다양한 비스테로이드성 소염진통제의 쥐 피부 투과

김민정,도희정,조원제,용철순,최한곤,이치호,김대덕 한국약제학회 2002 Journal of Pharmaceutical Investigation Vol.32 No.4

Rat skin permeation of various nonsteroidal antiinflammatory drugs (NSAIDs) was investigated in vitro using Franz diffusion cell at 37℃. The effect of various skin permeation enhancers was also observed as a preliminary study of developing transdermal delivery systems of NSAIDs. Lipophilicity of NSAIDs was determined from the partition coefficient (log P) in 1-octanol/water and 1-octanol/IPB mutual-saturated solutions. The solubility was determined in water, isotonic phosphate buffer (IPB), and propylene glycol (PG) at 37℃. The rat skin permeation rate of acetaminophen, piroxicam, and aceclofenac was almost negligible, although they were saturated in PG. Addition of 1 % permeation enhancer increased the permeation rate of ketoprofen, ketorolac, and diclofenac. However, the skin permeation rate of ibuprofen did not increase with the addition of various enhancers. Among the permeation enhancers tested, oleic acid was the most effective for various NSAIDs. Based on the daily dose, lipophilicity, and the skin permeation rate achieved in this study, ketoprofen and ketorolac seem to be the most promising drug candidates for transdermal delivery systems, especially when formulated with unsaturated fatty acids, such as oleic acid.

사업자 관점에서 본 소형 열병합발전 시스템의 지원제도 모색에 관한 연구

金正勳,李鳳容,高敏濟 弘益大學校 科學技術硏究所 1994 科學技術硏究論文集 Vol.5 No.-

The cogeneration system has an advantage of producing eletrical and thermal energy simultaneously, therefore, this system is encouragable to the business proprietor and the nation like us which has the problem of limited energy. Presently, there is a few cogeneration system for new city and industrial complex. But the building cogeneration system is dull in application because of legal limitation and poor tax support. In this paper, a economic propriety of the building system under the support which is applied to industrial system is simulate. And the effect of each support item on the economic propriety in aspect of payback period, is also simulated.

냉각탑용 프로펠러 팬의 설계

김재원,이정민 선문대학교 중소기업기술지원연구소 2001 선문공대 연구/기술 논문집 Vol.6 No.1

냉각탑에 쓰이는 프로펠러 팬의 설계와 개발은 선행 수치해석과 풍동에 의한 실험적 확인으로 이루어졌다. 팬의 날개 형상에서 가장 중요한 것은 공기 역학적 현상의 최적 설계이다. 본 연구에서의 수치해석 방법은 FINE/TURBO라는 상용 프로그램을 이용하여 날개 근처의 자세한 유선과 유량 등의 공학적 자료를 얻었다. 전산 해석 연구에서 얻어진 수치 해석의 결과는 풍동을 이용한 실험 결과와의 비교에서 우수한 정확도를 보여 주었다. 또한, 새로이 제안한 날개의 수치 해석결과 현재 시장에서 판매하고 있는 모델보다 상대적으로 우수한 결과가 도출되었다. Design and developments of a propeller fan for a cooling tower have been accomplished by both numerical prediction of performance and experimental validation with a wind tunnel. Main interest lies on blade geometry of a fan for optimal design of aerodynamic performance. A commercial program, Fine/Turbo used for the present numerical estimation, which gives us engineering information such as flow details near the blades and flow rate of the system. The numerical results are compared with experimental output and show good agreement in comparison between the two data. Also, new proposed model of a blade show improved performance relative to present model in the market.

임플란트 매식시 수직골 높이에 따른 응력분석

김민호,강재석,계기성 조선대학교 구강생물학연구소 2002 口腔生物學硏究 Vol.26 No.2

The purpose of this study was to compare the distributing pattern of stress on the finite element models with the different vertical bone level of implant fixture. The two kinds of finite element models were designed according to vertical bone level around fixture (4.0㎜ x 11.5㎜). The cemented crowns for mandibular first and second molars were made. Three- dimensional finite element model was created with the components of the implant and surrounding bone. Vertical loads were applied with force of 200N distributed within 0.5㎜ radius circle from the center of central fossa and distance 2mm and 4mm apart from the center of central fossa. Von-Mises stresses were recorded and compared in the supporting bone, fixtures, abutment screws, and crown. The results were as following: 1. In vertical loading at the center circle of central fossa on model 1 and 2, the difference from vertical bone in implant placement did not affect the stress Pattern on all components of implant except for crown. 2. With offset distance increasing and the bone level of implant decreasing, the concentration of stress occurred in the buccal side of long crown, around the buccal crestal bone, and on the fixture- abutment interface As a conclusion, the research showed a tendency to increase the stress on the supporting bone, fixture and screw under the offset loads when the vertical level of bone around fixture was different. Since the same vertical bone bed has more benefits than the different bone bed around fixtures, it is important to prepare a same vertical level of bone bed for the success of implants under occlusal loads.

저작근 골막하 박리를 이용한 만성 재발성 탈구의 치험례

심재환,김기홍,문진석,민병진,이원학,홍광진 大韓顎顔面成形再建外科學會 2003 Maxillofacial Plastic Reconstructive Surgery Vol.25 No.3

Chronic recurrent dislocation(CRD) of the jaw has various etilogical causes, including trauma, congenital or acquired neurological illness, ingestion of certain medicines, incorrdination of the neuromuscular astivity of the chewing muscles, articular anatomical alteration, etc. Various surgical methods have been advocated for the treatment of the CRD. They may be divided into two groups: procedures designed to limit translation of the condyle and procedures eliminating obstacles in the condylar path. Hypomobility of mandible can be developed after BSSRO and it is probably caused by scar contracture, atrophy, and myofibrosis. Many authors, therefore, emphasized the importance of physical therapy especially after BSSRO to prevent the complication. Based on that idea, we designed more conservative surgical method to limit mandibular openning compared the methods that previously introduced and tried to treat the CRD. This new method consists of extensive subperiosteal dissection of masseter and the temporalis muscle under local anesthesia and use of intermaxillary elastics for some periods.

FPD 결함검사를 위한 Vision Inspection System 설계에 관한 연구

박성재,김민수,김준식,주효남 湖西大學校 工業技術硏究所 2005 工業技術硏究所論文集 Vol.24 No.-

A system is designed and developed to acquire accurate images and to detect cell defects of Flat Panel Displays. Detailed analysis and experiments are performed to design and select the lighting, optical and camera sub-system as well as mechanical motion and position control sub-system. Sample images are acquired using the developed system and the processed result shows the good performance in detecting simple cell defects.

항만 통합 관리 시뮬레이터 설계 및 개발

이양민,김명근,이재기 동아대학교 공과대학부설 정보통신연구소 2007 情報技術硏究所論文誌 Vol.15 No.1

The quantity of goods transported of port process ability which is the possibility of computing power from the point of view where the competitive power of the nation becomes maximization proceess ability more important than anything. From many research, it conducts the various effort that automatic or intelligence of port, for the maximization port processing ability. Port has important national institution and always used to us for everyday. It is difficult to invest experimental due to improved cost expensive. For maximization ability of port, it is very frequently used through simulation and then predicts a result. This paper describes the "design method and port modeling for port integral management simulator development" that partitions into five phases for maximization ability of port. This paper describes to design simulator for design scheme and give elaboration for it through 3D modeiling of transported goods. Through make this simulator, will help to reseach for quantity of goods transported of port. 항만 통합 관리 시뮬레이터 개발 방안을 주제 로 한 본 논문에서는 크게 두 가지의 기법을 제안하였다. 첫째 항만 의 하역 과정에는 매우 많은 입력인자 와 단계가 존재하므로 각 과정별로 분리하고 문제 해결 방안을 단순화 시킬 수 있는 시뮬레이터 설계 방안을 제안하였다. 둘째 하역 과정별로 모듈 을 구성하고 각 모듈들이 시뮬레이터 되는 동안의 현실감 및 관찰을 수행하기 위한 3D 그래픽을 적용할 수 있는 방안을 기법을 제안 하였다. 첫째 제안은 하역 과정을 5단계로 분리하여 각각의 독립적인 모듈로 구성하고 이를 향후에 통합하는 방식을 취함 으로써 달성하였다 둘째 제안의 경우 는 현재 게임 동의 개발에 다양하게 적용되는 Direct 3D API를 적용하고 3D 장비생성에는 이미지 생성 툴을 활용함으로써 달성하였다. 이를 통하여 항만 하역 과정에 대한 효율적인 시뮬레이션을 수행할 수 있고 최적 처리 과정을 빠르게 도출할 수 있다. 더불어 시뮬레이션 과정을 가상 항만의 움직임과 함께 확인할 수 있어 실제 항만에서의 하역 과정을 유사하게 묘사할 수 있다. 향후 과제로는 항만에 실제 존재하는 풍속 파도의 움직임을 고려하고 더불어 배후 부지 및 도로 등과 연계할 수 있는 시뮬레이터를 개발, 구현하는 것이다.

선천성 완전방실차단이 동반된 신생아 루프스 1예

정재현,이은지,이은주,황진원,송영진,최병진,김일환,김종윤,허민영,김동욱 인제대학교 2009 仁濟醫學 Vol.30 No.-

Neonatal lupus is a rare syndrome occurring In neonates with tranplacentally acquired maternal autoantibodies, In particular anti-SSA/Ro-SSB/Ra antibodies. Manifestations include congenital heart block, cutaneous lesions, thrombocytopenia, neutropenia, pulmonary or neurological disease and hepatitis. The non-cardiac manifestations resolve by 6 months of age, congenital heart block is irreversible. We experienced a case of neonatal lupus with congenital complete heart block in a newborn of asyptomatic mother with anti-SSA/Ro-SSB/Ra antibodies.

Memory 소자 응용을 위한 BST(Ba_xSr_1-_xTiO_3) 강유전체 박막과 전극과의 계면특성

정민재,조정희,홍석민,김호건,김옥경 漢陽大學校 工學技術硏究所 1997 工學技術論文集 Vol.6 No.1

BaxSr1-xTiO3 powders were prepared by changing stoichiometry of Ba and Sr. After they were calcined and sintered at 1,200℃ and 1,300℃ respectively, BST sputtering targets were made in 3inch mould. For MIM structure capacitors. Pt-based structures such as Pt/TiN/SiO2/Si, Pt/Ti/Si3N4/Si, Pt/SiO2/Si, Ru/SiO2/Si and Ru/Si3N4/Si were used for bottom electrodes, and subsequently, the BaxSrl-xTiO3 thin films were sputtered on them. After the analysis of their structures by XRD, Al was evaporated on the BST films for MIM capacitor. We found that the structures of the films showed good crystallinity above 550℃ from the results of XRD measurements. The largest dielectric constant of films was obtained with 0.7mol% of Ba. The electric properties of the capacitors were very good with Pt/TiN/SiO2/Si electrodes.

국내 발전소별 바텀애시를 잔골재 대체재로 사용한 모르터의 특성에 대한 실험적 연구

송민섭,장재봉,조봉석,김재환,김용로,김무한 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1(구조계)

With the advance in industrial development and modern living comfort, the demand for electricity throughout the country is ever increasing. Also the annual consumption of coal by coal-fired power plants is increasing. The amount of ash produced in 2000 is estimated to be about 4.5 million tons. The disposal of this huge amount of ash introduces serious environmental problems. Fly ash among the ash produced is used in building industries as a substitute to cement in concrete and the concrete thus produced is said to be lighter and stronger. But bottom ash among the ash produced is not used because of its poor properties. But encouraging the use of bottom ash as a construction material is a sensible method of utilization as it avoids the problems and costs associated with disposal and provides an alternative aggregate source. This study is aimed at using bottom ash as an alternative fine aggregate source to provide a solution to disposal and insufficient fine aggregate for the production of concrete. So properties of bottom ash produced in power plants were estimated due to the difference of bottom ash produced in each plant. And mortar strength was estimated as basic data to use bottom ash in building industries.