeries, 846 cases(36.2%) were chemical peelings, 650 cases(27.8%) cryosurgeries, 255 cases(10.9%) CO_2, lasers, 209 cases(8.9%) dermabrasions, 113 cases(4.8%) scalpel surgeries, 61 cases(2.6%) Mohs micrographic surgeries, 50 cases(21.1%) sclerotherapy, 48 cases(2.0%) flap repair surgeries, 35 cases(1.5%) punch elevations, 15 cases(0.6%) hair transplantations, 13 cases(0.5%) epidermal grafts, and 2 cases(0.1%) autologous fat/collagen transplantations. 2) The ratio of male to female was 1 : 2.4 and the mean age of patients was 30.3 years. 3) A total of 1,354 cases of diseases were managed surgically : among them, the most frequent disease was scar(39.8%), followed by pigmentary disorders(30.8%), and benign or malignant tumors(21.2%). 4) With respect to the types of scars, acne scar was treated most frequently by chemical peeling (72.7% of 580 cases), atrophic scar by dermabrasion(37.3% of 126 cases), and hypertrophic scar (including burn scars) by cryosurgery(35.3% of 85 cases).

뇌졸중후 연하곤란 환자의 식이 상태 비교

신용일,양충용,김헌수,강문규,주민철,길은영,권영미 圓光大學校 醫科學硏究所 2004 圓光醫科學 Vol.19 No.2

지속성 외래 복막투석 환자의 복막염

신영태,황평주,김종학,강민규,구영선,양종오,장윤경,이강욱 충남대학교 의과대학 지역사회의학연구소 1999 충남의대잡지 Vol.26 No.1

CAPD has established itself as an effective method maintaining the patients with end stage renal disease. CAPD peritonitis is one of the most important complication of peritoneal dialysis. We analyzed the incidence, pathogens, and outcome of the peritonitis, of the 95 patients who underwent CAPD at CNUH from January 1993 to July 1998. The result were as follows : 1) A total of 72 episodes of peritonitis occurred during this periods. The incidence of peritonitis were 0.64/patient/year. 2) The first episode of peritonitis was occurred within a year in 75%, within two year in 95.8%. 3) The rate of positive and negative culture were 27.8% and 72.2% respectively. Gram positive organisms were cultured in 60%, Gram negative organisms in 40%. S. aureus were most prevalent organisms(30%). 4) The cure rate were 83.3% in Gram positive organisms and 62.5% in negative organisms. 5) Peritoneal catheter were removed in 18 cases. Among them, 7 cases are due to peritonitis. In conclusion, improved technology and increasing patients' effort to careful management of catheter will reduce the incidence of peritonitis.

漢方治療用 藥材의 地域特産性 調査硏究 : 生産 및 消費構造를 中心으로

辛民敎,柳聖圭,柳熙英 圓光大學校 1980 論文集 Vol.14 No.2

According to my research on the subject the followings are the conclusions: (Ⅰ)We should study regional characteristics of productions. (Ⅱ)We need the investigation and analysis of the soil and herb's qualities. (Ⅲ)And also we should study the comparative research on the subject of fertilization and herb's qualities. (Ⅳ)The fact that time of partial harvest of each herbs is how effective on qualities should be investigated. (Ⅴ)The improvements of herb's storage and market system form should be considered seriously. (Ⅵ)For the purposes of the analysis of essential efficacies and economic circumstances about oriental medical herbs, I would like summarize as follows as my conclusions. 1. I proposed, already, introduced synthetically established larger planting areas according to the studies of environmental biology and its medical plnats and economics, constituting 91 kinds including Ostericum Koreana. 2. According to the conclusion that 87 kinds of Korean products and 157 foreign products under comparative researches, I found out that producing of other many medical herbs could be productive in Korean wasted lands considering those herbs can grow even on the sandy lands in foreign countries which are successful in prod-ucing fruitful plants. 3. It is well-known fact that the efficacies of every medical herbs are depend upon temperature, water permeabilty, basic fertilization and after-fertilization. Skin groups should be collected at June or July, medical groups full-bloom or little bit later, flower groups full-bloom or after that, all herbal medicine full-bloom time, the roots in March or September, the fruits or seeds in September or October. 4. All medical herb products should be controlled under the sponsor of Monopoly Bureau just as ginseng. 5. According to the reports of WHO it is learned that oriental medicines have impricated and natural meanings, and after the early 1970 the exports of Korean medical herbs to foreign countries showed very encouraging. 6. At any rate, above mentioned facts must be handled at the government(ROK) level.

신용카드와 관련된 소비자문제경험연구

申順圭,金玟廷 啓明大學校 生活科學硏究所 1994 科學論集 Vol.20 No.-

The credit card, so called "the third currency", showed up as the new consumption pattern are increased rapidly. The whole problems of credit card of consumer damages is increasing because of recognitive lack on the credit card law of consumers In that credit card problem influenced directly consumer's economy, this study was attempted to investigate empirically consumer problem experiences according to credit card use consumer science. The concrete purpose of this study are as follows. ; 1) What extent is problem experience degree of credit card user? 2) According to socio-economic variables, demographic variables, purchase pattern, and consumer knowledge of credit card system, what differences are problem experience degree of credit card user? 3) What extent are the relative influences of variables affected credit card user's problem experience degree? The subjects of this study are restricted to the salaried men and women. By ?? program, the 328 data obtained were analyzed by frequency, mean, ANOVA, Multiple Regression Analysis and Duncan's multiple range test. The major findings of this study are summarized as follows ; 1) The problem experience degrees of credit card user were average 10.1, it was low but the majority of consumer had been experienced more than one problem. 2) The problem experience degree showed significant differences among the user groups, according to sex, age, income, monthly usage frequency of cards, consumer knowledge of credit card system. 3) The variables influenced on problem experience degree were possessive card quantities and sex. As possesive card quantities were more, and man than woman, showed higher problem experience degree.

디지탈 影像處理를 爲한 畵像表示 시스템에 關한 硏究

박규태,박명구,신태민,강현철 연세대학교 산업기술연구소 1983 논문집 Vol.15 No.2

A digital image display system is studied. A TV set is used for a display unit. The system is designed to display 256x212 pixels in a frame and 8 bit gray levels. A microcomputer system is utilized for the image processing which has a Z-80A cpu and s-100 bus. A image processing system which includes a refresh memory system is designed. Images taken by the input system are processed. The image sharpening techniques are introduced. The image edges are found and sharpend using Robert cross operator of spatial differentiation technique. The images are also processed to eliminate noise utilizing the neighbourhood averaging method.

만성 신부전환자의 혈청 갑상선홀몬 농도의 변화

김민범,이정호,신영태,김삼용,노흥규 충남대학교 의과대학 지역사회의학연구소 1989 충남의대잡지 Vol.16 No.1

To investigate the thyroid hormonal changes and their mechanisms in patients with chronic renal failure (CRF), the author measured serum levels of the thyroid hormones using radioimmu-noassay and calculated each ratio of serum thyroid hormones in 17 patients with CRF. Ten patients were on hemodialysis therapy and seven patients had not undergone hemodialysis. The following results were obtained. 1) The serum T3 and T4 concentrations were significantly lower in patients with CRF(0.7±0.47㎍/1 and 5.53±2.95㎍/dl, respectively) than in normal subjects(1.21±0.18㎍/1 and 9.46±1.92㎍/dl, respectively. 2) The serum FT4(free T4) concentration was significantly lower in patients with CRF(1.20±0.50μu/dl) than in normal subjects(1.01±0.48μu/dl). 4) The serum rT3(reverse T3) concentration in patients with CRF(285.7±148.1pg/ml) tends to be greater than normal subjects(204.6±43.3pg/ml). But is was not significant statistically. 5) The calculated serum concentration ratio of T3/T4 in patients with CRF(0.17±0.04: presented as Mean±SEM) did not differ significantly from that of normal subjects(0.13±0.01). But the serum concentration ratio of rT3/T4 in patients with CRF(78.78±18.98) was significantly greater than in normal subjects(21.90±1.04). 6) There was no significant difference in thyroid functions between male and female patients with CRF, and also between patients on hemodialysis and non-dialyzed uremic patients. It was concluded that the serum T3, T4, FT4 concentration were significantly decreased in patients with CRF, while the serum TSH concentration was significantly increased. The calculated serum concentration ratio of rT3/T4 was also significantly increased in patients with CRF. Thus is appears that abnormalities found in patients with CRF may reflect both the possible intrathyroidal abnormalities and alteration of serum rT3 metabolism with increased peripheral generation of rT3 from T4.