태권도 지도자들이 체육관 경영 시 고려하는 주요 요인 분석

조광민,이건희,김상유 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.3

Taekwondo which has adopted as a formula competitive games in 2004 Athens Olympic is establishing itself as world-widely recognized marshal arts, Taekwondo training centers which perform most of Taekwondo education, however, have been giving rise to many problems, Among others, reduction of the number of training peoples and limited an age group are the most serious ones. The purpose of this study was to help the Taekwondo trainers with solving various problems, such as facilities, trainer's quality, and training programs, and with consequently managing successful training center. It was abstracted by cluster random sampling method from Taekwondo Masters who work or operate Taekwondo Gym A questionnaire was sent to a Taekwondo Masters, Out of 300 copies, 196 copies were actually used in the practical analysis, Any copies with lost pages or insincere answers were excluded. For this study, SPSS 11.0 for Windows statistic package were used to analyzing collected samples, To analyze the data, frequency analysis, multiple responses, t-test, factor analysis, One-way ANOVA were conducted. And Scheffe method was used for the post analysis, investigating the propriety of the questionnaire, the factors analysis was executes by varimax after the professionals' review about the selecting Taekwondo Gym. As the result of the factor analysis, Factor 1 was named as the master's talent, Factor 2. as the accessive to the Taekwondo Gym and Factor 3 as the facility of Taekwondo Gym, And internal, external of Master, In the questionnaire of this study, reliability was used to verifying All Cronbach's a were over .700. As a conclusion, a diet program or a physical-training program need be developed forvarious groups of customers from the youth to the old, and training programs and in future study, marketing strategy for regional. needs should also be made.

저사이클 피로수명에 영향을 미치는 구상흑연주철의 흑연입자수의 영향

김민건,이병현,유병호 강원대학교 산업기술연구소 2000 産業技術硏究 Vol.20 No.B

Low cycle fatigue life of spheroidal graphite cast iron is determined by the morphological parameters of internal graphite. The aim of this study is to clarify the effect of the number of nodular grain of spheroidal graphite cast iron on low cycle fatigue life. Two specimens that have identical average nodular grain size by changing nodular grain volume fraction and different number of nodular grain count was tested. In this paper, the parameter governing fatigue life through fatigue test, the number of nodular grain seriously affect fatigue life and nodular grain size is no longer governing parameter of it.

마이크로홀 드릴링 머신의 개발 및 절삭성능 평가

김민건,유병호 한국공작기계학회 2001 한국생산제조학회지 Vol.10 No.5

In this paper, drill feed mechanism, cutting depth measuring device and sensing buzzer of drill contact were investigated in order to develop the micro-hole drilling machine. Also, measuring device of cutting resistance was developed in order to estimate cutting resistance from change of cutting condition. The results show that extremely-low feed rate(less then 17㎛/s) can be done and cutting depth can be measured by up to 1㎛ with develope drilling machine. Accordingly we could assemble a very cheap micro-hole drilling machine(ø0.05∼0.5mm). Also we got the some properties of cutting performance i.e. under the same condition, cutting torque decreases as increase of spindle speed and rapid feed of drill brings about the inferior cutting state under low spindle speed.

조혈모세포이식 환자에서 침습성 진균 감염에 대한 이트라코나졸 액과 플루코나졸 시럽의 예방 효과 : 전향적, 무작위, 비교 임상시험

최수미,이동건,최정현,박선희,엄기성,김유진,김희제,민창기,유진홍,김동욱,이종욱,민우성,신완식,김춘추 대한감염학회 2005 감염과 화학요법 Vol.37 No.2

목적 : 조혈모세포이식 환자에서 호중구 감소 기간 동안 이트라코나졸 액(ITZS)과 플루코나졸 시럽(FCZS)의 진균 감염에 대한 예방 효과를 전향적으로 비교해 보고자 하였다. 재료 및 방법 : 2001년 8월부터 2002년 6월까지 가톨릭 조혈모세포이식센터에 입원하여 동종 조혈모세포이식을 받은 만 18세 이상의 환자들을 각각 ITZS와 FCZS군으로 무작위 배정하여 침습성 진균 감염 발생과 약제 관련 부작용을 전향적으로 조사하였다. 결과 : ITZS군에 40명, FCZS군에 38명이 배정되었고, FCZS군 환자의 평균 나이가 더 많았다. 시험 약제 평균투여기간은 ITZS군 16.4일, FCZS군 21.9일로 ITZS군이 더 짧았다. 이는 ITZS군에서 소화기 부작용으로 인한 약제 중단이 더 많았기 때문으로 보인다. 시험 약제 투여 후 총 빌리루빈 수치의 유의한 증가가 관찰되었으나, 약제 관련 부작용은 모든 환자에서 가역적이었다. 호중구감소 기간동안 표재성 진균 감염은 두 군에서 모두 발생하지 않았고, 침습성 진균 감염은 ITZS군 5명(12.5%), FCZS군 8명(21.1%)으로 FCZS군에서 많았으나, 통계학적으로 유의하지 않았고, 사망률에도 유의한 차이는 없었다. 결론 : 침습성 진균 감염에 대한 이트라코나졸 액과플루코라졸 시럽의 예방 효과에 유의한 차이는 없었으나, 앞으로 더 많은 환자를 대상으로 잘 짝지어진 대조군 연구가 필요할 것으로 보인다. 부작용 중 간독성과 관련하여 이식시 투여되는 여러 약제들과의 상호작용에 대한 연구도 필요할 것이다. Background : Though fluconazole is widely used for antifungal prophylaxis, it is ineffective against mould infections including Aspergillus species. Itraconazole has a broader spectrum than fluconazole but the capsule form shows erratic bioavailability in neutropenic patients. In this study, we compared itraconazole oral solution (ITZS) with fluconazole syrup (FCZS) for the prevention of invasive fungal infection (IFI) in allogeneic hematopoietic stem cell transplant recipients. Materials and Methods : Adults receiving allogeneic hematopoietic stem cell transplantation (HSCT) from september 2001 to June 2002, were randomly allocated to either the ITZS group or the FCZS group. We prospectively evaluated the safety and efficacy of each drug. Results : Out of 78 patients (40 patients in the ITZS group and 38 patients in the FCZS group) who were eligible for this study, 37 patients completed the course of prophylaxis without any evidence of IFI. The mean duration of prophylaxis was 16.4 days for the ITZS group and 21.9 days for the FCZS group (P<0.006). Drug-related adverse events occurred in 28 patients (70.0%) and 19 patients (50.0%) in the ITZS group and the FCZS group, respectively. Common adverse events of ITZS were nausea, vomiting, and diarrhea. Drug-related reversible hepatotoxicity occurred in 4 patients in the ITZS group. There was a significant elevation of total bilirubin level in the ITZS group. The incidence of suspected IFI occurred in 5 patients (12.5%) who received ITZS, compared with 8 (21.1%) who received FCZS (P=0.372). There were no proven IFIs or superficial (oral/vaginal) fungal infections in both groups. Overall mortality was not different between the two groups (2.5% in the ITZS group versus 5.3% in the FCZS group, P=0.610). Conclusion : ITZS and FCZS showed similar protection against IFI during pre-engraftment period. Poor tolerability due to gastrointestinal troubles of ITZS might limit its success as prophylactic therapy. Well matched controlled study with large number of patients will be required in the future.

조혈모세포이식 환자에서 침습성 진균 감염에 대한 Micafungin의 예방 효과 및 안전성

김시현,이동건,최수미,권재철,박선희,최정현,유진홍,이성은,조병식,김유진,이석,김희제,민창기,조석구,김동욱,이종욱,민우성,박종원 대한감염학회 2010 감염과 화학요법 Vol.42 No.3

Background: Micafungin, a potent inhibitor of 1,3-β-D-glucan synthase, is a novel antifungal agent of the echinocandin class. In vitro study showed that micafungin was effective against Aspergillus species as well as Candida species, but clinical data on the prophylactic efficacy against invasive fungal infections (IFIs) other than candidiasis are still lacking. Materials and Methods: We identified 60 consecutive adult hematopoietic stem cell transplantation (HSCT) recipients who received at least 3 doses of micafungin during neutropenic period. Micafungin was started as an alternative in patients who were intolerant or had adverse events (AEs) to primary prophylactic antifungal agents. We retrospectively reviewed the medical records and analyzed the efficacy and safety of micafungin for prophylaxis against IFIs. Results: The patients either had autologous (n=9) or allogeneic (n=51: 1 syngeneic, 24 sibling, 26 unrelated donor) HSCT. Itraconazole oral solution (n=58) was the most frequently used first line antifungal agent for prophylaxis and was administered for median 11 days. The most frequent cause of switch to micafungin was vomiting (n=42). The duration of neutropenia and micafungin administration was median 13 and 12 days, respectively. A successful outcome was achieved in 45 (75%) patients. Empirical antifungal therapy was initiated in 13 (22%) patients. There were 2 cases (3.3%) of breakthrough fungal infections which comprised a probable invasive pulmonary aspergillosis and a possible invasive fungal sinusitis. There was no case of invasive candidiasis. A total of 53 (88%) patients experienced at least one AE regardless of causality during micafungin administration. The most frequent AEs were hypokalemia, vomiting, diarrhea, and elevated serum aspartate aminotransferase or alanine aminotransferase. Among the aforementioned AEs, only 1 case of diarrhea could be classified as a probable relation with micafungin when causality was assessed. There was no AEs that caused discontinuation of micafungin. Conclusions: Micafungin seems to be a safe and effective agent for prophylaxis of IFIs including aspergillosis as well as candidiasis in HSCT recipients. However, further large, prospective, and randomized comparative studies are warranted for aspergillosis.

조혈모세포이식 환자에서 발생한 Cytomegalovirus 질환의 특징 : 일개 대학변원에서 최근 10년간의 경험

최수미,이동건,박선희,김시현,김유진,민창기,김희제,이석,최정현,유진홍,김동욱,이종욱,민우성,신완식,김춘추 대한감염학회 2009 감염과 화학요법 Vol.41 No.1

Background : Studies on cytomegalovirus (CMV) diseases in Korean hematopoietic stem cell transplant (HSCT) recipients are lacking and do not reflect the recent trends of advances and changes. Therefore, we tried to analyze the clinical features of CMV diseases in HSCT recipients over the past 10 years at a tertiary university hospital in Korea. Methods : Retrospective review of medical records was done for all adult HSCT patients who received transplant at the Catholic HSCT Center from January 1998 to January 2008. Results : Forty-four cases (2.2%) of CMV diseases were identified. CMV pneumonia was diagnosed in 17 patients, retinitis in 16 patients, enterocolitis in 7 patients, esophagitis 1 patient, gastritis in 1 patient, duodenitis in 1 patient, and hepatitis in 1 patient. The median onset of symptom was 90 days after transplantation. Late CMV diseases accounted for 47.7%. CMV related death varied from 0 to 58.8% according to the involved organ. CMV retinitis was diagnosed relatively later in the course of transplantation mostly in patients who had chronic graft versus host disease (GVHD). On the contrary, CMV enterocolitis mainly occurred in patients who suffered from acute GVHD. The overall concurrent CMV reactivation was documented to be 63.6%: the concurrent CMV reactivation was observed only in 37.5% of patients with retinitis. Conclusions : We observed some differences in the pattern of CMV disease manifestation according to the involved organ and reconfirmed the fact that CMV pneumonia is the most common and fatal disease in HSCT recipients. Additionally, CMV retinitis was not uncommon in HSCT recipients. Since specific marker does not exist in predicting retinitis, regular ocular examination should be done thoroughly, especially in patients with chronic GVHD.

동종 조혈모세포이식 후 발생한 크립토콕쿠스 척추염 1예

고윤호,임동준,이성수,조유경,이동건,최정현,김유진,민창기,김동욱,박정미,김춘추,신완식 대한감염학회 2001 감염 Vol.33 No.4

Skeletal cryptococcosis is an uncommon infection. Cryptococcus is a common cause of meningitis and infects 7∼10% of patients with AIDS. As well as AIDS, the infection may be seen in association with leukemia, lymphoma, Hodgkin's disease, sarcoidosis, tuberculosis and diabetes, also in patients on steroid medication. But there is no case report of skeletal cryptococcosis following allogeneic hematopoietic stem cell transplantation. A 40-year-old woman was admitted to the hospital because of low back pain. She had chronic myelogenous leukemia for 2 years and underwent allogeneic hematopoietic stem cell transplantation 8 months ago. She have been treated with steroid and cyclosporine orally because of chronic graft versus host disease. On examination she was afebrile and had posterior lower lumbar tenderness. But, she had no reduced strength of low extremities. Open biopsy was underwent. Histology demonstrated budding, round-to-oval, refractile yeast-like organisms within debris. The results of a lumbar puncture were unremarkable and cerebrospinal fluid culture failed to grow bacteria and yeast. The patient was treated with amphotericin B (1 gram) and AmBisome□ (2.8 gram) over 6 weeks. Three months after cessation of therapy, the patient was doing well.(Korean J Infect Dis 33:298∼301, 2001)

FC 1-7 : Analysis of glucocorticoid-induced bone loss in Korean patients with dermatologic disease

( Min Gun Yoo ),( Ji Min Lee ),( Hee Won Jang ),( Hee Joo Kim ),( Il Hwan Kim ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2

Background: There are numerous adverse effects which are directly related to both the dose and duration of systemic corticosteroids treatment. One of the predictable and serious adverse effects is rapid bone loss with an increase in fracture risk. However, there have been not much clinical data on the relationship between corticosteroids and the development of osteoporosis in Korean dermatologic patients. Objectives: The purpose of our study was to analyze the clinical characteristics of 38 patients with steroid treatment and bone mineral density (BMD) test. Methods: Patient data from our institution from 2006 to 2013 were retrospectively reviewed. Thirty-eight patients with corticosteroids treatment who had been examined by BMD test were evaluated for their medication history and results of the BMD test. Results: Out of 38 patients, 25 patients with significant abnormal BMD (T score below -1.5) were evaluated. Of these, 15 patients had a history of long-term corticosteroid treatment in local clinic. As increasing the cumulative dose of corticosteroid, BMD showed a tendency to decrease. Conclusion: This study shows that corticosteroid-induced bone loss in Korean patients with dermatologic disease, particularly in cases of long-term use. It is important to bear in mind that corticosteroid-induced osteoporosis and to provide preventive and therapeutic options in the care of patients treated with corticosteroids.

제왕절개술시 Propofol 목표농도주입의 평가와 약동학적 변화

민상기,유은숙,김진수,길호영,원종진,한상건 대한정맥마취학회 2001 정맥마취 Vol.5 No.2

Background: Propofol has been used for the induction and maintenance agent of general anesthesia for cesarean section, but the pharmacokinetics of propofol will be different from in case of non-pregnancy. In order to evaluate the performance of computer-assisted continuous infusion (CACI) system and pharmacokinetic changes of propofol during cesarean section under general anesthesia, we measured the plasma concentrations of propofol, and compared those with the predicted plasma concentrations. Methods: Sixty pregnant women who received cesarean section under general anesthesia were studied. After the titration of adequate post-delivery target propofol concentration with bispectral index in twenty pregnant women, forty women were randomly assigned into the two different groups. In group I, after preoxygenation, anesthesia was induced with thiopental 4 ㎎/㎏ and succinylcholine 1 ㎎/㎏, and intubation was done. Vecuronium 0.1 ㎎/㎏ Ⅰ.Ⅴ. was administered for muscle relaxation, and mechanical ventilation was maintained with EtCO_2 between 30-35 ㎜Hg. Anesthesia was maintained with N_2O/O_2 (2:2 L/min) with enflurane before delivery, meanwhile, 3.5 ㎍/㎖ propofol target-controlled infusion (TCI) and 1.0 ng/㎖ fentanyl TCI with air/O_2 (2:2 L/min) were maintained after delivery. In group Ⅱ, anesthesia was induced with propofol (2.0 ㎎/㎏) and maintained with 3.5 ㎍/㎖ propofol TCI and air/O_2 (2:2 L/min), and after delivery the target concentration of propofol 5.0 ㎍/㎖ and 1.0 ng/㎖ fentanyl TCI were maintained. The bispectral index were monitored perioperatively. The plasma propofol concentrations were measured at 10 minute intervals and the predicted concentrations were evaluated with the performance errors (PE). Results: The target concentrations (Cp, 95% confidence interval) that could maintain 50% and 95% of patients hemodynamically stable with the bispectral index within 40 - 60 after delivery were 3.7 (3.20 - 3.92) ㎍/㎖ and 5.0 (4.67 - 5.74) ㎍/㎖ for propofol when it had been started since the induction of anesthesia. In group 1, the measured concentrations of propofol at 10 minute intervals after delivery were, 2.61 ± 0.74, 2.51 ± 0.60 and 2.23 ± 0.64 ㎍/㎖, and the median absolute performance errors (MAPE's) were 25.4%, 28.7% and 37.1% respectively. In group Ⅱ, the measured concentration at delivery was 1.94 ± 0.54 ㎍/㎖, and after delivery 2.38 ± 1.22, 2.11 ± 0.97 and 1.86 ± 1.04 ㎍/㎖ and the MAPE's were 39.1%, 52.8%, 60.2% and 63.0% respectively. The maximally increased bispectral index after the induction of anesthesia until delivery was significantly higher in group 1. Conclusions: It was concluded that CACI using the pharmacokinetic model of propofol for nonpregnancy could not provide the predicted target plasma concentrations with a sufficient accuracy in case of patients who received cesarean section under general anesthesia. But the measured propofol concentrations were enough to maintain an adequate sedation level for the cesarean section under general anesthesia with monitoring the bispectral index.

P433 : Malignant melanoma mimicking irritated seborrheic keratosis

( Min Gun Yoo ),( Jung Jin Shin ),( Jae Beom Park ),( Byoung Joon So ),( Il Hwan Kim ),( Soo Hong Seo ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.1