세 개의 히드록실기를 가진 양이온 계면활성제 합성 및 계면 특성에 관한 연구

이병민 ( Byung Min Lee ),김지현 ( Ji Hyun Kim ),김승수 ( Sung Soo Kim ),임종주 ( Jong Choo Lim ) 한국공업화학회 2012 공업화학 Vol.23 No.5

본 연구에서는 도데실 글리시딜 에테르와 아미노에탄올을 반응시킨 후 디메틸 설페이트로 4급화시켜 분자 내에 2개의 라우릴기, 3개의 히드록실기를 가진 양이온 계면활성제 BHMAS (N, N-bis-(3`-n-dodecyloxy-2`-hydroxypropyl)-N-methyl- 2-hydroxyethylammonium methyl sulfate)를 합성하였고, 생성물의 분자구조는 1 H-NMR, FT-IR 등의 기기분석을 통하여 확인하였다. 합성한 계면활성제의 CMC (critical micelle concentration)는 9.12 × 10 -4 mol/L이며, CMC에서의 표면장력은 28.71mN/m이었다. Maximum bubble pressure tensiometer를 사용하여 동적 표면장력을 측정한 결과, 공기와 수용액의 계면이 계면활성제 단분자에 의하여 포화되는 데 비교적 오랜 시간이 소요되었다. 1 wt% 계면활성제 수용액과 n-decane 사이의 계면장력은 0.045mN/m이며, 평형에 도달하는 데 약 5 min의 시간이 소요되었다. 합성된 계면활성제의 흡착 특성이 매우 우수하였으며, 합성한 양이온 계면활성제가 섬유표면에 효과적으로 흡착되어 유연효과를 나타낼 수 있음을 확인하였다. In this study, a cationic surfactant BHMAS (N,N-bis-(3`-n-dodecyloxy-2`-hydroxypropyl)-N-methyl-2-hydroxyethylammonium methyl sulfate) having two lauryl and three hydroxyl groups was synthesized by the reaction of n-dodecyl glycidyl ether and 2-aminoethanol followed by the quarternization with dimethyl sulfate. The structure of the product was elucidated by 1 H-NMR and FT-IR. The CMC (critical micelle concentration) and surface tension of BHMAS at CMC condition were found to be 9.12 × 10 -4mol/L and 28.71mN/m respectively. Dynamic surface tension measurements using a maximum bubble pressure tensiometer indicated that a relatively long time was required to saturate the interface between air and aqueous surfactant solution. The interfacial tension measured between 1 wt% surfactant solution and n-decane reached an equilibrium value of 0.045mN/m in 5 min. The adsorption capacity of the synthesized surfactant was observed to be excellent, which suggests that the surfactant can be used as a softening agent during a laundry process.

OB-28 : Perinatal Outcomes of Gestational Weight Gain and Insulin Therapy in Gestational and Pregestational Diabetic Women

( Ji Man Heo ),( Min Ji Choo ),( Hye Sook Im ),( Geum Joon Cho ),( Soon Cheol Hong ),( Min Jeong Oh ),( Hai Joong Kim ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.99 No.-

The aim of this study was to investigate the impact of excessive gestational weight gain (GWG) and insulin therapy on perinatal outcomes in women with gestational (GDM) and pregestational diabetes mellitus (DM). A study was conducted among 92 GDM, 45 DM women who delivered a live singleton infant at korea university ansan hospital, Korea, from January 2010 to January 2013. 137 women was categorized by GWG (inadequate, adequate, or excessive, according to the 2009 Institute of Medicine guidelines), by pregestational BMI (underweight, normal weight, overweight, or obese), and by insulin use. Perinatal outcomes were compared among those groups. There was a weak positive correlation between GWG and fetal birthweight (p<0.001, r=0.379). Excessive GWG associated with an increased rate of high birthweight (>4000g, p=0.006), and inadequate GWG associated with an increased rate of low birthweight (<2500g, p<0.001), Preterm birth (birth before 37 weeks` gestation, p=0.004), and neonatal intensive care unit (NICU) admission (p=0.007). There was a weak positive correlation between pregestational BMI and birthweight (p=0.04, r=0.176), but birthweight was no significantly difference among those 4 BMI groups. perinatal outcomes are not significantly different among the BMI groups. Insulin use associated with decreased rate of LBW, Preterm birth, and NICU admission (odds ratio=3.68, 3.99, and 3.08, respectively). Our study shows that GWG is more associated with adverse perinatal outcomes than pregestational BMI, and that insulin use associated with decreased rate of adverse perinatal outcomes in GDM and DM women. These results suggest that adequate weight control is important in GDM and DM women.

A rare case of adenoid basal cell carcinoma

( Ji Yoon Choo ),( Ju Hee Han ),( Ji Hyun Lee ),( Young Min Park ),( Jun Young Lee ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1

Adenoid type basal cell carcinoma (BCC) is rare histopathological variant accounting 5.9 % of all BCC. Clinically, adenoid BCC present as pigmented and nonpigmented nodule or ulcer without any site predilection. Herein, we report on a case of adenoid BCC occurring in unusual site. A 77-year-old female presented with a pruritic, 2cm-sized, skin-colored to brownish mass with telangiectasia on the trunk since childhood. She had no past history or family history of skin cancer. At dermoscopic examination we observed vascular pattern with linear-irregular vessels, multiple blue-gray dots and ovoid nests. The histopathological examination showed a multiple cyst-like structures with proliferation of basaloid cells that extended into the dermis. In the center of the cyst-like enlarged structure, the basaloid cells showed slightly enlarged, hyperchromatic nuclei and scanty cytoplasm. Immunohistochemical staining for CEA, EMA and S-100 was negative and P63 and Ki-67 was positive. After no evidence of distant metastasis was confirmed, wide excision was done.

A case of Vogt-Koyanagi-Harada (VKH) syndrome with alopecia universalis in an adolescent girl

( Ji Yoon Choo ),( Young Hoon Yoon ),( Ji Hyun Lee ),( Young Min Park ),( Jun Young Lee ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1

Vogt-Koyanagi-Harada (VKH) syndrome is a rare systemic disorder and an idiopathic autoimmune disease characterized by panuveitis in association with cutaneous, neurologic, and auditory abnormalities. It usually affects darker-pigmented individuals, especially members of the Asian, Indian, and Latin races. Women are more affected than men (2:1), and the peak incidence is seen in the third or fourth decade of life. It is rarely seen in children, with one study indicating that only 3% of all VKH cases are observed in childhood. The cutaneous features are alopecia and vitiligo or poliosis, dependent upon the site of melanocyte location. Alopecia usually appears as discrete, alopecic patches around the head. However, in our knowledge, only a few cases have been reported diffuse hair loss and only one previous case has been reported alopecia universalis with VKH syndrome. A 13-year-old woman presented with asymptomatic, diffuse hair loss and depigmented patches on the scalp since 1 year ago. She had been suffered total hair loss on the whole body after 2 months. She had uveitis, meningitis and tinnitus for several years, but no family history. According to clinical manifestation, diagnosis of VKH disease was established. Herein, we report a rare case of VKH syndrome with alopecia universalis in an adolescent period.

Hot Topics : P4: Regulation of IL-1α, IL-6 and Human β Defensin-2 in Human Epidermal Keratinocytes Exposed to Staphylococcus Aureus by Epidermal Growth Factor

( Ji Min Kim ),( Jung Eun Choo ),( Kyung Hyun Min ),( Sung Eun Chang ) 한국피부장벽학회 2015 한국피부장벽학회지 Vol.17 No.2

Staphylococcus aureus (S. aureus) skin colonization is universal in atopic dermatitis (AD) which is characterized by impaired skin barrier and decreased antimicrobial peptides (AMPs) with defective innate immune function. S. aureus also is known to increase in the patients who get epidermal growth factor (EGF) receptor inhibitors for the treatment of various cancers. Despite EGF has been successfully used topically to promote wound healing, potential role of EGF in chronic skin inflammatory disorders including AD has not been clarified. Thus, we investigated the effect of EGF on inflammatory cytokines and AMPs by ELISA assay in human epidermal keratinocyte treated with heat-inactivated S. aureus (HKSA). Intracellular signaling pathways such as ERK, NFκB and p38 were investigated using quantitative PCR. HKSA-induced IL-6 expression and mRNA levels of NFκB and p38 were decreased by EGF. Intriguingly, EGF increased the expression of IL-1α and human β defensin 2 (hBD2). Taken together, EGF may contribute to relieve inflammatory signals induced by S. aureus and to improve skin barrier function, suggesting a possible role of EGF in AD.

Whitish blotch - the most helpful dermoscopic finding of true vasculitis to select the optimal biopsy site

( Ji Yoon Choo ),( Ji Hyun Lee ),( Jun Young Lee ),( Young Min Park ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.2

Background: Cutaneous vasculitis is an inflammatory process of vessels whose diagnosis is based on the histologic evidence of endothelial damage. However, random selection of the biopsy site from lesions can’t always promise to confirm vasculitis. Objectives: To determine the dermoscopic features of ‘true vasculitis’ which may facilitate to select the optimal biopsy site. Methods: From the histopathologic data base of recent 2 years, 27 biopsy-proven cases with dermoscopic imagesavailable were finally included in this study. These cases were divided into two groups; ‘vasculitis’ or ‘vasculopathy’ group according to the histopathologic criteria for ‘true vasculitis’. Nine specimens fulfilled the standard criteria of vasculitis (‘vasculitis’ group) and 18 specimens who failed to satisfy the criteria were included in ‘vasculopathy’ group. We compared the dermoscopic images between two groups. Results: Whitish blotch was shown in 6 cases (75.0%) of ‘vasculitis’ group, whereas that in 2 (15.8%) of ‘vasculopathy’ group (P=0.006). Mottled purpuric pattern, orange-brown background, and purpuric globules were demonstrated in 100%, 66.7%, 55.6%, respectively, of ‘vasculitis’ cases, and in 83.3%, 77.8%, 50.0%, respectively, of ‘vasculopathy’ cases (P=0.495, 0.653, 1.0, respectively). Conclusion: Our results suggest the whitish blotch is the most helpful dermoscopic finding of true vasculitis to select the optimal biopsy site.

Squamous Cell Carcinoma Derived from Bowenoid Papulosis of the Vulva

( Ji Yoon Choo ),( Gyeong Sin Park ),( Hee Jin Jun ),( Ji Hyun Lee ),( Young Min Park ),( Jun Young Lee ) 대한피부과학회 2017 大韓皮膚科學會誌 Vol.55 No.4

LETTER TO THE EDITOR : Cutaneous Metastasis of Giant Cell-Rich Osteosarcoma

( Ji Yoon Choo ),( Ji Hyun Lee ),( Jun Young Lee ),( Young Min Park ) 대한피부과학회 2016 Annals of Dermatology Vol.28 No.2

Developmental Patterns of mST3GaIV mRNA Expression in the Mouse: In Situ Hybridization using DIG-labeled RNA Probes

Ji, Min-Young,Lee, Young-Choon,Do, Su-Il,Nam, Sang-Yun,Jung, Kyu-Yong,Kim, Hyoung-Min,Park, Jong-Kun,Choo, Young-Kug The Pharmaceutical Society of Korea 2000 Archives of Pharmacal Research Vol.23 No.5

mST3GaIV synthesizes ganglioside GM3, the precursor for simple and complex a- and b- series gangliosides, and the expression and regulation of mST3GaIV (CMP-NeuAc: lactosylceramide $\alpha$2,3-sialyltransferase) activity is central to the production of almost all gangliosides, a class of glycosphingolipids implicated in variety of cellular processes such as transmembrane signaling, synaptic transmission, specialized membrane domain formation and cell-cell interactions. To understand the developmental expression of mST3GaIV in mice, we investigated the spatial and temporal expression of mST3GaIV mRNA during the mouse embryogenesis [embryonic (E) days; 19, E11, E13, E15] by in situ hybridization with digoxigenin-labeled RNA probes. All tissues from 19 and E11 were positive for mST3GaIV mRNA. On E13, mST3GaIV mRNA was expressed in various neural and non-neural tissues. In contrast to these, on E15, the telencephalon and liver produced a strong expression of mST3GaIV which was a quite similar to that of E13. In this stage, mST3GaIV mRNA was also expressed in some non-neural tissues. These data indicate that mST3GaIV is differently expressed at developmental stages of embryo, and this may be importantly related with regulation of organogenesis in mice.

Effects of ESG Management of Retail Companies on Consumer Values and Attitudes

Choo Yeon KIM(Choo Yeon KIM),Ji Min PYO(Ji Min PYO),Seong Soo CHA(Seong Soo CHA) 한국유통과학회 2023 유통과학연구 Vol.21 No.4

Purpose: This study aims to investigate the effect of retailer’s ESG performance on consumption value. The research analyzed the effect of consumption value that can be obtained through ESG management of retail companies on consumer attitude and repurchase intention. Research design, data, and methodology: A research model and hypothesis were established, and statistical analysis was performed on a total of 278 samples of all age groups. To secure the reliability and validity of the data, confirmatory factor analysis and discriminant validity analysis were performed, and the causal relationship of latent variables was verified through path analysis. Results: As a result of the analysis, it was found that among the characteristics of consumption value according to ESG management, social value, economic value, accessible value, and eco-friendly value had an effect on social contribution attitude. Also, the economic value was found to have an effect on the self-actualization attitude, and both the social contribution attitude and the self-actualization attitude have an effect on the purchase intention. Conclusions: This study empirically analyzed the value of ESG management in the retail industry that consumers are paying attention to recently. This will serve as a basis for revising and supplementing the retail companies’ strategy in the near future.